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Subject Areas on Research
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A Systematic Literature Review Approach to Estimate the Therapeutic Index of Selected Immunosuppressant Drugs After Renal Transplantation.
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A longitudinal replicate study of immunosuppressive drugs: a College of American Pathologists study.
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A non-canonical RNA degradation pathway suppresses RNAi-dependent epimutations in the human fungal pathogen Mucor circinelloides.
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A prospective, randomized, multicenter study evaluating early corticosteroid withdrawal with Thymoglobulin in living-donor kidney transplantation.
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A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease.
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A systematic review of morphea treatments and therapeutic algorithm.
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Acquired Pelger-Huët anomaly in association with concomitant tacrolimus and mycophenolate mofetil in a liver transplant patient: a case report and review of the literature.
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Adenovirus infections in pediatric small bowel transplant recipients.
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Advances in pancreas transplantation: the University of Wisconsin experience.
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Advantage of rapamycin over mycophenolate mofetil when used with tacrolimus for simultaneous pancreas kidney transplants: randomized, single-center trial at 10 years.
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Alemtuzumab induction and antibody-mediated kidney rejection after simultaneous pancreas-kidney transplantation.
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An immune reconstitution syndrome-like illness associated with Cryptococcus neoformans infection in organ transplant recipients.
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An international ISHLT/ATS/ERS clinical practice guideline: diagnosis and management of bronchiolitis obliterans syndrome.
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Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action.
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Antifungal drug resistance evoked via RNAi-dependent epimutations.
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Antifungal effects of cyclosporine and FK 506 are mediated via immunophilin-dependent calcineurin inhibition.
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Association of hepatitis C with posttransplant diabetes in renal transplant patients on tacrolimus.
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Association of tacrolimus time-to-therapeutic range on renal dysfunction and acute cellular rejection after orthotopic heart transplantation in a high use basiliximab population.
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Belatacept-Based Maintenance Immunosuppression Controls the Post-Transplant Humoral Immune Response in Highly Sensitized Nonhuman Primates.
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Broad antifungal resistance mediated by RNAi-dependent epimutation in the basal human fungal pathogen Mucor circinelloides.
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Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivo.
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Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach.
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Calcineurin inhibition or mutation enhances cell wall inhibitors against Aspergillus fumigatus.
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Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain.
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Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis.
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Calcineurin is essential for survival during membrane stress in Candida albicans.
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Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains.
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Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans.
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Calcineurin is required for virulence of Cryptococcus neoformans.
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Calcineurin mediates pancreatic growth in protease inhibitor-treated mice.
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Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides.
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Calcineurin plays key roles in the dimorphic transition and virulence of the human pathogenic zygomycete Mucor circinelloides.
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Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans.
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Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1{alpha}, drives utrophin gene expression at the neuromuscular junction.
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Calcineurin. Structure, function, and inhibition.
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Calcium- and calcineurin-independent roles for calmodulin in Cryptococcus neoformans morphogenesis and high-temperature growth.
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Campath-1H in intestinal and multivisceral transplantation: preliminary data.
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Cell biology. A fungal Achilles' heel.
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Cellular and molecular targeting for nanotherapeutics in transplantation tolerance.
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Changing from cyclosporine to tacrolimus as salvage therapy for chronic graft-versus-host disease.
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Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation.
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Clinical Outcomes of Older Kidney Transplant Recipients.
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Clinical outcome after conversion to FK 506 (tacrolimus) therapy for acute graft-versus-host disease resistant to cyclosporine or for cyclosporine-associated toxicities.
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Comparison of four different immunosuppression protocols without long-term steroid therapy in kidney recipients monitored by surveillance biopsy: five-year outcomes.
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Composite tissue allotransplantation: development of a preclinical model in nonhuman primates.
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Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection.
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Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens.
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Cryptococcus neoformans methionine synthase: expression analysis and requirement for virulence.
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Diarrhea in a Patient With Combined Kidney-Pancreas Transplant.
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Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays.
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Drug-Resistant Epimutants Exhibit Organ-Specific Stability and Induction during Murine Infections Caused by the Human Fungal Pathogen Mucor circinelloides.
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Early and limited use of tacrolimus to avoid rejection in an alemtuzumab and sirolimus regimen for kidney transplantation: clinical results and immune monitoring.
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Effect of Early Everolimus-Facilitated Reduction of Tacrolimus on Efficacy and Renal Function in De Novo Liver Transplant Recipients: 24-Month Results for the North American Subpopulation.
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Effect of immunosuppressants on T-cell subsets observed in vivo using carboxy-fluorescein diacetate succinimidyl ester labeling.
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Effects of Immunosuppressive Medications on Mitochondrial Function.
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Effects of treatment with cyclosporine, FK 506, rapamycin, mycophenolic acid, or deoxyspergualin on vascular muscle proliferation in vitro and in vivo.
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Efficacy and safety of mammalian target of rapamycin inhibitors following intestinal and multivisceral transplantation.
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Efficacy and toxicity of a protocol using sirolimus, tacrolimus and daclizumab in a nonhuman primate renal allotransplant model.
