Cell Polarity

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  Subject Areas on Research

  • A CRISPR Screen Identifies the Cell Polarity Determinant Crumbs 3 as an Adeno-associated Virus Restriction Factor in Hepatocytes. 
  • A Ras1-Cdc24 signal transduction pathway mediates thermotolerance in the fungal pathogen Cryptococcus neoformans. 
  • A contractile actomyosin network linked to adherens junctions by Canoe/afadin helps drive convergent extension. 
  • A gene duplication of a septin reveals a developmentally regulated filament length control mechanism. 
  • A microtubule-destabilizing kinesin motor regulates spindle length and anchoring in oocytes. 
  • A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2/3-activating motor complex in yeast. 
  • ADF/cofilin promotes invadopodial membrane recycling during cell invasion in vivo. 
  • Alpha defensin-1 attenuates surgically induced osteoarthritis in association with promoting M1 to M2 macrophage polarization. 
  • Altered morphology of hippocampal dentate granule cell presynaptic and postsynaptic terminals following conditional deletion of TrkB. 
  • An active role for basement membrane assembly and modification in tissue sculpting. 
  • An auxin-dependent distal organizer of pattern and polarity in the Arabidopsis root. 
  • Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice. 
  • Ankyrin-G palmitoylation and βII-spectrin binding to phosphoinositide lipids drive lateral membrane assembly. 
  • Ankyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth. 
  • Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment. 
  • AnkyrinG is required to maintain axo-dendritic polarity in vivo. 
  • Apical and basolateral endocytic pathways of MDCK cells meet in acidic common endosomes distinct from a nearly-neutral apical recycling endosome. 
  • Apical-basal polarity: why plant cells don't stand on their heads. 
  • Arg kinase regulates epithelial cell polarity by targeting β1-integrin and small GTPase pathways. 
  • Arl2- and Msps-dependent microtubule growth governs asymmetric division. 
  • Assembly pathway of the anastral Drosophila oocyte meiosis I spindle. 
  • Asymmetric cell divisions promote stratification and differentiation of mammalian skin. 
  • Axl2 integrates polarity establishment, maintenance, and environmental stress response in the filamentous fungus Ashbya gossypii. 
  • Balancing acts: molecular control of mammalian iron metabolism. 
  • Blocking Interleukin (IL)4- and IL13-Mediated Phosphorylation of STAT6 (Tyr641) Decreases M2 Polarization of Macrophages and Protects Against Macrophage-Mediated Radioresistance of Inflammatory Breast Cancer. 
  • Brefeldin A rapidly disrupts plasma membrane polarity by blocking polar sorting in common endosomes of MDCK cells. 
  • Burden of rare deleterious variants in WNT signaling genes among 511 myelomeningocele patients. 
  • COBRA encodes a putative GPI-anchored protein, which is polarly localized and necessary for oriented cell expansion in Arabidopsis. 
  • COBRA, an Arabidopsis extracellular glycosyl-phosphatidyl inositol-anchored protein, specifically controls highly anisotropic expansion through its involvement in cellulose microfibril orientation. 
  • Caenorhabditis elegans beta-G spectrin is dispensable for establishment of epithelial polarity, but essential for muscular and neuronal function. 
  • Calcium signals and calpain-dependent necrosis are essential for release of coxsackievirus B from polarized intestinal epithelial cells. 
  • Cardiomyocyte cultures with controlled macroscopic anisotropy: a model for functional electrophysiological studies of cardiac muscle. 
  • Cdc42p, GTP hydrolysis, and the cell's sense of direction. 
  • Cell ingression and apical shape oscillations during dorsal closure in Drosophila. 
  • Cellular requirements for the small molecule forchlorfenuron to stabilize the septin cytoskeleton. 
  • Conditional root expansion mutants of Arabidopsis. 
  • Connectomics of the zebrafish's lateral-line neuromast reveals wiring and miswiring in a simple microcircuit. 
  • Conserved elements of the RAM signaling pathway establish cell polarity in the basidiomycete Cryptococcus neoformans in a divergent fashion from other fungi. 
  • Control of cell polarity and chemotaxis by Akt/PKB and PI3 kinase through the regulation of PAKa. 
  • Crosslinked hyaluronic acid hydrogels: a strategy to functionalize and pattern 
  • Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs. 
  • Direct involvement of yeast type I myosins in Cdc42-dependent actin polymerization. 
  • Directed cell migration on fibronectin gradients: effect of gradient slope. 
  • Directional Exosome Proteomes Reflect Polarity-Specific Functions in Retinal Pigmented Epithelium Monolayers. 
