Islets of Langerhans Transplantation
-
Subject Areas on Research
-
A novel approach to xenotransplantation combining surface engineering and genetic modification of isolated adult porcine islets.
-
A novel monoclonal antibody to CD40 prolongs islet allograft survival.
-
A reliable method for isolation of viable porcine islet cells.
-
Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death.
-
Advancing islet transplantation: from engraftment to the immune response.
-
Alternative immunomodulatory strategies for xenotransplantation: CD40/154 pathway-sparing regimens promote xenograft survival.
-
Anti-TCR mAb induces peripheral tolerance to alloantigens and delays islet allograft rejection in autoimmune diabetic NOD mice.
-
Belatacept and sirolimus prolong nonhuman primate islet allograft survival: adverse consequences of concomitant alefacept therapy.
-
Brain death significantly reduces isolated pancreatic islet yields and functionality in vitro and in vivo after transplantation in rats.
-
CD40-specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates.
-
CTLA4Ig prevents alloantibody formation following nonhuman primate islet transplantation using the CD40-specific antibody 3A8.
-
Clinical significance of bacterial cultures from 28 autologous islet cell transplant solutions.
-
Cytoprotection of PEG-modified adult porcine pancreatic islets for improved xenotransplantation.
-
Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells.
-
Differential Role of B Cells and IL-17 Versus IFN-γ During Early and Late Rejection of Pig Islet Xenografts in Mice.
-
Double genetic modification of adenovirus fiber with RGD polylysine motifs significantly enhances gene transfer to isolated human pancreatic islets.
-
Dual islet transplantation modeling of the instant blood-mediated inflammatory reaction.
-
ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms.
-
Effect of intraportal human islet transplantation on kidney graft survival in simultaneous kidney-islet allografts.
-
Enhanced isolated pancreatic islet recovery and functionality in rats by 17beta-estradiol treatment of brain death donors.
-
Enhancing human islet transplantation by localized release of trophic factors from PLG scaffolds.
-
Experience with a novel efalizumab-based immunosuppressive regimen to facilitate single donor islet cell transplantation.
-
Factors associated with insulin and narcotic independence after islet autotransplantation in patients with severe chronic pancreatitis.
-
First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--Chapter 4: pre-clinical efficacy and complication data required to justify a clinical trial.
-
Frequency of kidney rejection in diabetic patients undergoing simultaneous kidney and pancreatic islet cell transplantation.
-
Gene therapy in transplantation.
-
Genetic engineering of a suboptimal islet graft with A20 preserves beta cell mass and function.
-
High-resolution, noninvasive longitudinal live imaging of immune responses.
-
Hyperexpression of Foxp3 and IDO during acute rejection of islet allografts.
-
IL-15 expanded CD8+CD122+ cells: when do they suppress?
-
Impaired proinsulin processing is a characteristic of transplanted islets.
-
Improved quality of life following total pancreatectomy and auto-islet transplantation for chronic pancreatitis.
-
Improvement in outcomes of clinical islet transplantation: 1999-2010.
-
Islet cell xenotransplantation: a serious look toward the clinic.
-
Islet xenotransplantation using gal-deficient neonatal donors improves engraftment and function.
-
Islet-like cell clusters: viability, cell types, and subretinal transplantation in pancreatectomized cats.
-
Islets for all?
-
LFA-1-specific therapy prolongs allograft survival in rhesus macaques.
-
LMP-420, a small molecular inhibitor of TNF-α, prolongs islet allograft survival by induction of suppressor of cytokine signaling-1: synergistic effect with cyclosporin-A.
-
Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154.
-
Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154.
-
Maintaining functional islets through encapsulation in an injectable saccharide-peptide hydrogel.
-
Mold-casted non-degradable, islet macro-encapsulating hydrogel devices for restoration of normoglycemia in diabetic mice.
-
Nanoparticle delivery of donor antigens for transplant tolerance in allogeneic islet transplantation.
-
National Institutes of Health-Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities.
-
Nondepleting anti-CD40-based therapy prolongs allograft survival in nonhuman primates.
-
Novel sphingosine-1-phosphate receptor modulator KRP203 combined with locally delivered regulatory T cells induces permanent acceptance of pancreatic islet allografts.
-
PLG scaffold delivered antigen-specific regulatory T cells induce systemic tolerance in autoimmune diabetes.
-
Pancreas transplantation for patients with diabetes mellitus. American Diabetes Association.
-
Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation.
-
Pancreatic islet transplantation using the nonhuman primate (rhesus) model predicts that the portal vein is superior to the celiac artery as the islet infusion site.
-
Peripheral mobilization of recipient bone marrow-derived endothelial progenitor cells enhances pancreatic islet revascularization and engraftment after intraportal transplantation.
-
Permanent protection of PLG scaffold transplanted allogeneic islet grafts in diabetic mice treated with ECDI-fixed donor splenocyte infusions.
-
Permanent survival of fully MHC-mismatched islet allografts by targeting a single chemokine receptor pathway.
-
Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia.
-
Porcine islets as an alternative to human islets for transplantation.
-
Preclinical evaluation of tolerance induction protocols and islet transplantation in non-human primates.
-
Preemptive Tolerogenic Delivery of Donor Antigens for Permanent Allogeneic Islet Graft Protection.
-
Prevention of autoimmune islet allograft destruction by engraftment of donor T cells.
-
Rabbit antithymocyte globulin induction and sirolimus monotherapy supports prolonged islet allograft function in a nonhuman primate islet transplantation model.
-
Rapamycin-conditioned donor dendritic cells differentiate CD4CD25Foxp3 T cells in vitro with TGF-beta1 for islet transplantation.
-
Simultaneous pancreas-kidney transplantation at University of Wisconsin-Madison Hospital.
-
Solitary pancreas transplantation. Experience with 62 consecutive cases.
-
Suppression of beta cell energy metabolism and insulin release by PGC-1alpha.
-
Suppression of the c-Jun N-terminal kinase pathway by 17beta-estradiol can preserve human islet functional mass from proinflammatory cytokine-induced destruction.
-
Survival of allografted pancreatic islets in the subretinal space in rats.
-
Survival of subretinal pancreatic islet cell allografts and apoptosis in infiltrating lymphocytes in rats.
-
Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic mice.
-
THERAPY OF ENDOCRINE DISEASE: Islet transplantation for type 1 diabetes: so close and yet so far away.
-
The anterior chamber of the eye as a clinical transplantation site for the treatment of diabetes: a study in a baboon model of diabetes.
-
The contribution of Fc effector mechanisms in the efficacy of anti-CD154 immunotherapy depends on the nature of the immune challenge
-
Total pancreatectomy and autologous islet cell transplantation as a means to treat severe chronic pancreatitis.
-
Transient B-cell depletion combined with apoptotic donor splenocytes induces xeno-specific T- and B-cell tolerance to islet xenografts.
-
Transplantation of feline islets of Langerhans in the subretinal space of cat eyes.
-
What's new--what's hot in basic science: American Transplant Congress 2004.
-
Keywords of People