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Equivalent success of simultaneous pancreas kidney and solitary pancreas transplantation. A prospective trial of tacrolimus immunosuppression with percutaneous biopsy.
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Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei.
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Evaluation of tacrolimus abbreviated area-under-the-curve monitoring in renal transplant patients who are potentially at risk for adverse events.
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Everolimus with reduced tacrolimus improves renal function in de novo liver transplant recipients: a randomized controlled trial.
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FK 506 induction and rescue therapy in pancreas transplant recipients.
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FK 506 rescue therapy for resistant rejection episodes in liver transplant recipients.
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FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae.
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FK506 in combination with methotrexate for the prevention of graft-versus-host disease after marrow transplantation from matched unrelated donors.
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FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
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FKBP12 dimerization mutations effect FK506 binding and differentially alter calcineurin inhibition in the human pathogen Aspergillus fumigatus.
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FKBP12 is not required for the modulation of transforming growth factor beta receptor I signaling activity in embryonic fibroblasts and thymocytes.
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FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506.
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FKBP12 physically and functionally interacts with aspartokinase in Saccharomyces cerevisiae.
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FKBP12-Dependent Inhibition of Calcineurin Mediates Immunosuppressive Antifungal Drug Action in Malassezia.
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Frontal fibrosing alopecia: a retrospective review of 19 patients seen at Duke University.
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Functional Characteristics and Phenotypic Plasticity of CD57+PD1- CD4 T Cells and Their Relationship with Transplant Immunosuppression.
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Gq signaling causes glomerular injury by activating TRPC6.
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Guidance for liver transplant immunosuppression.
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Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents.
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Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase.
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Human immunodeficiency virus. Chaperoning a pathogen.
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Idiopathic intracranial hypertension following kidney transplantation: a case report and review of the literature.
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Imatinib mesylate for the treatment of steroid-refractory sclerotic-type cutaneous chronic graft-versus-host disease.
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Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands.
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Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast.
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Immunosuppressive protocols and immunological challenges related to hand transplantation.
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Immunotherapy with tacrolimus (FK506) does not select for resistance to calcineurin inhibitors in Candida albicans isolates from liver transplant patients.
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Impact of Tacrolimus Trough Variability on Acute Rejection Following Lung Transplantation.
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In Vitro and In Vivo Assessment of FK506 Analogs as Novel Antifungal Drug Candidates.
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In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients.
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In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus.
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Intra-articular depletion of macrophages increases acute synovitis and alters macrophage polarity in the injured mouse knee.
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Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression.
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Laryngeal transplantation in the setting of cancer: a rat model.
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Late graft loss and long-term outcome after isolated intestinal transplantation in children.
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Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs.
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Long-term results of tacrolimus in cyclosporine- and prednisone-dependent myasthenia gravis.
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Measuring disease progression in early Parkinson disease: the National Institutes of Health Exploratory Trials in Parkinson Disease (NET-PD) experience.
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Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin.
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Myristoylation of calcineurin B is not required for function or interaction with immunophilin-immunosuppressant complexes in the yeast Saccharomyces cerevisiae.
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Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers.
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No evidence of increased cancer incidence in children using topical tacrolimus for atopic dermatitis.
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Obesity following kidney transplantation and steroid avoidance immunosuppression.
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Outcome of transplantation for acute lymphoblastic leukemia in children with Down syndrome.
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Peripheral blood detection of systemic graft-specific xeno-antibodies following transplantation of human neural progenitor cells into the porcine spinal cord.
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Phase II Study of Allogeneic Transplantation for Older Patients With Acute Myeloid Leukemia in First Complete Remission Using a Reduced-Intensity Conditioning Regimen: Results From Cancer and Leukemia Group B 100103 (Alliance for Clinical Trials in Oncology)/Blood and Marrow Transplant Clinical Trial Network 0502.
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Pimecrolimus enhances TLR2/6-induced expression of antimicrobial peptides in keratinocytes.
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Polyhexamethylene biguanide and calcineurin inhibitors as novel antifungal treatments for Aspergillus keratitis.
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Posaconazole exhibits in vitro and in vivo synergistic antifungal activity with caspofungin or FK506 against Candida albicans.
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Posterior reversible encephalopathy syndrome independently associated with tacrolimus and sirolimus after multivisceral transplantation.
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Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506.
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Potentiation of progesterone receptor-mediated transcription by the immunosuppressant FK506.
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Pre-engraftment syndrome after myeloablative dual umbilical cord blood transplantation: risk factors and response to treatment.
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Preliminary assessment of safety and adherence to a once-daily immunosuppression regimen in kidney transplantation: Results of a randomized controlled pilot study.
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Preliminary experience with FK 506 in pancreas transplant recipients.
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Prolyl isomerases in yeast.
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Prospective, Randomized, Double-Blind, Phase III Clinical Trial of Anti-T-Lymphocyte Globulin to Assess Impact on Chronic Graft-Versus-Host Disease-Free Survival in Patients Undergoing HLA-Matched Unrelated Myeloablative Hematopoietic Cell Transplantation.