  • Drosophila RhoA regulates the cytoskeleton and cell-cell adhesion in the developing epidermis. 
  • Dysfunction of inflammation-resolving pathways is associated with exaggerated postoperative cognitive decline in a rat model of the metabolic syndrome. 
  • EB1-microtubule interactions in Xenopus egg extracts: role of EB1 in microtubule stabilization and mechanisms of targeting to microtubules. 
  • Electric fields and MAP kinase signaling can regulate early wound healing in lens epithelium. 
  • Electrical stimulation directly induces pre-angiogenic responses in vascular endothelial cells by signaling through VEGF receptors. 
  • Enhanced activation of human dendritic cells by inducible CD40 and Toll-like receptor-4 ligation. 
  • Enucleated cells reveal differential roles of the nucleus in cell migration, polarity, and mechanotransduction. 
  • Epithelial morphogenesis: apoptotic forces drive cell shape changes. 
  • FOXO1 regulates uterine epithelial integrity and progesterone receptor expression critical for embryo implantation. 
  • FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway. 
  • Fidelity in planar cell polarity signalling. 
  • Fission yeast Cyk3p is a transglutaminase-like protein that participates in cytokinesis and cell morphogenesis. 
  • Formins regulate the actin-related protein 2/3 complex-independent polarization of the centrosome to the immunological synapse. 
  • Frizzled5/8 is required in secondary mesenchyme cells to initiate archenteron invagination during sea urchin development. 
  • Glypican-4 regulated actin cytoskeletal reorganization in glucocorticoid treated trabecular meshwork cells and involvement of Wnt/PCP signaling. 
  • Grab your partner with both hands: cytoskeletal remodeling by Arp2/3 signaling. 
  • HIV-1 induces renal epithelial dedifferentiation in a transgenic model of HIV-associated nephropathy. 
  • Histone demethylases in neuronal differentiation, plasticity, and disease. 
  • Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf. 
  • IFN-beta1a inhibits the secretion of Th17-polarizing cytokines in human dendritic cells via TLR7 up-regulation. 
  • IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation. 
  • Identification of a somatodendritic targeting signal in the cytoplasmic domain of the transferrin receptor. 
  • In Vitro Differentiation of CD4+ T Cell Effector and Regulatory Subsets. 
  • In vitro effects of polyglutamine tracts on Ca2+-dependent depolarization of rat and human mitochondria: relevance to Huntington's disease. 
  • Innate immune mediator profiles and their regulation in a novel polarized immortalized epithelial cell model derived from human endocervix. 
  • Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans. 
  • Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis. 
  • Interstitial flow in a 3D microenvironment increases glioma invasion by a CXCR4-dependent mechanism. 
  • Isoprenylcysteine carboxylmethyltransferase function is essential for RAB4A-mediated integrin β3 recycling, cell migration and cancer metastasis. 
  • L-selectin shedding is activated specifically within transmigrating pseudopods of monocytes to regulate cell polarity in vitro. 
  • LAD-1, the Caenorhabditis elegans L1CAM homologue, participates in embryonic and gonadal morphogenesis and is a substrate for fibroblast growth factor receptor pathway-dependent phosphotyrosine-based signaling. 
  • Limiting lumens: a new role for Cdc42. 
  • Lipid rafts in protein sorting and cell polarity in budding yeast Saccharomyces cerevisiae. 
  • Micro-scale and meso-scale architectural cues cooperate and compete to direct aligned tissue formation. 
  • Microfluidic dielectrophoresis illuminates the relationship between microbial cell envelope polarizability and electrochemical activity. 
  • Monocyte Polarization is Altered by Total-Body Irradiation in Male Rhesus Macaques: Implications for Delayed Effects of Acute Radiation Exposure. 
  • Monocyte polarization in children with falciparum malaria: relationship to nitric oxide insufficiency and disease severity. 
  • Motor proteins 1: kinesins. 
  • Mouse retinal pigmented epithelial cell lines retain their phenotypic characteristics after transfection with human papilloma virus: a new tool to further the study of RPE biology. 
  • Myosins motor Miranda. 
  • NHERF1/EBP50 is an organizer of polarity structures and a diagnostic marker in ependymoma. 
  • NLRC3 expression in dendritic cells attenuates CD4+ T cell response and autoimmunity. 
  • Negative feedback enhances robustness in the yeast polarity establishment circuit. 
  • Numb regulates somatic cell lineage commitment during early gonadogenesis in mice. 
  • Organogenesis: molecular mechanisms of tubulogenesis. 
