Sequence Alignment

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  Subject Areas on Research

  • 1,2-Diacylglycerol choline phosphotransferase catalyzes the final step in the unique Treponema denticola phosphatidylcholine biosynthesis pathway. 
  • 14-3-3 proteins are part of an abscisic acid-VIVIPAROUS1 (VP1) response complex in the Em promoter and interact with VP1 and EmBP1. 
  • 29 mammalian genomes reveal novel exaptations of mobile elements for likely regulatory functions in the human genome. 
  • A BMP pathway regulates cell fate allocation along the sea urchin animal-vegetal embryonic axis. 
  • A Bayesian network approach to operon prediction. 
  • A Hausdorff-based NOE assignment algorithm using protein backbone determined from residual dipolar couplings and rotamer patterns. 
  • A bistable circuit involving SCARECROW-RETINOBLASTOMA integrates cues to inform asymmetric stem cell division. 
  • A catalog of neutral and deleterious polymorphism in yeast. 
  • A comprehensive structure-function analysis of Arabidopsis SNI1 defines essential regions and transcriptional repressor activity. 
  • A computational analysis of antisense off-targets in prokaryotic organisms. 
  • A conserved acidic patch in the Myb domain is required for activation of an endogenous target gene and for chromatin binding. 
  • A conserved amino acid sequence directing intracellular type III secretion by Salmonella typhimurium. 
  • A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors. 
  • A conserved family of enzymes that phosphorylate inositol hexakisphosphate. 
  • A critical role of STAYGREEN/Mendel's I locus in controlling disease symptom development during Pseudomonas syringae pv tomato infection of Arabidopsis. 
  • A defect in myoblast fusion underlies Carey-Fineman-Ziter syndrome. 
  • A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch. 
  • A flexible statistical model for alignment of label-free proteomics data--incorporating ion mobility and product ion information. 
  • A glucan synthase FKS1 homolog in cryptococcus neoformans is single copy and encodes an essential function. 
  • A high-resolution map of human evolutionary constraint using 29 mammals. 
  • A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10). 
  • A model for alignment of Env V1 and V2 hypervariable domains from human and simian immunodeficiency viruses. 
  • A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief. 
  • A multi-locus molecular phylogeny of the Lepidoziaceae: laying the foundations for a stable classification. 
  • A multigene phylogenetic synthesis for the class Lecanoromycetes (Ascomycota): 1307 fungi representing 1139 infrageneric taxa, 317 genera and 66 families. 
  • A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage. 
  • A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development. 
  • A phylogeny of Adelanthaceae (Jungermanniales, Marchantiophyta) based on nuclear and chloroplast DNA markers, with comments on classification, cryptic speciation and biogeography. 
  • A physical map of the mouse genome. 
  • A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. 
  • A recent outbreak of human immunodeficiency virus type 1 infection in southern China was initiated by two highly homogeneous, geographically separated strains, circulating recombinant form AE and a novel BC recombinant. 
  • A single amino acid defines cross-species reactivity of tree shrew (Tupaia belangeri) CD1d to human invariant natural killer T (iNKT) cells. 
  • A single transcription factor regulates evolutionarily diverse but functionally linked metabolic pathways in response to nutrient availability. 
  • A stochastic evolutionary model for protein structure alignment and phylogeny. 
  • A third distinct tumor necrosis factor receptor of orthopoxviruses. 
  • A variant of the LRP4 gene affects the risk of chronic lymphocytic leukaemia transformation to Richter syndrome. 
  • A whole-genome analysis of premature termination codons. 
  • A yeast cyclophilin gene essential for lactate metabolism at high temperature. 
  • ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase. 
  • Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains. 
  • Alignment of 1000 Genomes Project reads to reference assembly GRCh38. 
  • Allelic and locus heterogeneity in inherited venous malformations. 
  • Allelic diversity and gene genealogy at the self-incompatibility locus in the Solanaceae. 
  • Alterations of the X-linked lymphoproliferative disease gene SH2D1A in common variable immunodeficiency syndrome. 
  • Alternative splicing of an insect sodium channel gene generates pharmacologically distinct sodium channels. 
  • An active site tyrosine influences the ability of the dimethyl sulfoxide reductase family of molybdopterin enzymes to reduce S-oxides. 
  • An alanine in segment 3 of domain III (IIIS3) of the cockroach sodium channel contributes to the low pyrethroid sensitivity of an alternative splice variant. 
  • An alignment-free method to identify candidate orthologous enhancers in multiple Drosophila genomes. 
  • An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan. 
  • An enzyme that inactivates the inflammatory mediator leukotriene b4 restricts mycobacterial infection. 
  • An epilepsy/dyskinesia-associated mutation enhances BK channel activation by potentiating Ca2+ sensing. 
  • Ancient DNA from giant extinct lemurs confirms single origin of Malagasy primates. 
  • Ancient and recent positive selection transformed opioid cis-regulation in humans. 
  • AnkB, a periplasmic ankyrin-like protein in Pseudomonas aeruginosa, is required for optimal catalase B (KatB) activity and resistance to hydrogen peroxide. 
  • Ankyrin binding activity shared by the neurofascin/L1/NrCAM family of nervous system cell adhesion molecules. 
  • AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier. 
  • Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germline. 
  • Antigenicity and immunogenicity of HIV-1 consensus subtype B envelope glycoproteins. 
  • Aquaporin in Candida: characterization of a functional water channel protein. 
  • Aquaporins in Saccharomyces: Characterization of a second functional water channel protein. 
  • Arthropod relationships revealed by phylogenomic analysis of nuclear protein-coding sequences. 
  • Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis. 
  • Assessment of the Clinical Relevance of BRCA2 Missense Variants by Functional and Computational Approaches. 
  • Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder. 
  • Binding site on human immunoglobulin G for the affinity ligand HWRGWV. 
  • Biochemical and functional characterization of inositol 1,3,4,5, 6-pentakisphosphate 2-kinases. 
  • Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis. 
  • Biological, molecular, and structural analysis of a cytopathic variant from a molecularly cloned simian immunodeficiency virus. 
