Neoplasms, Second Primary

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  Subject Areas on Research

  • A Bayesian model for misclassified binary outcomes and correlated survival data with applications to breast cancer. 
  • A Phase 1a/b Open-Label, Dose-Escalation Study of Etigilimab Alone or in Combination with Nivolumab in Patients with Locally Advanced or Metastatic Solid Tumors. 
  • A Phase 2 study of combination therapy with arsenic trioxide and gemtuzumab ozogamicin in patients with myelodysplastic syndromes or secondary acute myeloid leukemia. 
  • A functional variant at the miR-885-5p binding site of CASP3 confers risk of both index and second primary malignancies in patients with head and neck cancer. 
  • A novel chromosomal rearrangement associated with therapy-related acute leukemia. 
  • A phase III trial evaluating the combination of cisplatin, etoposide, and radiation therapy with or without tamoxifen in patients with limited-stage small cell lung cancer: Cancer and Leukemia Group B Study (9235). 
  • ACR appropriateness criteria retreatment of recurrent head and neck cancer after prior definitive radiation expert panel on radiation oncology-head and neck cancer. 
  • ATM Variants in Breast Cancer: Implications for Breast Radiation Therapy Treatment Recommendations. 
  • Absence of PTEN germ-line mutations in men with a potential inherited predisposition to prostate cancer. 
  • Accuracy of segmentation of a commercial computer-aided detection system for mammography. 
  • Acute leukemia following treatment of malignant glioma. 
  • Acute myeloid leukemia ontogeny is defined by distinct somatic mutations. 
  • Adherence to Surveillance for Second Malignant Neoplasms and Cardiac Dysfunction in Childhood Cancer Survivors: A Childhood Cancer Survivor Study. 
  • American Cancer Society Colorectal Cancer Survivorship Care Guidelines. 
  • Anaplastic renal cell carcinoma following neuroblastoma. 
  • Aneuploid subpopulations in tumour-invaded lymph nodes from breast cancer patients. 
  • Angiosarcoma after breast-conserving therapy: long-term outcomes with hyperfractionated radiotherapy. 
  • Arterial thrombosis and second cancer in MPNs. 
  • Assessing the Effect of Lifetime Contralateral Breast Cancer Risk on the Selection of Contralateral Prophylactic Mastectomy for Unilateral Breast Cancer. 
  • Assessing the Prognostic Value of the Automated Bone Scan Index for Prostate Cancer-Reply. 
  • Association between breast density and subsequent breast cancer following treatment for ductal carcinoma in situ. 
  • Association of p53 codon 72 polymorphism with risk of second primary malignancy in patients with squamous cell carcinoma of the head and neck. 
  • Atypical vulvar lymphangioma. 
  • Azacitidine with or without Entinostat for the treatment of therapy-related myeloid neoplasm: further results of the E1905 North American Leukemia Intergroup study. 
  • B-lymphoblastic leukemia in a patient with chronic lymphocytic leukemia: Sequential development of biclonal B-cell neoplasms over a 23-year period in a single individual. 
  • Back pain and paraplegia in a fifteen-year-old boy. 
  • Biologic hazards of double primary neoplasms among patients with genitourinary malignancy. 
  • Breast cancer following spinal irradiation for a childhood cancer: A report from the Childhood Cancer Survivor Study. 
  • Breast cancer in patients treated for Hodgkin's disease: clinical and pathological analysis of 76 cases in 63 patients. 
  • Bronchogenic carcinoma after lung transplantation: frequency, clinical characteristics, and imaging findings. 
  • Carcinoma of the tongue in a long-term survivor of clear cell sarcoma of the kidney. 
  • Care of cancer survivors. 
  • Causes of death in long-term survivors of head and neck cancer. 
  • Chronic disease in the Childhood Cancer Survivor Study cohort: a review of published findings. 
  • Chronic medical conditions in adult survivors of retinoblastoma: Results of the Retinoblastoma Survivor Study. 
  • Classification of ipsilateral breast tumor recurrences after breast conservation therapy can predict patient prognosis and facilitate treatment planning. 
  • Clinical group and modified TNM stage for rhabdomyosarcoma: A review from the Children's Oncology Group. 
  • Combined-modality therapy for early-stage Hodgkin lymphoma: maintaining high cure rates while minimizing risks. 
  • Competing Mortality in Patients With Neuroendocrine Tumors. 
  • Concurrent acute myeloid leukemia with inv(16)(p13.1q22) and chronic lymphocytic leukemia: molecular evidence of two separate diseases. 
  • Concurrent chemotherapy and re-irradiation for locoregionally recurrent head and neck cancer. 
  • Connect MM® - the Multiple Myeloma Disease Registry: incidence of second primary malignancies in patients treated with lenalidomide. 
  • Contralateral testicular biopsy procedure in patients with unilateral testis cancer: is it indicated? 
  • Contribution of F-18 FDG PET-CT in the detection of systemic spread of primary central nervous system lymphoma. 
  • Descriptive characteristics of prostate cancer in patients with a history of primary male breast cancer - a SEER analysis. 
  • Diagnostic and clinical considerations in concomitant bone marrow involvement by plasma cell myeloma and chronic lymphocytic leukemia/monoclonal B-cell lymphocytosis: a series of 15 cases and review of literature. 
  • Does Fragmentation of Care in Locally Advanced Rectal Cancer Increase Patient Mortality? 
  • Donor cell-derived leukemias/myelodysplastic neoplasms in allogeneic hematopoietic stem cell transplant recipients: a clinicopathologic study of 10 cases and a comprehensive review of the literature. 
  • Dual-Energy CT Vital Iodine Tumor Burden for Response Assessment in Patients With Metastatic GIST Undergoing TKI Therapy: Comparison With Standard CT and FDG PET/CT Criteria. 
  • Early-stage melanoma and hematopoietic stem cell transplantation outcomes. 
  • Effect of Electronic Symptom Monitoring on Patient-Reported Outcomes Among Patients With Metastatic Cancer: A Randomized Clinical Trial. 
  • Elevated Risk of Radiation Therapy-Associated Second Malignant Neoplasms in Young African-American Women Survivors of Stage I-IIIA Breast Cancer. 
  • Esophageal and Esophagogastric Junction Cancers, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology. 
  • FAS and FASLG genetic variants and risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck. 
  • Fanconi anemia gene variants in therapy-related myeloid neoplasms. 
  • Fluctuating response of a cystic vestibular schwannoma to radiosurgery: case report. 
  • Genetic changes in contralateral bronchioloalveolar carcinomas of the lung. 
  • Genetic polymorphisms of p21 and risk of second primary malignancy in patients with index squamous cell carcinoma of the head and neck. 
  • Genetic variants in p53-related genes confer susceptibility to second primary malignancy in patients with index squamous cell carcinoma of head and neck. 
  • Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck. 
  • Genetic variants of the p53 and p73 genes jointly increase risk of second primary malignancies in patients after index squamous cell carcinoma of the head and neck. 
  • Genome-Wide Association Study to Identify Susceptibility Loci That Modify Radiation-Related Risk for Breast Cancer After Childhood Cancer. 
  • Germline genetic variants in men with prostate cancer and one or more additional cancers. 
  • Glutathione S-transferase polymorphisms and risk of second primary malignancy after index squamous cell carcinoma of the head and neck. 
  • Healthcare Cost Trajectories in the Last 2 Years of Life Among Patients With a Solid Metastatic Cancer: A Prospective Cohort Study. 
  • High rates of metachronous colon cancer or dysplasia after segmental resection or subtotal colectomy in Crohn's colitis. 
  • High risk of breast carcinoma after irradiation of young women with Hodgkin's disease. 
  • High-dose chemotherapy followed by autologous stem cell transplantation for relapsed or refractory Hodgkin lymphoma: prognostic features and outcomes. 
  • High-risk populations identified in Childhood Cancer Survivor Study investigations: implications for risk-based surveillance. 
  • Identification of a Germline Pyrin Variant in a Metastatic Melanoma Patient With Multiple Spontaneous Regressions and Immune-related Adverse Events. 
  • Impact of consolidation radiation therapy in stage III-IV diffuse large B-cell lymphoma with negative post-chemotherapy radiologic imaging. 
  • Incidence and Risk of Second Primary Malignant Neoplasm After a First Head and Neck Squamous Cell Carcinoma. 
  • Incidence and pattern of second primary malignancies in patients with index oropharyngeal cancers versus index nonoropharyngeal head and neck cancers. 
  • Incidence of secondary acute myelogenous leukemia after treatment of childhood acute lymphoblastic leukemia. 
