Amyloid beta-Protein Precursor
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Subject Areas on Research
- A molecular genetic study of intracerebral hemorrhage.
- A neuronal model of Alzheimer's disease: an insight into the mechanisms of oxidative stress-mediated mitochondrial injury.
- A novel species-specific RNA related to alternatively spliced amyloid precursor protein mRNAs.
- A prior feature SVM-MRF based method for mouse brain segmentation.
- ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein.
- APOE-mimetic peptides reduce behavioral deficits, plaques and tangles in Alzheimer's disease transgenics.
- Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside.
- Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis.
- Altered genetic response to beta-adrenergic receptor activation in late passage C6 glioma cells.
- Alzheimer's disease and apolipoprotein E-4 allele in an Amish population.
- Alzheimer's disease and possible gene interaction.
- Amyloid precursor protein 96-110 and beta-amyloid 1-42 elicit developmental anomalies in sea urchin embryos and larvae that are alleviated by neurotransmitter analogs for acetylcholine, serotonin and cannabinoids.
- Amyloid precursor protein and amyloid beta-peptide bind to ATP synthase and regulate its activity at the surface of neural cells.
- Amyloid precursor protein processing and Alzheimer's disease.
- Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease.
- Assessment of the genetic variance of late-onset Alzheimer's disease.
- Avid binding of beta A amyloid peptide to its own precursor.
- Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice.
- CD36 initiates the secretory phenotype during the establishment of cellular senescence.
- Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension.
- Consequences of inhibiting amyloid precursor protein processing enzymes on synaptic function and plasticity.
- Decoy mRNAs reduce beta-amyloid precursor protein mRNA in neuronal cells.
- Defective phorbol ester-stimulated secretion of beta-amyloid precursor protein from Alzheimer's disease fibroblasts.
- Distribution of amyloid precursor protein and amyloid-beta in ocular hypertensive C57BL/6 mouse eyes.
- Diverse inflammatory responses in transgenic mouse models of Alzheimer's disease and the effect of immunotherapy on these responses.
- Does epileptiform activity contribute to cognitive impairment in Alzheimer's disease?
- Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity.
- Effects of repetitive exposure to anesthetics and analgesics in the Tg2576 mouse Alzheimer's model.
- Focusing on IL-1-promotion of beta-amyloid precursor protein synthesis as an early event in Alzheimer's disease.
- Genes and recent developments in the epidemiology of Alzheimer's disease and related dementia.
- Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14.
- Genetic studies in Alzheimer's disease with an NACP/alpha-synuclein polymorphism.
- Genome-wide analysis of miRNA signature in the APPswe/PS1ΔE9 mouse model of alzheimer's disease.
- Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism.
- Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice.
- Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model.
- Human apolipoprotein E4 worsens acute axonal pathology but not amyloid-β immunoreactivity after traumatic brain injury in 3xTG-AD mice.
- Iatrogenic Alzheimer Disease? Amyloid-β Protein Transmission Between Humans.
- Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8.
- Increasing amyloid peptide precursor production and its impact on Alzheimer's disease.
- Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells.
- Interplay between stress-related genes may influence Alzheimer's disease development: The results of genetic interaction analyses of human data.
- Isolation and expression of multiple forms of beta amyloid protein precursor cDNAs.
- Large quantities of Abeta peptide are constitutively released during amyloid precursor protein metabolism in vivo and in vitro.
- Lewy body and Alzheimer pathology in a family with the amyloid-beta precursor protein APP717 gene mutation.
- Lithium treatment of APPSwDI/NOS2-/- mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype.
- Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease.
- Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease.
- Microglial oxyradical production: causes and consequences.
- Multiple forms of beta-amyloid peptide precursor RNAs in a single cell type.
- Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models.
- PDAPP; YFP double transgenic mice: a tool to study amyloid-beta associated changes in axonal, dendritic, and synaptic structures.
- Quantitative measurement of alternatively spliced amyloid precursor protein mRNA expression in Alzheimer's disease and normal brain by S1 nuclease protection analysis.
- Quantitative measurement of postural sway in mouse models of human neurodegenerative disease.
- Rarity of the Alzheimer disease-protective APP A673T variant in the United States.
- Re: Axonal injury in head injuries with very short survival.
- Reducing cerebral microvascular amyloid-beta protein deposition diminishes regional neuroinflammation in vasculotropic mutant amyloid precursor protein transgenic mice.
- Release of amino-terminal fragments from amyloid precursor protein reporter and mutated derivatives in cultured cells.
- Sequestration of amyloid beta-peptide.
- Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline.
- The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events.
- The apolipoprotein-E-mimetic COG112 protects amyloid precursor protein intracellular domain-overexpressing animals from Alzheimer's disease-like pathological features.
- The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP.
- The genetics of dementia in late life.
- The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice.
- Thymocytes and cultured thymic epithelial cells express transcripts encoding alpha-3, alpha-5 and beta-4 subunits of neuronal nicotinic acetylcholine receptors: preferential transcription of the alpha-3 and beta-4 genes by immature CD4 + 8 + thymocytes.
- Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease.
- [Investigation of neuroprotective activity of apolipoprotein E peptide mimetic Cog1410 in transgenic lines of Drosophila melanogaster].
- [Studying pathogenesis of Alzheimer's disease in a Drosophila melanogaster model: human APP overexpression in the brain of transgenic flies leads to deficit of the synaptic protein synaptotagmin].
- mNos2 deletion and human NOS2 replacement in Alzheimer disease models.
- p53-dependent control of transactivation of the Pen2 promoter by presenilins.