PC12 Cells

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  Subject Areas on Research

  • A functional alternative splicing mutation in human tryptophan hydroxylase-2. 
  • A laminin and nerve growth factor-laden three-dimensional scaffold for enhanced neurite extension. 
  • A new nerve guide conduit material composed of a biodegradable poly(phosphoester). 
  • A novel basal promoter element is required for expression of the rat tyrosine hydroxylase gene. 
  • A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death. 
  • A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. 
  • A2a/D2 receptor interactions are not observed in COS-7 cells transiently transfected with dopamine D2 and adenosine A2a receptor cDNA. 
  • Abnormal degradation of the neuronal stress-protective transcription factor HSF1 in Huntington's disease. 
  • Acrylamide-regulated neurofilament expression in rat pheochromocytoma cells. 
  • Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells. 
  • Activation of delta opioid receptors induces receptor insertion and neuropeptide secretion. 
  • Activation of the de novo biosynthesis of sphingolipids mediates angiotensin II type 2 receptor-induced apoptosis. 
  • Activation of the mitogen-activated protein kinase pathway through p75NTR: a common mechanism for the neurotrophin family. 
  • Adverse benzo[a]pyrene effects on neurodifferentiation are altered by other neurotoxicant coexposures: interactions with dexamethasone, chlorpyrifos, or nicotine in PC12 cells. 
  • Adverse neurodevelopmental effects of dexamethasone modeled in PC12 cells: identifying the critical stages and concentration thresholds for the targeting of cell acquisition, differentiation and viability. 
  • Ameliorating the developmental neurotoxicity of chlorpyrifos: a mechanisms-based approach in PC12 cells. 
  • Amelioration strategies fail to prevent tobacco smoke effects on neurodifferentiation: Nicotinic receptor blockade, antioxidants, methyl donors. 
  • An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy. 
  • Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis. 
  • Angiotensin II type 2 receptor mediates programmed cell death. 
  • Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis. 
  • BDE99 (2,2',4,4',5-pentabromodiphenyl ether) suppresses differentiation into neurotransmitter phenotypes in PC12 cells. 
  • Basal and stimulated protein S-nitrosylation in multiple cell types and tissues. 
  • Benzo[a]pyrene impairs neurodifferentiation in PC12 cells. 
  • Brominated and organophosphate flame retardants target different neurodevelopmental stages, characterized with embryonic neural stem cells and neuronotypic PC12 cells. 
  • Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis. 
  • Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death. 
  • Characterization of cholyl-leu-val-phe-phe-ala-OH as an inhibitor of amyloid beta-peptide polymerization. 
  • Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cells. 
  • Chlorpyrifos developmental neurotoxicity: interaction with glucocorticoids in PC12 cells. 
  • Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation. 
  • DISC1-dependent switch from progenitor proliferation to migration in the developing cortex. 
  • Decreasing nicotinic receptor activity and the spatial learning impairment caused by the NMDA glutamate antagonist dizocilpine in rats. 
  • Developmental cholinotoxicants: nicotine and chlorpyrifos. 
  • Developmental exposure to organophosphates triggers transcriptional changes in genes associated with Parkinson's disease in vitro and in vivo. 
  • Developmental neurotoxicants target neurodifferentiation into the serotonin phenotype: Chlorpyrifos, diazinon, dieldrin and divalent nickel. 
  • Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cells. 
  • Developmental neurotoxicity of organophosphates targets cell cycle and apoptosis, revealed by transcriptional profiles in vivo and in vitro. 
  • Developmental neurotoxicity of perfluorinated chemicals modeled in vitro. 
  • Developmental neurotoxicity resulting from pharmacotherapy of preterm labor, modeled in vitro: Terbutaline and dexamethasone, separately and together. 
  • Differential expression of the B'beta regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis. 
  • Differential expression of thyroid hormone receptor isoforms in neurons and astroglial cells. 
  • Disparate developmental neurotoxicants converge on the cyclic AMP signaling cascade, revealed by transcriptional profiles in vitro and in vivo. 
  • Distinction between differentiation, cell cycle, and apoptosis signals in PC12 cells by the nerve growth factor mutant delta9/13, which is selective for the p75 neurotrophin receptor. 
  • Diverse neurotoxicants converge on gene expression for neuropeptides and their receptors in an in vitro model of neurodifferentiation: effects of chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells. 
  • Does mechanism matter? Unrelated neurotoxicants converge on cell cycle and apoptosis during neurodifferentiation. 
  • Dye-coupling in three-dimensional histoculture of rat lingual frenulum. 
  • Dynamic and redundant regulation of LRRK2 and LRRK1 expression. 
  • Effects of tobacco smoke on PC12 cell neurodifferentiation are distinct from those of nicotine or benzo[a]pyrene. 
  • Electrical stimulation alters protein adsorption and nerve cell interactions with electrically conducting biomaterials. 
  • Encapsulation of biologics in self-assembled fibers as biostructural units for tissue engineering. 
  • Erbin suppresses the MAP kinase pathway. 
  • Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer. 
  • Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure. 
  • Identification of a novel cell attachment domain in the HIV-1 Tat protein and its 90-kDa cell surface binding protein. 
  • In vitro models reveal differences in the developmental neurotoxicity of an environmental polycylic aromatic hydrocarbon mixture compared to benzo[a]pyrene: Neuronotypic PC12 Cells and embryonic neural stem cells. 
  • Individual and combined effects of TrkA and p75NTR nerve growth factor receptors. A role for the high affinity receptor site. 
  • Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins. 
  • Intracellular third loops in AT1 and AT2 receptors determine subtype specificity. 
  • Is fipronil safer than chlorpyrifos? Comparative developmental neurotoxicity modeled in PC12 cells. 
  • Is oxidative stress involved in the developmental neurotoxicity of chlorpyrifos? 
  • Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells. 
  • Laminin oligopeptide derivatized agarose gels allow three-dimensional neurite extension in vitro. 
  • Light-emitting channelrhodopsins for combined optogenetic and chemical-genetic control of neurons. 
  • Lipid-based microtubular drug delivery vehicles. 
  • Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. 
  • Modeling the developmental neurotoxicity of chlorpyrifos in vitro: macromolecule synthesis in PC12 cells. 
  • Modeling the developmental neurotoxicity of chlorpyrifos in vitro: macromolecule synthesis in PC12 cells. 
  • Modeling the developmental neurotoxicity of nicotine in vitro: cell acquisition, growth and viability in PC12 cells. 
  • Molecular and cellular mechanism of angiotensin II-mediated apoptosis. 
  • Molecular mechanism of ERK dephosphorylation by striatal-enriched protein tyrosine phosphatase. 
  • NT-4-mediated rescue of lateral geniculate neurons from effects of monocular deprivation. 
  • Nerve growth factor specifically stimulates translation of eukaryotic elongation factor 1A-1 (eEF1A-1) mRNA by recruitment to polyribosomes in PC12 cells. 
  • Neuronal alpha-bungarotoxin receptors differ structurally from other nicotinic acetylcholine receptors. 
  • Neuronal cell attachment to fluorinated ethylene propylene films with covalently immobilized laminin oligopeptides YIGSR and IKVAV. II. 
  • Neuronal growth cone collapse and inhibition of protein fatty acylation by nitric oxide. 
  • Neurotrophin regulation of ionic currents and cell size depends on cell context. 
  • Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifos. 
  • Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon, and diazinon. 
  • Novel inhibitory action of tunicamycin homologues suggests a role for dynamic protein fatty acylation in growth cone-mediated neurite extension. 
  • Nuclear protein CBP is a coactivator for the transcription factor CREB. 
  • Nucleotide regulation of soluble guanylate cyclase substrate specificity. 
  • Organophosphate exposure during a critical developmental stage reprograms adenylyl cyclase signaling in PC12 cells. 
  • Orphan nuclear receptors in T lymphocyte development. 
  • Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells. 
  • Oxidative stress from diverse developmental neurotoxicants: antioxidants protect against lipid peroxidation without preventing cell loss. 
  • Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases. 
  • Polyphosphoester microspheres for sustained release of biologically active nerve growth factor. 
  • Protein kinase C is a target for diverse developmental neurotoxicants: transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells. 
  • Protein targeting in neurons and endocrine cells. 
  • Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickel. 
  • Selective inhibitors of death in mutant huntingtin cells. 
  • Silver impairs neurodevelopment: studies in PC12 cells. 
  • Silver nanoparticles compromise neurodevelopment in PC12 cells: critical contributions of silver ion, particle size, coating, and composition. 
  • Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective. 
  • Spatial control of neuronal cell attachment and differentiation on covalently patterned laminin oligopeptide substrates. 
  • Structural requirements for steady-state localization of the vesicular acetylcholine transporter. 
  • Structure-activity relationship studies of salubrinal lead to its active biotinylated derivative. 
  • Subcellular localization of full-length and truncated Trk receptor isoforms in polarized neurons and epithelial cells. 
  • Sustained release of proteins from electrospun biodegradable fibers. 
  • Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells. 
  • Synthesis and characterization of fluoropolymeric substrata with immobilized minimal peptide sequences for cell adhesion studies. I. 
  • Synthesis and characterization of polypyrrole-hyaluronic acid composite biomaterials for tissue engineering applications. 
  • Targeting of neurotrophic factors, their receptors, and signaling pathways in the developmental neurotoxicity of organophosphates in vivo and in vitro. 
  • The NF-kappa B-inducing kinase induces PC12 cell differentiation and prevents apoptosis. 
  • The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly. 
  • Transcriptional profiles for glutamate transporters reveal differences between organophosphates but similarities with unrelated neurotoxicants. 
  • Transcriptional profiles reveal similarities and differences in the effects of developmental neurotoxicants on differentiation into neurotransmitter phenotypes in PC12 cells. 
  • TrkB signaling is required for behavioral sensitization and conditioned place preference induced by a single injection of cocaine. 
  • Tryptophan hydroxylase-2 controls brain serotonin synthesis. 
  • Tyrosine hydroxylase transcription depends primarily on cAMP response element activity, regardless of the type of inducing stimulus. 
  • Unrelated developmental neurotoxicants elicit similar transcriptional profiles for effects on neurotrophic factors and their receptors in an in vitro model.