  • Incidental discovery of an appendiceal carcinoid tumor and a renal cell carcinoma. 
  • Increasing rates of breast cancer and cardiac surveillance among high-risk survivors of childhood Hodgkin lymphoma following a mailed, one-page survivorship care plan. 
  • Integrative tumor board: recurrent breast cancer or new primary? UCSF Osher Center for Integrative Medicine and UCSF Carol Franc Buck Breast Care Center. 
  • International Commission for Protection Against Environmental Mutagens and Carcinogens. Mutagenicity and carcinogenicity of topoisomerase-interactive agents. 
  • Intra-abdominal desmoid tumor after successful treatment for Hodgkin disease. 
  • Late Morbidity and Mortality Among Medulloblastoma Survivors Diagnosed Across Three Decades: A Report From the Childhood Cancer Survivor Study. 
  • Late morbidity and mortality in patients with Hodgkin's lymphoma treated during adulthood. 
  • Late-onset anorectal disease and psychosocial impact in survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. 
  • Lenalidomide after stem-cell transplantation for multiple myeloma. 
  • Lineage Switch Between B-Lymphoblastic Leukemia and Acute Myeloid Leukemia Intermediated by "Occult" Myelodysplastic Neoplasm: Two Cases of Adult Patients With Evidence of Genomic Instability and Clonal Selection by Chemotherapy. 
  • Long-Term Morbidity and Mortality Among Survivors of Neuroblastoma Diagnosed During Infancy: A Report From the Childhood Cancer Survivor Study. 
  • Long-term follow-Up of a randomized trial of two irradiation regimens for patients receiving allogeneic marrow transplants during first remission of acute myeloid leukemia. 
  • Long-term medical outcomes in survivors of extra-ocular retinoblastoma: the Memorial Sloan-Kettering Cancer Center (MSKCC) experience. 
  • Long-term outcome after marrow transplantation for severe aplastic anemia. 
  • Long-term outcome of concurrent chemotherapy and reirradiation for recurrent and second primary head-and-neck squamous cell carcinoma. 
  • Long-term results of therapy for stage C neuroblastoma. 
  • Long-term risk of subsequent ipsilateral lesions after surgery with or without radiotherapy for ductal carcinoma in situ of the breast. 
  • Long-term sequelae in survivors of childhood leukemia with Down syndrome: A childhood cancer survivor study report. 
  • Long-term survivors of childhood Ewing sarcoma: report from the childhood cancer survivor study. 
  • Longitudinal follow-up of adult survivors of Ewing sarcoma: A report from the Childhood Cancer Survivor Study. 
  • Longterm followup and quality of life after hematopoietic stem cell transplantation. 
  • Low risk of second primary malignancies among never smokers with human papillomavirus-associated index oropharyngeal cancers. 
  • Low-dose consolidation radiation therapy for early stage unfavorable Hodgkin lymphoma. 
  • Lymphoepithelioma-like carcinoma of the urinary bladder. 
  • Malignant melanoma in children. 
  • Management of primary squamous cell carcinoma at the mucocutaneous junction of an ileal conduit. 
  • Medical screening participation in the childhood cancer survivor study. 
  • Metachronous/concomitant B-cell neoplasms with discordant light-chain or heavy-chain isotype restrictions: evidence of distinct B-cell neoplasms rather than clonal evolutions. 
  • Modest advances in survival for patients with colorectal-associated peritoneal carcinomatosis in the era of modern chemotherapy. 
  • Molecular analysis of synchronous and metachronous tumors of the lung: impact on management and prognosis. 
  • Molecular detection of circulating Sezary cells in patients with mycosis fungoides: could it predict future development of secondary Sezary syndrome? A single-institution experience. 
  • Morbidity and Mortality Associated With Meningioma After Cranial Radiotherapy: A Report From the Childhood Cancer Survivor Study. 
  • Morbidity and mortality after treatment of Ewing sarcoma: A single-institution experience. 
  • Multidisciplinary approach to treatment of radiation-induced chest wall sarcoma. 
  • Multiple nephron-sparing procedures in solitary kidney with recurrent, metachronous, nonfamilial renal cell carcinoma. 
  • Multiple primary melanoma: incidence and risk factors in 283 patients. 
