RNA-Binding Proteins

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  Subject Areas on Research

  • 58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway. 
  • A 50-year-old woman with bilateral vocal cord paralysis and hilar mass. 
  • A PGC1β genetic variant associated with nevus count and melanoma mortality. 
  • A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein. 
  • A negative coregulator for the human ER. 
  • A new face on apoptosis: death-associated protein 3 and PDCD9 are mitochondrial ribosomal proteins. 
  • A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles. 
  • A potentially abundant junctional RNA motif stabilized by m6A and Mg2. 
  • A recombination-based assay demonstrates that the fragile X sequence is transcribed widely during development. 
  • A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cells†. 
  • A tumor-associated splice-isoform of MAP2K7 drives dedifferentiation in MBNL1-low cancers via JNK activation. 
  • A user's guide to the encyclopedia of DNA elements (ENCODE). 
  • ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer. 
  • ATM regulates a DNA damage response posttranscriptional RNA operon in lymphocytes. 
  • Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain. 
  • Acute spinal cord injury persistently reduces R/G RNA editing of AMPA receptors. 
  • Advancing the functional utility of PAR-CLIP by quantifying background binding to mRNAs and lncRNAs. 
  • Altered m6A Modification of Specific Cellular Transcripts Affects Flaviviridae Infection. 
  • An Ancient Family of RNA-Binding Proteins: Still Important! 
  • An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses. 
  • Analysis of post-transcriptional regulation during cancer progression using a donor-derived isogenic model of tumorigenesis. 
  • Anti-U1A monoclonal antibodies recognize unique epitope targets of U1A which are involved in the binding of U1 RNA. 
  • Aptamer-mediated delivery of splice-switching oligonucleotides to the nuclei of cancer cells. 
  • Association between the neuron-specific RNA-binding protein ELAVL4 and Parkinson disease. 
  • Association of Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Autoantibodies With DRB1*07:01 and Severe Myositis in Juvenile Myositis Patients. 
  • Association of genetic variants in the HDL receptor, SR-B1, with abnormal lipids in women with coronary artery disease. 
  • Autosomal-dominant distal myopathy associated with a recurrent missense mutation in the gene encoding the nuclear matrix protein, matrin 3. 
  • Bacterial Growth Inhibition Screen (BGIS): harnessing recombinant protein toxicity for rapid and unbiased interrogation of protein function. 
  • Base-pairing potential identified by in vitro selection predicts the kinked RNA backbone observed in the crystal structure of the alfalfa mosaic virus RNA-coat protein complex. 
  • Beating the heat: Phase separation in plant stress granules. 
  • Biological clocks and the coordination theory of RNA operons and regulons. 
  • Biopsychosocial influence on exercise-induced injury: genetic and psychological combinations are predictive of shoulder pain phenotypes. 
  • Borg proteins control septin organization and are negatively regulated by Cdc42. 
  • CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-α-Gabpa and stress-induced adaptive responses via NF-κB-cMYC. 
  • Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis. 
  • Cdc2 phosphorylation of nucleolin demarcates mitotic stages and Alzheimer's disease pathology. 
  • Cell cycle progression in G1 and S phases is CCR4 dependent following ionizing radiation or replication stress in Saccharomyces cerevisiae. 
  • Cell-type-specific repression of internal ribosome entry site activity by double-stranded RNA-binding protein 76. 
  • Cellular and viral splicing factors can modify the splicing pattern of CFTR transcripts carrying splicing mutations. 
  • Circular RNA circEsyt2 regulates vascular smooth muscle cell remodeling via splicing regulation. 
  • Cold-inducible RNA-binding protein (CIRBP) as a biomarker to predict recurrence of brain metastases. 
  • Comparative Loss-of-Function Screens Reveal ABCE1 as an Essential Cellular Host Factor for Efficient Translation of Paramyxoviridae and Pneumoviridae. 
  • Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas. 
  • Comparative analysis of LIN28-RNA binding sites identified at single nucleotide resolution. 
  • Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1. 
  • Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. 
  • Computational analysis reveals a correlation of exon-skipping events with splicing, transcription and epigenetic factors. 
  • Concerted motions in HIV-1 TAR RNA may allow access to bound state conformations: RNA dynamics from NMR residual dipolar couplings. 
  • Control of thymic T cell maturation, deletion and egress by the RNA-binding protein HuR. 
  • Conversion of protein phosphatase 1 catalytic subunit to a Mn(2+)-dependent enzyme impairs its regulation by inhibitor 1. 
  • Coordinated posttranscriptional mRNA population dynamics during T-cell activation. 
  • Coordinating expression of RNA binding proteins with their mRNA targets. 
  • Cotranscriptional association of mRNA export factor Yra1 with C-terminal domain of RNA polymerase II. 
  • Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer. 
  • Crystal structures of T. brucei MRP1/MRP2 guide-RNA binding complex reveal RNA matchmaking mechanism. 
  • Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8+ T Cells in Early Life. 
  • DO-RIP-seq to quantify RNA binding sites transcriptome-wide. 
  • Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism. 
  • Deletion of Siah-interacting protein gene in Drosophila causes cardiomyopathy. 
  • Design considerations for analyzing protein translation regulation by condensates. 
  • Desmoplastic small round cell tumor: using FISH as an ancillary technique to support cytologic diagnosis in an unusual case. 
  • Dhh1 regulates the G1/S-checkpoint following DNA damage or BRCA1 expression in yeast. 
  • Disentangling the genetics of lean mass. 
  • Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene. 
  • Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures. 
  • Down-regulation of MHC class I antigen presentation by HCMV; lessons for tumor immunology. 
  • Dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes hepatobiliary carcinogenesis in non-alcoholic fatty liver disease. 
  • ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system. 
  • ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells. 
  • Ectopic expression of Hel-N1, an RNA-binding protein, increases glucose transporter (GLUT1) expression in 3T3-L1 adipocytes. 
  • Effect of highly active antiretroviral therapy and thymic transplantation on immunoreconstitution in HIV infection. 
  • Efficient detection of RNA-protein interactions using tethered RNAs. 
  • Embryonic lethal abnormal visual RNA-binding proteins involved in growth, differentiation, and posttranscriptional gene expression. 
  • Enhanced sensitivity to cytochrome c-induced apoptosis mediated by PHAPI in breast cancer cells. 
  • Enterovirus 2Apro Cleavage of the YTHDF m6A Readers Implicates YTHDF3 as a Mediator of Type I Interferon-Driven JAK/STAT Signaling. 
  • Epigenetic Silencing of Recombinant Adeno-associated Virus Genomes by NP220 and the HUSH Complex. 
  • Epigenome-wide association study of metabolic syndrome in African-American adults. 
  • Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis. 
  • Epitranscriptomic Enhancement of Influenza A Virus Gene Expression and Replication. 
  • Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression. 
  • Eukaryotic mRNPs may represent posttranscriptional operons. 
  • Eukaryotic transcription termination factor La mediates transcript release and facilitates reinitiation by RNA polymerase III. 
  • Evidence that methylation of the FMR-I locus is responsible for variable phenotypic expression of the fragile X syndrome. 
  • Evolution of STEC virulence: Insights from the antipredator activities of Shiga toxin producing E. coli. 
  • Examination of factors associated with instability of the FMR1 CGG repeat. 
  • Exploring molecular diversity with combinatorial shape libraries. 
  • Expression of RNA-binding protein IMP3 (KOC) in benign urothelium and urothelial tumors. 
  • Expression of a peptide inhibitor of protein phosphatase 1 increases phosphorylation and activity of CREB in NIH 3T3 fibroblasts. 
  • Extracellular signal-regulated kinase regulation of tumor necrosis factor-alpha mRNA nucleocytoplasmic transport requires TAP-NxT1 binding and the AU-rich element. 