  • Boron-containing aptamers to ATP. 
  • C-terminal regions of the human telomerase catalytic subunit essential for in vivo enzyme activity. 
  • CARHSP1 is required for effective tumor necrosis factor alpha mRNA stabilization and localizes to processing bodies and exosomes. 
  • CNS1 encodes an essential p60/Sti1 homolog in Saccharomyces cerevisiae that suppresses cyclophilin 40 mutations and interacts with Hsp90. 
  • Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus. 
  • Calcium binding is required for calmodulin function in Aspergillus nidulans. 
  • Capitalizing on the complexities of estrogen receptor pharmacology in the quest for the perfect SERM. 
  • Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation. 
  • Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers. 
  • Cch1 mediates calcium entry in Cryptococcus neoformans and is essential in low-calcium environments. 
  • Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene. 
  • Changes in the pattern of adherens junction-associated beta-catenin accompany morphogenesis in the sea urchin embryo. 
  • Characterization and expression of a rice RAD23 gene. 
  • Characterization of COMMD protein-protein interactions in NF-kappaB signalling. 
  • Characterization of RanBP2-associated molecular components in neuroretina. 
  • Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies. 
  • Characterization of a selective inhibitor of inositol hexakisphosphate kinases: use in defining biological roles and metabolic relationships of inositol pyrophosphates. 
  • Characterization of a trimeric MPER containing HIV-1 gp41 antigen. 
  • Characterization of an iron-sulfur cluster assembly protein (ISU1) from Schizosaccharomyces pombe. 
  • Characterization of glycosylation profiles of HIV-1 transmitted/founder envelopes by mass spectrometry. 
  • Characterization of substrate phosphorylation and use of calmodulin mutants to address implications from the enzyme crystal structure of calmodulin-dependent protein kinase I. 
  • Characterization of the DNA- and metal-binding properties of Vibrio anguillarum fur reveals conservation of a structural Zn(2+) ion. 
  • Characterization of the interleukin 1 receptor-associated kinase 4 (IRAK4)-encoding gene in salmonid fish: the functional copy is rearranged in Oncorhynchus mykiss and that factor can impair TLR signaling in mammalian cells. 
  • Characterization of the rRNA genes of Ehrlichia chaffeensis and Anaplasma phagocytophila. 
  • Characterization of the role of cadherin in regulating cell adhesion during sea urchin development. 
  • Characterization of turkey inducible nitric oxide synthase and identification of its expression in the intestinal epithelium following astrovirus infection. 
  • Chemical modification and site-directed mutagenesis of conserved HXXH and PP-loop motif arginines and histidines in the murine bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase. 
  • Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. 
  • Class-level relationships in the phylum Cnidaria: molecular and morphological evidence. 
  • Cloning and characterization of PDE7B, a cAMP-specific phosphodiesterase. 
  • Cloning and characterization of SLP3: a novel member of the stomatin family expressed by olfactory receptor neurons. 
  • Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei. 
  • Cloning and characterization of a mammalian prenyl protein-specific protease. 
  • Cloning and characterization of two yeast genes encoding members of the CCCH class of zinc finger proteins: zinc finger-mediated impairment of cell growth. 
  • Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. 
  • Cloning of rat thymic stromal lymphopoietin receptor (TSLPR) and characterization of genomic structure of murine Tslpr gene. 
  • Cloning of zebrafish vsx1: expression of a paired-like homeobox gene during CNS development. 
  • Cloning, sequencing, and recombinant expression of the porcine inhibitor of carbonic anhydrase: a novel member of the transferrin family. 
  • Coarse and reliable geometric alignment for protein docking. 
  • Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1. 
  • Combining expression and comparative evolutionary analysis. The COBRA gene family. 
  • Compact organization of rRNA genes in the filamentous fungus Ashbya gossypii. 
  • Comparative analysis of the zeta-crystallin/quinone reductase gene in guinea pig and mouse. 
  • Comparative genomics based on massive parallel transcriptome sequencing reveals patterns of substitution and selection across 10 bird species. 
  • Comparison of likelihood and Bayesian methods for estimating divergence times using multiple gene Loci and calibration points, with application to a radiation of cute-looking mouse lemur species. 
  • Comparison of viral Env proteins from acute and chronic infections with subtype C human immunodeficiency virus type 1 identifies differences in glycosylation and CCR5 utilization and suggests a new strategy for immunogen design. 
  • Complex determinants in human immunodeficiency virus type 1 envelope gp120 mediate CXCR4-dependent infection of macrophages. 
  • Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. 
  • Comprehensive desmosome mutation analysis in north americans with arrhythmogenic right ventricular dysplasia/cardiomyopathy. 
  • Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope. 
  • Conservation of Y-linked genes during human evolution revealed by comparative sequencing in chimpanzee. 
  • Conserved cryptic recombination signals in Vkappa gene segments are cleaved in small pre-B cells. 
  • Construction of a fluorescent biosensor family. 
  • Contamination with E1A-positive wild-type adenovirus accounts for species-specific stimulation of islet cell proliferation by CCK: a cautionary note. 
  • Convergent evolution of escape from hepaciviral antagonism in primates. 
  • Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies. 
  • Cowpox virus encodes a fifth member of the tumor necrosis factor receptor family: a soluble, secreted CD30 homologue. 
  • Crk is required for apoptosis in Xenopus egg extracts. 
  • Crucial role of copper in detection of metal-coordinating odorants. 
  • Crystal structure of HPr kinase/phosphatase from Mycoplasma pneumoniae. 
  • Crystal structure of a pol alpha family DNA polymerase from the hyperthermophilic archaeon Thermococcus sp. 9 degrees N-7. 
  • Crystal structure of an activated response regulator bound to its target. 
  • Crystal structure of molybdopterin synthase and its evolutionary relationship to ubiquitin activation. 
  • Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution. 
  • Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin. 
  • Crystal structures of T. brucei MRP1/MRP2 guide-RNA binding complex reveal RNA matchmaking mechanism. 
  • Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding. 
  • Crystal structures of adenine phosphoribosyltransferase from Leishmania donovani. 
  • Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus. 
  • Crystal structures of the membrane-binding C2 domain of human coagulation factor V. 
  • Cysteine-rich regions of pig gastric mucin contain von willebrand factor and cystine knot domains at the carboxyl terminal(1). 
  • De novo assembly using low-coverage short read sequence data from the rice pathogen Pseudomonas syringae pv. oryzae. 
  • Deep divergence and rapid evolutionary rates in gut-associated Acetobacteraceae of ants. 
  • Defining an antigenic epitope on platelet factor 4 associated with heparin-induced thrombocytopenia. 
  • Defining fibronectin's cell adhesion synergy site by site-directed mutagenesis. 
  • Deletion of azoospermia factor a (AZFa) region of human Y chromosome caused by recombination between HERV15 proviruses. 
  • Design and characterization of a peptide mimotope of the HIV-1 gp120 bridging sheet. 
  • Designing an extracellular matrix protein with enhanced mechanical stability. 
  • DictyBase 2013: integrating multiple Dictyostelid species. 
  • Different mechanisms preclude mutant CLDN14 proteins from forming tight junctions in vitro. 
  • Different routes to the same ending: comparing the N-glycosylation processes of Haloferax volcanii and Haloarcula marismortui, two halophilic archaea from the Dead Sea. 
  • Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents. 
  • Differential activation of nitric-oxide synthase isozymes by calmodulin-troponin C chimeras. 
  • Differential induction of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase genes in Arabidopsis thaliana by wounding and pathogenic attack. 
  • Differential molecular mechanism of the estrogen action that regulates lactoferrin gene in human and mouse. 
  • Disentangling the Collema-Leptogium complex through a molecular phylogenetic study of the Collemataceae (Peltigerales, lichen-forming Ascomycota). 
  • Distinct functional properties of sodium channel variants are associated with usage of alternative exons in Nilaparvata lugens. 
  • Distinct functions of two isoforms of a homeobox gene, BP1 and DLX7, in the regulation of the beta-globin gene. 
  • Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis. 
  • Disulfide bond requirements for active Wnt ligands. 
  • Domain-oriented edge-based alignment of protein interaction networks. 
  • Dramatic mitochondrial gene rearrangements in the hermit crab Pagurus longicarpus (Crustacea, anomura). 
  • Drosophila as a model for epilepsy: bss is a gain-of-function mutation in the para sodium channel gene that leads to seizures. 
  • Drosophila stretchin-MLCK is a novel member of the Titin/Myosin light chain kinase family. 
  • Drosophila topo IIIalpha is required for the maintenance of mitochondrial genome and male germ-line stem cells. 
  • Dynamic DNA methylation across diverse human cell lines and tissues. 
  • Early elicitor induction in members of a novel multigene family coding for highly related RING-H2 proteins in Arabidopsis thaliana 
  • Emergence of SARS-CoV-2 through recombination and strong purifying selection. 
  • Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta. 
  • Evaluation of Lipin 2 as a candidate gene for autosomal dominant 1 high-grade myopia. 
  • Evaluation of envelope vaccines derived from the South African subtype C human immunodeficiency virus type 1 TV1 strain. 
  • Evidence for Dual Binding Sites for 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) in Insect Sodium Channels. 
  • Evidence for sexuality in the opportunistic fungal pathogen Aspergillus fumigatus. 
  • Evolution and diversity in human herpes simplex virus genomes. 
  • Evolution of genes and genomes on the Drosophila phylogeny. 
  • Evolution of the 12 kDa FK506-binding protein gene. 
  • Exome sequencing followed by large-scale genotyping fails to identify single rare variants of large effect in idiopathic generalized epilepsy. 
  • Exome sequencing followed by large-scale genotyping suggests a limited role for moderately rare risk factors of strong effect in schizophrenia. 
  • Expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam. 
  • Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase. 
  • Expression, purification and primary crystallographic study of human androgen receptor in complex with DNA and coactivator motifs. 
  • Extended ORF8 Gene Region Is Valuable in the Epidemiological Investigation of Severe Acute Respiratory Syndrome-Similar Coronavirus. 
  • Extending assembly of short DNA sequences to handle error. 
  • FOXP2 variation in great ape populations offers insight into the evolution of communication skills. 
  • Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes. 
  • Faster algorithms for optimal multiple sequence alignment based on pairwise comparisons. 
  • Finding regulatory DNA motifs using alignment-free evolutionary conservation information. 
  • Folding mechanism of a multiple independently-folding domain protein: double B domain of protein A. 
  • FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. 
  • Functional analysis of Wingless reveals a link between intercellular ligand transport and dorsal-cell-specific signaling. 
  • Fungal and algal gene expression in early developmental stages of lichen-symbiosis. 
  • GenBlastA: enabling BLAST to identify homologous gene sequences. 
  • Gene prediction and verification in a compact genome with numerous small introns. 
  • Genetic comparisons yield insight into the evolution of enamel thickness during human evolution. 
  • Genetic control of cuticle formation during embryonic development of Drosophila melanogaster. 
  • Genetic signatures in the envelope glycoproteins of HIV-1 that associate with broadly neutralizing antibodies. 
  • Genetic structure and genealogy in the Sphagnum subsecundum complex (Sphagnaceae: Bryophyta). 
  • Genetic variant rs16430 6bp > 0bp at the microRNA-binding site in TYMS and risk of sporadic breast cancer risk in non-Hispanic white women aged ≤ 55 years. 
  • Genetic variation in the 3' non-coding region of dengue viruses. 
  • Genetic variation in yellow fever virus: duplication in the 3' noncoding region of strains from Africa. 
  • Genome-wide survey and expression analysis of the OSCA gene family in rice. 
  • Genomics and expression profiles of the Hedgehog and Notch signaling pathways in sea urchin development. 
  • Getting more from less: algorithms for rapid protein identification with multiple short peptide sequences. 
  • Global panel of HIV-1 Env reference strains for standardized assessments of vaccine-elicited neutralizing antibodies. 
  • Glycosylation site-specific analysis of clade C HIV-1 envelope proteins. 
  • Guinea pig and bovine zeta-crystallins have distinct functional characteristics highlighting replacements in otherwise similar structures. 
  • HDAC6 is required for epidermal growth factor-induced beta-catenin nuclear localization. 
  • HIN-1, a putative cytokine highly expressed in normal but not cancerous mammary epithelial cells. 
  • HIV-1 gp140 epitope recognition is influenced by immunoglobulin DH gene segment sequence. 
  • Has the chimpanzee Y chromosome been sequenced? 
  • Heterotropic modulation of selectin affinity by allosteric antibodies affects leukocyte rolling. 
  • High titer HIV-1 V3-specific antibodies with broad reactivity but low neutralizing potency in acute infection and following vaccination. 
  • High-affinity interaction of poly(ADP-ribose) and the human DEK oncoprotein depends upon chain length. 
  • Highly complex neutralization determinants on a monophyletic lineage of newly transmitted subtype C HIV-1 Env clones from India. 
  • History and evolution of alpine plants endemic to the Qinghai-Tibetan Plateau: Aconitum gymnandrum (Ranunculaceae). 
  • Homologs of the vancomycin resistance D-Ala-D-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function. 
  • Horsetails and ferns are a monophyletic group and the closest living relatives to seed plants. 
  • Human GFRA1: cloning, mapping, genomic structure, and evaluation as a candidate gene for Hirschsprung disease susceptibility. 
  • Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression. 
  • Human nonsyndromic hereditary deafness DFNA17 is due to a mutation in nonmuscle myosin MYH9. 
  • IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria. 
  • Identification and cloning of a negative regulator of systemic acquired resistance, SNI1, through a screen for suppressors of npr1-1 
  • Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans. 
  • Identification and characterization of two Ca2+/CaM-dependent protein kinases required for normal nuclear division in Aspergillus nidulans. 
  • Identification and characterization of upstream open reading frames (uORF) in the 5' untranslated regions (UTR) of genes in Saccharomyces cerevisiae. 
  • Identification and mapping of type 1 neurofibromatosis (NF1) homologous loci. 
  • Identification of ENV determinants in V3 that influence the molecular anatomy of CCR5 utilization. 
  • Identification of a fetal exon in the human fast troponin T gene. 
  • Identification of a glycosaminoglycan-binding site in chemokine macrophage inflammatory protein-1alpha. 
  • Identification of a homogentisate-1,2-dioxygenase gene in the fungus Exophiala lecanii-corni: analysis and implications. 
  • Identification of a negative regulatory element involved in tissue-specific expression of mouse renin genes. 
  • Identification of a novel GTPase, the inducibly expressed GTPase, that accumulates in response to interferon gamma. 
  • Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction. 
  • Identification of a region of genetic variability among Bacillus anthracis strains and related species. 
  • Identification of additional members of human G-protein-coupled receptor kinase multigene family. 
  • Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate. 
  • Identification of asteroid genera with species capable of larval cloning. 
  • Identification of cis-suppression of human disease mutations by comparative genomics. 
  • Identification of the ligand-binding domains of CD22, a member of the immunoglobulin superfamily that uniquely binds a sialic acid-dependent ligand. 
  • Identification of the yeast cytidine deaminase CDD1 as an orphan C-->U RNA editase. 
  • Identifying branch-specific positive selection throughout the regulatory genome using an appropriate proxy neutral. 
  • Implementing a cumulative supermatrix approach for a comprehensive phylogenetic study of the Teloschistales (Pezizomycotina, Ascomycota). 
  • In vitro and in vivo expression of a nephritogenic Ig heavy chain determinant: pathogenic autoreactivity requires permissive light chains. 
  • In vivo genetic variability of the human immunodeficiency virus type 2 V3 region. 
  • InVEST: interactive and visual edge selection tool for constructing evolutionary trees. 
  • Incongruence between primary sequence data and the distribution of a mitochondrial atp1 group II intron among ferns and horsetails 
  • Incorporating Nearest-Neighbor Site Dependence into Protein Evolution Models. 
  • Independent ancient polyploidy events in the sister families Brassicaceae and Cleomaceae. 
  • Independent variation and positive selection in env V1 and V2 domains within maternal-infant strains of human immunodeficiency virus type 1 in vivo. 
  • Informative priors based on transcription factor structural class improve de novo motif discovery. 
  • Inhibition of calcium oxalate crystal growth in vitro by uropontin: another member of the aspartic acid-rich protein superfamily. 
  • Integrated detection of natural antisense transcripts using strand-specific RNA sequencing data. 
  • Integrating ambiguously aligned regions of DNA sequences in phylogenetic analyses without violating positional homology. 
  • Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions. 
  • Interaction of NPR1 with basic leucine zipper protein transcription factors that bind sequences required for salicylic acid induction of the PR-1 gene. 
  • Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases. 
  • Interrogation of individual intratumoral B lymphocytes from lung cancer patients for molecular target discovery. 
  • Intron retention in mRNA encoding ancillary subunit of insect voltage-gated sodium channel modulates channel expression, gating regulation and drug sensitivity. 
  • Investigating deep phylogenetic relationships among cyanobacteria and plastids by small subunit rRNA sequence analysis. 
  • Isoform specificity of ankyrin-B: a site in the divergent C-terminal domain is required for intramolecular association. 
  • Isolation and biochemical characterization of LEAP-2, a novel blood peptide expressed in the liver. 
  • Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A. 
  • Isolation and characterization of a new chemokine receptor gene, the putative chicken CXCR1. 
  • Isolation and characterization of cDNA clones encoding pig gastric mucin. 
  • Isolation of Vgr-2, a novel member of the transforming growth factor-beta-related gene family. 
  • Isolation of novel EGFR-specific VHH domains. 
  • Isolation of suppressor mutants of phosphatidylinositol 3-phosphate 5-kinase deficient cells in Schizosaccharomyces pombe. 
  • L-selectin binds to P-selectin glycoprotein ligand-1 on leukocytes: interactions between the lectin, epidermal growth factor, and consensus repeat domains of the selectins determine ligand binding specificity. 
  • LMNA, encoding lamin A/C, is mutated in partial lipodystrophy. 
  • Large introns in relation to alternative splicing and gene evolution: a case study of Drosophila bruno-3. 
  • Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs. 
  • LigAmp for sensitive detection of single-nucleotide differences. 
  • Lipid molecules induce p38α activation via a novel molecular switch. 
  • LvGroucho and nuclear beta-catenin functionally compete for Tcf binding to influence activation of the endomesoderm gene regulatory network in the sea urchin embryo. 
  • Major histocompatibility complex variation and evolution at a single, expressed DQA locus in two genera of elephants. 
  • Mating-type-specific and nonspecific PAK kinases play shared and divergent roles in Cryptococcus neoformans. 
  • Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody. 
  • Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection. 
  • Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex. 
  • Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner. 
  • MicroRNAs both promote and antagonize longevity in C. elegans. 
  • Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. 
  • Microsporidian methionine aminopeptidase type 2. 
  • Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains. 
  • Mitotic crossovers between diverged sequences are regulated by mismatch repair proteins in Saccaromyces cerevisiae. 
  • Mixed peptide sequencing and the FASTF/FASTS algorithms. 
  • Modeling the evolution of regulatory elements by simultaneous detection and alignment with phylogenetic pair HMMs. 
  • Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. 
  • Mojave toxin in venom of Crotalus helleri (Southern Pacific Rattlesnake): molecular and geographic characterization. 
  • Molecular analysis of HLA-B35 alleles and their relationship to HLA-B15 alleles. 
  • Molecular analysis of the Cryptococcus neoformans ADE2 gene, a selectable marker for transformation and gene disruption. 
  • Molecular analysis of the SCARECROW gene in maize reveals a common basis for radial patterning in diverse meristems. 
  • Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases. 
  • Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase. 
  • Molecular biology of alpha-adrenergic receptors: implications for receptor classification and for structure-function relationships. 
  • Molecular characterization of CLPT1, a SEC4-like Rab/GTPase of the phytopathogenic fungus Colletotrichum lindemuthianum which is regulated by the carbon source. 
  • Molecular characterization of a sodium channel gene from the Silkworm Bombyx mori. 
  • Molecular characterization of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. Differences from spontaneous anti-DNA in the content and location of VH CDR3 arginines. 
  • Molecular cloning and characterization of a novel histone deacetylase HDAC10. 
  • Molecular cloning and sequencing of zeta-crystallin/quinone reductase cDNA from human liver. 
  • Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. 
  • Molecular cloning of acid alpha-glucosidase cDNA of Japanese quail (Coturnix coturnix japonica) and the lack of its mRNA in acid maltase deficient quails. 
  • Molecular cloning of the cDNA and promoter sequences for the mouse sodium-hydrogen exchanger regulatory factor. 
  • Molecular evolution of X-linked accessory gland proteins in Drosophila pseudoobscura. 
  • Molecular evolution of human immunodeficiency virus env in humans and monkeys: similar patterns occur during natural disease progression or rapid virus passage. 
  • Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING. 
  • Molecular identification, cloning and characterization of transmitted/founder HIV-1 subtype A, D and A/D infectious molecular clones. 
  • Molecular insights into the phylogeny and subgeneric classification of Frullania Raddi (Frullaniaceae, Porellales). 
  • Molecular organization and alternative splicing in zipper, the gene that encodes the Drosophila non-muscle myosin II heavy chain. 
  • Molecular phylogenetic study at the generic boundary between the lichen-forming fungi Caloplaca and Xanthoria (Ascomycota, Teloschistaceae). 
  • Molecular phylogeny of Heteroplacidium, Placidium, and related catapyrenioid genera (Verrucariaceae, lichen-forming Ascomycota). 
  • Molecular phylogeny of the Mycobacterium avium complex demonstrates clinically meaningful divisions. 
  • Molecular structure and function of the novel BrnT/BrnA toxin-antitoxin system of Brucella abortus. 
  • Multiple colonisations of the western Indian Ocean by Pteropus fruit bats (Megachiroptera: Pteropodidae): the furthest islands were colonised first. 
  • Multiple origins of high reciprocal symbiotic specificity at an intercontinental spatial scale among gelatinous lichens (Collemataceae, Lecanoromycetes). 
  • Mutation and evolution of microsatellites in Drosophila melanogaster. 
  • Mutational analysis of potential zinc-binding residues in the active site of the enterococcal D-Ala-D-Ala dipeptidase VanX. 
  • Mutational analysis of the fractalkine chemokine domain. Basic amino acid residues differentially contribute to CX3CR1 binding, signaling, and cell adhesion. 
  • Mutational spectrum of the oral-facial-digital type I syndrome: a study on a large collection of patients. 
  • Mutations in SPATA5 Are Associated with Microcephaly, Intellectual Disability, Seizures, and Hearing Loss. 
  • Mutations in the BRWD3 gene cause X-linked mental retardation associated with macrocephaly. 
  • NMR structure note: solution structure of the core domain of MESD that is essential for proper folding of LRP5/6. 
  • NMR studies of RNA dynamics and structural plasticity using NMR residual dipolar couplings. 
  • Nature and distribution of large sequence polymorphisms in Saccharomyces cerevisiae. 
  • Near full-length clones and reference sequences for subtype C isolates of HIV type 1 from three different continents. 
  • Neisseria gonorrhoeae FitA interacts with FitB to bind DNA through its ribbon-helix-helix motif. 
  • Neuronal cell shape and neurite initiation are regulated by the Ndr kinase SAX-1, a member of the Orb6/COT-1/warts serine/threonine kinase family. 
  • Neuronal nitric-oxide synthase interaction with calmodulin-troponin C chimeras. 
  • New member of the trefoil factor family of proteins is an alpha-macroglobulin protease inhibitor. 
  • Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation. 
  • Normalization of the peripheral blood T cell receptor V beta repertoire after cultured postnatal human thymic transplantation in DiGeorge syndrome. 
  • Novel FOXF1 mutations in sporadic and familial cases of alveolar capillary dysplasia with misaligned pulmonary veins imply a role for its DNA binding domain. 
  • Novel Insights into Chromosome Evolution in Birds, Archosaurs, and Reptiles. 
  • Novel circular DNA viruses in stool samples of wild-living chimpanzees. 
  • Novel compound heterozygous mutations in MYO7A in a Chinese family with Usher syndrome type 1. 
  • Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. 
  • Nucleotide sequence, expression, and chromosomal mapping of Mrp and mapping of five related sequences. 
  • Nucleotide variation at the myrosinase-encoding locus, TGG1, and quantitative myrosinase enzyme activity variation in Arabidopsis thaliana. 
  • One species or at least eight? Delimitation and distribution of Frullania tamarisci (L.) Dumort. s. l. (Jungermanniopsida, Porellales) inferred from nuclear and chloroplast DNA markers. 
  • Organization and evolutionary trajectory of the mating type (MAT) locus in dermatophyte and dimorphic fungal pathogens. 
  • Organization of the MASP2 locus and its expression profile in mouse and rat. 
  • Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes. 
  • Overexpression of a Brassica rapa NGATHA gene in Arabidopsis thaliana negatively affects cell proliferation during lateral organ and root growth. 
  • Overexpression of the apple MpNPR1 gene confers increased disease resistance in Malus x domestica. 
  • Oxygen affinity and amino acid sequence of myoglobins from endothermic and ectothermic fish. 
  • PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation. 
  • PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. 
  • Patterns of nucleotide variation and reproductive isolation between a Mimulus allotetraploid and its progenitor species. 
  • Phase 1 gene therapy for Duchenne muscular dystrophy using a translational optimized AAV vector. 
  • Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies. 
  • Phosphoproteome analysis in yeast. 
  • Phycomyces MADB interacts with MADA to form the primary photoreceptor complex for fungal phototropism. 
  • Phylogenetic affiliations of members of the heterogeneous lichen-forming fungi of the genus Lecidea sensu Zahlbruckner (Lecanoromycetes, Ascomycota). 
  • Phylogenetic analyses of morphological evolution in the gametophyte and sporophyte generations of the moss order Hookeriales (Bryopsida). 
  • Phylogenetic evidence for the transfer of Pseudomonas cocovenenans (van Damme et al. 1960) to the genus Burkholderia as Burkholderia cocovenenans (van Damme et al. 1960) comb. nov. 
  • Phylogenetic reassessment of the Teloschistaceae (lichen-forming Ascomycota, Lecanoromycetes). 
  • Phylogenetic simulation of promoter evolution: estimation and modeling of binding site turnover events and assessment of their impact on alignment tools. 
  • Phylogenetic study of Catapyrenium s. str. (Verrucariaceae, lichen-forming Ascomycota) and related genus Placidiopsis. 
  • Phylogenetic utility of indels within ribosomal DNA and beta-tubulin sequences from fungi in the Rhizoctonia solani species complex. 
  • Phylogenomic analyses data of the avian phylogenomics project. 
  • Phylogeny and evolution of Malagasy plated lizards. 
  • Phylogeny and taxonomy of the family Arthrodermataceae (dermatophytes) using sequence analysis of the ribosomal ITS region. 
  • Phylogeny, biogeography, and processes of molecular differentiation in Quercus subgenus Quercus (Fagaceae). 
  • Phylotranscriptomic analysis of the origin and early diversification of land plants. 
  • Plasma IgG to linear epitopes in the V2 and V3 regions of HIV-1 gp120 correlate with a reduced risk of infection in the RV144 vaccine efficacy trial. 
  • Polytene chromosomal maps of 11 Drosophila species: the order of genomic scaffolds inferred from genetic and physical maps. 
  • Population genetic and phylogenetic evidence for positive selection on regulatory mutations at the factor VII locus in humans. 
  • Porcine CD80: cloning, characterization, and evidence for its role in direct human T-cell activation. 
  • Positive selection driving diversification in plant secondary metabolism. 
  • Post-transcriptional regulation of transcript abundance by a conserved member of the tristetraprolin family in Candida albicans. 
  • Precise localization of the FHIT gene to the common fragile site at 3p14.2 (FRA3B) and characterization of homozygous deletions within FRA3B that affect FHIT transcription in tumor cell lines. 
  • Precise mapping of recombination breakpoints suggests a common parent of two BC recombinant HIV type 1 strains circulating in China. 
  • Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver. 
  • Progressive Cactus is a multiple-genome aligner for the thousand-genome era. 
  • Proteases of Dermatophagoides pteronyssinus. 
  • Proteomic analysis of the NOS2 interactome in human airway epithelial cells. 
  • Pseudouridines have context-dependent mutation and stop rates in high-throughput sequencing. 
  • Purification and initial characterization of a putative blue light-regulated phosphodiesterase from Escherichia coli. 
  • Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. 
  • Purification of the human NF-E2 complex: cDNA cloning of the hematopoietic cell-specific subunit and evidence for an associated partner. 
  • QM/MM model of the mouse olfactory receptor MOR244-3 validated by site-directed mutagenesis experiments. 
  • RNase 1 genes from the family Sciuridae define a novel rodent ribonuclease cluster. 
  • RPGRIP1 is essential for normal rod photoreceptor outer segment elaboration and morphogenesis. 
  • RTK and TGF-beta signaling pathways genes in the sea urchin genome. 
  • Rank order metrics for quantifying the association of sequence features with gene regulation. 
  • Rapid evolution of a pollen-specific oleosin-like gene family from Arabidopsis thaliana and closely related species. 
  • Rapid identification of protein phosphatase 1-binding proteins by mixed peptide sequencing and data base searching. Characterization of a novel holoenzymic form of protein phosphatase 1. 
  • Rational design and generation of recombinant control reagents for bispecific antibodies through CDR mutagenesis. 
  • Real-time in vivo proteomic identification of novel kinase substrates in smooth muscle. 
  • Recessive-interfering mutations in the gibberellin signaling gene SLEEPY1 are rescued by overexpression of its homologue, SNEEZY. 
  • Reciprocal gut microbiota transplants from zebrafish and mice to germ-free recipients reveal host habitat selection. 
  • Recognition of lysine-rich peptide ligands by murine cortactin SH3 domain: CD, ITC, and NMR studies. 
  • Recruitment of CREB binding protein is sufficient for CREB-mediated gene activation. 
  • Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein. 
  • Regulation of basement membrane-reactive B cells in BXSB, (NZBxNZW)F1, NZB, and MRL/lpr lupus mice. 
  • Regulation of biliary secretion through apical purinergic receptors in cultured rat cholangiocytes. 
  • Regulation of intrasteric inhibition of the multifunctional calcium/calmodulin-dependent protein kinase. 
  • Regulation of systemic acquired resistance by NPR1 and its partners. 
  • Regulation of the ATM-activator protein Aven by CRM1-dependent nuclear export. 
  • Regulation of zipper-interacting protein kinase activity in vitro and in vivo by multisite phosphorylation. 
  • Regulation of β2-adrenergic receptor function by conformationally selective single-domain intrabodies. 
  • Regulatory elements governing transcription in specialized myofiber subtypes. 
  • Repressing a repressor: gibberellin-induced rapid reduction of the RGA protein in Arabidopsis. 
  • Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1. 
  • Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper. 
  • Role of conserved residues within the carboxy phosphate domain of carbamoyl phosphate synthetase. 
  • Role of phosphate-magnesium-binding regions in the high GTPase activity of rac1 protein. 
  • Role of septins in the orientation of forespore membrane extension during sporulation in fission yeast. 
  • SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development. 
  • SGP-1: prediction and validation of homologous genes based on sequence alignments. 
  • SMRTER, a Drosophila nuclear receptor coregulator, reveals that EcR-mediated repression is critical for development. 
  • SOCS36E, a novel Drosophila SOCS protein, suppresses JAK/STAT and EGF-R signalling in the imaginal wing disc. 
  • Saccharomyces cerevisiae RAD5-encoded DNA repair protein contains DNA helicase and zinc-binding sequence motifs and affects the stability of simple repetitive sequences in the genome. 
  • Screening the human exome: a comparison of whole genome and whole transcriptome sequencing. 
  • Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1. 
  • Sequence features of DNA binding sites reveal structural class of associated transcription factor. 
  • Serine 232 of the alpha(2A)-adrenergic receptor is a protein kinase C-sensitive effector coupling switch. 
  • Sex-specific homeodomain proteins Sxi1alpha and Sxi2a coordinately regulate sexual development in Cryptococcus neoformans. 
  • Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins. 
  • Simultaneous Bayesian estimation of alignment and phylogeny under a joint model of protein sequence and structure. 
  • Single origin and subsequent diversification of central Andean endemic Umbilicaria species. 
  • Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis. 
  • Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1. 
  • Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin. 
  • Solution structure of the core NFATC1/DNA complex. 
  • Sox8 is expressed at similar levels in gonads of both sexes during the sex determining period in turtles. 
  • Species delimitation in lemurs: multiple genetic loci reveal low levels of species diversity in the genus Cheirogaleus. 
  • Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase. 
  • Sprinter: a novel transmembrane protein required for Wg secretion and signaling. 
  • Stable interaction between beta-arrestin 2 and angiotensin type 1A receptor is required for beta-arrestin 2-mediated activation of extracellular signal-regulated kinases 1 and 2. 
  • Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. 
  • Structural adaptations that modulate monosaccharide, disaccharide, and trisaccharide specificities in periplasmic maltose-binding proteins. 
  • Structural and immunological comparison of indigenous human O6-methylguanine-DNA methyltransferase with that encoded by a cloned cDNA. 
  • Structural basis of the intrasteric regulation of myosin light chain kinases. 
  • Structural genomics of Pyrococcus furiosus: X-ray crystallography reveals 3D domain swapping in rubrerythrin. 
  • Structural requirements regulate endoproteolytic release of the L-selectin (CD62L) adhesion receptor from the cell surface of leukocytes. 
  • Structurally distinct and stage-specific adenylyl cyclase genes play different roles in Dictyostelium development. 
  • Structure and function of the ovine type 1 corticotropin releasing factor receptor (CRF1) and a carboxyl-terminal variant. 
  • Structure and hydride transfer mechanism of a moderate thermophilic dihydrofolate reductase from Bacillus stearothermophilus and comparison to its mesophilic and hyperthermophilic homologues. 
  • Structure of human Niemann-Pick C1 protein. 
  • Structure of mammalian protein geranylgeranyltransferase type-I. 
  • Structure of the CD59-encoding gene: further evidence of a relationship to murine lymphocyte antigen Ly-6 protein. 
  • Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. 
  • Structure of the human MutSalpha DNA lesion recognition complex. 
  • Structure of the outer membrane translocator domain of the Haemophilus influenzae Hia trimeric autotransporter. 
  • Structure of the ubiquitin-binding zinc finger domain of human DNA Y-polymerase eta. 
  • Structures of MERS1, the 5' processing enzyme of mitochondrial mRNAs in Trypanosoma brucei. 
  • Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family. 
  • Structures of regulatory machinery reveal novel molecular mechanisms controlling B. subtilis nitrogen homeostasis. 
  • Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein. 
  • Surface loop dynamics in adeno-associated virus capsid assembly. 
  • Syncoilin isoform organization and differential expression in murine striated muscle. 
  • Syndecans, cell surface heparan sulfate proteoglycans, are induced by a proline-rich antimicrobial peptide from wounds. 
  • Syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia caused by mutations in SLC30A10, a manganese transporter in man. 
  • T-BAS: Tree-Based Alignment Selector toolkit for phylogenetic-based placement, alignment downloads and metadata visualization: an example with the Pezizomycotina tree of life. 
  • TBX5-encoded T-box transcription factor 5 variant T223M is associated with long QT syndrome and pediatric sudden cardiac death. 
  • TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour. 
  • Targeting Pim Kinases and DAPK3 to Control Hypertension. 
  • Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain. 
  • Temperature-sensitive mutations in the III-IV cytoplasmic loop region of the skeletal muscle sodium channel gene in paramyotonia congenita. 
