Drug Delivery Systems

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  Subject Areas on Research

  • A Highly Effective and Ultra-Long-Acting Anti-Glaucoma Drug, with a Novel Periorbital Delivery Method. 
  • A cellular Trojan Horse for delivery of therapeutic nanoparticles into tumors. 
  • A comprehensive outlook on intracerebral therapy of malignant gliomas. 
  • A family of hierarchically self-assembling linear-dendritic hybrid polymers for highly efficient targeted gene delivery. 
  • A genetically engineered thermally responsive sustained release curcumin depot to treat neuroinflammation. 
  • A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosis. 
  • A moldable sustained release bupivacaine formulation for tailored treatment of postoperative dental pain. 
  • A need for effective adjuvants. 
  • A new continuous catheter delivery system. 
  • A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model. 
  • A paclitaxel-loaded recombinant polypeptide nanoparticle outperforms Abraxane in multiple murine cancer models. 
  • A phase I/II trial of pazopanib in combination with lapatinib in adult patients with relapsed malignant glioma. 
  • A polymer-metal composite stent. 
  • A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized 3He MRI. 
  • A synthetic mimic of the secretory granule for drug delivery. 
  • A thermally responsive biopolymer for intra-articular drug delivery. 
  • AAV does the shuffle. 
  • Active Targeting of Cancer Cells by Nanobody Decorated Polypeptide Micelle with Bio-orthogonally Conjugated Drug. 
  • Actively targeting solid tumours with thermoresponsive drug delivery systems that respond to mild hyperthermia. 
  • Aerosol delivery through an artificial airway. 
  • Alpha 2-macroglobulin binds CpG oligodeoxynucleotides and enhances their immunostimulatory properties by a receptor-dependent mechanism. 
  • An accelerated pathway for targeted cancer therapies. 
  • An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles. 
  • An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution. 
  • Anatomic compression caused by high-volume convection-enhanced delivery to the brain. 
  • Anti-invasive adjuvant therapy with imipramine blue enhances chemotherapeutic efficacy against glioma. 
  • Antibacterial efficacy of exogenous nitric oxide on periodontal pathogens. 
  • Antidote control of aptamer therapeutics: the road to a safer class of drug agents. 
  • Antiepidermal growth factor variant III scFv fragment: effect of radioiodination method on tumor targeting and normal tissue clearance. 
  • Antiglaucoma EP2 Agonists: A Long Road That Led Somewhere. 
  • Antimicrobial nanotechnology: its potential for the effective management of microbial drug resistance and implications for research needs in microbial nanotoxicology. 
  • Applications of nanotechnology to biotechnology commentary. 
  • Applications of nanotechnology to imaging and therapy of brain tumors. 
  • Aptamer applications for targeted cancer therapy. 
  • Aptamers: an emerging class of therapeutics. 
  • Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. 
  • Automated design of ligands to polypharmacological profiles. 
  • Available space and extracellular transport of macromolecules: effects of pore size and connectedness. 
  • Available volume fraction of macromolecules in the extravascular space of a fibrosarcoma: implications for drug delivery. 
  • Avidity and Cell Uptake of Integrin-Targeting Polypeptide Micelles is Strongly Shape-Dependent. 
  • Bevacizumab-induced alterations in vascular permeability and drug delivery: a novel approach to augment regional chemotherapy for in-transit melanoma. 
  • Biodegradable nanoparticle-entrapped vaccine induces cross-protective immune response against a virulent heterologous respiratory viral infection in pigs. 
  • Biophysical analysis of prototype microbicidal gels. 
  • Bottom up design of nanoparticles for anti-cancer diapeutics: "put the drug in the cancer's food". 
  • Brachytherapy using injectable seeds that are self-assembled from genetically encoded polypeptides in situ. 
  • Breathing new life into an old target: pulmonary disease drugs for Parkinson's disease therapy. 
  • CD19: a promising B cell target for rheumatoid arthritis. 
  • Carbamazepine extended-release capsules: a new treatment option for bipolar I disorder. 
  • Cell-Based Biohybrid Drug Delivery Systems: The Best of the Synthetic and Natural Worlds. 
  • Cell-Specific Chemical Delivery Using a Selective Nitroreductase-Nitroaryl Pair. 
  • Cell-specific aptamers for targeted therapies. 
  • Cellular transduction mechanisms of adeno-associated viral vectors. 
  • Central Nervous System Targets: Glial Cell Mechanisms in Chronic Pain. 
  • Cerebral ischemia/stroke and small ubiquitin-like modifier (SUMO) conjugation--a new target for therapeutic intervention? 
