Central Nervous System Neoplasms

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  Subject Areas on Research

  • A genetically modified allogeneic cellular vaccine generates MHC class I-restricted cytotoxic responses against tumor-associated antigens and protects against CNS tumors in vivo. 
  • A phase I study of panobinostat in pediatric patients with refractory solid tumors, including CNS tumors. 
  • A review of VEGF/VEGFR-targeted therapeutics for recurrent glioblastoma. 
  • Activity of 9-dimethylaminomethyl-10-hydroxycamptothecin against pediatric and adult central nervous system tumor xenografts. 
  • Activity of temozolomide in the treatment of central nervous system tumor xenografts. 
  • Acute toxicity of proton beam radiation for pediatric central nervous system malignancies. 
  • Adrenal relapse of primary central nervous system diffuse large B-cell lymphoma: A case report. 
  • Adult infiltrating gliomas with WHO 2016 integrated diagnosis: additional prognostic roles of ATRX and TERT. 
  • Altered telomeres in tumors with ATRX and DAXX mutations. 
  • An unusual presentation of chronic myelogenous leukemia: a review of isolated central nervous system relapse. 
  • Analysis of 60 reported glioma risk SNPs replicates published GWAS findings but fails to replicate associations from published candidate-gene studies. 
  • Antimetabolite therapy for lesser-risk B-lineage acute lymphoblastic leukemia of childhood: a report from Children's Oncology Group Study P9201. 
  • Autologous haematopoietic cell transplantation for non-Hodgkin lymphoma with secondary CNS involvement. 
  • B-Cell Depletion Reduces the Maturation of Cerebral Cavernous Malformations in Murine Models. 
  • Bevacizumab-associated osteonecrosis of the wrist and knee in three pediatric patients with recurrent CNS tumors. 
  • Bone marrow-generated dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors. 
  • Breast cancer following spinal irradiation for a childhood cancer: A report from the Childhood Cancer Survivor Study. 
  • Cancer in pregnancy: a review of the literature. Part I. 
  • Carboplatin-based primary chemotherapy for infants and young children with CNS tumors. 
  • Cell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor, EGFRvIII. 
  • Cellular mechanisms of cyclophosphamide resistance: model studies in human medulloblastoma cell lines. 
  • Central Nervous System Cancers, Version 1.2015. 
  • Central Nervous System Tumors in Uganda: Outcomes of Surgical Treatment and Complications Assessed Through Telephone Survey. 
  • Central nervous system cancers, version 2.2014. Featured updates to the NCCN Guidelines. 
  • Central nervous system cancers. 
  • Central nervous system cancers. 
  • Central nervous system cancers. 
  • Central nervous system cancers: Clinical Practice Guidelines in Oncology. 
  • Central nervous system involvement by cutaneous T cell lymphoma. 
  • Central nervous system lymphoma in immunocompetent patients: the North Shore-Long Island Jewish Health System experience. 
  • Central nervous system manifestations of marginal zone B-cell lymphoma. 
  • Central nervous system tumor distribution at a tertiary referral center in Uganda. 
  • Central nervous system. 
  • Childhood T-cell acute lymphoblastic leukemia: the Dana-Farber Cancer Institute acute lymphoblastic leukemia consortium experience. 
  • Cilengitide with metronomic temozolomide, procarbazine, and standard radiotherapy in patients with glioblastoma and unmethylated MGMT gene promoter in ExCentric, an open-label phase II trial. 
  • Clinical and Genetic Risk Prediction of Subsequent CNS Tumors in Survivors of Childhood Cancer: A Report From the COG ALTE03N1 Study. 
  • Comparative integrated molecular analysis of intraocular medulloepitheliomas and central nervous system embryonal tumors with multilayered rosettes confirms that they are distinct nosologic entities. 
  • Conformal radiation therapy for childhood CNS tumors. 
  • Cyclophosphamide, doxorubicin, vincristine, and prednisone for primary central nervous system lymphoma: short-duration response and multifocal intracerebral recurrence preceding radiotherapy. 
  • Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome-positive leukemia. 
  • Detection of glioma-associated gangliosides GM2, GD2, GD3, 3'-isoLM1 3',6'-isoLD1 in central nervous system tumors in vitro and in vivo using epitope-defined monoclonal antibodies. 
