Interleukin-10

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  Subject Areas on Research

  • A novel murine model of inflammatory bowel disease and inflammation-associated colon cancer with ulcerative colitis-like features. 
  • A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. 
  • Absence of posttraumatic arthritis following intraarticular fracture in the MRL/MpJ mouse. 
  • Aging alters macrophage properties in human skeletal muscle both at rest and in response to acute resistance exercise. 
  • Alopecia in IL-10-deficient mouse pups is c-kit-dependent and can be triggered by iron deficiency. 
  • An investigation of vago-regulatory and health-behavior accounts for increased inflammation in posttraumatic stress disorder. 
  • Angiotensin II synergizes with BAFF to promote atheroprotective regulatory B cells. 
  • Anti-inflammatory effect of physical training in heart failure: role of TNF-alpha and IL-10. 
  • Association of HLA alleles with Plasmodium falciparum severity in Malian children. 
  • Association of cytokine polymorphic inheritance and in vitro cytokine production in anti-CD3/CD28-stimulated peripheral blood lymphocytes. 
  • Associations of ABCB1 and IL-10 genetic polymorphisms with sirolimus-induced dyslipidemia in renal transplant recipients. 
  • Autocrine Complement Inhibits IL10-Dependent T-cell-Mediated Antitumor Immunity to Promote Tumor Progression. 
  • Autoimmunity: regulatory B cells--IL-35 and IL-21 regulate the regulators. 
  • B-lymphocyte contributions to human autoimmune disease. 
  • B10 cell regulation of health and disease. 
  • B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer. 
  • B10 cells: a functionally defined regulatory B cell subset. 
  • Baseline NT-proBNP and biomarkers of inflammation and necrosis in patients with ST-segment elevation myocardial infarction: insights from the APEX-AMI trial. 
  • CD19 expression in B cells is important for suppression of contact hypersensitivity. 
  • CD22 expression mediates the regulatory functions of peritoneal B-1a cells during the remission phase of contact hypersensitivity reactions. 
  • CD40 signaling of monocyte inflammatory cytokine synthesis through an ERK1/2-dependent pathway. A target of interleukin (il)-4 and il-10 anti-inflammatory action. 
  • CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes. 
  • Candidate gene variants of the immune system and sudden infant death syndrome. 
  • Ceftriaxone pharmacokinetics in interleukin-10-treated murine pneumococcal pneumonia. 
  • Changes in the production of IL-10 and TNF-alpha in skeletal muscle of rats with heart failure secondary to acute myocardial infarction. 
  • Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. 
  • Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function. 
  • Coadministration of IL-12 or IL-10 expression cassettes drives immune responses toward a Th1 phenotype. 
  • Comparative analysis of antigen loading strategies of dendritic cells for tumor immunotherapy. 
  • Control of IFN-alphaA by CD73: implications for mucosal inflammation. 
  • Cowpox virus induces interleukin-10 both in vitro and in vivo. 
  • Cytokine expression in vivo during murine herpetic stromal keratitis. Effect of protective antibody therapy. 
  • Cytokine gene polymorphisms are not associated with bronchiolitis obliterans syndrome or survival after lung transplant. 
  • Cytokine genotypes in kidney, heart, and lung recipients: consequences for acute and chronic rejection. 
  • Cytokine induction of the ability of human monocyte CD44 to bind hyaluronan is mediated primarily by TNF-alpha and is inhibited by IL-4 and IL-13. 
  • Cytokine production at the site of disease in human tuberculosis. 
  • Cytokines and immune response in the tumor microenvironment. 
  • Cytokines in pancreatic carcinoma: correlation with phenotypic characteristics and prognosis. 
  • Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: relevance to mechanism of heart allograft tolerance. 
  • Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis. 
  • Distinct innate responses are induced by attenuated Salmonella enterica serovar Typhimurium mutants. 
  • Early-life experience decreases drug-induced reinstatement of morphine CPP in adulthood via microglial-specific epigenetic programming of anti-inflammatory IL-10 expression. 
  • Epigallocatechin gallate affects human dendritic cell differentiation and maturation. 
  • Ethnicity greatly influences cytokine gene polymorphism distribution. 
  • Exacerbation of systemic inflammation and increased cerebral infarct volume with cardiopulmonary bypass after focal cerebral ischemia in the rat. 
  • Exercise training changes IL-10/TNF-alpha ratio in the skeletal muscle of post-MI rats. 
  • Full Spectrum of LPS Activation in Alveolar Macrophages of Healthy Volunteers by Whole Transcriptomic Profiling. 
  • GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) mice. 
  • Glutamine reduces cytokine release, organ damage, and mortality in a rat model of endotoxemia. 
  • Helicobacter infection decreases reproductive performance of IL10-deficient mice. 
  • Helicobacter typhlonius and Helicobacter rodentium differentially affect the severity of colon inflammation and inflammation-associated neoplasia in IL10-deficient mice. 
  • Human peripheral mononuclear cells do not show proinflammatory patterns of cytokine transcription in early trauma: a preliminary report. 
  • IL-10 induces regulatory T cell apoptosis by up-regulation of the membrane form of TNF-alpha. 
  • IL-10 stimulatory effects on human NK cells explored by gene profile analysis. 
  • IL-10+ regulatory B cells are enriched in cord blood and may protect against cGVHD after cord blood transplantation. 
  • IL-10-producing regulatory B cells (B10 cells) in autoimmune disease. 
  • IL-10-producing regulatory B10 cells inhibit intestinal injury in a mouse model. 
  • IL-15 induces strong but short-lived tumor-infiltrating CD8 T cell responses through the regulation of Tim-3 in breast cancer. 
  • Identifying regulatory B cells (B10 cells) that produce IL-10 in mice. 
  • Improvement in the Spatial Distribution of Pain, Somatic Symptoms, and Depression After a Weight Loss Intervention. 
  • In vivo cytokine-associated responses to biomaterials. 
  • Increased E-selectin, IL-8 and IL-10 gene expression in human skin after minimal trauma. 
  • Inflammation markers and their trajectories after deep vein thrombosis in relation to risk of post-thrombotic syndrome. 
  • Inflammatory cytokine gene expression in THP-1 cells exposed to Stachybotrys chartarum and Aspergillus versicolor. 
  • Inhibitory role of CD19 in the progression of experimental autoimmune encephalomyelitis by regulating cytokine response. 
  • Interaction of Bordetella pertussis with mast cells, modulation of cytokine secretion by pertussis toxin. 
  • Interleukin 10 is induced by recombinant HIV-1 Nef protein involving the calcium/calmodulin-dependent phosphodiesterase signal transduction pathway. 
  • Interleukin 10 treatment for rheumatoid arthritis. 
  • Interleukin-10 promoter variants predict HPV-positive tumors and survival of squamous cell carcinoma of the oropharynx. 
  • Interleukin-10: An Immune-Activating Cytokine in Cancer Immunotherapy. 
  • Interleukin-10: therapeutic prospects in rheumatoid arthritis. 
  • Inverse relationship of plasma prostaglandin E2 and blood mononuclear cell cyclooxygenase-2 with disease severity in children with Plasmodium falciparum malaria. 
  • Kinetics of cytokine expression during primary human immunodeficiency virus type 1 infection. 
  • LMP-420, a small molecular inhibitor of TNF-α, prolongs islet allograft survival by induction of suppressor of cytokine signaling-1: synergistic effect with cyclosporin-A. 
  • Lack of evidence for the dichotomy of TH1 and TH2 predominance in HIV-infected individuals. 
  • Leukocyte-derived IL-10 reduces subepithelial fibrosis associated with chronically inhaled endotoxin. 
  • Long-term interleukin 10 therapy in chronic hepatitis C patients has a proviral and anti-inflammatory effect. 
  • Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model. 
  • Low interleukin-12 activity in severe Plasmodium falciparum malaria. 
  • Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells. 
  • Mast cell interleukin-10 drives localized tolerance in chronic bladder infection. 
  • Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis. 
  • Microtubule acetylation amplifies p38 kinase signalling and anti-inflammatory IL-10 production. 
  • Modulation of Human Macrophage Responses to Mycobacterium tuberculosis by Silver Nanoparticles of Different Size and Surface Modification. 
  • Modulation of alloimmunity to major histocompatibility complex class I by cotransfer of cytokine genes in vivo. 
  • Modulation of cytokines and chemokines, limited pulmonary vascular bed permeability, and prevention of septicemia and death with ceftriaxone and interleukin-10 in pneumococcal pneumonia. 
  • Nasal vaccination with troponin reduces troponin specific T-cell responses and improves heart function in myocardial ischemia-reperfusion injury. 
  • Natural IgM Switches the Function of Lipopolysaccharide-Activated Murine Bone Marrow-Derived Dendritic Cells to a Regulatory Dendritic Cell That Suppresses Innate Inflammation. 
  • Neonatal co-infection with helicobacter species markedly accelerates the development of inflammation-associated colonic neoplasia in IL-10(-/-) mice. 
  • Neuropathic pain is constitutively suppressed in early life by anti-inflammatory neuroimmune regulation. 
  • Non-erythroid effects of erythropoietin. 
  • Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice. 
  • Opioid Self-Administration is Attenuated by Early-Life Experience and Gene Therapy for Anti-Inflammatory IL-10 in the Nucleus Accumbens of Male Rats. 
  • Oral immunogenicity of the plant proteinase bromelain. 
  • Pathogenic Correlates of Simian Immunodeficiency Virus-Associated B Cell Dysfunction. 
  • Peritoneal cavity regulatory B cells (B10 cells) modulate IFN-γ+CD4+ T cell numbers during colitis development in mice. 
