Baculoviridae

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  Subject Areas on Research

  • 6-Azasteroids: potent dual inhibitors of human type 1 and 2 steroid 5 alpha-reductase. 
  • A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. 
  • Activation of four enzymes by two series of calmodulin mutants with point mutations in individual Ca2+ binding sites. 
  • Appearance of protease activities coincides with p10 and polyhedrin-driven protein production in the baculovirus expression system: effects on yield. 
  • Baculovirus-infected insect cells expressing peptide-MHC complexes elicit protective antitumor immunity. 
  • Biochemical characterization of the multifunctional Ca2+/calmodulin-dependent protein kinase type IV expressed in insect cells. 
  • Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation. 
  • Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-expressed recombinant desmogleins. 
  • Characterization of human Gadd45, a p53-regulated protein. 
  • Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. 
  • Design, expression, and immunogenicity of a soluble HIV trimeric envelope fragment adopting a prefusion gp41 configuration. 
  • Effects of herbal products and their constituents on human cytochrome P450(2E1) activity. 
  • Evidence for regulation of the human ABL tyrosine kinase by a cellular inhibitor. 
  • Evidence that direct binding of G beta gamma to the GIRK1 G protein-gated inwardly rectifying K+ channel is important for channel activation. 
  • Expression of catalytically active human multifunctional glycogen-debranching enzyme and lysosomal acid alpha-glucosidase in insect cells. 
  • Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex. 
  • Functional characterization of medaka CYP3A38 and CYP3A40: kinetics and catalysis by expression in a recombinant baculovirus system. 
  • High level expression of mammalian protein farnesyltransferase in a baculovirus system. The purified protein contains zinc. 
  • Human IL-1 beta processing and secretion in recombinant baculovirus-infected Sf9 cells is blocked by the cowpox virus serpin crmA. 
  • Human substance P receptor expressed in Sf9 cells couples with multiple endogenous G proteins. 
  • Identification of key amino acids responsible for the substantially higher affinities of human type 1 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD1) for substrates, coenzymes, and inhibitors relative to human 3beta-HSD2. 
  • Identification of the G protein-coupled receptor kinase phosphorylation sites in the human beta2-adrenergic receptor. 
  • Immunoaffinity purification of epitope-tagged human beta 2-adrenergic receptor to homogeneity. 
  • Immunogenicity of recombinant human immunodeficiency virus type 1-like particles expressing gp41 derivatives in a pre-fusion state. 
  • Induction of neutralizing antibodies and cytotoxic T lymphocytes in Balb/c mice immunized with virus-like particles presenting a gp120 molecule from a HIV-1 isolate of clade A. 
  • Interaction of NPR1 with basic leucine zipper protein transcription factors that bind sequences required for salicylic acid induction of the PR-1 gene. 
  • Isolation of protein prenyltransferases from bovine brain and baculovirus expression system. 
  • Mutational analysis of the autoinhibitory domain of calmodulin kinase II. 
  • Negative antagonists promote an inactive conformation of the beta 2-adrenergic receptor. 
  • Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family. 
  • Phosphorylation of Gz alpha by protein kinase C blocks interaction with the beta gamma complex. 
  • Protein kinase C beta II specifically binds to and is activated by F-actin. 
  • Purification and characterization of recombinant human mineralocorticoid receptor. 
  • Selective inhibition of kindling development by intraventricular administration of TrkB receptor body. 
  • T-antigen kinase inhibits simian virus 40 DNA replication by phosphorylation of intact T antigen on serines 120 and 123. 
  • The expression of a functional, secreted human lysyl hydroxylase in a baculovirus system. 
  • The higher affinity of human type 1 3beta-hydroxysteroid dehydrogenase (3beta-HSD1) for substrate and inhibitor steroids relative to human 3beta-HSD2 is validated in MCF-7 tumor cells and related to subunit interactions. 
  • The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2. 
  • VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation.