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Subject Areas on Research
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A functional alternative splicing mutation in human tryptophan hydroxylase-2.
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A laminin and nerve growth factor-laden three-dimensional scaffold for enhanced neurite extension.
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A novel basal promoter element is required for expression of the rat tyrosine hydroxylase gene.
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A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death.
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A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
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Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease.
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Acrylamide-regulated neurofilament expression in rat pheochromocytoma cells.
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Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells.
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Activation of the de novo biosynthesis of sphingolipids mediates angiotensin II type 2 receptor-induced apoptosis.
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Activation of the mitogen-activated protein kinase pathway through p75NTR: a common mechanism for the neurotrophin family.
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Adverse benzo[a]pyrene effects on neurodifferentiation are altered by other neurotoxicant coexposures: interactions with dexamethasone, chlorpyrifos, or nicotine in PC12 cells.
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Adverse neurodevelopmental effects of dexamethasone modeled in PC12 cells: identifying the critical stages and concentration thresholds for the targeting of cell acquisition, differentiation and viability.
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Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells.
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Amelioration strategies fail to prevent tobacco smoke effects on neurodifferentiation: Nicotinic receptor blockade, antioxidants, methyl donors.
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An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy.
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Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis.
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Angiotensin II type 2 receptor mediates programmed cell death.
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Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis.
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BDE99 (2,2',4,4',5-pentabromodiphenyl ether) suppresses differentiation into neurotransmitter phenotypes in PC12 cells.
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Benzo[a]pyrene impairs neurodifferentiation in PC12 cells.
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Brominated and organophosphate flame retardants target different neurodevelopmental stages, characterized with embryonic neural stem cells and neuronotypic PC12 cells.
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Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death.
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Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cells.
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Chlorpyrifos developmental neurotoxicity: interaction with glucocorticoids in PC12 cells.
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Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation.
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Decreasing nicotinic receptor activity and the spatial learning impairment caused by the NMDA glutamate antagonist dizocilpine in rats.
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Developmental cholinotoxicants: nicotine and chlorpyrifos.
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Developmental exposure to organophosphates triggers transcriptional changes in genes associated with Parkinson's disease in vitro and in vivo.
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Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel.
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Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells.
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Developmental neurotoxicity of organophosphates targets cell cycle and apoptosis, revealed by transcriptional profiles in vivo and in vitro.
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Developmental neurotoxicity of perfluorinated chemicals modeled in vitro.
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Developmental neurotoxicity resulting from pharmacotherapy of preterm labor, modeled in vitro: Terbutaline and dexamethasone, separately and together.
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Differential expression of the B'beta regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis.
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Differential expression of thyroid hormone receptor isoforms in neurons and astroglial cells.
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Disparate developmental neurotoxicants converge on the cyclic AMP signaling cascade, revealed by transcriptional profiles in vitro and in vivo.
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Distinction between differentiation, cell cycle, and apoptosis signals in PC12 cells by the nerve growth factor mutant delta9/13, which is selective for the p75 neurotrophin receptor.
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Diverse neurotoxicants converge on gene expression for neuropeptides and their receptors in an in vitro model of neurodifferentiation: effects of chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells.
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Does mechanism matter? Unrelated neurotoxicants converge on cell cycle and apoptosis during neurodifferentiation.
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Dye-coupling in three-dimensional histoculture of rat lingual frenulum.
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Dynamic and redundant regulation of LRRK2 and LRRK1 expression.
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Effects of tobacco smoke on PC12 cell neurodifferentiation are distinct from those of nicotine or benzo[a]pyrene.
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Electrical stimulation alters protein adsorption and nerve cell interactions with electrically conducting biomaterials.
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Erbin suppresses the MAP kinase pathway.
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Examination of diverse iron-chelating agents for the protection of differentiated PC12 cells against oxidative injury induced by 6-hydroxydopamine and dopamine.
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Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer.
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Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure.
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Identification of a novel cell attachment domain in the HIV-1 Tat protein and its 90-kDa cell surface binding protein.
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In vitro models reveal differences in the developmental neurotoxicity of an environmental polycylic aromatic hydrocarbon mixture compared to benzo[a]pyrene: Neuronotypic PC12 Cells and embryonic neural stem cells.
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Individual and combined effects of TrkA and p75NTR nerve growth factor receptors. A role for the high affinity receptor site.
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Intracellular third loops in AT1 and AT2 receptors determine subtype specificity.
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Is fipronil safer than chlorpyrifos? Comparative developmental neurotoxicity modeled in PC12 cells.
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Is oxidative stress involved in the developmental neurotoxicity of chlorpyrifos?
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Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells.
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Laminin oligopeptide derivatized agarose gels allow three-dimensional neurite extension in vitro.
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Lipid-based microtubular drug delivery vehicles.
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Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression.
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Modeling the developmental neurotoxicity of chlorpyrifos in vitro: macromolecule synthesis in PC12 cells.
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Modeling the developmental neurotoxicity of chlorpyrifos in vitro: macromolecule synthesis in PC12 cells.
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Modeling the developmental neurotoxicity of nicotine in vitro: cell acquisition, growth and viability in PC12 cells.
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Molecular and cellular mechanism of angiotensin II-mediated apoptosis.
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Molecular mechanism of ERK dephosphorylation by striatal-enriched protein tyrosine phosphatase.
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NT-4-mediated rescue of lateral geniculate neurons from effects of monocular deprivation.
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Nerve growth factor specifically stimulates translation of eukaryotic elongation factor 1A-1 (eEF1A-1) mRNA by recruitment to polyribosomes in PC12 cells.
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Neuronal cell attachment to fluorinated ethylene propylene films with covalently immobilized laminin oligopeptides YIGSR and IKVAV. II.
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Neurotrophin regulation of ionic currents and cell size depends on cell context.
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Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos.
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Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon, and diazinon.
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Nuclear protein CBP is a coactivator for the transcription factor CREB.
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Nucleotide regulation of soluble guanylate cyclase substrate specificity.
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Organophosphate exposure during a critical developmental stage reprograms adenylyl cyclase signaling in PC12 cells.
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Orphan nuclear receptors in T lymphocyte development.
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Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells.
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Oxidative stress from diverse developmental neurotoxicants: antioxidants protect against lipid peroxidation without preventing cell loss.
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Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases.
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Probing and preventing quantum dot-induced cytotoxicity with multimodal alpha-lipoic acid in multiple dimensions of the peripheral nervous system.
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Protein kinase C is a target for diverse developmental neurotoxicants: transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells.
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Protein targeting in neurons and endocrine cells.
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Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickel.
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Silver impairs neurodevelopment: studies in PC12 cells.
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Silver nanoparticles compromise neurodevelopment in PC12 cells: critical contributions of silver ion, particle size, coating, and composition.
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Spatial control of neuronal cell attachment and differentiation on covalently patterned laminin oligopeptide substrates.
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Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative.
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Synthesis and characterization of fluoropolymeric substrata with immobilized minimal peptide sequences for cell adhesion studies. I.
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Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro.
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The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly.
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Transcriptional profiles for glutamate transporters reveal differences between organophosphates but similarities with unrelated neurotoxicants.
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Transcriptional profiles reveal similarities and differences in the effects of developmental neurotoxicants on differentiation into neurotransmitter phenotypes in PC12 cells.
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TrkB signaling is required for behavioral sensitization and conditioned place preference induced by a single injection of cocaine.
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Tyrosine hydroxylase transcription depends primarily on cAMP response element activity, regardless of the type of inducing stimulus.
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Unrelated developmental neurotoxicants elicit similar transcriptional profiles for effects on neurotrophic factors and their receptors in an in vitro model.