Clostridium difficile

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  Subject Areas on Research

  • A Randomized, Placebo-controlled Trial of Fidaxomicin for Prophylaxis of Clostridium difficile-associated Diarrhea in Adults Undergoing Hematopoietic Stem Cell Transplantation. 
  • A case-control study of community-associated Clostridium difficile infection: no role for proton pump inhibitors. 
  • A comparison between National Healthcare Safety Network laboratory-identified event reporting versus traditional surveillance for Clostridium difficile infection. 
  • A mathematical model to evaluate the routine use of fecal microbiota transplantation to prevent incident and recurrent Clostridium difficile infection. 
  • Alternative therapies for Clostridium difficile infections. 
  • Appendectomy and Clostridium difficile colitis: relationships revealed by clinical observations and immunology. 
  • Assessing the relative burden of hospital-acquired infections in a network of community hospitals. 
  • Assessment of Clostridium difficile-associated disease surveillance definitions, North Carolina, 2005. 
  • Association between NSAIDs and Clostridium difficile-Associated Diarrhea: A Systematic Review and Meta-Analysis. 
  • Association of Duration and Type of Surgical Prophylaxis With Antimicrobial-Associated Adverse Events. 
  • Busulfan and metronidazole: an often forgotten but significant drug interaction. 
  • Clostridial toxins: sensing a target in a hostile gut environment. 
  • Clostridium Difficile Infection from a Surgical Perspective. 
  • Clostridium difficile cure with fecal microbiota transplantation in a child with Pompe disease: a case report. 
  • Clostridium difficile infection among kidney transplant recipients: frequency, clinical presentation, and outcome. 
  • Clostridium difficile infection in obstetric and gynecologic patients. 
  • Clostridium difficile: a new look at an old but increasingly deadly infection. 
  • Community-associated Clostridium difficile infection: experience of a veteran affairs medical center in southeastern USA. 
  • Comparison of seven techniques for typing international epidemic strains of Clostridium difficile: restriction endonuclease analysis, pulsed-field gel electrophoresis, PCR-ribotyping, multilocus sequence typing, multilocus variable-number tandem-repeat analysis, amplified fragment length polymorphism, and surface layer protein A gene sequence typing. 
  • Comparison of the burdens of hospital-onset, healthcare facility-associated Clostridium difficile Infection and of healthcare-associated infection due to methicillin-resistant Staphylococcus aureus in community hospitals. 
  • Comparison of two rapid assays for Clostridium difficile Common antigen and a C difficile toxin A/B assay with the cell culture neutralization assay. 
  • Decontamination of targeted pathogens from patient rooms using an automated ultraviolet-C-emitting device. 
  • Defining surgical therapy for pseudomembranous colitis with toxic megacolon. 
  • Distal ventriculoperitoneal shunt failure secondary to Clostridium difficile colitis. 
  • Effectiveness of targeted enhanced terminal room disinfection on hospital-wide acquisition and infection with multidrug-resistant organisms and Clostridium difficile: a secondary analysis of a multicentre cluster randomised controlled trial with crossover design (BETR Disinfection). 
  • Efficacy and safety of fidaxomicin compared with oral vancomycin for the treatment of adults with Clostridium difficile-associated diarrhea: data from the OPT-80-003 and OPT-80-004 studies. 
  • Enhanced disinfection leads to reduction of microbial contamination and a decrease in patient colonization and infection. 
  • Enhanced terminal room disinfection and acquisition and infection caused by multidrug-resistant organisms and Clostridium difficile (the Benefits of Enhanced Terminal Room Disinfection study): a cluster-randomised, multicentre, crossover study. 
  • Evaluation of repeat Clostridium difficile enzyme immunoassay testing. 
  • Expert Consensus on Metrics to Assess the Impact of Patient-Level Antimicrobial Stewardship Interventions in Acute-Care Settings. 
  • Extrinsic surgical denervation inhibits Clostridium difficile toxin A-induced enteritis in rats. 
  • Fecal leukocytes in stool specimens submitted for Clostridium difficile toxin assay. 
  • Fidaxomicin for treatment of clostridium difficile-associated diarrhea and its potential role for prophylaxis. 
  • Fulminant Clostridium difficile enteritis causing abdominal compartment syndrome. 
  • Getting to a Man's Heart through His Colon. 
  • High-density microarray of small-subunit ribosomal DNA probes. 
  • Hospital ward antibiotic prescribing and the risks of Clostridium difficile infection. 
  • Hospital-acquired Clostridium difficile infections: estimating all-cause mortality and length of stay. 
  • Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins. 
  • Iatrogenic gastric acid suppression and the risk of nosocomial Clostridium difficile infection. 
  • Identification of novel risk factors for community-acquired Clostridium difficile infection using spatial statistics and geographic information system analyses. 
  • Identification of population at risk for future Clostridium difficile infection following hospital discharge to be targeted for vaccine trials. 
  • Impact of change to molecular testing for Clostridium difficile infection on healthcare facility-associated incidence rates. 
  • Impact of strain type on detection of toxigenic Clostridium difficile: comparison of molecular diagnostic and enzyme immunoassay approaches. 
  • Incidence of and risk factors for community-associated Clostridium difficile infection: a nested case-control study. 
  • Increased environmental sample area and recovery of Clostridium difficile spores from hospital surfaces by quantitative PCR and enrichment culture. 
  • Inhibition of Clostridium difficile toxin A-induced colitis in rats by APAZA. 
  • Multidisciplinary Approach to Clostridium difficile Infection in Adult Surgical Patients. 
  • Nosocomial infections within the first month of solid organ transplantation. 
  • Novel and emerging sources of Clostridioides difficile infection. 
  • Pain and palliative care pharmacotherapy literature summaries and analyses. 
  • Prevalence and predictors of C. difficile infections in hospitalized patients with major surgical procedures in the USA: Analysis using traditional and machine learning methods. 
  • Proposed checklist of hospital interventions to decrease the incidence of healthcare-associated Clostridium difficile infection. 
  • Recommendations for surveillance of Clostridium difficile-associated disease. 
  • Restoring the Microbiome in Critically Ill Patients: Are Probiotics Our True Friends When We Are Seriously Ill? 
  • Role of the environment in the transmission of Clostridium difficile in health care facilities. 
  • Severity of Clostridium difficile-associated diarrhea in solid organ transplant patients. 
  • Strategies to prevent clostridium difficile infections in acute care hospitals. 
  • Substance P activation of enteric neurons in response to intraluminal Clostridium difficile toxin A in the rat ileum. 
  • The capsaicin VR1 receptor mediates substance P release in toxin A-induced enteritis in rats. 
  • The microecology of Clostridium difficile. 
  • Thrombocytopenia in hospitalized patients with severe clostridium difficile infection. 
  • Using Clinical Scenarios to Understand Preventability of Clostridium difficile Infections by Inpatient Antibiotic Stewardship Programs. 
  • Vital signs: improving antibiotic use among hospitalized patients. 
  • Yield of stool culture with isolate toxin testing versus a two-step algorithm including stool toxin testing for detection of toxigenic Clostridium difficile.