  • FXR1 splicing is important for muscle development and biomolecular condensates in muscle cells. 
  • Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI. 
  • Flipping the script: viral capitalization of RNA modifications. 
  • Fragile X males with unmethylated, full mutation trinucleotide repeat expansions have elevated levels of FMR1 messenger RNA. 
  • Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. 
  • Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP. 
  • Genetic and phenotypic spectrum in the NONO-associated syndromic disorder. 
  • Genetic variants in the TEP1 gene are associated with prostate cancer risk and recurrence. 
  • Genetic variants of the LIN28B gene predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy. 
  • Genetic variants on chromosome 1q41 influence ocular axial length and high myopia. 
  • Genome-wide regulatory analysis using en masse nuclear run-ons and ribonomic profiling with autoimmune sera. 
  • Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. 
  • HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells. 
  • Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly. 
  • Hel-N1, an RNA-binding protein, is a ligand for an A + U rich region of the GLUT1 3' UTR. 
  • Hel-N1: an autoimmune RNA-binding protein with specificity for 3' uridylate-rich untranslated regions of growth factor mRNAs. 
  • Herpes simplex virus proteins ICP27 and UL47 associate with polyadenylate-binding protein and control its subcellular distribution. 
  • High levels of nucleolar expression of nucleolin are associated with better prognosis in patients with stage II pancreatic ductal adenocarcinoma. 
  • ICP34.5-dependent and -independent activities of salubrinal in herpes simplex virus-1 infected cells. 
  • IL-10 stimulatory effects on human NK cells explored by gene profile analysis. 
  • Identification of N⁶ -methyladenosine reader proteins. 
  • Identification of Proteins Bound to Dengue Viral RNA In Vivo Reveals New Host Proteins Important for Virus Replication. 
  • Identification of a DNA Damage-Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers. 
  • Identification of autoantigens recognized by the 2F5 and 4E10 broadly neutralizing HIV-1 antibodies. 
  • Identification of cis elements directing termination of yeast nonpolyadenylated snoRNA transcripts. 
  • Identification of specific protein-RNA target sites using libraries of natural sequences. 
  • Identification of the RNA recognition element of the RBPMS family of RNA-binding proteins and their transcriptome-wide mRNA targets. 
  • Identifying mRNA subsets in messenger ribonucleoprotein complexes by using cDNA arrays. 
  • Immunological approach to the study of hormone action: regulation of the phosphorylation state of protein phosphatase inhibitor-1 by hormones. 
  • Importance of the Conserved Carboxyl-Terminal CNOT1 Binding Domain to Tristetraprolin Activity In Vivo. 
  • Improving SARS-CoV-2 structures: Peer review by early coordinate release. 
  • In vitro RNA selection identifies RNA ligands that specifically bind to eukaryotic translation initiation factor 4B: the role of the RNA remotif. 
  • In vitro RNA selection of an autoimmune epitope on stem-loop II of U1 RNA. 
  • In vitro selection of aptamers from RNA libraries. 
  • Increased Protein Degradation Improves Influenza Virus Nucleoprotein-Specific CD8+ T Cell Activation In Vitro but Not in C57BL/6 Mice. 
  • Inhibition of cell proliferation by an RNA ligand that selectively blocks E2F function. 
  • Integrative regulatory mapping indicates that the RNA-binding protein HuR couples pre-mRNA processing and mRNA stability. 
  • Interactions of human nucleotide excision repair protein XPA with DNA and RPA70 Delta C327: chemical shift mapping and 15N NMR relaxation studies. 
  • Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA. 
  • Interleukin-6 and type I interferon-regulated genes and chemokines mark disease activity in dermatomyositis. 
  • Intraocular Medulloepitheliomas and Embryonal Tumors With Multilayered Rosettes of the Brain: Comparative Roles of LIN28A and C19MC. 
  • Iron-dependent regulation of the divalent metal ion transporter. 
  • LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer. 
  • LIN28B promotes the development of neuroendocrine prostate cancer. 
  • La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate. 
  • La gets its wings. 
  • Large introns in relation to alternative splicing and gene evolution: a case study of Drosophila bruno-3. 
  • Lin28a Regulates Pathological Cardiac Hypertrophic Growth Through Pck2-Mediated Enhancement of Anabolic Synthesis. 
  • Lin28b Regulates Fetal Regulatory T Cell Differentiation through Modulation of TGF-β Signaling. 
  • Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor. 
  • Mapping nonverbal IQ in young boys with fragile X syndrome. 
  • Mechanisms coordinating ELAV/Hu mRNA regulons. 
  • Merlin facilitates ubiquitination and degradation of transactivation-responsive RNA-binding protein. 
  • Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error. 
  • MicroRNA target site identification by integrating sequence and binding information. 
  • Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. 
  • Molecular determinants of nuclear protein phosphatase-1 regulation by NIPP-1. 
  • Molecular-assisted immunohistochemical optimization. 
  • Mosaicism for an FMR1 gene deletion in a fragile X female. 
  • Mouse models of Casc3 reveal developmental functions distinct from other components of the exon junction complex. 
  • Moving messages in the developing brain-emerging roles for mRNA transport and local translation in neural stem cells. 
  • Multifunctional roles for the protein translocation machinery in RNA anchoring to the endoplasmic reticulum. 
  • Multiple structural elements define the specificity of recombinant human inhibitor-1 as a protein phosphatase-1 inhibitor. 
  • Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search for genetic variability of the insulin-stimulated glycogen synthesis pathway of skeletal muscle in NIDDM patients. 
  • Mutations in CIC and FUBP1 contribute to human oligodendroglioma. 
  • Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation. 
  • Necroptosis regulates tumor repopulation after radiotherapy via RIP1/RIP3/MLKL/JNK/IL8 pathway. 
  • New insights into the role of antinuclear antibodies in systemic lupus erythematosus. 
  • Newborns of obese parents have altered DNA methylation patterns at imprinted genes. 
  • Nuclear RNA-binding proteins. 
  • Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair. 
  • Oncoprotein AEG-1 is an endoplasmic reticulum RNA-binding protein whose interactome is enriched in organelle resident protein-encoding mRNAs. 
  • Opposing effects of cancer-type-specific SPOP mutants on BET protein degradation and sensitivity to BET inhibitors. 
  • Organizing mRNA export. 
  • Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy. 
  • PGC-1 coactivators regulate MITF and the tanning response. 
  • PHAS proteins as mediators of the actions of insulin, growth factors and cAMP on protein synthesis and cell proliferation. 
  • Pairing of competitive and topologically distinct regulatory modules enhances patterned gene expression. 
  • Partial demixing of RNA-protein complexes leads to intradroplet patterning in phase-separated biological condensates. 
  • Pathogen virulence factors as molecular probes of basic plant cellular functions. 
  • Phase Ib Study of the BET Inhibitor GS-5829 as Monotherapy and Combined with Enzalutamide in Patients with Metastatic Castration-Resistant Prostate Cancer. 
  • Phosphoregulation provides specificity to biomolecular condensates in the cell cycle and cell polarity. 
  • Physiologic importance of protein phosphatase inhibitors. 
  • Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies. 
  • Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression. 
  • PolyQ-dependent RNA-protein assemblies control symmetry breaking. 
  • Positive and negative phosphorylation regulates RIP1- and RIP3-induced programmed necrosis. 
  • Post-transcriptional gene regulation by HuR promotes a more tumorigenic phenotype. 
  • Post-transcriptional regulation in corticogenesis: how RNA-binding proteins help build the brain. 
  • Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine. 
  • Post-transcriptional regulation of myotube elongation and myogenesis by Hoi Polloi. 
  • Posttranscriptional generation of macromolecular complexes. 
  • Posttranscriptional m(6)A Editing of HIV-1 mRNAs Enhances Viral Gene Expression. 