  • Channeling a new focus for heart failure: insights into ion channels. 
  • Characterization of restricted diffusion in uni- and multi-lamellar vesicles using short distance iMQCs. 
  • Chemokines, neuronal-glial interactions, and central processing of neuropathic pain. 
  • Choosing between percutaneous coronary intervention and coronary artery bypass grafting for patients with multivessel disease: what can we learn from the Arterial Revascularization Therapy Study (ARTS)? 
  • Clinical benefits of pegylated proteins in oncology. 
  • Clinical end points in coronary stent trials: a case for standardized definitions. 
  • Clinical utility of a patient-specific algorithm for simulating intracerebral drug infusions. 
  • Clopidogrel use and long-term clinical outcomes after drug-eluting stent implantation. 
  • Co-opting biology to deliver drugs. 
  • Collagen shield delivery of tissue plasminogen activator: functional and pharmacokinetic studies of anterior segment delivery. 
  • Colocalization of gadolinium-diethylene triamine pentaacetic acid with high-molecular-weight molecules after intracerebral convection-enhanced delivery in humans. 
  • Combined Tc-99m sestamibi first-pass radionuclide angiography and cardiac SPECT imaging during arbutamine infusion delivered by a computerized closed-loop system. 
  • Comparison of Inhaled Drug Delivery in Patients With One- and Two-level Laryngotracheal Stenosis. 
  • Comparison of intratumoral bolus injection and convection-enhanced delivery of radiolabeled antitenascin monoclonal antibodies. 
  • Comparison of zotarolimus-eluting and sirolimus-eluting stents in patients with native coronary artery disease: a randomized controlled trial. 
  • Complement activation and cardiac surgery: a novel target for improving outcomes. 
  • Complexation hydrogels for oral protein delivery: an in vitro assessment of the insulin transport-enhancing effects following dissolution in simulated digestive fluids. 
  • Conjugates of antisense oligonucleotides with the Tat and antennapedia cell-penetrating peptides: effects on cellular uptake, binding to target sequences, and biologic actions. 
  • Connecting genetic risk to disease end points through the human blood plasma proteome. 
  • Consensus report of the national cancer institute clinical trials planning meeting on pancreas cancer treatment. 
  • Controlled apoptosis by a thermally toggled nanoscale amplifier of cellular uptake. 
  • Controlled release of biologics for the treatment of type 2 diabetes. 
  • Controlled targeting of liposomal doxorubicin via the folate receptor in vitro. 
  • Convection enhanced delivery of macromolecules for brain tumors. 
  • Convection-enhanced delivery of cintredekin besudotox (interleukin-13-PE38QQR) followed by radiation therapy with and without temozolomide in newly diagnosed malignant gliomas: phase 1 study of final safety results. 
  • Convection-enhanced delivery of free gadolinium with the recombinant immunotoxin MR1-1. 
  • Convection-enhanced delivery of therapeutics for brain disease, and its optimization. 
  • Coronary artery stents: evaluating new designs for contemporary percutaneous intervention. 
  • Critical issues in delivery of RNAi therapeutics in vivo. 
  • Current status of biodegradable stents. 
  • Current status of therapy of solid tumors: brain tumor therapy. 
  • Cytosolic delivery of macromolecules. 3. Synthesis and characterization of acid-sensitive bis-detergents. 
  • DNA delivery from hyaluronic acid-collagen hydrogels via a substrate-mediated approach 
  • Decision models for assessing the cost effectiveness of drug-eluting stents. 
  • Degradable polymeric vehicles for postoperative pain management. 
  • Delivering therapy to target: improving the odds for successful drug development. 
  • Delivery of small molecule mast cell activators for West Nile Virus vaccination using acetalated dextran microparticles. 
  • Design of thermally responsive, recombinant polypeptide carriers for targeted drug delivery. 
  • Designing preclinical perceptibility measures to evaluate topical vaginal gel formulations: relating user sensory perceptions and experiences to formulation properties. 
  • Detection of infusate leakage in the brain using real-time imaging of convection-enhanced delivery. 
  • Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic. 
  • Development of universal antidotes to control aptamer activity. 
  • Differential cell responses to nanoparticle docetaxel and small molecule docetaxel at a sub-therapeutic dose range. 
  • Dilution of microbicide gels with vaginal fluid and semen simulants: effect on rheological properties and coating flow. 
  • Direct Optical Imaging of Graphene In Vitro by Nonlinear Femtosecond Laser Spectral Reshaping 
  • Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: a report by the Cintredekin Besudotox Intraparenchymal Study Group. 
  • Distance from the coronary ostium to the culprit lesion in acute ST-elevation myocardial infarction and its implications regarding the potential prevention of proximal plaque rupture. 
  • Dollars and stents: the economics of drug-eluting stents. 
  • Doxorubicin-conjugated polypeptide nanoparticles inhibit metastasis in two murine models of carcinoma. 
  • Drug delivery to solid tumors by elastin-like polypeptides. 
  • Drug development of lyso-thermosensitive liposomal doxorubicin: Combining hyperthermia and thermosensitive drug delivery. 
  • Drug targeting using thermally responsive polymers and local hyperthermia. 
  • Drug-eluting stents "deliver heartburn": how do we spell relief going forward? 
  • Drug-eluting stents in acute myocardial infarction: is science catching up with practice? 
  • Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens. 
  • Dry powder vaccines for mucosal administration: critical factors in manufacture and delivery. 
  • Dynamic MR imaging of the biliary system using hepatocyte-specific contrast agents. 
  • EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. 
  • Editorial: Convection-enhanced delivery. 
  • Effect of hemoglobin target on progression of kidney disease: a secondary analysis of the CHOIR (Correction of Hemoglobin and Outcomes in Renal Insufficiency) trial. 
  • Effect of pazopanib on tumor microenvironment and liposome delivery. 
  • Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. 
  • Efficacy, Safety, and Tolerability of an Extended-Release Orally Disintegrating Methylphenidate Tablet in Children 6-12 Years of Age with Attention-Deficit/Hyperactivity Disorder in the Laboratory Classroom Setting. 
  • Elastin-Like Polypeptides for Biomedical Applications. 
  • Electric field of a six-needle array electrode used in drug and DNA delivery in vivo: analytical versus numerical solution. 
  • Electric fields in tumors exposed to external voltage sources: implication for electric field-mediated drug and gene delivery. 
  • Employing Macrophage-Derived Microvesicle for Kidney-Targeted Delivery of Dexamethasone: An Efficient Therapeutic Strategy against Renal Inflammation and Fibrosis. 
  • Encapsulation and controlled release of retinol from silicone particles for topical delivery. 
  • Engineered nanomaterials for biophotonics applications: improving sensing, imaging, and therapeutics. 
  • Enhanced Release of Molecules upon Ultraviolet (UV) Light Irradiation from Photoresponsive Hydrogels Prepared from Bifunctional Azobenzene and Four-Arm Poly(ethylene glycol). 
  • Enhanced chemotherapy delivery by intraarterial infusion and blood-brain barrier disruption in malignant brain tumors: the Sherbrooke experience. 
  • Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles. 
  • Enhanced osteogenic activity of poly(ester urea) scaffolds using facile post-3D printing peptide functionalization strategies. 
  • Enzyme-Responsive Delivery of Multiple Proteins with Spatiotemporal Control 
  • EphrinA I-targeted nanoshells for photothermal ablation of prostate cancer cells. 
  • Epicardial delivery of XC001 gene therapy for refractory angina coronary treatment (The EXACT Trial): Rationale, design, and clinical considerations. 
  • Evaluating intra-articular drug delivery for the treatment of osteoarthritis in a rat model. 
  • Evaluation of a delivery system providing long-term release of cyclosporine. 
  • Evolving revascularization approaches for myocardial ischemia. 
  • Exosomes in Pancreatic Cancer: from Early Detection to Treatment. 
  • Exploitation of intracellular pH gradients in the cellular delivery of macromolecules. 
  • Extended release, 6-month formulations of leuprolide acetate for the treatment of advanced prostate cancer: achieving testosterone levels below 20 ng/dl. 
  • Fabrication of Elastin-Like polypeptide Nanoparticles for Drug Delivery by Electrospraying 
  • Factor Xa-protease activated receptor interface: a paradigm for combination pharmacotherapy. 
  • First theoretic analysis of magnetic drug targeting in the lung. 
  • Fluocinolone acetonide sustained drug delivery device for chronic central retinal vein occlusion: 12-month results. 
  • Fluocinolone acetonide sustained drug delivery device to treat severe uveitis. 
  • From Composition to Cure: A Systems Engineering Approach to Anticancer Drug Carriers. 
  • Fusion of fibroblast growth factor 21 to a thermally responsive biopolymer forms an injectable depot with sustained anti-diabetic action. 
  • Fusions of elastin-like polypeptides to pharmaceutical proteins. 
  • Future directions in hyperthermia biology. 
  • Gefitinib (Iressa, ZD1839) and tyrosine kinase inhibitors: the wave of the future in cancer therapy. 
  • Gene delivery through cell culture substrate adsorbed DNA complexes 
  • Genetic polymorphism and function of glutathione S-transferases in tumor drug resistance. 
  • Genetically Encoded Elastin-Like Polypeptides for Drug Delivery. 
  • Genetically encoded elastin-like polypeptide nanoparticles for drug delivery. 
  • Gravity-induced coating flows of vaginal gel formulations: in vitro experimental analysis. 
  • Group VI phospholipases A2: homeostatic phospholipases with significant potential as targets for novel therapeutics. 
  • Heat-targeted drug delivery: A promising approach for organsparing treatment of bladder cancer.THERMODOX®. 
  • Heuristics for the Optimal Presentation of Bioactive Peptides on Polypeptide Micelles. 
  • Highlights from the American Heart Association annual scientific sessions 2001: November 11 to 14, 2001. 
  • Highlights of the Year in JACC 2006. 
  • Hydrogel-nanoparticle composites for optically modulated cancer therapeutic delivery. 
  • Hyperthermia as adjunct to intravesical chemotherapy for bladder cancer. 
  • Hyperthermia mediated liposomal drug delivery. 
  • Imaging of Nanoparticle Distribution to Assess Treatments That Alter Delivery. 
  • Imaging of convection enhanced delivery of toxins in humans. 
  • Immunonanoshells for targeted photothermal ablation in medulloblastoma and glioma: an in vitro evaluation using human cell lines. 
  • Immunonanoshells for targeted photothermal ablation of tumor cells. 
  • Implantable, polymeric systems for modulated drug delivery. 
  • Improving DNA double-strand repair inhibitor KU55933 therapeutic index in cancer radiotherapy using nanoparticle drug delivery. 
  • Improving interstitial transport of macromolecules through reduction in cell volume fraction in tumor tissues. 
  • In Situ Drug Delivery to Breast Cancer-Associated Extracellular Matrix. 
  • In situ forming injectable hydrogels for drug delivery and wound repair. 
  • In vitro and in vivo evaluation of a water-in-oil microemulsion system for enhanced peptide intestinal delivery. 
  • In vitro characterization of nebulizer delivery of liposomal amphotericin B aerosols. 
  • In vitro characterization of vascular endothelial growth factor and dexamethasone releasing hydrogels for implantable probe coatings. 
  • In-stent pseudo-restenosis due to an organized thrombus six months after implantation of a sirolimus-eluting stent. 
  • Induction of hyperintense signal on T2-weighted MR images correlates with infusion distribution from intracerebral convection-enhanced delivery of a tumor-targeted cytotoxin. 
  • Inference on treatment effects for targeted clinical trials under enrichment design. 
  • Injectable intratumoral depot of thermally responsive polypeptide-radionuclide conjugates delays tumor progression in a mouse model. 
  • Innovations in design and delivery of chemotherapy for brain tumors. 
  • Integration of molecular diagnostics with therapeutics: implications for drug discovery and patient care. 
  • Interpreting properties of microbicide drug delivery gels: analyzing deployment kinetics due to squeezing. 
  • Intra-Target Microdosing (ITM): A Novel Drug Development Approach Aimed at Enabling Safer and Earlier Translation of Biological Insights Into Human Testing. 
  • Intra-tumoral heterogeneity of gemcitabine delivery and mass transport in human pancreatic cancer. 
  • Intraarterial Microdosing: A Novel Drug Development Approach, Proof-of-Concept PET Study in Rats. 
  • Intracerebral infusate distribution by convection-enhanced delivery in humans with malignant gliomas: descriptive effects of target anatomy and catheter positioning. 
  • Intratracheal catheters as drug delivery systems. 
  • Intravitreal sustained release corticosteroid-5-fluoruracil conjugate in the treatment of experimental proliferative vitreoretinopathy. 
  • Intravitreal sustained-release cyclosporine in the treatment of experimental uveitis. 
  • Intravitreal sustained-release dexamethasone device in the treatment of experimental uveitis. 
  • Invalidity of an Oft-Cited Estimate of the Relative Harms of Electronic Cigarettes. 
  • Iontophoretic delivery of dexamethasone phosphate for non-infectious, non-necrotising anterior scleritis, dose-finding clinical trial. 
  • Kinetic-dependent Killing of Oral Pathogens with Nitric Oxide. 
  • Laser-Assisted Delivery of Topical Cidofovir in the Treatment of Plantar Warts. 
  • Laser-assisted delivery of vitamin C, vitamin E, and ferulic acid formula serum decreases fractional laser postoperative recovery by increased beta fibroblast growth factor expression. 
  • Lipid structures: a brief history of multisomes. 
  • Lipid-based microtubular drug delivery vehicles. 
