-
Subject Areas on Research
-
2016 American College of Rheumatology/European League Against Rheumatism Criteria for Minimal, Moderate, and Major Clinical Response in Juvenile Dermatomyositis: An International Myositis Assessment and Clinical Studies Group/Paediatric Rheumatology International Trials Organisation Collaborative Initiative.
-
A Systematic Literature Review Approach to Estimate the Therapeutic Index of Selected Immunosuppressant Drugs After Renal Transplantation.
-
A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type.
-
A comparison of Zn2+- and Ca2+-triggered depolarization of liver mitochondria reveals no evidence of Zn2+-induced permeability transition.
-
A comparison of tacrolimus and cyclosporine in liver transplantation: effects on renal function and cardiovascular risk status.
-
A controlled, double-blind, randomized trial of verapamil and cyclosporine in cadaver renal transplant patients.
-
A longitudinal replicate study of immunosuppressive drugs: a College of American Pathologists study.
-
A novel approach to the treatment of chronic allograft nephropathy.
-
A randomized, double-blind study comparing the efficacy, safety and optimal dose of two formulations of cyclosporin, Neoral and Sandimmun, in patients with severe psoriasis. OLP302 Study Group.
-
A role for leukotrienes in cyclosporine nephrotoxicity.
-
A toxicity study of trimetrexate used in combination with cyclosporine as acute graft-versus-host disease prophylaxis in HLA-mismatched, related donor bone marrow transplants.
-
Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases.
-
Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway.
-
Acute graft-versus-host disease: analysis of risk factors after allogeneic marrow transplantation and prophylaxis with cyclosporine and methotrexate.
-
Allogeneic marrow transplantation for myelodysplastic syndrome with advanced disease morphology: a phase II study of busulfan, cyclophosphamide, and total-body irradiation and analysis of prognostic factors.
-
Allogeneic marrow transplantation in patients with severe systemic sclerosis: resolution of dermal fibrosis.
-
Alterations in renal function in psoriasis patients treated with cyclosporine, 5 mg/kg/day.
-
An individual bioequivalence approach to compare the intrasubject variability of two ciclosporin formulations, SangCya and Neoral.
-
An international ISHLT/ATS/ERS clinical practice guideline: diagnosis and management of bronchiolitis obliterans syndrome.
-
An intravitreal device providing sustained release of cyclosporine and dexamethasone.
-
Antifungal activities of antineoplastic agents: Saccharomyces cerevisiae as a model system to study drug action.
-
Antifungal effects of cyclosporine and FK 506 are mediated via immunophilin-dependent calcineurin inhibition.
-
Antisense oligodeoxynucleotides prevent acute cardiac allograft rejection via a novel, nontoxic, highly efficient transfection method.
-
Aplastic anaemia as an autoimmune complication of thymoma.
-
Avascular necrosis following bone marrow transplantation: a case-control study.
-
Bone density loss during treatment of chronic GVHD.
-
Brequinar sodium potentiates the effects of cyclosporine in experimental small bowel transplantation.
-
Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection.
-
CYP3A-like cytochrome P450-mediated metabolism and polarized efflux of cyclosporin A in Caco-2 cells.
-
Calcineurin in fungal virulence and drug resistance: Prospects for harnessing targeted inhibition of calcineurin for an antifungal therapeutic approach.
-
Calcineurin is essential for survival during membrane stress in Candida albicans.
-
Calcineurin is essential in cyclosporin A- and FK506-sensitive yeast strains.
-
Calcineurin is required for hyphal elongation during mating and haploid fruiting in Cryptococcus neoformans.
-
Calcineurin is required for virulence of Cryptococcus neoformans.
-
Calcineurin mediates pancreatic growth in protease inhibitor-treated mice.
-
Calcineurin mutants render T lymphocytes resistant to cyclosporin A.
-
Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy.
-
Calcineurin regulates cyclin D1 accumulation in growth-stimulated fibroblasts.
-
Calcineurin. Structure, function, and inhibition.
-
Cell biology. A fungal Achilles' heel.
-
Changing from cyclosporine to tacrolimus as salvage therapy for chronic graft-versus-host disease.
-
Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus.
-
Chronic kidney disease after hematopoietic cell transplantation: a systematic review.
-
Chronic thromboxane synthase inhibition with CGS 12970 in human cyclosporine nephrotoxicity.
-
Circulating mitochondria in deceased organ donors are associated with immune activation and early allograft dysfunction.
-
Clinical outcome after conversion to FK 506 (tacrolimus) therapy for acute graft-versus-host disease resistant to cyclosporine or for cyclosporine-associated toxicities.
-
Clinical outcome of interval cadaveric renal transplantation in cardiac allograft recipients.
-
Clinical trial of focal segmental glomerulosclerosis in children and young adults.
-
Collaborative multicenter investigation of marrow transplantation for sickle cell disease: current results and future directions.
-
Comparative Analysis of Mass-Spectrometry-Based Proteomic Methods for Protein Target Discovery Using a One-Pot Approach.
-
Comparative study of cyclosporine and FK 506 dosage requirements in adult and pediatric orthotopic liver transplant patients.
-
Comparison of four different immunosuppression protocols without long-term steroid therapy in kidney recipients monitored by surveillance biopsy: five-year outcomes.
-
Comparison of topical dry eye medications for the treatment of keratoconjunctivitis sicca in a botulinum toxin B-induced mouse model.
-
Cryptococcus neoformans isolates from transplant recipients are not selected for resistance to calcineurin inhibitors by current immunosuppressive regimens.
-
Cryptococcus neoformans methionine synthase: expression analysis and requirement for virulence.
-
Cyclosporin A inhibits chromium(VI)-induced apoptosis and mitochondrial cytochrome c release and restores clonogenic survival in CHO cells.
-
Cyclosporin A inhibits inositol 1,4,5-trisphosphate binding to its receptors and release of calcium from intracellular stores in peritoneal macrophages.
-
Cyclosporin A therapy for Wegener's granulomatosis.
-
Cyclosporin A-related cerebral vasculopathy.
-
Cyclosporin and asthma.
-
Cyclosporine for Dry Eye Associated With Nivolumab: A Case Progressing to Corneal Perforation.
-
Cyclosporine increases hepatocyte synthesis of the immunosuppressive free radical nitric oxide.
-
Cyclosporine or cyclosporine plus methylprednisolone for prophylaxis of graft-versus-host disease: a prospective, randomized trial.
-
Cyclosporine suppresses hepatitis C virus in vitro and increases the chance of a sustained virological response after liver transplantation.
-
Cyclosporine versus tacrolimus treated liver transplant recipients with chronic hepatitis C: outcomes analysis of the UNOS/OPTN database.
-
Cyclosporine, methotrexate, and prednisone compared with cyclosporine and prednisone for prevention of acute graft-vs.-host disease: effect on chronic graft-vs.-host disease and long-term survival.
-
Cyclosporine, methotrexate, and prednisone compared with cyclosporine and prednisone for prophylaxis of acute graft-versus-host disease.
-
Cyclosporine-inhibitable blood-brain barrier drug transport influences clinical morphine pharmacodynamics.
-
Cyclosporine-inhibitable cerebral drug transport does not influence clinical methadone pharmacodynamics.
-
Cytomegalovirus keratitis after penetrating keratoplasty.
-
Delayed cardiac xenograft rejection in a pig-to-baboon model treated with a tolerance-inducing regimen and donor bone marrow infusion.
-
Determination of the functional status of alloreactive T cells by interferon-gamma kinetics.
-
Diabetic complications associated with new-onset diabetes mellitus in renal transplant recipients.
-
Do patient preferences influence decisions on treatment for patients with steroid-refractory ulcerative colitis?
-
Dry eye medication use and expenditures: data from the medical expenditure panel survey 2001 to 2006.
-
Effect of age and gender on the activity of human hepatic CYP3A.
-
Effect of an intravitreal cyclosporine implant on experimental uveitis in horses.
-
Effect of cyclosporin pharmacokinetics on renal allograft outcome in African-Americans.
-
Effect of cyclosporine on renal function in survivors of liver transplantation after 1 year.
-
Effect of immunosuppressants on T-cell subsets observed in vivo using carboxy-fluorescein diacetate succinimidyl ester labeling.
-
Effect of surrogate tolerogenesis on the vascular rejection of pig heart xenografts.
-
Effects of Immunosuppressive Medications on Mitochondrial Function.
-
Effects of cyclosporine on human B-cell lymphoma development in vivo.
-
Effects of immunosuppression and pretransplant splenectomy in newborn cardiac xenograft survival.
-
Effects of thromboxane synthase inhibition with CGS 13080 in human cyclosporine nephrotoxicity.
-
Effects of treatment with cyclosporine, FK 506, rapamycin, mycophenolic acid, or deoxyspergualin on vascular muscle proliferation in vitro and in vivo.
-
Electrical stimulation of neonatal cardiac myocytes activates the NFAT3 and GATA4 pathways and up-regulates the adenylosuccinate synthetase 1 gene.
-
Equivalence of 2 effective graft-versus-host disease prophylaxis regimens: results of a prospective double-blind randomized trial.
-
Equivalent success of simultaneous pancreas kidney and solitary pancreas transplantation. A prospective trial of tacrolimus immunosuppression with percutaneous biopsy.
-
Etoposide, vincristine, and cyclosporin A with standard-dose radiation therapy in newly diagnosed diffuse intrinsic brainstem gliomas: a pediatric oncology group phase I study.
-
Evaluation of a delivery system providing long-term release of cyclosporine.
-
Evidence for a gene controlling the induction of transplantation tolerance.
-
Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D.
-
Expression of heme oxygenase-1 can determine cardiac xenograft survival.
-
FK 506 induction and rescue therapy in pancreas transplant recipients.
-
FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506.
-
Fractionated total-body irradiation and high-dose etoposide as a preparatory regimen for bone marrow transplantation for 94 patients with chronic myelogenous leukemia in chronic phase.
-
HIV-1 infection: fooling the gatekeeper.
-
Heart xenograft survival with chimeric pig donors and modest immune suppression.
-
Hyperbaric oxygen and cyclosporine as a combined treatment regimen to prevent skin allograft rejection in immunohistoincompatible mice.
-
Immune status assay (ISA): a noninvasive procedure for studying allograft rejection.
-
Immunophilins interact with calcineurin in the absence of exogenous immunosuppressive ligands.
-
Immunosuppressant target protein FKBP12 is required for P-glycoprotein function in yeast.
-
Immunosuppressive and nonimmunosuppressive cyclosporine analogs are toxic to the opportunistic fungal pathogen Cryptococcus neoformans via cyclophilin-dependent inhibition of calcineurin.
-
Immunosuppressive therapy for pediatric aplastic anemia: a North American Pediatric Aplastic Anemia Consortium study.
-
Immunosuppressive therapy in pediatric inflammatory bowel disease: results of a survey of the North American Society for Pediatric Gastroenterology and Nutrition. Subcommittee on Immunosuppressive Use of the Pediatric IBD Collaborative Research Forum.
-
Impact of improving immunosuppressive treatment on outcome in cadaveric kidney transplantation.
-
Implication of mitochondrial involvement in apoptotic activity of fragile histidine triad gene: application of synchronous luminescence spectroscopy.
-
In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus isolates from transplant and nontransplant patients.
-
In vitro interactions between antifungals and immunosuppressants against Aspergillus fumigatus.
-
In vitro metabolism of cyclosporine A by human kidney CYP3A5.
-
Incidence of cytomegalovirus disease in renal transplantation without antilymphocyte induction: is prophylaxis necessary?
-
Induction of T cell CD7 gene transcription by nonmitogenic ionomycin-induced transmembrane calcium flux.
-
Induction therapy with basiliximab allows delayed initiation of cyclosporine and preserves renal function after cardiac transplantation.
-
Infections during a randomized trial comparing cyclosporine to FK 506 immunosuppression in liver transplantation.
-
Influence of early posttransplantation prednisone and calcineurin inhibitor dosages on the incidence of new-onset diabetes.
-
Inhibition of complement, evoked antibody, and cellular response prevents rejection of pig-to-primate cardiac xenografts.
-
Intravitreal sustained-release cyclosporine in the treatment of experimental uveitis.
-
Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression.
-
LMP-420, a small molecular inhibitor of TNF-α, prolongs islet allograft survival by induction of suppressor of cytokine signaling-1: synergistic effect with cyclosporin-A.
-
Lack of specificity of cyclosporine immunoassays. Results of a College of American Pathologists Study.
-
Late graft loss and long-term outcome after isolated intestinal transplantation in children.
-
Late withdrawal of cyclosporine in stable renal transplant recipients.
-
Living unrelated kidney donation: an underutilized resource?
-
Long-term follow-up of a controlled trial comparing a combination of methotrexate plus cyclosporine with cyclosporine alone for prophylaxis of graft-versus-host disease in patients administered HLA-identical marrow grafts for leukemia.
-
Long-term follow-up of a randomized trial of graft-versus-host disease prevention by methotrexate/cyclosporine versus methotrexate alone in patients given marrow grafts for severe aplastic anemia.
-
Long-term follow-up of three controlled trials comparing cyclosporine versus methotrexate for graft-versus-host disease prevention in patients given marrow grafts for leukemia.
-
Long-term results of tacrolimus in cyclosporine- and prednisone-dependent myasthenia gravis.
-
Management of childhood onset nephrotic syndrome.
-
Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors.
-
Methotrexate and cyclosporine for graft-vs.-host disease prevention: what length of therapy with cyclosporine?
-
Molecular cloning and characterization of Aspergillus nidulans cyclophilin B.
-
Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin.
-
Mutations that perturb cyclophilin A ligand binding pocket confer cyclosporin A resistance in Saccharomyces cerevisiae.
-
Myeloablative Versus Reduced-Intensity Hematopoietic Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndromes.
-
Myristoylation of calcineurin B is not required for function or interaction with immunophilin-immunosuppressant complexes in the yeast Saccharomyces cerevisiae.
-
Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers.
-
Novel motif in calcineurin catalytic subunit is required for septal localization of calcineurin in Aspergillus fumigatus.
-
Outcome of transplantation for acute lymphoblastic leukemia in children with Down syndrome.
-
Pharmacokinetic and safety evaluation of SangCya vs Neoral or Sandimmune in stable renal transplant recipients.
-
Pharmacokinetic comparison of two cyclosporine A formulations, SangCya (Sang-35) and Neoral, in stable adult liver transplant recipients.
-
Pharmacotherapy for human immunodeficiency virus-associated nephropathy.
-
Piceatannol in combination with low doses of cyclosporine A prolongs kidney allograft survival in a stringent rat transplantation model.
-
Polyhexamethylene biguanide and calcineurin inhibitors as novel antifungal treatments for Aspergillus keratitis.
-
Potentiation of CD3-induced expression of the linker for activation of T cells (LAT) by the calcineurin inhibitors cyclosporin A and FK506.
-
Prevention of autoimmune islet allograft destruction by engraftment of donor T cells.
-
Prevention of experimental cyclosporin-induced interstitial fibrosis by losartan and enalapril.
-
Progress in the treatment of rheumatoid arthritis.
-
Prolonged discordant xenograft survival and delayed xenograft rejection in a pig-to-baboon orthotopic cardiac xenograft model.
-
Prolyl isomerases in yeast.
-
Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements.
-
R73A and H144Q mutants of the yeast mitochondrial cyclophilin Cpr3 exhibit a low prolyl isomerase activity in both peptide and protein-folding assays.
-
Rapamycin antagonizes cyclosporin A- and tacrolimus (FK506)-mediated augmentation of linker for activation of T cell expression in T cells.
-
Rapamycin increases transforming growth factor-beta mRNA expression in immortalized rat proximal renal tubular cells.
-
Recipient Kupffer cell influx into xenografted liver.
-
Recurrent acute inflammatory demyelinating polyradiculitis after allogeneic bone marrow transplantation.
-
Regulation of tumor necrosis factor cytotoxicity by calcineurin.
-
Related umbilical cord blood transplantation in patients with thalassemia and sickle cell disease.
-
Renal dysfunction in allogeneic hematopoietic cell transplantation.
-
Renal function with cyclosporine C2 monitoring, enteric-coated mycophenolate sodium and basiliximab: a 12-month randomized trial in renal transplant recipients.
-
Renal transplantation at the University of Wisconsin in the cyclosporine era.
-
Renal transplantation in the cyclosporine era.
-
Renal transplantation under FK 506 in African-Americans: early experience.
-
Renal transplantation under cyclosporine and FK 506 for hemolytic uremic syndrome.
-
Resolution of Pembrolizumab-Associated Steroid-Refractory Lichenoid Dermatitis with Cyclosporine.
-
Retrospective analysis of the use of cyclosporine in myasthenia gravis.
-
Review: implants.