  • Posttranscriptional regulation of protein expression in human epithelial carcinoma cells by adenine-uridine-rich elements in the 3'-untranslated region of tumor necrosis factor-alpha messenger RNA. 
  • Posttransplant lymphoproliferative disorder after umbilical cord blood transplantation in children. 
  • Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. 
  • Protein aggregation behavior regulates cyclin transcript localization and cell-cycle control. 
  • Protein interactions among the vaccinia virus late transcription factors. 
  • Protein phosphatase regulation by endogenous inhibitors. 
  • Proteome-wide search reveals unexpected RNA-binding proteins in Saccharomyces cerevisiae. 
  • Pseudouridine and N6-methyladenosine modifications weaken PUF protein/RNA interactions. 
  • Quenching of DNA cross-link precursors of chloroethylnitrosoureas and attenuation of DNA interstrand cross-linking by glutathione. 
  • RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure. 
  • RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs. 
  • RINT-1 interacts with MSP58 within nucleoli and plays a role in ribosomal gene transcription. 
  • RIP3 induces apoptosis independent of pronecrotic kinase activity. 
  • RNA Binding Proteins Control Transdifferentiation of Hepatic Stellate Cells into Myofibroblasts. 
  • RNA Controls PolyQ Protein Phase Transitions. 
  • RNA binding specificity of a Drosophila snRNP protein that shares sequence homology with mammalian U1-A and U2-B" proteins. 
  • RNA contributions to the form and function of biomolecular condensates. 
  • RNA modification of an RNA modifier prevents self-RNA sensing. 
  • RNA recognition: towards identifying determinants of specificity. 
  • RNA regulons: coordination of post-transcriptional events. 
  • RNA-binding protein DUS16 plays an essential role in primary miRNA processing in the unicellular alga Chlamydomonas reinhardtii. 
  • RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression. 
  • RNA-binding protein HuR enhances p53 translation in response to ultraviolet light irradiation. 
  • Randomization and selection of RNA to identify targets for RRM RNA-binding proteins and antibodies. 
  • Randomized, Double-Blind, Placebo-Controlled Trial of the Effect of Vitamin D3 on the Interferon Signature in Patients With Systemic Lupus Erythematosus. 
  • Rbm8a haploinsufficiency disrupts embryonic cortical development resulting in microcephaly. 
  • Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma. 
  • Recessive Rare Variants in Deoxyhypusine Synthase, an Enzyme Involved in the Synthesis of Hypusine, Are Associated with a Neurodevelopmental Disorder. 
  • Recruitment of endoplasmic reticulum-targeted and cytosolic mRNAs into membrane-associated stress granules. 
  • Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes. 
  • Regulation of glioblastoma stem cells by retinoic acid: role for Notch pathway inhibition. 
  • Regulation of myeloid leukaemia by the cell-fate determinant Musashi. 
  • Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. 
  • Ribonomic analysis of human Pum1 reveals cis-trans conservation across species despite evolution of diverse mRNA target sets. 
  • Ribotrap : targeted purification of RNA-specific RNPs from cell lysates through immunoaffinity precipitation to identify regulatory proteins and RNAs. 
  • SHAPE reveals transcript-wide interactions, complex structural domains, and protein interactions across the Xist lncRNA in living cells. 
  • SNIP1 inhibits NF-kappa B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. 
  • Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity. 
  • Selection of a subset of mRNAs from combinatorial 3' untranslated region libraries using neuronal RNA-binding protein Hel-N1. 
  • Separate domains of the Ran GTPase interact with different factors to regulate nuclear protein import and RNA processing. 
  • Sequences within a small yeast RNA required for inhibition of internal initiation of translation: interaction with La and other cellular proteins influences its inhibitory activity. 
  • Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106. 
  • Sex-Specific Genetic Associations for Barrett's Esophagus and Esophageal Adenocarcinoma. 
  • Signal transduction. Unexpected mediators of protein phosphorylation. 
