Macrophages, Alveolar

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  Subject Areas on Research

  • 8-ISO-PGF2alpha production by alveolar macrophages exposed to hyperoxia. 
  • A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs. 
  • Alveolar Epithelial Cell-Derived Prostaglandin E2 Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation. 
  • Alveolar macrophage apoptosis and TNF-alpha, but not p53, expression correlate with murine response to bleomycin. 
  • Alveolar macrophages from overweight/obese subjects with asthma demonstrate a proinflammatory phenotype. 
  • An IL-9-pulmonary macrophage axis defines the allergic lung inflammatory environment. 
  • Antioxidants preserve macrophage phagocytosis of Pseudomonas aeruginosa during hyperoxia. 
  • Apoptotic and inflammatory effects induced by different particles in human alveolar macrophages. 
  • Brief Glutamine Pretreatment Increases Alveolar Macrophage CD163/Heme Oxygenase-1/p38-MAPK Dephosphorylation Pathway and Decreases Capillary Damage but Not Neutrophil Recruitment in IL-1/LPS-Insufflated Rats. 
  • Calcium oxalate and iron accumulation in sarcoidosis. 
  • Characterization of the innate immune response to chronic aspiration in a novel rodent model. 
  • Coexisting endogenous and exogenous lipoid pneumonia and pulmonary alveolar proteinosis in a patient with neurodevelopmental disease. 
  • Control of antiviral innate immune response by protein geranylgeranylation. 
  • Cryptococcus neoformans is resistant to surfactant protein A mediated host defense mechanisms. 
  • Cryptococcus neoformans {alpha} strains preferentially disseminate to the central nervous system during coinfection. 
  • Detection of granulocyte-macrophage colony-stimulating factor in patients with pulmonary alveolar proteinosis. 
  • Differential activity of protein kinase C in alveolar and peritoneal macrophages. 
  • Efficient CD4Cre-Mediated Conditional KRas Expression in Alveolar Macrophages and Alveolar Epithelial Cells Causes Fatal Hyperproliferative Pneumonitis. 
  • Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages. 
  • Exhaled nitric oxide (NO), NO synthase activity, and regulation of nuclear factor (NF)-kappaB. 
  • Fine ambient particles induce oxidative stress and metal binding genes in human alveolar macrophages. 
  • Flow Cytometric Analysis of Myeloid Cells in Human Blood, Bronchoalveolar Lavage, and Lung Tissues. 
  • Full Spectrum of LPS Activation in Alveolar Macrophages of Healthy Volunteers by Whole Transcriptomic Profiling. 
  • Functional heterogeneity of alveolar macrophage population based on expression of CXCL2. 
  • Gammaherpesvirus-induced lung pathology is altered in the absence of macrophages. 
  • Gastroesophageal reflux-associated aspiration alters the immune response in asthma. 
  • Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE₂. 
  • Hepcidin expression in human airway epithelial cells is regulated by interferon-γ. 
  • Human immunodeficiency virus (HIV)-infected human blood monocytes and peritoneal macrophages have reduced anticryptococcal activity whereas HIV-infected alveolar macrophages retain normal activity. 
  • Hyaluronan fragments contribute to the ozone-primed immune response to lipopolysaccharide. 
  • IL-10 and class 1 histone deacetylases act synergistically and independently on the secretion of proinflammatory mediators in alveolar macrophages. 
  • Identification of App1 as a regulator of phagocytosis and virulence of Cryptococcus neoformans. 
  • Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for Legionella pneumophila intracellular growth. 
  • Identification of a tissue-specific, C/EBPβ-dependent pathway of differentiation for murine peritoneal macrophages. 
  • Identification of myeloid cell subsets in murine lungs using flow cytometry. 
  • Immune control of tuberculosis by IFN-gamma-inducible LRG-47. 
  • Immunology of infection caused by Cryptococcus neoformans. 
  • Increased lethality and defective pulmonary clearance of Streptococcus pneumoniae in microsomal prostaglandin E synthase-1-knockout mice. 
  • Induction of interleukin-6 mRNA in rat alveolar macrophages by in vitro exposure to both Cryptococcus neoformans and anti-C. neoformans antiserum. 
  • Inverse correlation of maturity and antibacterial activity in human dendritic cells. 
  • Iron accumulation in lung allografts after transplantation. 
  • Iron increases expression of iron-export protein MTP1 in lung cells. 
  • Isolation and Characterization of Human Lung Myeloid Cells. 
  • Know Where You Are: Pulmonary Macrophage Locations in the Human Lung. 
  • Lipopolysaccharide O-antigen promotes persistent murine bacteremia. 
  • Lysosomal Disorders Drive Susceptibility to Tuberculosis by Compromising Macrophage Migration. 
  • MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages. 
  • Macrophage immunoregulatory pathways in tuberculosis. 
  • Mitochondrial oxidant production by a pollutant dust and NO-mediated apoptosis in human alveolar macrophage. 
  • Mouse pulmonary interstitial macrophages mediate the pro-tumorigenic effects of IL-9. 
  • Nonclassical Monocytes Sense Hypoxia, Regulate Pulmonary Vascular Remodeling, and Promote Pulmonary Hypertension. 
  • Ozone inhalation promotes CX3CR1-dependent maturation of resident lung macrophages that limit oxidative stress and inflammation. 
  • Ozone primes alveolar macrophage-derived innate immunity in healthy human subjects. 
  • Phagocyte-generated superoxide reduces Fe3+ to displace it from the surface of asbestos. 
  • Prevention of acute lung injury in swine: depletion of pulmonary intravascular macrophages using liposomal clodronate. 
  • Prolonged function of macrophage, von Willebrand factor-deficient porcine pulmonary xenografts. 
  • Pulmonary effects of inhalation of spark-generated silver nanoparticles in Brown-Norway and Sprague-Dawley rats. 
  • Pulmonary fibrogenesis after three consecutive inhalation exposures to chrysotile asbestos. 
  • Pulmonary toxicity after exposure to military-relevant heavy metal tungsten alloy particles. 
  • RNA-containing cytoplasmic inclusion bodies in ciliated bronchial epithelium months to years after acute Kawasaki disease. 
  • Role of hyaluronan and hyaluronan-binding proteins in human asthma. 
  • Role of surface complexed iron in oxidant generation and lung inflammation induced by silicates. 
  • Seasonal variations in air pollution particle-induced inflammatory mediator release and oxidative stress. 
  • Superoxide dismutase influences the virulence of Cryptococcus neoformans by affecting growth within macrophages. 
  • TRPV4 channels augment macrophage activation and ventilator-induced lung injury. 
  • The RNA uridyltransferase Zcchc6 is expressed in macrophages and impacts innate immune responses. 
  • The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation. 
  • The lung is protected from spontaneous inflammation by autophagy in myeloid cells. 
  • The stimulation of cellular phospholipid uptake by surfactant apoproteins. 
  • Timing of valproic acid in acute lung injury: prevention is the best therapy? 
  • Uptake of itraconazole by alveolar macrophages. 
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  Keywords of People

  • Chen, Jun, Professor of Medicine, Duke Cancer Institute
  • Grambow, Steven C., Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
  • Gunn, Michael Dee, Professor of Medicine, Integrative Immunobiology
  • Taylor, Gregory Alan, Professor in Medicine, Integrative Immunobiology