Brain Tissue Transplantation
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Subject Areas on Research
- A mechanism-based complementary screening approach for the amelioration and reversal of neurobehavioral teratogenicity.
- Clinical prospects for neural grafting therapy for hippocampal lesions and epilepsy.
- Development of fetal hippocampal grafts in intact and lesioned hippocampus.
- Development of long-distance efferent projections from fetal hippocampal grafts depends upon pathway specificity and graft location in kainate-lesioned adult hippocampus.
- Effect of levodopa priming on dopamine neuron transplant efficacy and induction of abnormal involuntary movements in parkinsonian rats.
- Enhanced cell survival in fetal hippocampal suspension transplants grafted to adult rat hippocampus following kainate lesions: a three-dimensional graft reconstruction study.
- Fetal hippocampal cells grafted to kainate-lesioned CA3 region of adult hippocampus suppress aberrant supragranular sprouting of host mossy fibers.
- Fetal hippocampal grafts containing CA3 cells restore host hippocampal glutamate decarboxylase-positive interneuron numbers in a rat model of temporal lobe epilepsy.
- Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian rats.
- Interneuron Transplantation Rescues Social Behavior Deficits without Restoring Wild-Type Physiology in a Mouse Model of Autism with Excessive Synaptic Inhibition.
- Neural grafting reverses prenatal drug-induced alterations in hippocampal PKC and related behavioral deficits.
- Neurite outgrowth from progeny of epidermal growth factor-responsive hippocampal stem cells is significantly less robust than from fetal hippocampal cells following grafting onto organotypic hippocampal slice cultures: effect of brain-derived neurotrophic factor.
- Pattern of long-distance projections from fetal hippocampal field CA3 and CA1 cell grafts in lesioned CA3 of adult hippocampus follows intrinsic character of respective donor cells.
- Prolonged postlesion transplantation delay adversely influences survival of both homotopic and heterotopic fetal hippocampal cell grafts in Kainate-lesioned CA3 region of adult hippocampus.
- Quantitative graft integration of fetal hippocampal transplants labeled with 5' bromodeoxyuridine into normal adult hippocampus.
- Scientific and ethical concerns in neural fetal tissue transplantation.
- Selective laser-activated lesioning of prelabeled fetal hippocampal grafts by intracellular photolytic chromophore.
- Survival of grafted fetal neural cells in kainic acid lesioned CA3 region of adult hippocampus depends upon cell specificity.
- Unintended changes in cognition, mood, and behavior arising from cell-based interventions for neurological conditions: ethical challenges.
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Keywords of People
- Turner, Dennis Alan, Professor of Neurosurgery, Biomedical Engineering