  • Mutational profiling of therapy-related myelodysplastic syndromes and acute myeloid leukemia by next generation sequencing, a comparison with de novo diseases. 
  • Myeloid neoplasms secondary to plasma cell myeloma: an intrinsic predisposition or therapy-related phenomenon? A clinicopathologic study of 41 cases and correlation of cytogenetic features with treatment regimens. 
  • Neighborhood deprivation and clinical outcomes among head and neck cancer patients. 
  • New malignant diseases after allogeneic marrow transplantation for childhood acute leukemia. 
  • No free lunch: secondary neoplasms after stereotactic radiation. 
  • Nucleotide excision repair core gene polymorphisms and risk of second primary malignancy in patients with index squamous cell carcinoma of the head and neck. 
  • Obesity-related parameters and colorectal adenoma development. 
  • Oncologic Safety of Prophylactic Nipple-Sparing Mastectomy in a Population With BRCA Mutations: A Multi-institutional Study. 
  • Outcomes of patients who undergo aggressive induction therapy for secondary acute myeloid leukemia. 
  • Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast. 
  • Patterns of occurrence of second primary non-mammary malignancies in breast cancer patients: results from 1382 consecutive autopsies. 
  • Potential therapeutic effect of epigenetic therapy on treatment-induced neuroendocrine prostate cancer. 
  • Predictors of long-term durable response in de novo HER2-positive metastatic breast cancer and the real-world treatment experience at two institutions. 
  • Predictors of surveillance mammography outcomes in women with a personal history of breast cancer. 
  • Prior chemoradiotherapy adversely impacts outcomes of recurrent and second primary head and neck cancer treated with concurrent chemotherapy and reirradiation. 
  • Protein patterns and proteins that identify subtypes of glioblastoma multiforme. 
  • Radiation and Second Primary Thyroid Cancer Following Index Head and Neck Cancer. 
  • Radiation-Induced Angiosarcoma after Breast-Cancer Treatment. 
  • Recombinant interferon-alpha2b added to oral cyclophosphamide either as induction or maintenance in treatment-naive follicular lymphoma: final analysis of CALGB 8691. 
  • Reduced Morbidity and Mortality in Survivors of Childhood Acute Lymphoblastic Leukemia: A Report From the Childhood Cancer Survivor Study. 
  • Relationship between tamoxifen use and high risk endometrial cancer histologic types. 
  • Reply to Dr Altundag from the authors of 'Management of breast cancer brain metastases; a practical review'. 
  • Reply to Second malignancies in Ewing sarcoma survivors. 
  • Response to Mroczkowski. 
  • Risk and outcomes for second primary human papillomavirus-related and -unrelated head and neck malignancy. 
  • Risk of acute myeloid leukemia and myelodysplastic syndrome among older women receiving anthracycline-based adjuvant chemotherapy for breast cancer on Modern Cooperative Group Trials (Alliance A151511). 
  • Risk of late effects of treatment in children newly diagnosed with standard-risk acute lymphoblastic leukaemia: a report from the Childhood Cancer Survivor Study cohort. 
  • Risk of metachronous breast cancer after BRCA mutation-associated ovarian cancer. 
  • Risk of second primary cancers among survivors of gynecological cancers. 
  • Risk of second primary cancers in individuals diagnosed with index smoking- and non-smoking- related cancers. 
  • Risk of second primary tumors in men diagnosed with prostate cancer: a population-based cohort study. 
  • Risk, Risk Factors, and Surveillance of Subsequent Malignant Neoplasms in Survivors of Childhood Cancer: A Review. 
  • Role of imaging in low-grade cutaneous B-cell lymphoma presenting in the skin. 
  • Screening and surveillance for second malignant neoplasms in adult survivors of childhood cancer: a report from the childhood cancer survivor study. 
  • Sebaceous gland carcinoma: a subtle second malignancy following radiation therapy in patients with bilateral retinoblastoma. 
  • Second malignancies in young children with primary brain tumors following treatment with prolonged postoperative chemotherapy and delayed irradiation: a Pediatric Oncology Group study. 
  • Second malignancy risk associated with treatment of Hodgkin's lymphoma: meta-analysis of the randomised trials. 
  • Second malignant neoplasms of the head and neck in survivors of retinoblastoma. 
  • Second primary cancers in survivors of childhood cancer. 
  • Second primary malignancies following the treatment of early stage ovarian cancer: update of a study by the National Cancer Institute of Canada--Clinical Trials Group (NCIC-CTG). 
  • Secondary gastrointestinal cancer in childhood cancer survivors: a cohort study. 
  • Sequential development of histiocytic sarcoma and diffuse large b-cell lymphoma in a patient with a remote history of follicular lymphoma with genotypic evidence of a clonal relationship: a divergent (bilineal) neoplastic transformation of an indolent B-cell lymphoma in a single individual. 
  • Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck. 
  • Smoking history predicts for increased risk of second primary lung cancer: a comprehensive analysis. 
  • Society of Surgical Oncology-American Society for Radiation Oncology consensus guideline on margins for breast-conserving surgery with whole-breast irradiation in stages I and II invasive breast cancer. 
  • Solid tumor second primary neoplasms: who is at risk, what can we do? 
  • Squamous cell carcinoma arising in inverted papilloma. 
  • Stage I-II nodular lymphocyte-predominant Hodgkin lymphoma: a multi-institutional study of adult patients by ILROG. 
  • Subsequent malignancies in children treated for Hodgkin's disease: associations with gender and radiation dose. 
  • Subsequent malignant neoplasms in the Childhood Cancer Survivor Study: Occurrence of cancer types in which human papillomavirus is an established etiologic risk factor. 
  • Summaries for patients. Increased risk for gastrointestinal cancer in childhood cancer survivors. 
  • Systematic esophageal endoscopy screening in patients previously treated for head and neck squamous-cell carcinoma. 
  • Testicular cancer survivorship: research strategies and recommendations. 
  • The cancer is over, now what?: Understanding risk, changing outcomes. 
  • The characteristics of bladder cancer after radiotherapy for prostate cancer. 
  • The impact of surgery on ductal carcinoma in situ outcomes: the use of mastectomy. 
  • The utility of tolonium chloride rinse in the diagnosis of recurrent or second primary cancers in patients with prior upper aerodigestive tract cancer. 
  • Therapy-related acute lymphoblastic leukemia without 11q23 abnormality: report of six cases and a literature review. 
  • Thyroid nodules and survivors of Hodgkin's disease. 
  • Timing and Number of Cutaneous Squamous Cell Carcinomas in Transplant Recipients. 
  • Trajectories of Suffering in the Last Year of Life Among Patients With a Solid Metastatic Cancer. 
  • Transitional cell carcinoma in a prostatic remnant 10 years after radical cystectomy. 
  • Treatment-related neuroendocrine prostate cancer resulting in Cushing's syndrome. 
  • Trends in the risk and burden of second primary malignancy among survivors of smoking-related cancers in the United States. 
  • Twenty-five year follow-up of childhood Wilms tumor: a report from the Childhood Cancer Survivor Study. 
  • Twenty-five-year follow-up among survivors of childhood acute lymphoblastic leukemia: a report from the Childhood Cancer Survivor Study. 
  • Twice-daily reirradiation for recurrent and second primary head-and-neck cancer with gemcitabine, paclitaxel, and 5-fluorouracil chemotherapy. 
  • Whole-body magnetic resonance imaging (WB-MRI) as surveillance for subsequent malignancies in survivors of hereditary retinoblastoma: a pilot study. 
  • Whole-body magnetic resonance imaging as surveillance for subsequent malignancies in preadolescent, adolescent, and young adult survivors of germline retinoblastoma: An update. 
  • [Bilateral breast cancer after Hodgkin disease. Clinical and pathological characteristics and therapeutic possibilities: an analysis of 13 cases]. 
  • p14ARF genetic polymorphisms and susceptibility to second primary malignancy in patients with index squamous cell carcinoma of the head and neck. 
  • p73 G4C14-to-A4T14 polymorphism and risk of second primary malignancy after index squamous cell carcinoma of head and neck. 
  • t(11;16)(q23;p13)/KMT2A-CREBBP in hematologic malignancies: presumptive evidence of myelodysplasia or therapy-related neoplasm? 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Buckley, Anne Frances, Assistant Professor of Pathology, Pathology
  • Esclamado, Ramon Mitra, Richard Hall Chaney, Sr. Distinguished Professor Emeritus of Otolaryngology, Head and Neck Surgery & Communication Sciences
  • Stoecker, Maggie Marie, Assistant Professor of Pathology, Pathology