Subject Areas on Research
- A conserved transcriptional enhancer regulates RAG gene expression in developing B cells.
- A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation.
- A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes.
- Advances in the understanding and treatment of human severe combined immunodeficiency.
- An immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system.
- Computational tools for understanding sequence variability in recombination signals.
- Contributions of beta2-microglobulin-dependent molecules and lymphocytes to iron regulation: insights from HfeRag1(-/-) and beta2mRag1(-/-) double knock-out mice.
- Enhancer control of local accessibility to V(D)J recombinase.
- Impaired social recognition memory in recombination activating gene 1-deficient mice.
- Isolation of genes negatively or positively co-expressed with human recombination activating gene 1 (RAG1) by differential display PCR (DD RT-PCR).
- Neoteny in lymphocytes: Rag1 and Rag2 expression in germinal center B cells.
- Orchestrating T-cell receptor α gene assembly through changes in chromatin structure and organization.
- Regulation of V(D)J recombination: a dominant role for promoter positioning in gene segment accessibility.
- V(D)J recombinase activity in a subset of germinal center B lymphocytes.
- Variable Extent of Lineage-Specificity and Developmental Stage-Specificity of Cohesin and CCCTC-Binding Factor Binding Within the Immunoglobulin and T Cell Receptor Loci.
- hBRAG, a novel B cell lineage cDNA encoding a type II transmembrane glycoprotein potentially involved in the regulation of recombination activating gene 1 (RAG1).
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