-
Risk factors for acute graft-versus-host disease associated with cyclosporine and methotrexate prophylaxis.
-
SILAC-pulse proteolysis: A mass spectrometry-based method for discovery and cross-validation in proteome-wide studies of ligand binding.
-
Safety and pharmacokinetics of daclizumab in pediatric renal transplant recipients.
-
Sequential phase II Southwest Oncology Group studies (S0112 and S0301) of daunorubicin and cytarabine by continuous infusion, without and with ciclosporin, in older patients with previously untreated acute myeloid leukaemia.
-
Should abdominal cluster transplantation be abandoned?
-
Signal-transduction cascades as targets for therapeutic intervention by natural products.
-
Sirolimus conversion regimen versus continued calcineurin inhibitors in liver allograft recipients: a randomized trial.
-
Stable isotope labeling strategy for protein-ligand binding analysis in multi-component protein mixtures.
-
StableIsotope Labeling with Amino Acids in Cell Culture (SILAC)-based strategy for proteome-wide thermodynamic analysis of protein-ligand binding interactions.
-
Stimulation of thymocyte proliferation by phosphorothioate DNA oligonucleotides.
-
Synergistic effect of calcineurin inhibitors and fluconazole against Candida albicans biofilms.
-
T cell CD7 mRNA expression is regulated by both transcriptional and post-transcriptional mechanisms.
-
T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+.
-
T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration.
-
T-cell-mediated pure red-cell aplasia in systemic lupus erythematosus: response to cyclosporin A and mycophenolate mofetil.
-
Tacrolimus versus Cyclosporine after Hematopoietic Cell Transplantation for Acquired Aplastic Anemia.
-
Tacrolimus with mycophenolate mofetil (MMF) or sirolimus vs. cyclosporine with MMF in cardiac transplant patients: 1-year report.
-
Targeting the calcineurin pathway enhances ergosterol biosynthesis inhibitors against Trichophyton mentagrophytes in vitro and in a human skin infection model.
-
Targets of immunophilin-immunosuppressant complexes are distinct highly conserved regions of calcineurin A.
-
Teaching old drugs new tricks: reincarnating immunosuppressants as antifungal drugs.
-
Thalidomide as salvage therapy for chronic graft-versus-host disease.
-
The development of chronic graft-versus-host disease: an analysis of screening studies and the impact of corticosteroid use at 100 days after transplantation.
-
The natural history of renal function following orthotopic heart transplant.
-
Thermodynamic analysis of cyclosporin a binding to cyclophilin a in a lung tumor tissue lysate.
-
Thoracic organ transplantation at Papworth Hospital.
-
Three-year posttransplant graft survival in renal-transplant patients with graft function at 6 months receiving tacrolimus or cyclosporine microemulsion within a triple-drug regimen.
-
Throughput and efficiency of a mass spectrometry-based screening assay for protein-ligand binding detection.
-
Treatment of Cyclosporin A retains host defense against invasive pulmonary aspergillosis in a non-immunosuppressive murine model by preserving the myeloid cell population.
-
Treatment of pyoderma gangrenosum with cyclosporine.
-
Treatment with rapamycin and mycophenolic acid reduces arterial intimal thickening produced by mechanical injury and allows endothelial replacement.
-
Use of etoposide in combination with cyclosporin for purging multidrug-resistant leukemic cells from bone marrow in a mouse model.
-
Use of etoposide in combination with cyclosporine for purging multidrug resistant leukemic cells from bone marrow in a mouse model.
-
Use of protein phosphatase inhibitors.
-
Use of protein phosphatase inhibitors.
-
Vascularized composite allograft transplant survival in miniature swine: is MHC tolerance sufficient for acceptance of epidermis?
-
Vincristine therapy for severe platelet alloimmunization.
-
Weaning of immunosuppression in liver transplant recipients.
-
vph6 mutants of Saccharomyces cerevisiae require calcineurin for growth and are defective in vacuolar H(+)-ATPase assembly.
-
Keywords of People
-
Middleton, John Paul,
Professor of Medicine,
Medicine, Nephrology
-
Patz Jr., Edward F.,
James and Alice Chen Distinguished Professor of Radiology,
Pathology
-
Steinbach, William J.,
Samuel L. Katz Distinguished Professor of Pediatrics,
Duke Innovation & Entrepreneurship