  • Single-molecule identification of the target RNAs of different RNA binding proteins simultaneously in cells. 
  • Single-walled carbon nanotubes increase pandemic influenza A H1N1 virus infectivity of lung epithelial cells. 
  • Site-specific RNA cleavage generates the 3' end of a poxvirus late mRNA. 
  • Spliceosomal immunophilins. 
  • Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response. 
  • Structure and function of the native and recombinant mitochondrial MRP1/MRP2 complex from Trypanosoma brucei. 
  • Structures of the T. brucei kRNA editing factor MRB1590 reveal unique RNA-binding pore motif contained within an ABC-ATPase fold. 
  • SymROP: ROP protein with identical helices redesigned by all-atom contact analysis and molecular dynamics. 
  • Systematic analysis of posttranscriptional gene expression. 
  • Systemic lupus erythematosus: a matter of life and death. 
  • Systems proteomics of cardiac chromatin identifies nucleolin as a regulator of growth and cellular plasticity in cardiomyocytes. 
  • TIA nuclear proteins regulate the alternate splicing of lysyl hydroxylase 2. 
  • TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death. 
  • Targeting nucleolin for better survival in diffuse large B-cell lymphoma. 
  • The 58-kda microspherule protein (MSP58) represses human telomerase reverse transcriptase (hTERT) gene expression and cell proliferation by interacting with telomerase transcriptional element-interacting factor (TEIF). 
  • The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men. 
  • The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned. 
  • The DEAH-box RNA helicase RHAU binds an intramolecular RNA G-quadruplex in TERC and associates with telomerase holoenzyme. 
  • The Drosophila Tis11 protein and its effects on mRNA expression in flies. 
  • The Epstein-Barr virus nuclear protein SM is both a post-transcriptional inhibitor and activator of gene expression. 
  • The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons. 
  • The RNA binding protein DND1 is elevated in a subpopulation of pro-spermatogonia and targets chromatin modifiers and translational machinery during late gestation. 
  • The RNA-binding protein DND1 acts sequentially as a negative regulator of pluripotency and a positive regulator of epigenetic modifiers required for germ cell reprogramming. 
  • The U1 RNA-binding site of the U1 small nuclear ribonucleoprotein (snRNP)-associated A protein suggests a similarity with U2 snRNPs. 
  • The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress. 
  • The double-stranded RNA binding protein 76:NF45 heterodimer inhibits translation initiation at the rhinovirus type 2 internal ribosome entry site. 
  • The exon junction complex in neural development and neurodevelopmental disease. 
  • The human fetal lymphocyte lineage: identification by CD27 and LIN28B expression in B cell progenitors. 
  • The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms. 
  • The m6A reader IMP2 directs autoimmune inflammation through an IL-17- and TNFα-dependent C/EBP transcription factor axis. 
  • The mRNA Cap 2'-O-Methyltransferase CMTR1 Regulates the Expression of Certain Interferon-Stimulated Genes. 
  • The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer. 
  • The ribonome: a dominant force in co-ordinating gene expression. 
  • The roles of structural dynamics in the cellular functions of RNAs. 
  • Transcriptional diversity during lineage commitment of human blood progenitors. 
  • Trophoblast class I major histocompatibility complex (MHC) products are resistant to rapid degradation imposed by the human cytomegalovirus (HCMV) gene products US2 and US11. 
  • Uncovering the Role of RNA-Binding Protein hnRNP K in B-Cell Lymphomas. 
  • Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex. 
  • Why is Hu where? Shuttling of early-response-gene messenger RNA subsets. 
  • XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A. 
  • iPABP, an inducible poly(A)-binding protein detected in activated human T cells. 
  • ifet-1 is a broad-scale translational repressor required for normal P granule formation in C. elegans. 
  • m6A and YTHDF proteins contribute to the localization of select neuronal mRNAs. 
  • mRNA structure determines specificity of a polyQ-driven phase separation. 
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  Keywords of People

  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology