RNA, Antisense

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  Subject Areas on Research

  • A single stem-loop structure within the HTLV-1 Rex response element is sufficient to mediate Rex activity in vivo. 
  • Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. 
  • Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells. 
  • Caenorhabditis elegans beta-G spectrin is dispensable for establishment of epithelial polarity, but essential for muscular and neuronal function. 
  • Calmodulin is required for cell-cycle progression during G1 and mitosis. 
  • Decreased frequency and highly aberrant spectrum of ultraviolet-induced mutations in the hprt gene of mouse fibroblasts expressing antisense RNA to DNA polymerase zeta. 
  • Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase zeta. 
  • Experimental evidence for the secondary structure of the hepatitis delta virus ribozyme. 
  • Expression of chimeric tRNA-driven antisense transcripts renders NIH 3T3 cells highly resistant to Moloney murine leukemia virus replication. 
  • High-fidelity mRNA amplification for gene profiling. 
  • Identification of neural transcription factors required for the differentiation of three neuronal subtypes in the sea urchin embryo. 
  • Imprinted expression of the canine IGF2R, in the absence of an anti-sense transcript or promoter methylation. 
  • Infectious pathogen detection arrays: viral detection in cell lines and postmortem brain tissue. 
  • Integrated detection of natural antisense transcripts using strand-specific RNA sequencing data. 
  • Novel retrotransposed imprinted locus identified at human 6p25. 
  • Novel therapies for pancreatic adenocarcinoma. 
  • RNA interference: antiviral defense and genetic tool. 
  • Short-term kinetics of tumor antigen expression in response to vaccination. 
  • Submucosal glands are the predominant site of CFTR expression in the human bronchus. 
  • The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. 
  • Transfection of ovarian cancer cells with tumor necrosis factor-alpha (TNF-alpha) antisense mRNA abolishes the proliferative response to interleukin-1 (IL-1) but not TNF-alpha. 
  • Transforming growth factor-beta1 antisense treatment of rat vein grafts reduces the accumulation of collagen and increases the accumulation of h-caldesmon. 
  • Up-regulated P21CIP1 expression is part of the regulation quantitatively controlling serum deprivation-induced apoptosis. 
  • lambda RNA internal standards quantify sensitivity and amplification efficiency of mammalian gene expression profiling. 
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  Keywords of People

  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology