Critical Illness

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  Subject Areas on Research

  • "One Piece at a Time": The Cache of Acute Kidney Injury Data in the Electronic Medical Record. 
  • A Framework for Improving Chronic Critical Illness Care: Adapting the Medical Home's Central Tenets. 
  • A National Emergency Airway Registry for children: landscape of tracheal intubation in 15 PICUs. 
  • A case of mistaken identity: persistent sciatic artery stenosis as a cause of critical limb ischemia. 
  • A cost and outcomes comparison of a novel integrated pediatric air and ground transportation system. 
  • A descriptive evaluation of transfusion practices in patients receiving mechanical ventilation. 
  • A few of our favorite unconfirmed ideas. 
  • A novel approach to maintain gut mucosal integrity using an oral enzyme supplement. 
  • A nurse's guide to early detection of umbilical venous catheter complications in infants. 
  • A prognostic model for one-year mortality in patients requiring prolonged mechanical ventilation. 
  • A randomized evaluation of bispectral index-augmented sedation assessment in neurological patients. 
  • A randomized trial of glutamine and antioxidants in critically ill patients. 
  • A randomized trial of supplemental parenteral nutrition in underweight and overweight critically ill patients: the TOP-UP pilot trial. 
  • A review of the use of adjunctive therapies in severe acute asthma exacerbation in critically ill children. 
  • A universal decision support system. Addressing the decision-making needs of patients, families, and clinicians in the setting of critical illness. 
  • Active rehabilitation during extracorporeal membrane oxygenation as a bridge to lung transplantation. 
  • Addressing Patient Emotional and Existential Needs During Serious Illness: Results of the Outlook Randomized Controlled Trial. 
  • Addressing the Psychological Symptoms of Critical Illness: The Importance of "Negative" Trials in Guiding Next Steps. 
  • Aggressive versus conservative initiation of antimicrobial treatment in critically ill surgical patients with suspected intensive-care-unit-acquired infection: a quasi-experimental, before and after observational cohort study. 
  • Alternative lipid emulsions as a new standard of care for total parenteral nutrition: finally available in the United States?. 
  • An assessment of US physicians' training in religion, spirituality, and medicine. 
  • An expanded series of distal bypass using the distal vein patch technique to improve prosthetic graft performance in critical limb ischemia. 
  • An official American Thoracic Society statement: Treatment of fungal infections in adult pulmonary and critical care patients. 
  • Anesthesia for interventional neuroradiology. 
  • Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients. 
  • Aspergillus infections in transplant and non-transplant surgical patients. 
  • Association between intravenous chloride load during resuscitation and in-hospital mortality among patients with SIRS. 
  • Association between the choice of IV crystalloid and in-hospital mortality among critically ill adults with sepsis*. 
  • Association of an Electroencephalography-Based Risk Score With Seizure Probability in Hospitalized Patients. 
  • Association of gender with outcomes in critically ill patients. 
  • Barriers to enrollment in a randomized controlled trial of hydrocortisone for cardiovascular insufficiency in term and late preterm newborn infants. 
  • Beyond thrombosis: the versatile platelet in critical illness. 
  • Brainstem dysfunction as a predictor of death in the nonneurologically injured. 
  • CE: A Review of Current Practice in Transfusion Therapy. 
  • Care of the Neonatal Intensive Care Unit Graduate after Discharge. 
  • Central nervous system modulation of respiratory function in the critically ill. 
  • Changing preferences for survival after hospitalization with advanced heart failure. 
  • Choice of fluid in acute illness: what should be given? An international consensus. 
  • Choices of seriously ill patients about cardiopulmonary resuscitation: correlates and outcomes. SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. 
  • Chronic critical illness. 
  • Chronic critical illness: the growing challenge to health care. 
  • Clergy-laity support and patients' mood during serious illness: a cross-sectional epidemiologic study. 
  • Clinical Impact of External Laryngeal Manipulation During Laryngoscopy on Tracheal Intubation Success in Critically Ill Children. 
  • Clinical Momentum in the Intensive Care Unit. A Latent Contributor to Unwanted Care. 
  • Clinical Pharmacology Studies in Critically Ill Children. 
  • Clinical Practice Guidelines From the AABB: Red Blood Cell Transfusion Thresholds and Storage. 
  • Clinical review: Optimizing enteral nutrition for critically ill patients--a simple data-driven formula. 
  • Cognitive and physical rehabilitation of intensive care unit survivors: results of the RETURN randomized controlled pilot investigation. 
  • Communicating prognosis with parents of critically ill infants: direct observation of clinician behaviors. 
  • Communication practices on 4 Harvard surgical services: a surgical safety collaborative. 
  • Consensus statement on continuous EEG in critically ill adults and children, part I: indications. 
  • Consensus statement on continuous EEG in critically ill adults and children, part II: personnel, technical specifications, and clinical practice. 
  • Cost and health care utilization in ARDS--different from other critical illness? 
  • Cost of Medical Care of Patients with Advanced Serious Illness in Singapore (COMPASS): prospective cohort study protocol. 
  • Critical care cardiology research: a call to action. 
  • Critical illness hyperglycemia in pediatric cardiac surgery. 
  • Current medication practice and tracheal intubation safety outcomes from a prospective multicenter observational cohort study. 
  • De-Escalation of Antibiotics Does Not Increase Mortality in Critically Ill Surgical Patients. 
  • Definitions of cardiovascular insufficiency and relation to outcomes in critically ill newborn infants. 
  • Delirium in Critically Ill Children: An International Point Prevalence Study. 
  • Demand-flow airway pressure release ventilation as a partial ventilatory support mode: comparison with synchronized intermittent mandatory ventilation and pressure support ventilation. 
  • Development and preliminary evaluation of a telephone-based mindfulness training intervention for survivors of critical illness. 
  • Development and validation of a printed information brochure for families of chronically critically ill patients. 
  • Differences in blood pressure by measurement technique in neurocritically ill patients: A technological assessment. 
  • Differences in one-year health outcomes and resource utilization by definition of prolonged mechanical ventilation: a prospective cohort study. 
  • Does artificial nutrition improve outcome of critical illness? An alternative viewpoint! 
  • Early mobilization in critically ill patients: patients' mobilization level depends on health care provider's profession. 
  • Economic evaluation of propofol and lorazepam for critically ill patients undergoing mechanical ventilation. 
  • Effect of Location on Tracheal Intubation Safety in Cardiac Disease-Are Cardiac ICUs Safer? 
  • Effect of Palliative Care-Led Meetings for Families of Patients With Chronic Critical Illness: A Randomized Clinical Trial. 
  • Effectiveness of right heart catheterization: time for a randomized trial. 
  • Effects of a Telephone- and Web-based Coping Skills Training Program Compared with an Education Program for Survivors of Critical Illness and Their Family Members. A Randomized Clinical Trial. 
  • Effects of gender on the health and development of medically at-risk infants. 
  • Effects of maternal depressive symptoms and infant gender on the interactions between mothers and their medically at-risk infants. 
  • Effects of pharmaconutrients on cellular dysfunction and the microcirculation in critical illness. 
  • Elevated admission N-terminal pro-brain natriuretic peptide level predicts the development of atrial fibrillation in general surgical intensive care unit patients. 
  • End-stage renal disease and intensive care unit prognosis: are current tools good enough? 
  • Engaging Survivors of Critical Illness in Health Care Assessment and Policy Development. Ethical and Practical Complexities. 
  • Ensuring Optimal Survival and Post-ICU Quality of Life in High-Risk ICU Patients: Permissive Underfeeding Is Not Safe! 
  • Enteral fish oil in critical illness: perspectives and systematic review. 
  • Erythromycin vs metoclopramide for facilitating gastric emptying and tolerance to intragastric nutrition in critically ill patients. 
  • Estimates of future physical functioning by seriously ill hospitalized patients, their families, and their physicians. 
  • Ethical and regulatory challenges associated with the exception from informed consent requirements for emergency research: from experimental design to institutional review board approval. 
  • Evaluating a critically ill patient with metabolic acidosis: the ifosfamide paradigm. 
  • Evolving approaches to assessing and monitoring patient-ventilator interactions. 
  • Examination of QTc Values in Critically Ill Patients Diagnosed with Delirium and Prescribed Atypical Antipsychotics. 
  • Exploring the vagueness of Religion & Spirituality in complex pediatric decision-making: a qualitative study. 
  • Extracorporeal membrane oxygenation for severe refractory respiratory failure secondary to 2009 H1N1 influenza A. 
  • Fluconazole population pharmacokinetics and dosing for prevention and treatment of invasive Candidiasis in children supported with extracorporeal membrane oxygenation. 
  • Fluids are drugs: type, dose and toxicity. 
  • Frequency of Desaturation and Association With Hemodynamic Adverse Events During Tracheal Intubations in PICUs. 
  • Fulminant pertussis: a multi-center study with new insights into the clinico-pathological mechanisms. 
  • Gastric motility function in critically ill patients tolerant vs intolerant to gastric nutrition. 
  • Gastropexy using the Carter-Thomason device in lieu of T-fasteners in a critically ill, severely obese patient: an innovative technique. 
  • Glutamine Supplementation in Parenteral Nutrition and Intensive Care Unit Patients: Are We Throwing the Baby Out With the Bathwater? 
  • Glutamine and antioxidants in the critically ill patient: a post hoc analysis of a large-scale randomized trial. 
  • Glutamine attenuates tumor necrosis factor-alpha release and enhances heat shock protein 72 in human peripheral blood mononuclear cells. 
  • Glutamine in critical illness: the time has come, the time is now. 
  • Glutamine-mediated attenuation of cellular metabolic dysfunction and cell death after injury is dependent on heat shock factor-1 expression. 
  • Glutamine. 
  • Glutamine: mode of action in critical illness. 
  • Glutamine: role in critical illness and ongoing clinical trials. 
  • Glutamine: role in gut protection in critical illness. 
  • Glutamine: the first clinically relevant pharmacological regulator of heat shock protein expression? 
  • Glycemic control in patients undergoing coronary artery bypass graft surgery: Clinical features, predictors, and outcomes. 
  • Goal-directed or goal-misdirected - how should we interpret the literature? 
  • Health values of the seriously ill. SUPPORT investigators. 
  • Hyperglycemia-related mortality in critically ill patients varies with admission diagnosis. 
  • Hypocaloric compared with eucaloric nutritional support and its effect on infection rates in a surgical intensive care unit: a randomized controlled trial. 
  • Hyponatremia and the use of vasopressin receptor antagonists in critically ill patients. 
  • ICU procedures of the critically ill. 
  • Identifying pediatric emergence delirium by using the PAED Scale: a quality improvement project. 
  • Impact of the pulmonary artery catheter in critically ill patients: meta-analysis of randomized clinical trials. 
  • Improving post-intensive care unit neuropsychiatric outcomes: understanding cognitive effects of physical activity. 
  • Incidence and Risk Factors for Intensive Care Unit-related Post-traumatic Stress Disorder in Veterans and Civilians. 
  • Incidence and risk factors for venous thromboembolism in critically ill children after trauma. 
  • Incidence, management, and outcomes of cardiovascular insufficiency in critically ill term and late preterm newborn infants. 
  • Increased Occurrence of Tracheal Intubation-Associated Events During Nights and Weekends in the PICU. 
  • Increases of cardiac troponin in conditions other than acute coronary syndrome and heart failure. 
  • Inflammasome expression and cytomegalovirus viremia in critically ill patients with sepsis. 
  • Influence of donor base deficit status on recipient outcomes in liver transplantation. 
  • Influence of stress and nursing leadership on job satisfaction of pediatric intensive care unit nurses. 
  • Inhibitory effects of hyperglycemia on neural activity of the vagus in rats. 
  • Insulin-like growth factor 1 and delirium. 
  • Intensity of renal support in critically ill patients with acute kidney injury. 
  • Intensive insulin therapy in critically ill patients. 
  • Intensive insulin therapy in the neurocritical care setting is associated with poor clinical outcomes. 
  • Intrahospital Transport of the Critically Ill Adult: A Standardized Evaluation Plan. 
  • Is it time for individualized thromboprophylaxis regimens in the ICU? 
  • Is there a difference in bloodstream infections in critically ill patients associated with ready-to-use versus compounded parenteral nutrition? 
  • Is there still a role for high-frequency oscillatory ventilation in neonates, children and adults? 
  • Lacosamide in status epilepticus: Update on the TRENdS study. 
  • Life threatening liver disease during treatment with monoclonal antibodies. 
  • Life-saving treatments and disabilities. Are all QALYs created equal? 
  • Measurement of high-sensitivity troponin T in noncardiac medical intensive care unit patients. Correlation to mortality and length of stay. 
  • Measurement of quality and assurance of safety in the critically ill. 
  • Measuring Adaptive Coping of Hospitalized Patients With a Severe Medical Condition: The Sickness Insight in Coping Questionnaire. 
  • Measuring the effect of inappropriate initial antibiotic therapy on outcomes of patients with Gram-negative sepsis: An imprecise science. 
  • Mechanical Ventilator Discontinuation Process. 
  • Medical and economic implications of prolonged mechanical ventilation and expedited post-acute care. 
  • Metabolic and nutritional support of critically ill patients: consensus and controversies. 
  • Metabolomic derangements are associated with mortality in critically ill adult patients. 
  • Model for End-Stage Liver Disease score predicts mortality in critically ill cirrhotic patients. 
  • Molecular Mechanisms Linking Autonomic Dysfunction and Impaired Cardiac Contractility in Critical Illness. 
  • Monitoring oxygen delivery in the critically ill. 
  • Muscle mass and physical recovery in ICU: innovations for targeting of nutrition and exercise. 
  • National Academy of Clinical Biochemistry laboratory medicine practice guidelines: use of cardiac troponin and B-type natriuretic peptide or N-terminal proB-type natriuretic peptide for etiologies other than acute coronary syndromes and heart failure. 
  • Natriuretic peptide testing for the evaluation of critically ill patients with shock in the intensive care unit: a prospective cohort study. 
  • Neurologic and Functional Morbidity in Critically Ill Children With Bronchiolitis. 
  • Nocturnal Dexmedetomidine in Nonintubated, Critically Ill Patients: Sleep or Sedation? 
  • Non invasive monitoring in mechanically ventilated pediatric patients. 
  • Nontraditional modes of mechanical ventilation: progress or distraction? 
  • Nurse perception of Bispectral Index monitoring as an adjunct to sedation scale assessment in the critically ill paediatric patient. 
  • Nutrition therapy for the critically ill surgical patient: we need to do better! 
  • Nutrition therapy in critically ill infants and children. 
  • Nutritional support in critically ill patients. 
  • Older age, aggressiveness of care, and survival for seriously ill, hospitalized adults. SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. 
  • Omeprozole therapy in pediatric patients after liver and intestinal transplantation. 
  • One Size Does Not Fit All: Disease Profiles of Serious Illness Patients Receiving Specialty Palliative Care. 
  • One-year trajectories of care and resource utilization for recipients of prolonged mechanical ventilation: a cohort study. 
  • Operationalizing the Measuring What Matters Spirituality Quality Metric in a Population of Hospitalized, Critically Ill Patients and Their Family Members. 
  • Optimizing energy and protein balance in the ICU. 
  • Optimizing the dose of glutamine dipeptides and antioxidants in critically ill patients: a phase I dose-finding study. 
  • Organ cross talk in the critically ill: the heart and kidney. 
  • Organ donation and treatment of the multi-organ donor. 
  • Organ protective mechanisms common to extremes of physiology: a window through hibernation biology. 
  • Outcome of liver transplantation in critically ill patients with alcoholic cirrhosis: survival according to medical variables and sobriety. 
  • Oxygen in Acute Illness: More or Less? 
  • Oxygen: Providing Too Much of a Good Thing? 
  • Parenteral glutamine increases serum heat shock protein 70 in critically ill patients. 
  • Parenteral nutrition and calorie delivery in the ICU: controversy, clarity, or call to action? 
  • Patient race and decisions to withhold or withdraw life-sustaining treatments for seriously ill hospitalized adults. SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. 
  • Patterns of Sedation Weaning in Critically Ill Children Recovering From Acute Respiratory Failure. 
  • Pediatric Acute Respiratory Distress Syndrome in Pediatric Allogeneic Hematopoietic Stem Cell Transplants: A Multicenter Study. 
  • Pediatric cardiovascular drug dosing in critically ill children and extracorporeal membrane oxygenation. 
  • Performance of the Paediatric Index of Mortality 3 and Paediatric Logistic Organ Dysfunction 2 Scores in Critically Ill Children. 
  • Performance-enhancing sports supplements: role in critical care. 
  • Peripheral vascular complications during transcatheter aortic valve replacement: management and potential role of chronic steroid use. 
  • Persistent systemic inflammation in chronic critical illness. 
  • Pharmacokinetics and Dosing of Anti-infective Drugs in Patients on Extracorporeal Membrane Oxygenation: A Review of the Current Literature. 
  • Pharmaconutrition and nutrition therapy in critical illness. Preface. 
  • Pharmaconutrition review: physiological mechanisms. 
  • Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients. 
  • Precision Medicine for Critical Illness and Injury. 
  • Predicting critical illness mortality and personalizing therapy: moving to multi-dimensional data. 
  • Probiotic administration and the incidence of nosocomial infection in pediatric intensive care: a randomized placebo-controlled trial. 
  • Probiotic and synbiotic therapy in critical illness: a systematic review and meta-analysis. 
  • Prognostic accuracy of Acute Physiology and Chronic Health Evaluation II scores in critically ill cancer patients. 
  • Project CAPE: a high-fidelity, in situ simulation program to increase Critical Access Hospital Emergency Department provider comfort with seriously ill pediatric patients. 
  • Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family Study. 
  • Protein-energy nutrition in the ICU is the power couple: A hypothesis forming analysis. 
  • Protocolized sedation vs usual care in pediatric patients mechanically ventilated for acute respiratory failure: a randomized clinical trial. 
  • Relationship Between Adverse Tracheal Intubation Associated Events and PICU Outcomes. 
  • Relationship of body mass index to subsequent mortality among seriously ill hospitalized patients. SUPPORT Investigators. The Study to Understand Prognoses and Preferences for Outcome and Risks of Treatments. 
  • Relationship of vitamin D deficiency to clinical outcomes in critically ill patients. 
  • Renal systems biology of patients with systemic inflammatory response syndrome. 
  • Reply: Do We Really Know How to Use High-Frequency Oscillatory Ventilation in Critically Ill Children? 
  • Researching breathlessness in palliative care: consensus statement of the National Cancer Research Institute Palliative Care Breathlessness Subgroup. 
  • Respiratory Viral Coinfections in the PICU: More Is Not Better...But Is It Worse? 
  • Response to "Reassessing the death risk related to probiotics in critically ill patients". 
  • Restoring the Microbiome in Critically Ill Patients: Are Probiotics Our True Friends When We Are Seriously Ill? 
  • Risk factors and impact of major bleeding in critically ill patients receiving heparin thromboprophylaxis. 
  • Role of L-glutamine in critical illness: new insights. 
  • Role of the microbiome, probiotics, and 'dysbiosis therapy' in critical illness. 
  • ST2 Predicts Mortality and Length of Stay in a Critically Ill Noncardiac Intensive Care Unit Population. 
  • Safety and effectiveness of meropenem in infants with suspected or complicated intra-abdominal infections. 
  • Sedation and subglottic stenosis in critically ill children. 
  • Sedatives and Analgesics Given to Infants in Neonatal Intensive Care Units at the End of Life. 
  • Setting the vision: applied patient-reported outcomes and smart, connected digital healthcare systems to improve patient-centered outcomes prediction in critical illness. 
  • Should Early Mobilization Be Routine in Mechanically Ventilated Patients? 
  • Should modulation of p50 be a therapeutic target in the critically ill? 
  • Statins and delirium during critical illness: a multicenter, prospective cohort study. 
  • Strict glycemic targets need not be so strict: a more permissive glycemic range for critically ill children. 
  • Supplemental Parenteral Nutrition: Review of the Literature and Current Nutrition Guidelines. 
  • Surveillance for unexplained deaths and critical illnesses due to possibly infectious causes, United States, 1995-1998. 
  • Survival in critical illness is associated with early activation of mitochondrial biogenesis. 
  • Symptomatic event reduction with extended-duration betrixaban in acute medically ill hospitalized patients. 
  • Tailoring nutrition therapy to illness and recovery. 
  • Temperature profile and outcomes of neonates undergoing whole body hypothermia for neonatal hypoxic-ischemic encephalopathy. 
  • The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United States. 
  • The SUPPORT prognostic model. Objective estimates of survival for seriously ill hospitalized adults. Study to understand prognoses and preferences for outcomes and risks of treatments. 
  • The Uniformed Services University's Surgical Critical Care Initiative (SC2i): Bringing Precision Medicine to the Critically Ill. 
  • The Voice of Surrogate Decision-Makers. Family Responses to Prognostic Information in Chronic Critical Illness. 
  • The authors reply. 
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  • The challenge of measuring community values in ways appropriate for setting health care priorities. 
  • The chronically critically ill patient: pediatric considerations. 
  • The effectiveness of right heart catheterization in the initial care of critically ill patients. SUPPORT Investigators. 
  • The epidemiology of chronic critical illness in the United States*. 
  • The evolution of nutrition in critical care: how much, how soon? 
  • The future of critical care nutrition therapy. 
  • The impact of delirium on clinical outcomes in mechanically ventilated surgical and trauma patients. 
  • The number of tracheal intubation attempts matters! A prospective multi-institutional pediatric observational study. 
  • The structure of critical care transfer networks. 
  • The use of vasoactive agents via peripheral intravenous access during transport of critically III infants and children. 
  • Therapeutic Alliance between the Caregivers of Critical Illness Survivors and Intensive Care Unit Clinicians. 
  • Tight glycemic control reduces infection and improves neurological outcome in critically ill neurosurgical and neurological patients. 
  • Timing is everything? Reconciling the results of recent trials in acute kidney injury. 
  • Tools to Promote Shared Decision Making in Serious Illness: A Systematic Review. 
  • Toward Solving the Sedation-Assessment Conundrum: Neurofunction Monitoring. 
  • Transabdominal duplex ultrasonography for bedside inferior vena cava filter placement: examples, technique, and review. 
  • Transfusion in critical care - a UK regional audit of current practice. 
  • Transfusion of fresh frozen plasma in critically ill surgical patients is associated with an increased risk of infection. 
  • Transporting Critically Ill Children-Are We All on the Same Page? 
  • Usability Testing of an Electronic Patient-Reported Outcome System for Survivors of Critical Illness. 
  • Use of daily Acute Physiology and Chronic Health Evaluation (APACHE) II scores to predict individual patient survival rate. 
  • Use of high flow nasal cannula in critically ill infants, children, and adults: a critical review of the literature. 
  • Using Technology to Create a More Humanistic Approach to Integrating Palliative Care into the Intensive Care Unit. 
  • What is the ideal crystalloid? 
  • Winning the war against ICU-acquired weakness: new innovations in nutrition and exercise physiology. 
  • Worry about child health in mothers of hospitalized medically fragile infants. 
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  Keywords of People

  • O'Connor, Christopher Michael, Richard Sean Stack, M.D. / Guidant Foundation Professor of Cardiology, Medicine, Clinical Pharmacology
  • Olsen, Maren Karine, Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
  • Turner, David Ashley, Associate Professor of Pediatrics, Pediatrics, Critical Care Medicine