Telomere

• 

  Subject Areas on Research

  • A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk. 
  • Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction. 
  • Aging andlongevity: towards the next millennium. The Bat Sheva Le Rothschild International Seminar on Cellular, Molecular and Genetic Aspects of Aging and Longevity. Zichron Yaacov, Israel, 7-12 December 1997. 
  • Altered telomeres in tumors with ATRX and DAXX mutations. 
  • Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae. 
  • Amplification of telomeric DNA directly correlates with metastatic potential of human and murine cancers of various histological origin. 
  • Assessment of candidate ocular biomarkers of ageing in a South African adult population: relationship with chronological age and systemic biomarkers. 
  • Assignment of the creatine transporter gene (SLC6A8) to human chromosome Xq28 telomeric to G6PD. 
  • Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. 
  • C-terminal regions of the human telomerase catalytic subunit essential for in vivo enzyme activity. 
  • Characterization of the EBV-Induced Persistent DNA Damage Response. 
  • Chromosomal translocation and segmental duplication in Cryptococcus neoformans. 
  • Chromosome aberrations resulting from double-strand DNA breaks at a naturally occurring yeast fragile site composed of inverted ty elements are independent of Mre11p and Sae2p. 
  • Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with alpha-particles simulating radon progeny. 
  • Chromosome manipulation: a systematic approach toward understanding human chromosome structure and function. 
  • Chromosome rearrangements and aneuploidy in yeast strains lacking both Tel1p and Mec1p reflect deficiencies in two different mechanisms. 
  • Competition between adjacent meiotic recombination hotspots in the yeast Saccharomyces cerevisiae. 
  • Creation of human tumour cells with defined genetic elements. 
  • Dependence of the regulation of telomere length on the type of subtelomeric repeat in the yeast Saccharomyces cerevisiae. 
  • Disappearance of the telomere dysfunction-induced stress response in fully senescent cells. 
  • Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. 
  • Distinct Responses of Stem Cells to Telomere Uncapping-A Potential Strategy to Improve the Safety of Cell Therapy. 
  • Distinct functions of POT1 at telomeres. 
  • Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. 
  • Early-Life Intelligence Predicts Midlife Biological Age. 
  • Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: a longitudinal study. 
  • Fine-structure mapping of meiosis-specific double-strand DNA breaks at a recombination hotspot associated with an insertion of telomeric sequences upstream of the HIS4 locus in yeast. 
  • Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. 
  • Further exclusion of FSHD1B from the telomeric region of 10q. 
  • Genetic Control of Genomic Alterations Induced in Yeast by Interstitial Telomeric Sequences. 
  • Genetic regulation of telomere-telomere fusions in the yeast Saccharomyces cerevisae. 
  • Genetic variants in the TEP1 gene are associated with prostate cancer risk and recurrence. 
  • Genome rearrangements caused by interstitial telomeric sequences in yeast. 
  • Hepatocyte telomere shortening and senescence are general markers of human liver cirrhosis. 
  • Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. 
  • Increased expression of senescence markers in cystic fibrosis airways. 
  • Inflammation, telomere length, and grip strength: a 10-year longitudinal study. 
  • Influence of ATM function on telomere metabolism. 
  • Inositol diphosphate signaling regulates telomere length. 
  • Inositol phosphate synthesis and the nuclear processes they affect. 
  • Insight into the molecular pathophysiology of myelodysplastic syndromes: targets for novel therapy. 
  • Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae. 
  • Internalizing disorders and leukocyte telomere erosion: a prospective study of depression, generalized anxiety disorder and post-traumatic stress disorder. 
  • Involvement of the checkpoint protein Mec1p in silencing of gene expression at telomeres in Saccharomyces cerevisiae. 
  • Leukocyte telomere length is associated with disability in older u.s. Population. 
  • Leukocyte telomere length, breast cancer risk in the offspring: the relations with father's age at birth. 
  • Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk. 
  • Loss of hPot1 function leads to telomere instability and a cut-like phenotype. 
  • Methylation of the FSHD syndrome-linked subtelomeric repeat in normal and FSHD cell cultures and tissues. 
  • Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. 
  • NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia. 
  • No association between telomere length and survival among the elderly and oldest old. 
  • Nucleolar organization, ribosomal DNA array stability, and acrocentric chromosome integrity are linked to telomere function. 
  • Ocular parameters of biological ageing in HIV-infected individuals in South Africa: relationship with chronological age and systemic biomarkers of ageing. 
  • On the interplay of telomeres, nevi and the risk of melanoma. 
  • POT1 association with TRF2 regulates telomere length. 
  • Perceived age as clinically useful biomarker of ageing: cohort study. 
  • Perifosine as a potential novel anti-telomerase therapy. 
  • Premature cell senescence and T cell receptor-independent activation of CD8+ T cells in juvenile idiopathic arthritis. 
  • Putative telomere-recruiting domain in the catalytic subunit of human telomerase. 
  • Race-Ethnicity, Poverty, Urban Stressors, and Telomere Length in a Detroit Community-based Sample. 
  • Rapid telomere shortening in children. 
  • Relevance and safety of telomerase for human tissue engineering. 
  • Religiosity and Telomere Length in Colorectal Cancer Patients in Saudi Arabia. 
  • Religious Involvement and Telomere Length in Women Family Caregivers. 
  • Replication, recombination, and repair: going for the gold. 
  • Replicative senescence revisited. 
  • Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1. 
  • SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice. 
  • Senescent phenotypes and telomere lengths of peripheral blood T-cells mobilized by acute exercise in humans. 
  • Shortened telomere length is associated with increased risk of cancer: a meta-analysis. 
  • Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. 
  • Subtelomeric deletion of chromosome 10p15.3: clinical findings and molecular cytogenetic characterization. 
  • Subtelomeric deletions of chromosome 6p: molecular and cytogenetic characterization of three new cases with phenotypic overlap with Ritscher-Schinzel (3C) syndrome. 
  • TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. 
  • TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. 
  • Telomerase activity in human ovarian carcinoma. 
  • Telomerase activity in normal leukocytes and in hematologic malignancies. 
  • Telomerase reverse transcriptase is required for the localization of telomerase RNA to cajal bodies and telomeres in human cancer cells. 
  • Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes. 
  • Telomere dysfunction causes alveolar stem cell failure. 
  • Telomere length and TERT functional polymorphisms are not associated with risk of squamous cell carcinoma of the head and neck. 
  • Telomere length and mortality: a study of leukocytes in elderly Danish twins. 
  • Telomere length and periodontal attachment loss: a prospective cohort study. 
  • Telomere length is associated with sleep duration but not sleep quality in adults with human immunodeficiency virus. 
  • Telomere maintenance and the etiology of adult glioma. 
  • Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. 
  • Telomere shortening in cultured autografts of patients with burns. 
  • Telomere shortening in formerly abused and never abused women. 
  • Telomere structure and maintenance gene variants and risk of five cancer types. 
  • Telomeres and the natural lifespan limit in humans. 
  • Tethering telomeric double- and single-stranded DNA-binding proteins inhibits telomere elongation. 
  • The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae. 
  • The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast. 
  • The Saccharomyces cerevisiae suppressor of choline sensitivity (SCS2) gene is a multicopy Suppressor of mec1 telomeric silencing defects. 
  • The association of cataract with leukocyte telomere length in older adults: defining a new marker of aging. 
  • The heritability of telomere length among the elderly and oldest-old. 
  • The isolation of a yeast artificial chromosome (YAC) contig extending for 2 megabases in the vicinity of the von Hippel Lindau disease gene. 
  • The long and the short of telomeres in bone marrow recipient SCID patients. 
  • The protein hSnm1B is stabilized when bound to the telomere-binding protein TRF2. 
  • The roles of telomeres and telomerase in cell life span. 
  • The telomere hypothesis of cellular aging. 
  • The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. 
  • Topoisomerase I plays a critical role in suppressing genome instability at a highly transcribed G-quadruplex-forming sequence. 
  • Transcription factors are required for the meiotic recombination hotspot at the HIS4 locus in Saccharomyces cerevisiae. 
  • Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. 
  • Workshop on immunizations in older adults: identifying future research agendas. 
  • hSnm1B is a novel telomere-associated protein. 
• 

  Keywords of People

  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Diplas, Bill, Research Assistant, Ph D Student, Pathology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Sullivan, Beth Ann, Associate Professor of Molecular Genetics and Microbiology, Duke Science & Society
  • Yan, Hai, Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine, Pathology