  • Lipid-coated microgels for the triggered release of doxorubicin. 
  • Liposomal amphotericin B: clinical experience and perspectives. 
  • Liposomes-entrapped chondroitin sulphate: ultrastructural characterization and in vitro biocompatibility. 
  • Local delivery methods of therapeutic agents in the treatment of diffuse intrinsic brainstem gliomas. 
  • Local drug delivery to conserve hearing: mechanisms of action of eluted dexamethasone within the cochlea. 
  • Localized delivery of nitric oxide from hydrogels inhibits neointima formation in a rat carotid balloon injury model. 
  • Long circulating genetically encoded intrinsically disordered zwitterionic polypeptides for drug delivery. 
  • Long-term safety of combined intracerebral delivery of free gadolinium and targeted chemotherapeutic agent PRX321. 
  • Maji: a new tool to prevent overhydration of children receiving intravenous fluid therapy in low-resource settings. 
  • Management of peripheral nerve block catheters at home. 
  • Masking and triggered unmasking of targeting ligands on nanocarriers to improve drug delivery to brain tumors. 
  • Materials characterization of the low temperature sensitive liposome (LTSL): effects of the lipid composition (lysolipid and DSPE-PEG2000) on the thermal transition and release of doxorubicin 
  • Mechanistic Investigation of Site-specific DNA Methylating Agents Targeting Breast Cancer Cells. 
  • Mechanosensitive channels in striated muscle and the cardiovascular system: not quite a stretch anymore. 
  • Mitogen-activated protein kinases as potential targets for pain killers. 
  • Modular nanotransporters for targeted intracellular delivery of drugs: folate receptors as potential targets. 
  • Modular nanotransporters: a multipurpose in vivo working platform for targeted drug delivery. 
  • Molecular and Materials Engineering for Delivery of Peptide Drugs to Treat Type 2 Diabetes. 
  • Molecular determinants of sensitivity to antitumor agents. 
  • Molecular engineering of proteins and polymers for targeting and intracellular delivery of therapeutics. 
  • Monitoring practices following epidural analgesics for pain management: a follow-up survey. 
  • Monoclonal antibodies as targeted therapy in hematologic malignancies in older adults. 
  • Monoclonal antibodies for brain tumour treatment. 
  • Mucosal immunity to infection with implications for vaccine development. 
  • Mucosal targeting of a BoNT/A subunit vaccine adjuvanted with a mast cell activator enhances induction of BoNT/A neutralizing antibodies in rabbits. 
  • Multitargeted Nanoparticles Deliver Synergistic Drugs across the Blood-Brain Barrier to Brain Metastases of Triple Negative Breast Cancer Cells and Tumor-Associated Macrophages. 
  • NMR studies of an immunomodulatory benzodiazepine binding to its molecular target on the mitochondrial F(1)F(0)-ATPase. 
  • Nanoantibiotics: a new paradigm for the treatment of surgical infection. 
  • Nanomolecular targeting of dendritic cells for ovarian cancer therapy. 
  • Nanoparticle Encapsulation of Synergistic Immune Agonists Enables Systemic Codelivery to Tumor Sites and IFNβ-Driven Antitumor Immunity. 
  • Nanoparticle delivery of chemosensitizers improve chemotherapy efficacy without incurring additional toxicity. 
  • Nanoparticle engineered TRAIL-overexpressing adipose-derived stem cells target and eradicate glioblastoma via intracranial delivery. 
  • Nanoparticle-mediated delivery of a rapidly activatable prodrug of SN-38 for neuroblastoma therapy. 
  • Nanoparticle-mediated local delivery of Methylprednisolone after spinal cord injury. 
  • Nanoparticles and their applications in cell and molecular biology. 
  • Nanoparticles for urothelium penetration and delivery of the histone deacetylase inhibitor belinostat for treatment of bladder cancer. 
  • Nanotechnologies and regenerative medical approaches for space and terrestrial medicine. 
  • Nebulizer delivery of micafungin aerosols. 
  • Nerve growth factor: structure, function and therapeutic implications for Alzheimer's disease. 
  • Neutrally charged phosphorodiamidate morpholino antisense oligomers: uptake, efficacy and pharmacokinetics. 
  • New technology and clinical applications of nanomedicine: highlights of the second annual meeting of the American Academy of Nanomedicine (Part I). 
  • New testosterone buccal system (Striant) delivers physiological testosterone levels: pharmacokinetics study in hypogonadal men. 
  • Non-viral DNA delivery from porous hyaluronic acid hydrogels in mice 
  • Noncoding RNAs: biology and applications-a Keystone Symposia report. 
  • Noninvasive imaging and quantification of epidermal growth factor receptor kinase activation in vivo. 
  • Novel delivery of oligonucleotides using a topical hydrogel tissue sealant in a murine partial nephrectomy model. 
  • Novel intrathecal and subcutaneous catheter delivery systems in the mouse. 
  • Novel therapeutic approaches to advanced prostate cancer. 
  • Numerical evaluation of spray position for improved nasal drug delivery. 
  • On Command Drug Delivery via Cell-Conveyed Phototherapeutics. 
  • Ophthalmic Drug Delivery Using Iontophoresis: Recent Clinical Applications. 
  • Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents. 
  • Optimizing Advances in Nanoparticle Delivery for Cancer Immunotherapy. 
  • Over-pressure suppresses ultrasonic-induced drug uptake. 
  • Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors. 
  • Overview of Taris GemRIS, a Novel Drug Delivery System for Bladder Cancer. 
  • PTEN hamartomatous tumor syndromes (PHTS): rare syndromes with great relevance to common cancers and targeted drug development. 
  • Personalized and targeted therapy of esophageal squamous cell carcinoma: an update. 
  • Perspective on fast-evolving photoacoustic tomography. 
  • Pharmacological advances in the treatment of insomnia. 
  • Pharmacological strategies for the prevention of Alzheimer's disease. 
  • Phase I trial of doxorubicin-containing low temperature sensitive liposomes in spontaneous canine tumors. 
  • Phenylboronic Acid-polymers for Biomedical Applications. 
  • Photocontrolled micellar aggregation of amphiphilic DNA-azobenzene conjugates. 
  • Photopolymerizable hydrogels for tissue engineering applications. 
  • Plasmonics-enhanced and optically modulated delivery of gold nanostars into brain tumor. 
  • Polymer-delivered subcutaneous leuprolide acetate formulations achieve and maintain castrate concentrations of testosterone in four open-label studies in patients with advanced prostate cancer. 
  • Poor drug distribution as a possible explanation for the results of the PRECISE trial. 
  • Preclinical toxicity evaluation of a novel immunotoxin, D2C7-(scdsFv)-PE38KDEL, administered via intracerebral convection-enhanced delivery in rats. 
  • Predicted patient demand for a new delivery system for glaucoma medicine. 
  • Preparation of in vivo cleavable agglomerated liposomes suitable for modulated pulmonary drug delivery. 
  • Prevention of experimental proliferative vitreoretinopathy with a biodegradable intravitreal implant for the sustained release of fluorouracil. 
  • Prevention of venous thrombosis in microvascular surgery by transmural release of heparin from a polyanhydride polymer. 
  • Priming for virus-specific CD8+ but not CD4+ cytotoxic T lymphocytes with synthetic lipopeptide is influenced by acylation units and liposome encapsulation. 
  • Progress Toward the Clinical Translation of Bioinspired Peptide and Protein Assemblies. 
  • Progress in orthopedic biomaterials and drug delivery. 
  • Providing Safe and Effective Preventative Antiretroviral Prophylaxis to HIV-exposed Newborns via a Novel Drug Delivery System in Tanzania. 
  • Pulmonary Delivery of Therapeutic and Diagnostic Gases. 
  • Quantitative Study of the Interaction of Multivalent Ligand-Modified Nanoparticles with Breast Cancer Cells with Tunable Receptor Density. 
  • Quantitative analysis of intratumoral infusion of color molecules. 
  • Quetiapine XR: current status for the treatment of major depressive disorder. 
  • RNA Aptamer-targeted Inhibition of NF-κB Suppresses Non-small Cell Lung Cancer Resistance to Doxorubicin. 
  • Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease. 
  • Rapid identification of cell-specific, internalizing RNA aptamers with bioinformatics analyses of a cell-based aptamer selection. 
  • Rational design of "heat seeking" drug loaded polypeptide nanoparticles that thermally target solid tumors. 
  • Rationale and design of the comParIson Of sacubitril/valsartaN versus Enalapril on Effect on nt-pRo-bnp in patients stabilized from an acute Heart Failure episode (PIONEER-HF) trial. 
  • Reawakening the cellular death program in neoplasia through the therapeutic blockade of IAP function. 
  • Recent trends in protein and peptide-based biomaterials for advanced drug delivery. 
  • Redirecting Vesicular Transport to Improve Nonviral Delivery of Molecular Cargo. 
  • Reimplantation of a fluocinolone acetonide sustained drug delivery implant for chronic uveitis. 
  • Remote triggered release of doxorubicin in tumors by synergistic application of thermosensitive liposomes and gold nanorods. 
  • Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage. 
  • Respiration triggered magnetic drug targeting in the lungs. 
  • Revival of the abandoned therapeutic wortmannin by nanoparticle drug delivery. 
  • Role of G12 proteins in oncogenesis and metastasis. 
  • Roles of chemokines CCL2 and CCL5 in the pharmacokinetics of PEGylated liposomal doxorubicin in vivo and in patients with recurrent epithelial ovarian cancer. 
  • Safety and pharmacokinetics of an intraocular fluocinolone acetonide sustained delivery device. 
  • Safety of intraparenchymal convection-enhanced delivery of cintredekin besudotox in early-phase studies. 
  • Salivary gland malignancies: the role for chemotherapy and molecular targeted agents. 
  • Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice. 
  • Seeing into cells. The promise of in vivo molecular imaging in oncology. 
  • Self-assembling chimeric polypeptide–doxorubicin conjugate nanoparticles that abolish tumours after a single injection 
  • Sensitivity Analysis of a Pharmacokinetic Model of Vaginal Anti-HIV Microbicide Drug Delivery. 
  • Signaling cascades as drug targets in model and pathogenic fungi. 
  • Simultaneous restenosis of Taxus and Cypher drug-eluting stents. 
  • Size matters--nanotechnology and therapeutics in rheumatology and immunology. 
  • Small molecule delivery across a perforated artificial membrane by thermoreversible hydrogel poloxamer 407. 
  • Specific and high-level targeting of radiolabeled octreotide analogues to human medulloblastoma xenografts. 
  • Squeezing flows of vaginal gel formulations relevant to microbicide drug delivery. 
  • Stress alleviation and reward enhancement: two promising targets for relapse prevention. 
  • Structural optimization of a "smart" doxorubicin-polypeptide conjugate for thermally targeted delivery to solid tumors. 
  • Substrate-mediated DNA delivery: role of the cationic polymer structure and extent of modification 
  • Surface-tethered DNA complexes for enhanced gene delivery 
  • Sustained VEGF delivery via PLGA nanoparticles promotes vascular growth. 
  • Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury. 
  • Sustained intra-articular delivery of IL-1RA from a thermally-responsive elastin-like polypeptide as a therapy for post-traumatic arthritis. 
  • Sustained release of BMP-2 in a lipid-based microtube vehicle. 
  • Synthesis of IR-780 dye-conjugated abiraterone for prostate cancer imaging and therapy. 
  • Targeted alpha-particle radiotherapy with 211At-labeled monoclonal antibodies. 
  • Targeted delivery in primary and metastatic brain tumors: summary report of the seventh annual meeting of the Blood-Brain Barrier Disruption Consortium. 
  • Targeted drug delivery by thermally responsive polymers. 
  • Targeted drug delivery to C6 glioma by transferrin-coupled liposomes. 
  • Targeted inhibition of alphavbeta3 integrin with an RNA aptamer impairs endothelial cell growth and survival. 
  • Targeted therapy in rectal cancer. 
  • Targeted therapy in renal cell carcinoma. 
  • Targeting BDNF/TrkB pathways for preventing or suppressing epilepsy. 
  • Targeting GSNOR for functional recovery in a middle-aged mouse model of stroke. 
  • Targeting Inflammasomes to Treat Neurological Diseases. 
  • Targeting aldehyde dehydrogenase: a potential approach for cell labeling. 
  • Targeting blood-brain barrier sphingolipid signaling reduces basal P-glycoprotein activity and improves drug delivery to the brain. 
  • Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. 
  • Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. 
  • Targeting ovarian cancer-initiating cells. 
  • Targeting protein neddylation: a novel therapeutic strategy for the treatment of cancer. 
  • Targets to tackle--the pathophysiology of the disease. 
  • Teaching old receptors new tricks: biasing seven-transmembrane receptors. 
  • Temozolomide delivered by intracerebral microinfusion is safe and efficacious against malignant gliomas in rats. 
  • Temperature and pH sensitive hydrogels: an approach towards smart semen-triggered vaginal microbicidal vehicles. 
  • Temperature-sensitive polymer-nanoshell composites for photothermally modulated drug delivery 
  • Testing the Efficacy of Pharmacological Agents in a Pericardial Target Delivery Model in the Swine. 
  • The Biomarkers Consortium: practice and pitfalls of open-source precompetitive collaboration. 
  • The Cobalt chromium STent with Antiproliferative for Restenosis II (COSTAR II) trial study design: advancing the active-control evaluation of second-generation drug-eluting stents. 
  • The Impact of Prefilled Syringes on Endophthalmitis Following Intravitreal Injection of Ranibizumab. 
