Islets of Langerhans Transplantation
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Subject Areas on Research
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A novel approach to xenotransplantation combining surface engineering and genetic modification of isolated adult porcine islets.
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A novel monoclonal antibody to CD40 prolongs islet allograft survival.
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A reliable method for isolation of viable porcine islet cells.
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Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death.
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Advancing islet transplantation: from engraftment to the immune response.
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Alternative immunomodulatory strategies for xenotransplantation: CD40/154 pathway-sparing regimens promote xenograft survival.
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Anti-TCR mAb induces peripheral tolerance to alloantigens and delays islet allograft rejection in autoimmune diabetic NOD mice.
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Belatacept and sirolimus prolong nonhuman primate islet allograft survival: adverse consequences of concomitant alefacept therapy.
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Brain death significantly reduces isolated pancreatic islet yields and functionality in vitro and in vivo after transplantation in rats.
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CD40-specific costimulation blockade enhances neonatal porcine islet survival in nonhuman primates.
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CTLA4Ig prevents alloantibody formation following nonhuman primate islet transplantation using the CD40-specific antibody 3A8.
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Clinical significance of bacterial cultures from 28 autologous islet cell transplant solutions.
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Cytoprotection of PEG-modified adult porcine pancreatic islets for improved xenotransplantation.
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Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells.
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Differential Role of B Cells and IL-17 Versus IFN-γ During Early and Late Rejection of Pig Islet Xenografts in Mice.
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Double genetic modification of adenovirus fiber with RGD polylysine motifs significantly enhances gene transfer to isolated human pancreatic islets.
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Dual islet transplantation modeling of the instant blood-mediated inflammatory reaction.
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ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms.
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Early barriers to neonatal porcine islet engraftment in a dual transplant model.
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Effect of intraportal human islet transplantation on kidney graft survival in simultaneous kidney-islet allografts.
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Enhanced isolated pancreatic islet recovery and functionality in rats by 17beta-estradiol treatment of brain death donors.
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Enhancing human islet transplantation by localized release of trophic factors from PLG scaffolds.
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Experience with a novel efalizumab-based immunosuppressive regimen to facilitate single donor islet cell transplantation.
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Factors associated with insulin and narcotic independence after islet autotransplantation in patients with severe chronic pancreatitis.
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First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--Chapter 4: pre-clinical efficacy and complication data required to justify a clinical trial.
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Frequency of kidney rejection in diabetic patients undergoing simultaneous kidney and pancreatic islet cell transplantation.
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Gene therapy in transplantation.
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Genetic engineering of a suboptimal islet graft with A20 preserves beta cell mass and function.
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High-resolution, noninvasive longitudinal live imaging of immune responses.
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Hyperexpression of Foxp3 and IDO during acute rejection of islet allografts.
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IL-15 expanded CD8+CD122+ cells: when do they suppress?
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Impaired proinsulin processing is a characteristic of transplanted islets.
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Improved quality of life following total pancreatectomy and auto-islet transplantation for chronic pancreatitis.
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Improvement in outcomes of clinical islet transplantation: 1999-2010.
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Islet cell xenotransplantation: a serious look toward the clinic.
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Islet xenotransplantation using gal-deficient neonatal donors improves engraftment and function.
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Islet-like cell clusters: viability, cell types, and subretinal transplantation in pancreatectomized cats.
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Islets for all?
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LFA-1-specific therapy prolongs allograft survival in rhesus macaques.
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LMP-420, a small molecular inhibitor of TNF-α, prolongs islet allograft survival by induction of suppressor of cytokine signaling-1: synergistic effect with cyclosporin-A.
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Long-term survival and function of intrahepatic islet allografts in baboons treated with humanized anti-CD154.
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Long-term survival and function of intrahepatic islet allografts in rhesus monkeys treated with humanized anti-CD154.
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Long-term tolerance of islet allografts in nonhuman primates induced by apoptotic donor leukocytes.
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Mold-casted non-degradable, islet macro-encapsulating hydrogel devices for restoration of normoglycemia in diabetic mice.
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Nanoparticle delivery of donor antigens for transplant tolerance in allogeneic islet transplantation.