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Protocol-based nurse coordinator management of ambulatory tacrolimus dosing in de novo renal transplant recipients-A single-center experience with a large African American population.
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Pseudo-Pelger-Huët anomaly induced by medications: a clinicopathologic study in comparison with myelodysplastic syndrome-related pseudo-Pelger-Huët anomaly.
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Pseudo-Pelger-Huët anomaly induced by transplant medications.
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Pulmonary infiltrates and eosinophilia in an FK 506 liver transplant recipient.
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R73A and H144Q mutants of the yeast mitochondrial cyclophilin Cpr3 exhibit a low prolyl isomerase activity in both peptide and protein-folding assays.
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Rapamycin antagonizes cyclosporin A- and tacrolimus (FK506)-mediated augmentation of linker for activation of T cell expression in T cells.
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Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor.
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Regulation of tumor necrosis factor cytotoxicity by calcineurin.
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Role of low-dose calcineurin inhibitor regimens in pediatric kidney transplantation.
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Safety and pharmacokinetics of daclizumab in pediatric renal transplant recipients.
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Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans.
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Signal-transduction cascades as targets for therapeutic intervention by natural products.
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Sirolimus conversion regimen versus continued calcineurin inhibitors in liver allograft recipients: a randomized trial.
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Stem cell transplantation for the treatment of Fanconi anaemia using a fludarabine-based cytoreductive regimen and T-cell-depleted related HLA-mismatched peripheral blood stem cell grafts.
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Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus.
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Sublingual tacrolimus for immunosuppression in lung transplantation: a potentially important therapeutic option in cystic fibrosis.
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Superiority of rapamycin over tacrolimus in preserving nonhuman primate Treg half-life and phenotype after adoptive transfer.
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Surfactant protein D binding to Aspergillus fumigatus hyphae is calcineurin-sensitive.
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Survival after bronchiolitis obliterans syndrome.
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Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans.
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Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms.
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System for integrated adherence monitoring: real-time non-adherence risk assessment in pediatric kidney transplantation.
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T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+.
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Tacrolimus (FK506) alone or in combination with methotrexate or methylprednisolone for the prevention of acute graft-versus-host disease after marrow transplantation from HLA-matched siblings: a single-center study.
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Tacrolimus (FK506) in allogeneic bone marrow transplantation for severe aplastic anemia following orthotopic liver transplantation.
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Tacrolimus and sirolimus: when bad things happen to good drugs.
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Tacrolimus dose requirements in African-American and Caucasian kidney transplant recipients on mycophenolate and prednisone.
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Tacrolimus inhibits Th1 and Th17 responses in MuSK-antibody positive myasthenia gravis patients.
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Tacrolimus to Belatacept Conversion Following Hand Transplantation: A Case Report.
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Tacrolimus versus Cyclosporine after Hematopoietic Cell Transplantation for Acquired Aplastic Anemia.
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Targeting Calcium Release-activated Calcium Channel Is Not Sufficient to Prevent Rejection in Nonhuman Primate Kidney Transplantation.
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Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model.
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Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast.
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Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A.
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Teaching old drugs new tricks: reincarnating immunosuppressants as antifungal drugs.
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Template-based docking of a prolactin receptor proline-rich motif octapeptide to FKBP12: implications for cytokine receptor signaling.
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The C2 domain protein Cts1 functions in the calcineurin signaling circuit during high-temperature stress responses in Cryptococcus neoformans.
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The RAM1 gene encoding a protein-farnesyltransferase beta-subunit homologue is essential in Cryptococcus neoformans.
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The allo- and viral-specific immunosuppressive effect of belatacept, but not tacrolimus, attenuates with progressive T cell maturation.
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The calcineurin target, Crz1, functions in azole tolerance but is not required for virulence of Candida albicans.
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The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein.
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The immunosuppressant FK506 inhibits amino acid import in Saccharomyces cerevisiae.
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The importance of studying history: lessons learnt from a trial of tacrolimus in myasthenia gravis.
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The role of alemtuzumab in facilitating maintenance immunosuppression minimization following solid organ transplantation.
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Transposon mobilization in the human fungal pathogen Cryptococcus is mutagenic during infection and promotes drug resistance in vitro.
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Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates.
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Treatment with rapamycin and mycophenolic acid reduces arterial intimal thickening produced by mechanical injury and allows endothelial replacement.
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Two Cases and a Review of Graft-Versus-Host Disease and the Role of Hepatitis C Treatment in Liver Transplant Patients.
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Uncontrolled transposition following RNAi loss causes hypermutation and antifungal drug resistance in clinical isolates of Cryptococcus neoformans.
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Understanding the impact of HLA molecular mismatch in solid organ transplantation: Are we there yet?
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Update on new immunomodulatory agents.
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Use of Everolimus After Multivisceral Transplantation: A Report of Two Cases.
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vph6 mutants of Saccharomyces cerevisiae require calcineurin for growth and are defective in vacuolar H(+)-ATPase assembly.