  • Different patterns of relapse associated with three intensive treatment regimens for pediatric E-rosette positive T-cell leukemia: a Pediatric Oncology Group study. 
  • Dose intensive melphalan and cyclophosphamide with autologous hematopoietic stem cells for recurrent medulloblastoma or germinoma. 
  • Effect of imaging and catheter characteristics on clinical outcome for patients in the PRECISE study. 
  • Embryonal central nervous system neoplasms arising in infants and young children: a pediatric brain tumor consortium study. 
  • Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations. 
  • Exomic sequencing of four rare central nervous system tumor types. 
  • Germline genetic landscape of pediatric central nervous system tumors. 
  • Glioblastoma multiforme: a review of where we have been and where we are going. 
  • Glioblastoma multiforme: an emerging paradigm of anti-VEGF therapy. 
  • Gliomatosis cerebri: cytologic and autopsy findings in a case involving the entire neuraxis. 
  • Glioneuronal tumors of the central nervous system. 
  • Hematologic toxicity during craniospinal irradiation: the impact of prior chemotherapy. 
  • High-dose methotrexate for primary CNS lymphoma in the elderly. 
  • High-dose therapy with hematopoietic cell transplantation for patients with central nervous system involvement by non-Hodgkin's lymphoma. 
  • Immunohistochemistry of the glial fibrillary acidic protein: basic and applied considerations. 
  • Improved grading of IDH-mutated astrocytic gliomas. 
  • Intensive chemotherapy and immunotherapy in patients with newly diagnosed primary CNS lymphoma: CALGB 50202 (Alliance 50202). 
  • Intensive chemotherapy with and without cranial radiation for Burkitt leukemia and lymphoma: final results of Cancer and Leukemia Group B Study 9251. 
  • Intracerebral Flexner-Wintersteiner Rosette-Rich Tumor With Somatic RB1 Mutation: A CNS Embryonal Tumor With Retinoblastic Differentiation. 
  • Invasiveness is associated with metastasis and decreased survival in hemangiopericytoma of the central nervous system. 
  • Irinotecan treatment for recurrent malignant glioma using an every-3-week regimen. 
  • Isolated Central Nervous System Chloroma as a Presenting Sign of Relapsed Pediatric Acute Lymphoblastic Leukemia. 
  • Lactotetraose series ganglioside 3',6'-isoLD1 in tumors of central nervous and other systems in vitro and in vivo. 
  • Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis. 
  • Longitudinal assessment of late-onset neurologic conditions in survivors of childhood central nervous system tumors: a Childhood Cancer Survivor Study report. 
  • Low-stage medulloblastoma: final analysis of trial comparing standard-dose with reduced-dose neuraxis irradiation. 
  • Microglioma, a histiocytic neoplasm of the central nervous system. 
  • Molecular phenotype of simian virus 40 large T antigen-induced primitive neuroectodermal tumors in four different lines of transgenic mice. 
  • Mutant metabolic enzymes are at the origin of gliomas. 
  • NCCN Guidelines Insights: Central Nervous System Cancers, Version 1.2017. 
  • No free lunch: secondary neoplasms after stereotactic radiation. 
  • Noncutaneous malignant tumors in the PUVA follow-up study: 1975-1996. 
  • O6-benzylguanine-mediated enhancement of chemotherapy. 
  • O6-benzylguanine-mediated enhancement of nitrosourea activity in Mer- central nervous system tumor xenografts--implications for clinical trials. 
  • O6-methylguanine-DNA methyltransferase (MGMT) immunohistochemistry as a predictor of resistance to temozolomide in primary CNS lymphoma. 
  • Outcome of CNS disease at diagnosis in disseminated small noncleaved-cell lymphoma and B-cell leukemia: a Children's Cancer Group study. 
  • Pediatric Neuro-Oncology: Time to Go Molecular. 
  • Performance status and age as independent predictors of survival among AIDS patients with primary CNS lymphoma: a multivariate analysis of a multi-institutional experience. 
  • Phase 2 study of temozolomide in children and adolescents with recurrent central nervous system tumors: a report from the Children's Oncology Group. 
  • Phase 2 trial of erlotinib plus sirolimus in adults with recurrent glioblastoma. 
  • Phase I and pharmacokinetic study of the oral farnesyltransferase inhibitor lonafarnib administered twice daily to pediatric patients with advanced central nervous system tumors using a modified continuous reassessment method: a Pediatric Brain Tumor Consortium Study. 
  • Phase I study of SU5416, a small molecule inhibitor of the vascular endothelial growth factor receptor (VEGFR) in refractory pediatric central nervous system tumors. 
  • Phase I study of intraventricular administration of rituximab in patients with recurrent CNS and intraocular lymphoma. 
  • Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study. 
  • Phase I trial of carmustine plus O6-benzylguanine for patients with recurrent or progressive malignant glioma. 
  • Phase II study of imatinib mesylate and hydroxyurea for recurrent grade III malignant gliomas. 
  • Phase III clinical evaluation of gadoteridol injection: experience in pediatric neuro-oncologic MR imaging. 
  • Pigmented Lesions of the Nervous System and the Neural Crest: Lessons From Embryology. 
  • Pilocytic astrocytoma: correlation between the initial imaging features and clinical aggressiveness. 
  • Preparing an oncolytic poliovirus recombinant for clinical application against glioblastoma multiforme. 
  • Primary CNS lymphoma in HIV positive and negative patients: comparison of clinical characteristics, outcome and prognostic factors. 
  • Primary central nervous system histiocytic sarcoma: A case report and review of literature. 
  • Primary central nervous system lymphoma with systemic metastasis: case report and review. 
  • Primary central nervous system lymphomas: a 30-year experience at a single institution. 
  • Primary central nervous system recurrence after paclitaxel therapy for epithelial ovarian malignancy. 
  • Promising survival and concomitant radiation plus temozolomide followed by adjuvant temozolomide. 
  • Recent advances in the treatment of malignant astrocytoma. 
  • Reply to M.C. Chamberlain. 
  • Results of treatment with hyper-CVAD, a dose-intensive regimen, in adult acute lymphocytic leukemia. 
  • Risk assessment for developing gliomas: a comparison of two cytogenetic approaches. 
  • SEER insights. 
  • Safety and Diagnostic Efficacy of Gadobenate Dimeglumine in MRI of the Brain and Spine of Neonates and Infants. 
  • Second messenger systems in human gliomas. 
  • Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial. 
  • Single nucleotide polymorphisms of matrix metallopeptidase 3 and risk of gliomas in a Chinese Han population. 
  • Studies of primary central nervous system lymphoma with fluorine-18-fluorodeoxyglucose positron emission tomography. 
  • Surgical neuropathology update: a review of changes introduced by the WHO classification of tumours of the central nervous system, 4th edition. 
  • Tagging SNPs in non-homologous end-joining pathway genes and risk of glioma. 
  • Template for Reporting Results of Biomarker Testing of Specimens From Patients With Tumors of the Central Nervous System. 
  • The Utility of Expert Diagnosis in Surgical Neuropathology: Analysis of Consultations Reviewed at 5 National Comprehensive Cancer Network Institutions. 
  • The developmental biology of brain tumors. 
  • The potential of cerebrospinal fluid-based liquid biopsy approaches in CNS tumors. 
  • Topotecan for the treatment of recurrent or progressive central nervous system tumors - a pediatric oncology group phase II study. 
  • Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations. 
  • Trastuzumab emtansine (T-DM1) versus lapatinib plus capecitabine in patients with HER2-positive metastatic breast cancer and central nervous system metastases: a retrospective, exploratory analysis in EMILIA. 
  • Treatment of newly diagnosed glioblastoma multiforme. 
  • Trends in primary central nervous system lymphoma incidence and survival in the U.S. 
  • Understanding the Revised Fourth Edition of the World Health Organization Classification of Tumours of the Central Nervous System (2016) for Clinical Decision-making: A Guide for Oncologists Managing Patients with Glioma. 
  • Unusual association of congenital kyphosis and conus lipoma presenting as a double spinal cord tether. 
  • Utility of postmortem magnetic resonance imaging in clinical neuropathology. 
  • Viruses as therapeutic agents against malignant disease of the central nervous system. 
  • Viruses for the treatment of malignant glioma. 
  • ZD6474, a novel tyrosine kinase inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor, inhibits tumor growth of multiple nervous system tumors. 
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  Keywords of People

  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Immunology
  • Yan, Hai, Henry S. Friedman Distinguished Professor of Neuro-Oncology in the School of Medicine, Pathology