Telomere

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  Subject Areas on Research

  • A G-quadruplex DNA-affinity Approach for Purification of Enzymatically Active G4 Resolvase1. 
  • A Xenopus egg factor with DNA-binding properties characteristic of terminus-specific telomeric proteins. 
  • A comparison of feature selection methodologies and learning algorithms in the development of a DNA methylation-based telomere length estimator. 
  • A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk. 
  • Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction. 
  • Aging andlongevity: towards the next millennium. The Bat Sheva Le Rothschild International Seminar on Cellular, Molecular and Genetic Aspects of Aging and Longevity. Zichron Yaacov, Israel, 7-12 December 1997. 
  • Altered telomeres in tumors with ATRX and DAXX mutations. 
  • Amino acid changes in Xrs2p, Dun1p, and Rfa2p that remove the preferred targets of the ATM family of protein kinases do not affect DNA repair or telomere length in Saccharomyces cerevisiae. 
  • Amplification of telomeric DNA directly correlates with metastatic potential of human and murine cancers of various histological origin. 
  • Assessment of candidate ocular biomarkers of ageing in a South African adult population: relationship with chronological age and systemic biomarkers. 
  • Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study. 
  • Association of Leukocyte Telomere Length With Mortality Among Adult Participants in 3 Longitudinal Studies. 
  • C-terminal regions of the human telomerase catalytic subunit essential for in vivo enzyme activity. 
  • Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes. 
  • Characterization of the EBV-Induced Persistent DNA Damage Response. 
  • Chromosomal translocation and segmental duplication in Cryptococcus neoformans. 
  • Chromosome aberrations resulting from double-strand DNA breaks at a naturally occurring yeast fragile site composed of inverted ty elements are independent of Mre11p and Sae2p. 
  • Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with alpha-particles simulating radon progeny. 
  • Chromosome rearrangements and aneuploidy in yeast strains lacking both Tel1p and Mec1p reflect deficiencies in two different mechanisms. 
  • Competition between adjacent meiotic recombination hotspots in the yeast Saccharomyces cerevisiae. 
  • Creation of human tumour cells with defined genetic elements. 
  • Cytokinesis breaks dicentric chromosomes preferentially at pericentromeric regions and telomere fusions. 
  • Dependence of the regulation of telomere length on the type of subtelomeric repeat in the yeast Saccharomyces cerevisiae. 
  • Digital phenotyping by consumer wearables identifies sleep-associated markers of cardiovascular disease risk and biological aging. 
  • Disappearance of the telomere dysfunction-induced stress response in fully senescent cells. 
  • Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner. 
  • Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. 
  • Distinct Responses of Stem Cells to Telomere Uncapping-A Potential Strategy to Improve the Safety of Cell Therapy. 
  • Distinct functions of POT1 at telomeres. 
  • Do donors matter? Short telomeres and survival after lung transplant. 
  • Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. 
  • Early-Life Intelligence Predicts Midlife Biological Age. 
  • Early-life exposure to famine and late-life depression: Does leukocyte telomere length mediate the association? 
  • Exposure to violence during childhood is associated with telomere erosion from 5 to 10 years of age: a longitudinal study. 
  • Fine-structure mapping of meiosis-specific double-strand DNA breaks at a recombination hotspot associated with an insertion of telomeric sequences upstream of the HIS4 locus in yeast. 
  • Finishing the euchromatic sequence of the human genome. 
  • Formation of telomeric repeat-containing RNA (TERRA) foci in highly proliferating mouse cerebellar neuronal progenitors and medulloblastoma. 
  • Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas. 
  • Further exclusion of FSHD1B from the telomeric region of 10q. 
  • Genetic Control of Genomic Alterations Induced in Yeast by Interstitial Telomeric Sequences. 
  • Genetic predisposition to longer telomere length and risk of childhood, adolescent and adult-onset ependymoma. 
  • Genetic regulation of telomere-telomere fusions in the yeast Saccharomyces cerevisae. 
  • Genetic variants in the TEP1 gene are associated with prostate cancer risk and recurrence. 
  • Genome rearrangements caused by interstitial telomeric sequences in yeast. 
  • Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans. 
  • Genotype/phenotype correlations in two patients with 12q subtelomere deletions. 
  • Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA. 
  • Human chromosomes with shorter telomeres and large heterochromatin regions have a higher frequency of acquired somatic cell aneuploidy. 
  • Impaired Cytomegalovirus Immunity in Idiopathic Pulmonary Fibrosis Lung Transplant Recipients with Short Telomeres. 
  • Increased expression of senescence markers in cystic fibrosis airways. 
  • Inflammation, telomere length, and grip strength: a 10-year longitudinal study. 
  • Influence of ATM function on telomere metabolism. 
  • Influences of inbreeding and genetics on telomere length in mice. 
  • Inositol diphosphate signaling regulates telomere length. 
  • Inositol phosphate synthesis and the nuclear processes they affect. 
  • Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae. 
  • Internalizing disorders and leukocyte telomere erosion: a prospective study of depression, generalized anxiety disorder and post-traumatic stress disorder. 
  • Involvement of the checkpoint protein Mec1p in silencing of gene expression at telomeres in Saccharomyces cerevisiae. 
  • Is telomere length a biomarker for aging: cross-sectional evidence from the west of Scotland? 
  • Is telomere length socially patterned? Evidence from the West of Scotland Twenty-07 Study. 
  • Leukocyte telomere dynamics and human hematopoietic stem cell kinetics during somatic growth. 
  • Leukocyte telomere length is associated with disability in older u.s. Population. 
  • Leukocyte telomere length, breast cancer risk in the offspring: the relations with father's age at birth. 
  • Long telomeres in need of a SNP: Germline contributions of telomere maintenance to glioma. 
  • Long-term male-specific chronic pain via telomere- and p53‑mediated spinal cord cellular senescence. 
  • Longer genotypically-estimated leukocyte telomere length is associated with increased adult glioma risk. 
  • Loss of hPot1 function leads to telomere instability and a cut-like phenotype. 
  • Lung Transplant Outcomes in Patients With Pulmonary Fibrosis With Telomere-Related Gene Variants. 
  • Lymphocyte telomere length predicts clinical outcomes of HPV-positive oropharyngeal cancer patients after definitive radiotherapy. 
  • Methylation of the FSHD syndrome-linked subtelomeric repeat in normal and FSHD cell cultures and tissues. 
  • Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma. 
  • Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. 
  • Mutational Dissection of Telomeric DNA Binding Requirements of G4 Resolvase 1 Shows that G4-Structure and Certain 3'-Tail Sequences Are Sufficient for Tight and Complete Binding. 
  • NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia. 
  • Nucleolar organization, ribosomal DNA array stability, and acrocentric chromosome integrity are linked to telomere function. 
  • Ocular parameters of biological ageing in HIV-infected individuals in South Africa: relationship with chronological age and systemic biomarkers of ageing. 
  • On the interplay of telomeres, nevi and the risk of melanoma. 
  • Optimism and telomere length among African American adults in the Jackson Heart Study. 
  • POT1 association with TRF2 regulates telomere length. 
  • POT1 mutation spectrum in tumour types commonly diagnosed among POT1-associated hereditary cancer syndrome families. 
  • Pan-cancer analysis of whole genomes. 
  • Perifosine as a potential novel anti-telomerase therapy. 
  • Premature cell senescence and T cell receptor-independent activation of CD8+ T cells in juvenile idiopathic arthritis. 
  • Putative telomere-recruiting domain in the catalytic subunit of human telomerase. 
  • Race-Ethnicity, Poverty, Urban Stressors, and Telomere Length in a Detroit Community-based Sample. 
  • Rapid telomere shortening in children. 
  • Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis. 
  • Rare and Common Variants in KIF15 Contribute to Genetic Risk of Idiopathic Pulmonary Fibrosis. 
  • Real-time quantitative PCR of telomerase mRNA is useful for the differentiation of benign and malignant pancreatic disorders. 
  • Recombination between heterologous human acrocentric chromosomes. 
  • Recombination modulates how selection affects linked sites in Drosophila. 
  • Relevance and safety of telomerase for human tissue engineering. 
  • Religiosity and Telomere Length in Colorectal Cancer Patients in Saudi Arabia. 
  • Religiosity and Telomere Length: Moderating Effect of Religiosity on the Relationship Between High-Risk Polymorphisms of the Apolipoprotein E and TOMM40 Gene and Telomere Length. 
  • Religiosity, depression and telomere length in Chinese older adults. 
  • Religious Involvement and Telomere Length in Women Family Caregivers. 
  • Replication, recombination, and repair: going for the gold. 
  • Replicative senescence revisited. 
  • Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1. 
  • SARS-CoV-2 triggers DNA damage response in Vero E6 cells. 
  • SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice. 
  • Senescent phenotypes and telomere lengths of peripheral blood T-cells mobilized by acute exercise in humans. 
  • Shortened telomere length is associated with increased risk of cancer: a meta-analysis. 
  • Significance of bronchiolocentric fibrosis in patients with histopathological usual interstitial pneumonia. 
  • Stabilization of short telomeres and telomerase activity accompany immortalization of Epstein-Barr virus-transformed human B lymphocytes. 
  • Subtelomeric deletion of chromosome 10p15.3: clinical findings and molecular cytogenetic characterization. 
  • Subtelomeric deletions of chromosome 6p: molecular and cytogenetic characterization of three new cases with phenotypic overlap with Ritscher-Schinzel (3C) syndrome. 
  • TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene. 
  • TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. 
  • Telomerase activity in human ovarian carcinoma. 
  • Telomerase activity in normal leukocytes and in hematologic malignancies. 
  • Telomerase reverse transcriptase is required for the localization of telomerase RNA to cajal bodies and telomeres in human cancer cells. 
  • Telomere Attrition in Childhood Cancer Survivors. 
  • Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes. 
  • Telomere dysfunction causes alveolar stem cell failure. 
  • Telomere length analysis from minimally-invasively collected samples: Methods development and meta-analysis of the validity of different sampling techniques: American Journal of Human Biology. 
  • Telomere length and TERT functional polymorphisms are not associated with risk of squamous cell carcinoma of the head and neck. 
  • Telomere length and periodontal attachment loss: a prospective cohort study. 
  • Telomere length in patients with unclassifiable interstitial lung disease: a cohort study. 
  • Telomere length is associated with sleep duration but not sleep quality in adults with human immunodeficiency virus 
  • Telomere maintenance and the etiology of adult glioma. 
  • Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. 
  • Telomere shortening in cultured autografts of patients with burns. 
  • Telomere shortening in formerly abused and never abused women 
  • Telomere structure and maintenance gene variants and risk of five cancer types. 
  • Telomere-length dependent T-cell clonal expansion: A model linking ageing to COVID-19 T-cell lymphopenia and mortality. 
  • Telomere-to-telomere assembly of a complete human X chromosome. 
  • Telomeres and the natural lifespan limit in humans. 
  • Telomeres are shortened in acinar-to-ductal metaplasia lesions associated with pancreatic intraepithelial neoplasia but not in isolated acinar-to-ductal metaplasias. 
  • Telomeric repeat-containing RNA (TERRA) constitutes a nucleoprotein component of extracellular inflammatory exosomes. 
  • Tethering telomeric double- and single-stranded DNA-binding proteins inhibits telomere elongation. 
  • The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae. 
  • The MUC5B promoter polymorphism and telomere length in patients with chronic hypersensitivity pneumonitis: an observational cohort-control study. 
  • The Mre11p/Rad50p/Xrs2p complex and the Tel1p function in a single pathway for telomere maintenance in yeast. 
  • The Saccharomyces cerevisiae suppressor of choline sensitivity (SCS2) gene is a multicopy Suppressor of mec1 telomeric silencing defects. 
  • The deacetylase Sir2 from the yeast Clavispora lusitaniae lacks the evolutionarily conserved capacity to generate subtelomeric heterochromatin. 
  • The heritability of telomere length among the elderly and oldest-old. 
  • The long and the short of telomeres in bone marrow recipient SCID patients. 
  • The protein hSnm1B is stabilized when bound to the telomere-binding protein TRF2. 
  • The roles of telomeres and telomerase in cell life span. 
  • The telomere hypothesis of cellular aging. 
  • The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. 
  • Topoisomerase I plays a critical role in suppressing genome instability at a highly transcribed G-quadruplex-forming sequence. 
  • Transcription factors are required for the meiotic recombination hotspot at the HIS4 locus in Saccharomyces cerevisiae. 
  • Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. 
  • Workshop on immunizations in older adults: identifying future research agendas. 
  • hSnm1B is a novel telomere-associated protein. 
  • iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Sullivan, Beth Ann, Professor of Molecular Genetics and Microbiology, Duke Science & Society