  • Testing for divergent transmission histories among cultural characters: a study using Bayesian phylogenetic methods and Iranian tribal textile data. 
  • Tetrameric c-di-GMP mediates effective transcription factor dimerization to control Streptomyces development. 
  • The 1.2 A structure of the human sulfite oxidase cytochrome b(5) domain. 
  • The 100-genomes strains, an S. cerevisiae resource that illuminates its natural phenotypic and genotypic variation and emergence as an opportunistic pathogen. 
  • The 2.1 A structure of Aerococcus viridans L-lactate oxidase (LOX). 
  • The 70-kDa heat shock cognate protein (Hsc73) gene is enhanced by ovarian hormones in the ventromedial hypothalamus. 
  • The Affinity of Brominated Phenolic Compounds for Human and Zebrafish Thyroid Receptor β: Influence of Chemical Structure. 
  • The Arabidopsis RGA gene encodes a transcriptional regulator repressing the gibberellin signal transduction pathway. 
  • The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome. 
  • The Chlamydia trachomatis Protease CPAF Contains a Cryptic PDZ-Like Domain with Similarity to Human Cell Polarity and Tight Junction PDZ-Containing Proteins. 
  • The Dh gene of Drosophila melanogaster encodes a diuretic peptide that acts through cyclic AMP. 
  • The Early-Acting Peroxin PEX19 Is Redundantly Encoded, Farnesylated, and Essential for Viability in Arabidopsis thaliana. 
  • The Erwinia amylovora avrRpt2EA gene contributes to virulence on pear and AvrRpt2EA is recognized by Arabidopsis RPS2 when expressed in pseudomonas syringae. 
  • The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machinery. 
  • The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing. 
  • The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation. 
  • The GroES antigens of Mycobacterium avium and Mycobacterium paratuberculosis. 
  • The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. 
  • The RNA Ontology Consortium: an open invitation to the RNA community. 
  • The RNA polymerase II CTD kinase CTDK-I affects pre-mRNA 3' cleavage/polyadenylation through the processing component Pti1p. 
  • The T4 phage SF1B helicase Dda is structurally optimized to perform DNA strand separation. 
  • The TetR family of transcriptional repressors. 
  • The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. 
  • The calmodulin-dependent protein phosphatase catalytic subunit (calcineurin A) is an essential gene in Aspergillus nidulans. 
  • The cloning of GRK7, a candidate cone opsin kinase, from cone- and rod-dominant mammalian retinas. 
  • The crystal structure of Escherichia coli MoeA and its relationship to the multifunctional protein gephyrin. 
  • The crystal structure of a thermophilic glucose binding protein reveals adaptations that interconvert mono and di-saccharide binding sites. 
  • The crystal structure of the TetR family transcriptional repressor SimR bound to DNA and the role of a flexible N-terminal extension in minor groove binding. 
  • The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase. 
  • The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome. 
  • The draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus) 
  • The evolution of homing endonuclease genes and group I introns in nuclear rDNA. 
  • The evolutionary history of ferns inferred from 25 low‐copy nuclear genes 
  • The genomic underpinnings of apoptosis in Strongylocentrotus purpuratus. 
  • The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist. 
  • The human TTP protein: sequence, alignment with related proteins, and chromosomal localization of the mouse and human genes. 
  • The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae. 
  • The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. 
  • The phosphoCTD-interacting domain of Topoisomerase I. 
  • The phylogeny of extant starfish (Asteroidea: Echinodermata) including Xyloplax, based on comparative transcriptomics. 
  • The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase. 
  • The regulation of DNA topoisomerase II by casein kinase II. 
  • The segment polarity gene porcupine encodes a putative multitransmembrane protein involved in Wingless processing. 
  • The unusual UBZ domain of Saccharomyces cerevisiae polymerase η. 
  • Three crocodilian genomes reveal ancestral patterns of evolution among archosaurs. 
  • Three periods of regulatory innovation during vertebrate evolution. 
  • Transcriptional regulation of N-acetylglutamate synthase. 
  • Two forms of mitochondrial DNA ligase III are produced in Xenopus laevis oocytes. 
  • Tyrosine phosphorylation at a site highly conserved in the L1 family of cell adhesion molecules abolishes ankyrin binding and increases lateral mobility of neurofascin. 
  • Unconventional ubiquitin recognition by the ubiquitin-binding motif within the Y family DNA polymerases iota and Rev1. 
  • Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases. 
  • Using comparative genomic data to test for fast-X evolution. 
  • Utilization of immunoglobulin G Fc receptors by human immunodeficiency virus type 1: a specific role for antibodies against the membrane-proximal external region of gp41. 
  • V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr mice. 
  • Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. 
  • Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. 
  • Verification of a new gene on Saccharomyces cerevisiae chromosome III. 
  • WASABI: an automated sequence processing system for multigene phylogenies. 
  • Whole genome re-sequencing to identify suppressor mutations of mutant and foreign Escherichia coli FtsZ. 
  • Whole-genome positive selection and habitat-driven evolution in a shallow and a deep-sea urchin. 
  • Yantar, a conserved arginine-rich protein is involved in Drosophila hemocyte development. 
  • Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins. 
  • hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. 
  • p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity. 
  • p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. 
  • ΔN-TRPV1: A Molecular Co-detector of Body Temperature and Osmotic Stress. 
• 

  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Ferreira, Paulo Alexandre, Associate Professor in Ophthalmology, Pathology
  • Gordan, Raluca Mihaela, Associate Professor in Biostatistics & Bioinformatics, Computer Science
  • Hartemink, Alexander J., Professor in the Department of Computer Science, Biology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Integrative Immunobiology
  • Krangel, Michael S., George Barth Geller Distinguished Professor of Immunology, Integrative Immunobiology
  • McConnell, Eleanor Schildwachter, Associate Professor in the School of Nursing, School of Nursing
  • Patz Jr., Edward F., James and Alice Chen Distinguished Professor of Radiology, Pathology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology
  • Sullivan, Daniel Carl, Professor Emeritus of Radiology, Radiology
  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology