Critical Illness

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  Subject Areas on Research

  • "One Piece at a Time": The Cache of Acute Kidney Injury Data in the Electronic Medical Record. 
  • A Call to Move From Point-in-Time Toward Comprehensive Dynamic Risk Prediction in Critically Ill Patients With Heart Failure. 
  • A Framework for Improving Chronic Critical Illness Care: Adapting the Medical Home's Central Tenets. 
  • A National Emergency Airway Registry for children: landscape of tracheal intubation in 15 PICUs. 
  • A Pharmacy-Based Electronic Handoff Tool to Reduce Discharge Prescribing of Atypical Antipsychotics Initiated in the Intensive Care Unit: A Quality Improvement Initiative. 
  • A Pilot Randomized Trial of an Interactive Web-based Tool to Support Surrogate Decision Makers in the Intensive Care Unit. 
  • A case of mistaken identity: persistent sciatic artery stenosis as a cause of critical limb ischemia. 
  • A cost and outcomes comparison of a novel integrated pediatric air and ground transportation system. 
  • A descriptive evaluation of transfusion practices in patients receiving mechanical ventilation. 
  • A few of our favorite unconfirmed ideas. 
  • A greater analgesia, sedation, delirium order set quality score is associated with a decreased duration of mechanical ventilation in cardiovascular surgery patients. 
  • A guide to enteral nutrition in intensive care units: 10 expert tips for the daily practice. 
  • A metabolomic endotype of bioenergetic dysfunction predicts mortality in critically ill patients with acute respiratory failure. 
  • A novel approach to maintain gut mucosal integrity using an oral enzyme supplement. 
  • A pilot study to explore the safety of perioperative postpyloric enteral nutrition. 
  • A prognostic model for one-year mortality in patients requiring prolonged mechanical ventilation. 
  • A randomized evaluation of bispectral index-augmented sedation assessment in neurological patients. 
  • A randomized trial of glutamine and antioxidants in critically ill patients. 
  • A randomized trial of supplemental parenteral nutrition in underweight and overweight critically ill patients: the TOP-UP pilot trial. 
  • A review of the use of adjunctive therapies in severe acute asthma exacerbation in critically ill children. 
  • A technique for rapid exchange of continuous renal replacement therapy. 
  • A universal decision support system. Addressing the decision-making needs of patients, families, and clinicians in the setting of critical illness. 
  • ACC/AHA/ASE 2003 guideline update for the clinical application of echocardiography: summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (ACC/AHA/ASE Committee to Update the 1997 Guidelines for the Clinical Application of Echocardiography). 
  • Accidental communities: race, emergency medicine, and the problem of polyheme. 
  • Accuracy of the Emergency Severity Index triage instrument for identifying elder emergency department patients receiving an immediate life-saving intervention. 
  • Active rehabilitation during extracorporeal membrane oxygenation as a bridge to lung transplantation. 
  • Acute right ventricular dysfunction: real-time management with echocardiography. 
  • Acute skeletal muscle wasting and dysfunction predict physical disability at hospital discharge in patients with critical illness. 
  • Addressing Patient Emotional and Existential Needs During Serious Illness: Results of the Outlook Randomized Controlled Trial. 
  • Addressing the Psychological Symptoms of Critical Illness: The Importance of "Negative" Trials in Guiding Next Steps. 
  • Admission Psychosocial Characteristics of Critically Ill Children and Acute Stress. 
  • Adult emergency department patients with sickle cell pain crisis: a learning collaborative model to improve analgesic management. 
  • Advance Care Planning Claims and Health Care Utilization Among Seriously Ill Patients Near the End of Life. 
  • Aggressive versus conservative initiation of antimicrobial treatment in critically ill surgical patients with suspected intensive-care-unit-acquired infection: a quasi-experimental, before and after observational cohort study. 
  • Alternative lipid emulsions as a new standard of care for total parenteral nutrition: finally available in the United States? 
  • An assessment of US physicians' training in religion, spirituality, and medicine. 
  • An expanded series of distal bypass using the distal vein patch technique to improve prosthetic graft performance in critical limb ischemia. 
  • An official American Thoracic Society statement: Treatment of fungal infections in adult pulmonary and critical care patients. 
  • Anesthesia for interventional neuroradiology. 
  • Anticoagulation and Antiplatelet Therapy for Prevention of Venous and Arterial Thrombotic Events in Critically Ill Patients With COVID-19: COVID-PACT. 
  • Antimicrobial de-escalation in the critically ill patient and assessment of clinical cure: the DIANA study. 
  • Antimotility agents for the treatment of acute noninfectious diarrhea in critically ill patients: A practice management guideline from the Eastern Association for the Surgery of Trauma. 
  • Apolipoprotein E4 polymorphism as a genetic predisposition to delirium in critically ill patients. 
  • Aspergillus infections in transplant and non-transplant surgical patients. 
  • Assessment of Clinical Palliative Care Trigger Status vs Actual Needs Among Critically Ill Patients and Their Family Members. 
  • Assessment of parent understanding in conferences for critically ill neonates. 
  • Association between intravenous chloride load during resuscitation and in-hospital mortality among patients with SIRS. 
  • Association between the choice of IV crystalloid and in-hospital mortality among critically ill adults with sepsis*. 
  • Association of an Electroencephalography-Based Risk Score With Seizure Probability in Hospitalized Patients. 
  • Association of gender with outcomes in critically ill patients. 
  • Barriers to enrollment in a randomized controlled trial of hydrocortisone for cardiovascular insufficiency in term and late preterm newborn infants. 
  • Beyond the AJR: "Assessment of Brain Injury Using Portable, Low-Field Magnetic Resonance Imaging at the Bedside of Critically Ill Patients". 
  • Beyond thrombosis: the versatile platelet in critical illness. 
  • Boarding of Critically Ill Patients in the Emergency Department. 
  • Brainstem dysfunction as a predictor of death in the nonneurologically injured. 
  • Care of the Neonatal Intensive Care Unit Graduate after Discharge. 
  • Central nervous system modulation of respiratory function in the critically ill. 
  • Changes in comorbidities, diagnoses, therapies and outcomes in a contemporary cardiac intensive care unit population. 
  • Changing preferences for survival after hospitalization with advanced heart failure. 
  • Characteristics and Outcomes of Critically Ill Children With Multisystem Inflammatory Syndrome. 
  • Characteristics and Outcomes of Individuals With Pre-existing Kidney Disease and COVID-19 Admitted to Intensive Care Units in the United States. 
  • Characterizing the Language Used to Discuss Death in Family Meetings for Critically Ill Infants. 
  • Choice of fluid in acute illness: what should be given? An international consensus. 
  • Chronic critical illness. 
  • Chronic critical illness: the growing challenge to health care. 
  • Clergy-laity support and patients' mood during serious illness: a cross-sectional epidemiologic study. 
  • Clinical Impact of External Laryngeal Manipulation During Laryngoscopy on Tracheal Intubation Success in Critically Ill Children. 
  • Clinical Momentum in the Intensive Care Unit. A Latent Contributor to Unwanted Care. 
  • Clinical Pharmacology Studies in Critically Ill Children. 
  • Clinical characteristics and outcomes of critically ill mechanically ventilated COVID-19 patients receiving interleukin-6 receptor antagonists and corticosteroid therapy: a preliminary report from a multinational registry. 
  • Clinical review: Optimizing enteral nutrition for critically ill patients--a simple data-driven formula. 
  • Clinical year in review I: quality improvement for pulmonary and critical care medicine, lung transplantation, rehabilitation for pulmonary and critically ill patients, and sleep medicine. 
  • Co-designed and consensus based development of a quality improvement checklist of patient and family-centered actionable processes of care for adults with persistent critical illness. 
  • Cognitive and physical rehabilitation of intensive care unit survivors: results of the RETURN randomized controlled pilot investigation. 
  • Commentary on "Guidelines for the provision of nutrition support therapy in the adult critically ill patient: The American Society for Parenteral and Enteral Nutrition". 
  • Communicating prognosis with parents of critically ill infants: direct observation of clinician behaviors. 
  • Communication practices on 4 Harvard surgical services: a surgical safety collaborative. 
  • Comparison of Fibrin Monomers and D-dimers to predict thrombotic events in critically ill patients with COVID-19 pneumonia: A retrospective study. 
  • Congenital anomalies of the kidney and urinary tract (CAKUT) in critically ill infants: a multicenter cohort study. 
  • Consensus statement on continuous EEG in critically ill adults and children, part I: indications. 
  • Consensus statement on continuous EEG in critically ill adults and children, part II: personnel, technical specifications, and clinical practice. 
  • Core outcome measures for clinical effectiveness trials of nutritional and metabolic interventions in critical illness: an international modified Delphi consensus study evaluation (CONCISE). 
  • Cost and health care utilization in ARDS--different from other critical illness? 
  • Cost of Medical Care of Patients with Advanced Serious Illness in Singapore (COMPASS): prospective cohort study protocol. 
  • Cricoid Pressure During Induction for Tracheal Intubation in Critically Ill Children: A Report From National Emergency Airway Registry for Children. 
  • Critical Care Cardiology Trials Network (CCCTN): a cohort profile. 
  • Critical care cardiology research: a call to action. 
  • Critical illness hyperglycemia in pediatric cardiac surgery. 
  • Current Controversies in Caring for the Critically Ill Pulmonary Embolism Patient. 
  • Current medication practice and tracheal intubation safety outcomes from a prospective multicenter observational cohort study. 
  • D-dimer levels in VTE patients with distal and proximal clots. 
  • Damage- and pathogen-associated molecular patterns play differential roles in late mortality after critical illness. 
  • De-Escalation of Antibiotics Does Not Increase Mortality in Critically Ill Surgical Patients. 
  • Dealing with "Difficult" Patients and Families: Making a Case for Trauma-informed Care in the Intensive Care Unit. 
  • Defining the Value Proposition for Specialist Palliative Care Delivered in Intensive Care Units. 
  • Definitions of cardiovascular insufficiency and relation to outcomes in critically ill newborn infants. 
  • Delirium is a robust predictor of morbidity and mortality among critically ill patients treated in the cardiac intensive care unit. 
  • Demand-flow airway pressure release ventilation as a partial ventilatory support mode: comparison with synchronized intermittent mandatory ventilation and pressure support ventilation. 
  • Demographics, Care Patterns, and Outcomes of Patients Admitted to Cardiac Intensive Care Units: The Critical Care Cardiology Trials Network Prospective North American Multicenter Registry of Cardiac Critical Illness. 
  • Developing the family support tool: An interactive, web-based tool to help families navigate the complexities of surrogate decision making in ICUs. 
  • Development and preliminary evaluation of EMPOWER for surrogate decision-makers of critically ill patients. 
  • Development and preliminary evaluation of a telephone-based mindfulness training intervention for survivors of critical illness. 
  • Development and validation of a printed information brochure for families of chronically critically ill patients. 
  • Differences in blood pressure by measurement technique in neurocritically ill patients: A technological assessment. 
  • Differences in one-year health outcomes and resource utilization by definition of prolonged mechanical ventilation: a prospective cohort study. 
  • DirEct versus VIdeo LaryngosCopE (DEVICE): protocol and statistical analysis plan for a randomised clinical trial in critically ill adults undergoing emergency tracheal intubation. 
  • Does artificial nutrition improve outcome of critical illness? An alternative viewpoint! 
  • Drug Trials in Status Epilepticus: Current Evidence and Future Concepts. 
  • Early Palliative Care Consultation in the Medical ICU: A Cluster Randomized Crossover Trial. 
  • Early Recognition of Preventable Factors Associated with Delirium Saves Lives and Costs. 
  • Early Vasopressor Utilization Strategies and Outcomes in Critically Ill Patients With Severe Traumatic Brain Injury. 
  • Early mobilization in critically ill patients: patients' mobilization level depends on health care provider's profession. 
  • Economic evaluation of propofol and lorazepam for critically ill patients undergoing mechanical ventilation. 
  • Editorial: Objective measurement of nutrition and metabolism in the ICU: the future of personalized metabolic therapy. 
  • Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial. 
  • Effect of Location on Tracheal Intubation Safety in Cardiac Disease-Are Cardiac ICUs Safer? 
  • Effect of Palliative Care-Led Meetings for Families of Patients With Chronic Critical Illness: A Randomized Clinical Trial. 
  • Effect of acute lung injury and acute respiratory distress syndrome on outcome in critically ill trauma patients. 
  • Effect of tocilizumab on clinical outcomes at 15 days in patients with severe or critical coronavirus disease 2019: randomised controlled trial. 
  • Effectiveness of right heart catheterization: time for a randomized trial. 
  • Effects of ABO Matching of Platelet Transfusions in Critically Ill Children. 
  • Effects of a Personalized Web-Based Decision Aid for Surrogate Decision Makers of Patients With Prolonged Mechanical Ventilation: A Randomized Clinical Trial. 
  • Effects of a Telephone- and Web-based Coping Skills Training Program Compared with an Education Program for Survivors of Critical Illness and Their Family Members. A Randomized Clinical Trial. 
  • Effects of mindfulness training programmes delivered by a self-directed mobile app and by telephone compared with an education programme for survivors of critical illness: a pilot randomised clinical trial. 
  • Effects of nursing interventions on intracranial pressure. 
  • Effects of patient-level noise abatement orders on sound levels experienced by critically ill subarachnoid hemorrhage patients: an observational study. 
  • Effects of pharmaconutrients on cellular dysfunction and the microcirculation in critical illness. 
  • End-stage renal disease and intensive care unit prognosis: are current tools good enough? 
  • Engaging Survivors of Critical Illness in Health Care Assessment and Policy Development. Ethical and Practical Complexities. 
  • Ensuring Optimal Survival and Post-ICU Quality of Life in High-Risk ICU Patients: Permissive Underfeeding Is Not Safe! 
  • Enteral Nutrition Can Be Given to Patients on Vasopressors. 
  • Enteral fish oil in critical illness: perspectives and systematic review. 
  • Epidemiology and Outcomes of SARS-CoV-2 Infection or Multisystem Inflammatory Syndrome in Children vs Influenza Among Critically Ill Children. 
  • Erythromycin vs metoclopramide for facilitating gastric emptying and tolerance to intragastric nutrition in critically ill patients. 
  • Estimates of future physical functioning by seriously ill hospitalized patients, their families, and their physicians. 
  • Ethical and regulatory challenges associated with the exception from informed consent requirements for emergency research: from experimental design to institutional review board approval. 
  • Etomidate, adrenal function, and mortality in critically ill patients. 
  • European Heart Rhythm Association (EHRA) consensus document on management of arrhythmias and cardiac electronic devices in the critically ill and post-surgery patient, endorsed by Heart Rhythm Society (HRS), Asia Pacific Heart Rhythm Society (APHRS), Cardiac Arrhythmia Society of Southern Africa (CASSA), and Latin American Heart Rhythm Society (LAHRS). 
  • Evaluating a critically ill patient with metabolic acidosis: the ifosfamide paradigm. 
  • Evolving approaches to assessing and monitoring patient-ventilator interactions. 
  • Examination of QTc Values in Critically Ill Patients Diagnosed with Delirium and Prescribed Atypical Antipsychotics. 
  • Exploring the vagueness of Religion & Spirituality in complex pediatric decision-making: a qualitative study. 
  • Extended prophylaxis of venous thromboembolism with betrixaban in acutely ill medical patients with and without cancer: insights from the APEX trial. 
  • Extended-duration betrixaban versus shorter-duration enoxaparin for venous thromboembolism prophylaxis in critically ill medical patients: an APEX trial substudy. 
  • Extracellular Mitochondrial DNA and N-Formyl Peptides in Trauma and Critical Illness: A Systematic Review. 
  • Extracorporeal Membrane Oxygenation in Critically Ill Children. 
  • Extracorporeal membrane oxygenation for severe refractory respiratory failure secondary to 2009 H1N1 influenza A. 
  • Extracorporeal membrane oxygenation in critically ill neonatal and pediatric patients with acute respiratory failure: a guide for the clinician. 
  • Facilitating communication for critically ill patients and their family members: Study protocol for two randomized trials implemented in the U.S. and France. 
  • Feeding intolerance in critically ill patients with COVID-19. 
  • Fibroblast Growth Factor 23 Associates with Death in Critically Ill Patients. 
  • Fibroblast Growth Factor 23 Levels Associate with AKI and Death in Critical Illness. 
  • Fifty Years of Mechanical Ventilation-1970s to 2020. 
  • Fluconazole population pharmacokinetics and dosing for prevention and treatment of invasive Candidiasis in children supported with extracorporeal membrane oxygenation. 
  • Fluid overload and mortality in children receiving continuous renal replacement therapy: the prospective pediatric continuous renal replacement therapy registry. 
  • Fluids are drugs: type, dose and toxicity. 
  • Frequency of Desaturation and Association With Hemodynamic Adverse Events During Tracheal Intubations in PICUs. 
  • Fulminant pertussis: a multi-center study with new insights into the clinico-pathological mechanisms. 
  • Functional electrical stimulation in-bed cycle ergometry in mechanically ventilated patients: a multicentre randomised controlled trial. 
  • Gastric motility function in critically ill patients tolerant vs intolerant to gastric nutrition. 
  • Gastropexy using the Carter-Thomason device in lieu of T-fasteners in a critically ill, severely obese patient: an innovative technique. 
  • Gender Disparities in Adult Health: An Examination of Three Measures of Morbidity 
  • Glutamine Supplementation in Parenteral Nutrition and Intensive Care Unit Patients: Are We Throwing the Baby Out With the Bathwater? 
  • Glutamine and antioxidants in the critically ill patient: a post hoc analysis of a large-scale randomized trial. 
  • Glutamine attenuates tumor necrosis factor-alpha release and enhances heat shock protein 72 in human peripheral blood mononuclear cells. 
  • Glutamine in critical illness: the time has come, the time is now. 
  • Glutamine-mediated attenuation of cellular metabolic dysfunction and cell death after injury is dependent on heat shock factor-1 expression. 
  • Glutamine. 
  • Glutamine: mode of action in critical illness. 
  • Glutamine: role in critical illness and ongoing clinical trials. 
  • Glutamine: role in gut protection in critical illness. 
  • Glutamine: the first clinically relevant pharmacological regulator of heat shock protein expression? 
  • Glycemic control in patients undergoing coronary artery bypass graft surgery: Clinical features, predictors, and outcomes. 
  • Goal-directed or goal-misdirected - how should we interpret the literature? 
  • Haloperidol for the management of delirium in adult intensive care unit patients: A systematic review and meta-analysis of randomized controlled trials. 
  • Health values of the seriously ill. 
  • Health values of the seriously ill. SUPPORT investigators. 
  • Helping the Demand Find the Supply: Messaging the Value of Specialty Palliative Care Directly to Those With Serious Illnesses. 
  • Hospital change to mixed lipid emulsion from soybean oil-based lipid emulsion for parenteral nutrition in hospitalized and critically ill adults improves outcomes: a pre-post-comparative study. 
  • How Surrogate Decision-Makers for Patients With Chronic Critical Illness Perceive and Carry Out Their Role. 
  • Hydroxyethyl starch or saline in intensive care. 
  • Hypercoagulability and coronavirus disease 2019-associated hypoxemic respiratory failure: Mechanisms and emerging management paradigms. 
  • Hyperglycemia-related mortality in critically ill patients varies with admission diagnosis. 
  • Hypocaloric compared with eucaloric nutritional support and its effect on infection rates in a surgical intensive care unit: a randomized controlled trial. 
  • Hyponatremia and the use of vasopressin receptor antagonists in critically ill patients. 
  • ICU procedures of the critically ill. 
  • Identification of Distinct Clinical Subphenotypes in Critically Ill Patients With COVID-19. 
  • Identifying Palliative Care Champions to Promote High-Quality Care to Those with Serious Illness. 
  • Identifying pediatric emergence delirium by using the PAED Scale: a quality improvement project. 
  • Impact of Contrast Echocardiography on Outcomes in Critically Ill Patients. 
  • Impact of Failure of Noninvasive Ventilation on the Safety of Pediatric Tracheal Intubation. 
  • Impact of the pulmonary artery catheter in critically ill patients: meta-analysis of randomized clinical trials. 
  • Improving Outcomes Measurement in Palliative Care: The Lasting Impact of Randy Curtis and his Collaborators. 
  • Improving Quality of Care for Seriously Ill Patients: Opportunities for Hospitalists. 
  • Improving post-intensive care unit neuropsychiatric outcomes: understanding cognitive effects of physical activity. 
  • Incidence and Factors Associated With Major Amputation in Patients With Peripheral Artery Disease: Insights From the EUCLID Trial. 
  • Incidence and Risk Factors for Intensive Care Unit-related Post-traumatic Stress Disorder in Veterans and Civilians. 
  • Incidence, management, and outcomes of cardiovascular insufficiency in critically ill term and late preterm newborn infants. 
  • Increased Occurrence of Tracheal Intubation-Associated Events During Nights and Weekends in the PICU. 
  • Indirect calorimetry in critical illness: a new standard of care? 
  • Inflammasome expression and cytomegalovirus viremia in critically ill patients with sepsis. 
  • Influence of donor base deficit status on recipient outcomes in liver transplantation. 
  • Influence of stress and nursing leadership on job satisfaction of pediatric intensive care unit nurses. 
  • Inhibitory effects of hyperglycemia on neural activity of the vagus in rats. 
  • Insulin-like growth factor 1 and delirium. 
  • Intensity of renal support in critically ill patients with acute kidney injury. 
  • Intensive insulin therapy in critically ill patients. 
  • Intensive insulin therapy in the neurocritical care setting is associated with poor clinical outcomes. 
  • Interleukin-1 receptor-associated kinase-1: more evidence. 
  • International Study of the Epidemiology of Platelet Transfusions in Critically Ill Children With an Underlying Oncologic Diagnosis. 
  • Intrahospital Transport of the Critically Ill Adult: A Standardized Evaluation Plan. 
  • Intraoperative adherence to a low tidal volume ventilation strategy in critically ill patients with preexisting acute lung injury. 
  • Invasive aspergillosis in critically ill patients: Review of definitions and diagnostic approaches. 
  • Investigating SOFA, delta-SOFA and MPM-III for mortality prediction among critically ill patients at a private tertiary hospital ICU in Kenya: A retrospective cohort study. 
  • Is it time for individualized thromboprophylaxis regimens in the ICU? 
  • Is there a difference in bloodstream infections in critically ill patients associated with ready-to-use versus compounded parenteral nutrition? 
  • Is there still a role for high-frequency oscillatory ventilation in neonates, children and adults? 
  • Ketamine Use for Tracheal Intubation in Critically Ill Children Is Associated With a Lower Occurrence of Adverse Hemodynamic Events. 
  • Kidney Recovery and Death in Critically Ill Patients With COVID-19-Associated Acute Kidney Injury Treated With Dialysis: The STOP-COVID Cohort Study. 
  • Lacosamide in status epilepticus: Update on the TRENdS study. 
  • Learning from Discharge Experiences of Intensive Care Unit Survivors and Their Families: Is Consistency a Solution? 
  • Life threatening liver disease during treatment with monoclonal antibodies. 
  • Life-saving treatments and disabilities. Are all QALYs created equal? 
  • Literature review and global consensus on management of acute radiation syndrome affecting nonhematopoietic organ systems. 
  • Long-Term Neurobehavioral and Quality of Life Outcomes of Critically Ill Children after Glycemic Control. 
  • Lung Ultrasound Training in the Critically Ill: Comment. 
  • Measurement of quality and assurance of safety in the critically ill. 
  • Measuring Adaptive Coping of Hospitalized Patients With a Severe Medical Condition: The Sickness Insight in Coping Questionnaire. 
  • Measuring the effect of inappropriate initial antibiotic therapy on outcomes of patients with Gram-negative sepsis: An imprecise science. 
  • Mechanical Ventilator Discontinuation Process. 
  • Medical and economic implications of prolonged mechanical ventilation and expedited post-acute care. 
  • Meta-Analysis of the Role of Intermittent Pneumatic Compression of the Lower Limbs to Prevent Venous Thromboembolism in Critically Ill Patients. 
  • Metabolic and nutritional support of critically ill patients: consensus and controversies. 
  • Metabolic support in the critically ill: a consensus of 19. 
  • Metabolomic derangements are associated with mortality in critically ill adult patients. 
  • Methemoglobinemia in critically ill burned patients. 
  • Methodologic Challenges in the Diagnosis of Acute Kidney Injury in Children With Diabetic Ketoacidosis. 
  • Micronutrient deficiencies in critically ill patients receiving continuous renal replacement therapy. 
  • Misconceptions concerning gastroesophageal reflux in children. 
  • Mitochondrial Dysfunction in Critical Illness: Implications for Nutritional Therapy. 
  • Mobility Levels With Physical Rehabilitation Delivered During and After Extracorporeal Membrane Oxygenation: A Marker of Illness Severity or an Indication of Recovery? 
  • Model for End-Stage Liver Disease score predicts mortality in critically ill cirrhotic patients. 
  • Models of Peer Support to Remediate Post-Intensive Care Syndrome: A Report Developed by the Society of Critical Care Medicine Thrive International Peer Support Collaborative. 
  • Monitoring oxygen delivery in the critically ill. 
  • Mortality and religion/spirituality: a brief review of the research. 
  • Muscle mass and physical recovery in ICU: innovations for targeting of nutrition and exercise. 
  • National Academy of Clinical Biochemistry laboratory medicine practice guidelines: use of cardiac troponin and B-type natriuretic peptide or N-terminal proB-type natriuretic peptide for etiologies other than acute coronary syndromes and heart failure. 
  • Neurologic and Functional Morbidity in Critically Ill Children With Bronchiolitis. 
  • No question too small: development of a question prompt list for parents of critically ill infants. 
  • Nocturnal Dexmedetomidine in Nonintubated, Critically Ill Patients: Sleep or Sedation? 
  • Non invasive monitoring in mechanically ventilated pediatric patients. 
  • Noninvasive Determination of Blood Pressure by Heart Sound Analysis Compared With Intra-Arterial Monitoring in Critically Ill Children-A Pilot Study of a Novel Approach. 
  • Nontraditional modes of mechanical ventilation: progress or distraction? 
  • Novel approaches to metabolic assessment and structured exercise to promote recovery in ICU survivors. 
  • Nurse perception of Bispectral Index monitoring as an adjunct to sedation scale assessment in the critically ill paediatric patient. 
  • Nutrition Therapy in Sepsis. 
  • Nutrition assessment of the critically ill adult. 
  • Nutrition therapy and critical illness: practical guidance for the ICU, post-ICU, and long-term convalescence phases. 
  • Nutrition therapy for the critically ill surgical patient: we need to do better! 
  • Nutrition therapy in critically ill infants and children. 
  • Nutritional support in critically ill patients. 
  • Obesity, inflammatory and thrombotic markers, and major clinical outcomes in critically ill patients with COVID-19 in the US. 
  • Occurrence and complications of tracheal reintubation in critically ill adults. 
  • Older age, aggressiveness of care, and survival for seriously ill, hospitalized adults. SUPPORT Investigators. Study to Understand Prognoses and Preferences for Outcomes and Risks of Treatments. 
  • Omeprozole therapy in pediatric patients after liver and intestinal transplantation. 
  • One Size Does Not Fit All: Disease Profiles of Serious Illness Patients Receiving Specialty Palliative Care. 
  • One-year trajectories of care and resource utilization for recipients of prolonged mechanical ventilation: a cohort study. 
  • Operationalizing the Measuring What Matters Spirituality Quality Metric in a Population of Hospitalized, Critically Ill Patients and Their Family Members. 
  • Optimal Dosing of Meropenem in a Small Cohort of Critically Ill Children Receiving Continuous Renal Replacement Therapy. 
  • Optimizing energy and protein balance in the ICU. 
  • Optimizing the dose of glutamine dipeptides and antioxidants in critically ill patients: a phase I dose-finding study. 
  • Organ cross talk in the critically ill: the heart and kidney. 
  • Organ donation and treatment of the multi-organ donor. 
  • Organ protective mechanisms common to extremes of physiology: a window through hibernation biology. 
  • Oscillating Continuous Cardiac Output in Postoperative Critically Ill Patients: Is this Phenomenon Accurate, Artifact, or Error? 
  • Overcoming challenges to enteral nutrition delivery in critical care. 
  • Oxygen in Acute Illness: More or Less? 
  • Oxygen: Providing Too Much of a Good Thing? 
  • PLX-PAD Cell Treatment of Critical Limb Ischaemia: Rationale and Design of the PACE Trial. 
  • Palliative Care Consultation Is Underutilized in Critically Ill General Surgery Patients. 
  • Palliative Care Planner: A Pilot Study to Evaluate Acceptability and Usability of an Electronic Health Records System-integrated, Needs-targeted App Platform. 
  • Palliative Care Use for Critically Ill Patients With Brain Metastases. 
  • Parenteral glutamine increases serum heat shock protein 70 in critically ill patients. 
  • Parenteral nutrition and calorie delivery in the ICU: controversy, clarity, or call to action? 
  • Patient and Family Engagement in Critical Illness. 
  • Patient-level interventions to prevent the acquisition of resistant gram-negative bacteria in critically ill patients: a systematic review. 
  • Pediatric cardiovascular drug dosing in critically ill children and extracorporeal membrane oxygenation. 
  • Performance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States. 
  • Performance of the Paediatric Index of Mortality 3 and Paediatric Logistic Organ Dysfunction 2 Scores in Critically Ill Children. 
  • Performance-enhancing sports supplements: role in critical care. 
  • Peripheral vascular complications during transcatheter aortic valve replacement: management and potential role of chronic steroid use. 
  • Persistent hypermetabolism and longitudinal energy expenditure in critically ill patients with COVID-19. 
  • Persistent systemic inflammation in chronic critical illness. 
  • Pharmacodynamics and pharmacokinetics of milrinone administration to increase oxygen delivery in critically ill patients. 
  • Pharmacokinetic and Pharmacodynamic Profiling of Minocycline for Injection following a Single Infusion in Critically Ill Adults in a Phase IV Open-Label Multicenter Study (ACUMIN). 
  • Pharmaconutrition and nutrition therapy in critical illness. Preface. 
  • Pharmaconutrition review: physiological mechanisms. 
  • Physical Rehabilitation in Critically Ill Children: A Multicenter Point Prevalence Study in the United States. 
  • Physician Decision-Making in the Setting of Advanced Illness: An Examination of Patient Disposition and Physician Religiousness. 
  • Physiology and regulation. Ionized calcium, magnesium and lactate measurements in critical care settings. 
  • Platelet Transfusion Practices in Critically Ill Children. 
  • Point-Counterpoint: Indirect Calorimetry Is Essential for Optimal Nutrition Therapy in the Intensive Care Unit. 
  • Poor correlation between perihematomal MRI hyperintensity and brain swelling after intracerebral hemorrhage. 
  • Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients. 
  • Precision Medicine for Critical Illness and Injury. 
  • Predicting critical illness mortality and personalizing therapy: moving to multi-dimensional data. 
  • Predictors of Vasopressin Responsiveness in Critically Ill Adults. 
  • Predictors of short-term mortality in patients undergoing percutaneous dilatational tracheostomy. 
  • Prevalence, Risk Factors, and Outcomes of Financial Stress in Survivors of Critical Illness. 
  • Prevention of Complications in the Cardiac Intensive Care Unit: A Scientific Statement From the American Heart Association. 
  • Prevention of Critical Care Complications in the Coronary Intensive Care Unit: Protocols, Bundles, and Insights From Intensive Care Studies. 
  • Probiotic and synbiotic therapy in critical illness: a systematic review and meta-analysis. 
  • Probiotic and synbiotic therapy in the critically ill: State of the art. 
  • Proceedings from the Society of Interventional Radiology research consensus panel on critical limb ischemia. 
  • Prognostic accuracy of Acute Physiology and Chronic Health Evaluation II scores in critically ill cancer patients. 
  • Project CAPE: a high-fidelity, in situ simulation program to increase Critical Access Hospital Emergency Department provider comfort with seriously ill pediatric patients. 
  • Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family Study. 
  • Protein and calorie prescription for children and young adults receiving continuous renal replacement therapy: a report from the Prospective Pediatric Continuous Renal Replacement Therapy Registry Group. 
  • Protein-energy nutrition in the ICU is the power couple: A hypothesis forming analysis. 
  • Randomized trial of light versus deep sedation on mental health after critical illness. 
  • Rationale and design for the study Apixaban versus ClopidoGRel on a background of aspirin in patient undergoing InfraPoPliteal angioplasty for critical limb ischemia: AGRIPPA trial. 
  • Red blood cell transfusion threshold and mortality in cardiac intensive care unit patients. 
  • Registry Assessment of Peripheral Interventional Devices objective performance goals for superficial femoral and popliteal artery peripheral vascular interventions. 
  • Relationship Between Adverse Tracheal Intubation Associated Events and PICU Outcomes. 
  • Relationship of body mass index to subsequent mortality among seriously ill hospitalized patients. SUPPORT Investigators. The Study to Understand Prognoses and Preferences for Outcome and Risks of Treatments. 
  • Relationship of vitamin D deficiency to clinical outcomes in critically ill patients. 
  • Renal systems biology of patients with systemic inflammatory response syndrome. 
  • Reply to the letter: "Letter to the editor regarding differentiating fat embolism from critical illness associated cerebral microbleeds.". 
  • Research interrupted: applying the CONSERVE 2021 Statement to a randomized trial of rehabilitation during critical illness affected by the COVID-19 pandemic. 
  • Respiratory Viral Coinfections in the PICU: More Is Not Better...But Is It Worse? 
  • Response to "Reassessing the death risk related to probiotics in critically ill patients". 
  • Restoring the Microbiome in Critically Ill Patients: Are Probiotics Our True Friends When We Are Seriously Ill? 
  • Review of evolution and current status of protein requirements and provision in acute illness and critical care. 
  • Risk Factors for Post-Traumatic Stress Disorder Symptoms in Surrogate Decision-Makers of Patients with Chronic Critical Illness. 
  • Risk factors and impact of major bleeding in critically ill patients receiving heparin thromboprophylaxis. 
  • Role of L-glutamine in critical illness: new insights. 
  • Role of Social Workers in Family Conferences for Critically Ill Infants. 
  • Role of anabolic testosterone agents and structured exercise to promote recovery in ICU survivors. 
  • Role of heat shock protein and cytokine expression as markers of clinical outcomes with glutamine-supplemented parenteral nutrition in surgical ICU patients. 
  • Role of the microbiome, probiotics, and 'dysbiosis therapy' in critical illness. 
  • SICQ Coping and the Health-Related Quality of Life and Recovery of Critically Ill ICU Patients: A Prospective Cohort Study. 
  • Safety and Effectiveness of Retrograde Arterial Access for Endovascular Treatment of Critical Limb Ischemia. 
  • Safety and effectiveness of meropenem in infants with suspected or complicated intra-abdominal infections. 
  • Sedation and subglottic stenosis in critically ill children. 
  • Sedation practices in a cohort of critically ill patients receiving prolonged mechanical ventilation. 
  • Sedatives and Analgesics Given to Infants in Neonatal Intensive Care Units at the End of Life. 
  • Sepsis may not be a risk factor for mortality in patients with acute kidney injury treated with continuous renal replacement therapy. 
  • Setting the vision: applied patient-reported outcomes and smart, connected digital healthcare systems to improve patient-centered outcomes prediction in critical illness. 
  • Short-Term Adverse Outcomes Associated With Hypoglycemia in Critically Ill Children. 
  • Should Early Mobilization Be Routine in Mechanically Ventilated Patients? 
  • Should modulation of p50 be a therapeutic target in the critically ill? 
  • Sleep in the Intensive Care Unit: Biological, Environmental, and Pharmacologic Implications for Nurses. 
  • Society of Critical Care Medicine's International Consensus Conference on Prediction and Identification of Long-Term Impairments After Critical Illness. 
  • Spatial methods for evaluating critical care and trauma transport: A scoping review. 
  • Statins and delirium during critical illness: a multicenter, prospective cohort study. 
  • Strict glycemic targets need not be so strict: a more permissive glycemic range for critically ill children. 
  • Successful Identification of Anatomical Markers and Placement of Feeding Tubes in Critically Ill Patients via Camera-Assisted Technology with Real-Time Video Guidance. 
  • Supplemental Parenteral Nutrition: Review of the Literature and Current Nutrition Guidelines. 
  • Suppression of Fibrinolysis and Hypercoagulability, Severity of Hypoxemia, and Mortality in COVID-19 Patients: A Retrospective Cohort Study. 
  • Surveillance for unexplained deaths and critical illnesses due to possibly infectious causes, United States, 1995-1998. 
  • Survival in critical illness is associated with early activation of mitochondrial biogenesis. 
  • Sustained Improvement in Tracheal Intubation Safety Across a 15-Center Quality-Improvement Collaborative: An Interventional Study From the National Emergency Airway Registry for Children Investigators. 
  • Symptomatic event reduction with extended-duration betrixaban in acute medically ill hospitalized patients. 
  • Tailoring nutrition therapy to illness and recovery. 
  • Temperature profile and outcomes of neonates undergoing whole body hypothermia for neonatal hypoxic-ischemic encephalopathy. 
  • The Association between Patient Health Status and Surrogate Decision Maker Post-Traumatic Stress Disorder Symptoms in Chronic Critical Illness. 
  • The CRIT Study: Anemia and blood transfusion in the critically ill--current clinical practice in the United States. 
  • The Intersection Between Heart Failure and Critical Care Cardiology: An International Perspective on Structure, Staffing, and Design Considerations. 
  • The Obesity Paradox and Effects of Early Nutrition: Is There a Paradox, or Is There Not? 
  • The Patient and Family Member Experience of Financial Stress Related to Critical Illness. 
  • The SUPPORT prognostic model. Objective estimates of survival for seriously ill hospitalized adults. Study to understand prognoses and preferences for outcomes and risks of treatments. 
  • The Society for Clinical Trials opposes US legislation to permit marketing of unproven medical therapies for seriously ill patients. 
  • The Uniformed Services University's Surgical Critical Care Initiative (SC2i): Bringing Precision Medicine to the Critically Ill. 
  • The Voice of Surrogate Decision-Makers. Family Responses to Prognostic Information in Chronic Critical Illness. 
  • The authors reply. 
  • The authors reply. 
  • The authors reply. 
  • The challenge of measuring community values in ways appropriate for setting health care priorities. 
  • The effectiveness of right heart catheterization in the initial care of critically ill patients. SUPPORT Investigators. 
  • The epidemiology of chronic critical illness in the United States*. 
  • The evolution of nutrition in critical care: how much, how soon? 
  • The future of critical care nutrition therapy. 
  • The impact of delirium on clinical outcomes in mechanically ventilated surgical and trauma patients. 
  • The natural history and outcomes of line-associated upper extremity deep venous thromboses in critically ill patients. 
  • The number of tracheal intubation attempts matters! A prospective multi-institutional pediatric observational study. 
  • The structure of critical care transfer networks. 
  • The use of vasoactive agents via peripheral intravenous access during transport of critically III infants and children. 
  • Therapeutic Alliance between the Caregivers of Critical Illness Survivors and Intensive Care Unit Clinicians. 
  • Therapeutic Anticoagulation with Heparin in Critically Ill Patients with Covid-19. 
  • Thromboelastography and rotational thromboelastometry in bleeding patients with coagulopathy: Practice management guideline from the Eastern Association for the Surgery of Trauma. 
  • Timing is everything? Reconciling the results of recent trials in acute kidney injury. 
  • Tools to Promote Shared Decision Making in Serious Illness: A Systematic Review. 
  • Top Ten Tips Palliative Care Clinicians Should Know About Caring for Children in Neonatal and Pediatric Intensive Care Units. 
  • Top Ten Tips Palliative Care Clinicians Should Know About Prognostication in Critical Illness and Heart, Kidney, and Liver Diseases. 
  • Toward Solving the Sedation-Assessment Conundrum: Neurofunction Monitoring. 
  • Towards use of POCUS to evaluate hemodynamics in critically ill neonates: caution before adoption in this population. 
  • Transabdominal duplex ultrasonography for bedside inferior vena cava filter placement: examples, technique, and review. 
  • Transcranial Doppler Ultrasound During Critical Illness in Children: Survey of Practices in Pediatric Neurocritical Care Centers. 
  • Transfusion in critical care - a UK regional audit of current practice. 
  • Transfusion of fresh frozen plasma in critically ill surgical patients is associated with an increased risk of infection. 
  • Transporting Critically Ill Children-Are We All on the Same Page? 
  • Treatments Associated with Lower Mortality among Critically Ill COVID-19 Patients: A Retrospective Cohort Study. 
  • Update in hospital palliative care. 
  • Urinary Neutrophil Gelatinase-Associated Lipocalin Predicts Intensive Care Unit Admission Diagnosis: A Prospective Cohort Study. 
  • Usability Testing of an Electronic Patient-Reported Outcome System for Survivors of Critical Illness. 
  • Use of Placental/Umbilical Blood Sampling for Neonatal Admission Blood Cultures: Benefits, Challenges, and Strategies for Implementation. 
  • Use of high flow nasal cannula in critically ill infants, children, and adults: a critical review of the literature. 
  • Using Technology to Create a More Humanistic Approach to Integrating Palliative Care into the Intensive Care Unit. 
  • VanA rectal swab screening as a predictor of subsequent vancomycin-resistant enterococcal bloodstream infection in critically ill adults. 
  • Wait! Wait! I Am Not Dead Yet! 
  • What is the ideal crystalloid? 
  • Winning the war against ICU-acquired weakness: new innovations in nutrition and exercise physiology. 
  • Worry about child health in mothers of hospitalized medically fragile infants. 
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  Keywords of People

  • O'Connor, Christopher Michael, Richard Sean Stack, M.D. Distinguished Professor, Medicine, Clinical Pharmacology
  • Olsen, Maren Karine, Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Turner, David Ashley, Consulting Professor in the Department of Pediatrics, Pediatrics, Critical Care Medicine