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National Institutes of Health-Sponsored Clinical Islet Transplantation Consortium Phase 3 Trial: Manufacture of a Complex Cellular Product at Eight Processing Facilities.
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Nondepleting anti-CD40-based therapy prolongs allograft survival in nonhuman primates.
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Novel sphingosine-1-phosphate receptor modulator KRP203 combined with locally delivered regulatory T cells induces permanent acceptance of pancreatic islet allografts.
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Operational immune tolerance towards transplanted allogeneic pancreatic islets in mice and a non-human primate.
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PLG scaffold delivered antigen-specific regulatory T cells induce systemic tolerance in autoimmune diabetes.
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Pancreas transplantation for patients with diabetes mellitus. American Diabetes Association.
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Pancreatic islet cell therapy for type I diabetes: understanding the effects of glucose stimulation on islets in order to produce better islets for transplantation.
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Pancreatic islet transplantation using the nonhuman primate (rhesus) model predicts that the portal vein is superior to the celiac artery as the islet infusion site.
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Peripheral mobilization of recipient bone marrow-derived endothelial progenitor cells enhances pancreatic islet revascularization and engraftment after intraportal transplantation.
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Permanent protection of PLG scaffold transplanted allogeneic islet grafts in diabetic mice treated with ECDI-fixed donor splenocyte infusions.
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Permanent survival of fully MHC-mismatched islet allografts by targeting a single chemokine receptor pathway.
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Phase 3 Trial of Transplantation of Human Islets in Type 1 Diabetes Complicated by Severe Hypoglycemia.
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Porcine islets as an alternative to human islets for transplantation.
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Preclinical evaluation of tolerance induction protocols and islet transplantation in non-human primates.
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Preemptive Tolerogenic Delivery of Donor Antigens for Permanent Allogeneic Islet Graft Protection.
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Prevention of autoimmune islet allograft destruction by engraftment of donor T cells.
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Rabbit antithymocyte globulin induction and sirolimus monotherapy supports prolonged islet allograft function in a nonhuman primate islet transplantation model.
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Rapamycin-conditioned donor dendritic cells differentiate CD4CD25Foxp3 T cells in vitro with TGF-beta1 for islet transplantation.
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Receptor tyrosine kinase MerTK suppresses an allogenic type I IFN response to promote transplant tolerance.
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Simultaneous pancreas-kidney transplantation at University of Wisconsin-Madison Hospital.
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Solitary pancreas transplantation. Experience with 62 consecutive cases.
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Suppression of beta cell energy metabolism and insulin release by PGC-1alpha.
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Suppression of the c-Jun N-terminal kinase pathway by 17beta-estradiol can preserve human islet functional mass from proinflammatory cytokine-induced destruction.
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Survival of allografted pancreatic islets in the subretinal space in rats.
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Survival of subretinal pancreatic islet cell allografts and apoptosis in infiltrating lymphocytes in rats.
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Systemic transforming growth factor-beta1 gene therapy induces Foxp3+ regulatory cells, restores self-tolerance, and facilitates regeneration of beta cell function in overtly diabetic nonobese diabetic mice.
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THERAPY OF ENDOCRINE DISEASE: Islet transplantation for type 1 diabetes: so close and yet so far away.
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The anterior chamber of the eye as a clinical transplantation site for the treatment of diabetes: a study in a baboon model of diabetes.
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The contribution of Fc effector mechanisms in the efficacy of anti-CD154 immunotherapy depends on the nature of the immune challenge.
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The role of human CD46 in early xenoislet engraftment in a dual transplant model.
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Tolerance of Vascularized Islet-Kidney Transplants in Rhesus Monkeys.
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Total pancreatectomy and autologous islet cell transplantation as a means to treat severe chronic pancreatitis.
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Transient B-cell depletion combined with apoptotic donor splenocytes induces xeno-specific T- and B-cell tolerance to islet xenografts.
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Transplantation of feline islets of Langerhans in the subretinal space of cat eyes.
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What's new--what's hot in basic science: American Transplant Congress 2004.
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Keywords of People