  • The Weak Link: Optimization of the Ligand-Nanoparticle Interface To Enhance Cancer Cell Targeting by Polymer Micelles. 
  • The chicken chorioallantoic membrane model in biology, medicine and bioengineering 
  • The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors. 
  • The development and testing of aptamers for cancer. 
  • The effect of hyperbranched polyglycerol coatings on drug delivery using degradable polymer nanoparticles. 
  • The injured cochlea as a target for inflammatory processes, initiation of cell death pathways and application of related otoprotectives strategies. 
  • The integration of hyperthermia and drug delivery. 
  • The potential of aptamers as anticoagulants. 
  • The relation between clinical features, angiographic findings, and the target lesion revascularization rate in patients receiving the endeavor zotarolimus-eluting stent for treatment of native coronary artery disease: an analysis of ENDEAVOR I, ENDEAVOR II, ENDEAVOR II Continued Access Registry, and ENDEAVOR III. 
  • The reliable targeting of specific drug release profiles by integrating arrays of different albumin-encapsulated microsphere types. 
  • The role of cavitation in acoustically activated drug delivery. 
  • The treatment of colorectal carcinoma: standard chemotherapy and beyond. 
  • The use of lipid microtubes as a novel slow-release delivery system for laryngeal injection. 
  • Therapeutic strategies for sickle cell disease: towards a multi-agent approach. 
  • Therapeutic strategies to improve drug delivery across the blood-brain barrier. 
  • Thermal cycling enhances the accumulation of a temperature-sensitive biopolymer in solid tumors. 
  • Thermo-responsive systems for controlled drug delivery 
  • Thrombogenesis in atrial fibrillation contributing mechanisms and natural history. 
  • Thrombosis and drug-eluting stents: an objective appraisal. 
  • Top-down particle fabrication: control of size and shape for diagnostic imaging and drug delivery. 
  • Toward a systems engineering approach to cancer drug delivery. 
  • Transdermal delivery of macromolecules by erbium:YAG laser. 
  • Transdermal drug delivery enhanced and controlled by erbium:YAG laser: a comparative study of lipophilic and hydrophilic drugs. 
  • Transport of drugs from blood vessels to tumour tissue. 
  • Transvascular drug delivery in solid tumors. 
  • Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs. 
  • Tumor radiosensitization by monomethyl auristatin E: mechanism of action and targeted delivery. 
  • Tunable leuko-polymersomes that adhere specifically to inflammatory markers. 
  • Ultrasound-mediated drug delivery. 
  • Ultrasound-mediated release of hydrophilic and lipophilic agents from echogenic liposomes. 
  • Uptake of New Lipid-coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells. 
  • Use of fibrin sealant as a hemostatic agent after liver biopsy in swine. 
  • Verification of supraselective drug delivery for retinoblastoma using intra-arterial gadolinium. 
  • Wnt signaling in development, disease and translational medicine. 
  • XIAP as target for therapeutic apoptosis in prostate cancer. 
  • [Protein transduction domain peptide mediates delivery to the brain via the blood-brain barrier in Drosophila]. 
  • α7-Nicotinic receptors and cognition. 
• 

  Keywords of People

  • Abbruzzese, James, D. C. I. Distinguished Professor of Medical Oncology, Medicine, Medical Oncology
  • Anwar, Muhammad Farooq, Assistant Professor of Anesthesiology, Anesthesiology, Pain Management
  • Canelas, Dorian, Associate Professor of the Practice of Chemistry, Chemistry
  • Cianciolo, George James, Associate Professor Emeritus of Pathology, Pathology
  • Craciunescu, Oana, Professor of Radiation Oncology, Radiation Oncology
  • Fekrat, Sharon, Professor of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery
  • Katz, David F., Nello L. Teer, Jr. Distinguished Professor of Biomedical Engineering, in the Edmund T. Pratt, Jr. School of Engineering, Biomedical Engineering
  • Needham, David, Professor in the Department of Mechanical Engineering and Materials Science, Thomas Lord Department of Mechanical Engineering and Materials Science
  • Nielsen, Karen Cristina, Associate Professor of Anesthesiology, Anesthesiology, Ambulatory
  • Palmer, Gregory M., Associate Professor of Radiation Oncology, Radiation Oncology
  • Patel, Uptal Dinesh, Adjunct Professor in the Department of Medicine, Medicine, Nephrology
  • Reker, Daniel, Assistant Professor of Biomedical Engineering, Biomedical Engineering
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Biomedical Engineering
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Sullivan, Daniel Carl, Professor Emeritus of Radiology, Radiology