  • Peyer's patch CD8+ memory T cells secrete T helper type 1 and type 2 cytokines and provide help for immunoglobulin secretion. 
  • Protection against autoimmunity in nonlymphopenic hosts by CD4+ CD25+ regulatory T cells is antigen-specific and requires IL-10 and TGF-beta. 
  • Rapid, comprehensive analysis of human cytokine mRNA and its application to the study of acute renal allograft rejection. 
  • Reduced interleukin-12 and transforming growth factor-beta1 in severe childhood malaria: relationship of cytokine balance with disease severity. 
  • Reduced peripheral PGE2 biosynthesis in Plasmodium falciparum malaria occurs through hemozoin-induced suppression of blood mononuclear cell cyclooxygenase-2 gene expression via an interleukin-10-independent mechanism. 
  • Regulation of inflammation in the adipose tissue in cancer cachexia: effect of exercise. 
  • Regulation of mucosal and systemic antibody responses by T helper cell subsets, macrophages, and derived cytokines following oral immunization with live recombinant Salmonella. 
  • Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice. 
  • Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice. 
  • Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis. 
  • Regulatory B cells as inhibitors of immune responses and inflammation. 
  • Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions. 
  • Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. 
  • Regulatory B cells suppress imiquimod-induced, psoriasis-like skin inflammation. 
  • Regulatory B cells that produce IL-10: a breath of fresh air in allergic airway disease. 
  • Regulatory B10 cell development and function. 
  • Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo. 
  • Renovascular disease is associated with low producer genotypes of the anti-inflammatory cytokine interleukin-10. 
  • Retrovirus-elicited interleukin-12 and tumour necrosis factor-alpha as inducers of interferon-gamma-mediated pathology in mouse AIDS. 
  • Role for hedgehog pathway in regulating growth and function of invariant NKT cells. 
  • Role of mast cells in inflammatory bowel disease and inflammation-associated colorectal neoplasia in IL-10-deficient mice. 
  • Serum elevation of B lymphocyte stimulator does not increase regulatory B cells in glioblastoma patients undergoing immunotherapy. 
  • Serum levels of the proinflammatory cytokines interleukin-1 beta (IL-1beta), IL-6, IL-8, IL-10, tumor necrosis factor alpha, and IL-12(p70) in Malian children with severe Plasmodium falciparum malaria and matched uncomplicated malaria or healthy controls. 
  • Signatures associated with rejection or recurrence in HER-2/neu-positive mammary tumors. 
  • Significance of cytokine gene polymorphism in renal transplantation. 
  • Soluble alpha2-macroglobulin receptor is increased in endotracheal aspirates from infants and children after cardiopulmonary bypass. 
  • Spatial organization of bacterial flora in normal and inflamed intestine: a fluorescence in situ hybridization study in mice. 
  • Specific genetic polymorphisms of IL10-592 AA and IL10-819 TT genotypes lead to the key role for inducing docetaxel-induced liver injury in breast cancer patients. 
  • Stimulation of thymocyte proliferation by phosphorothioate DNA oligonucleotides. 
  • Systematic Review and Meta-analysis: Gene Association Studies in Neonatal Sepsis. 
  • T cells down-regulate macrophage TNF production by IRAK1-mediated IL-10 expression and control innate hyperinflammation. 
  • Targeting the local tumor microenvironment with vaccinia virus expressing B7.1 for the treatment of melanoma. 
  • Temporal changes in biomarkers and their relationships to reperfusion and to clinical outcomes among patients with ST segment elevation myocardial infarction. 
  • Thalidomide suppressed IL-1beta while enhancing TNF-alpha and IL-10, when cells in whole blood were stimulated with lipopolysaccharide. 
  • The Regulatory B Cell Compartment Expands Transiently During Childhood and Is Contracted in Children With Autoimmunity. 
  • The age-related increase in low-grade systemic inflammation (Inflammaging) is not driven by cytomegalovirus infection. 
  • The development and function of memory regulatory T cells after acute viral infections. 
  • The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. 
  • The dual role of IL-10. 
  • The linker for activation of B cells (LAB)/non-T cell activation linker (NTAL) regulates triggering receptor expressed on myeloid cells (TREM)-2 signaling and macrophage inflammatory responses independently of the linker for activation of T cells. 
  • Tolerance induced by apoptotic antigen-coupled leukocytes is induced by PD-L1+ and IL-10-producing splenic macrophages and maintained by T regulatory cells. 
  • Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells. 
  • Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease. 
  • Ultraviolet light exposure suppresses contact hypersensitivity by abrogating endothelial intercellular adhesion molecule-1 up-regulation at the elicitation site. 
  • [IL-21 induces regulatory B cell differentiation and immunosuppressive effect through cognate interaction with T cells]. 
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  Keywords of People

  • Lee, Walter T, Associate Professor of Surgery, Radiation Oncology
  • Yang, Yiping, Professor of Medicine, Immunology