  • PAK kinases Ste20 and Pak1 govern cell polarity at different stages of mating in Cryptococcus neoformans. 
  • Perspective on Epithelial-Mesenchymal Transitions in Embryos. 
  • Phosphoregulation provides specificity to biomolecular condensates in the cell cycle and cell polarity. 
  • Plasma membrane polarization during mating in yeast cells. 
  • Plasmids for expression of chimeric and truncated kinesin proteins. 
  • Polar axis fixation in Fucus zygotes: components of the cytoskeleton and extracellular matrix. 
  • Polarity and stratification of the epidermis. 
  • Polarity in skin development and cancer. 
  • Polarity of alpha-galactosidase A uptake by renal tubule cells. 
  • Polarized Exosome Release from the Retinal Pigmented Epithelium. 
  • Polarized secretory trafficking directs cargo for asymmetric dendrite growth and morphogenesis. 
  • Polarized transport of membrane and secreted proteins during lumen morphogenesis. 
  • Principles that govern competition or co-existence in Rho-GTPase driven polarization. 
  • Projections from the ventral cochlear nucleus to the inferior colliculus and the contralateral cochlear nucleus in guinea pigs. 
  • Protein aggregation behavior regulates cyclin transcript localization and cell-cycle control. 
  • Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cells. 
  • Radial migration: Retinal neurons hold on for the ride. 
  • Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis. 
  • Re-orientation and faster, directed migration of lens epithelial cells in a physiological electric field. 
  • Regulated spindle orientation buffers tissue growth in the epidermis. 
  • Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye. 
  • Regulation of biliary secretion through apical purinergic receptors in cultured rat cholangiocytes. 
  • Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b. 
  • Release of intracellular calcium stores facilitates coxsackievirus entry into polarized endothelial cells. 
  • Requirement of dendritic Akt degradation by the ubiquitin-proteasome system for neuronal polarity. 
  • RhoG regulates endothelial apical cup assembly downstream from ICAM1 engagement and is involved in leukocyte trans-endothelial migration. 
  • Role of TGF-β receptor III localization in polarity and breast cancer progression. 
  • Roles of wingless in patterning the larval epidermis of Drosophila. 
  • STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression. 
  • Saccharomyces cerevisiae Bzz1p is implicated with type I myosins in actin patch polarization and is able to recruit actin-polymerizing machinery in vitro. 
  • Scaffold-mediated symmetry breaking by Cdc42p. 
  • Scd5p and clathrin function are important for cortical actin organization, endocytosis, and localization of sla2p in yeast. 
  • Self-organization of apical membrane protein sorting in epithelial cells. 
  • Septin Form and Function at the Cell Cortex. 
  • Spatial guidance of cell asymmetry: septin GTPases show the way. 
  • Spherical Caps in Cell Polarization. 
  • Spindle positioning and its impact on vertebrate tissue architecture and cell fate. 
  • Stretch-regulated exocytosis/endocytosis in bladder umbrella cells. 
  • Sub-circuits of a gene regulatory network control a developmental epithelial-mesenchymal transition. 
  • Symmetry-breaking polarization driven by a Cdc42p GEF-PAK complex. 
  • Talaromyces marneffei promotes M2-like polarization of human macrophages by downregulating SOCS3 expression and activating the TLR9 pathway. 
  • Targeting of the synaptic vesicle protein synaptobrevin in the axon of cultured hippocampal neurons: evidence for two distinct sorting steps. 
  • The Chlamydia trachomatis Protease CPAF Contains a Cryptic PDZ-Like Domain with Similarity to Human Cell Polarity and Tight Junction PDZ-Containing Proteins. 
  • The Cryptococcus neoformans Rho-GDP dissociation inhibitor mediates intracellular survival and virulence. 
  • The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains. 
  • The Drosophila afadin homologue Canoe regulates linkage of the actin cytoskeleton to adherens junctions during apical constriction. 
  • The Drosophila segment polarity gene dishevelled encodes a novel protein required for response to the wingless signal. 
  • The actin cytoskeleton as a barrier to virus infection of polarized epithelial cells. 
  • The polarity and magnitude of ambient charge influences three-dimensional neurite extension from DRGs. 
  • The state of the septin cytoskeleton from assembly to function. 
  • The varying roles of macrophages in kidney injury and repair. 
  • Transfer of the Septin Ring to Cytokinetic Remnants in ER Stress Directs Age-Sensitive Cell-Cycle Re-entry. 
  • Transplantation of full-thickness retina in the rhodopsin transgenic pig. 
  • Two CDC42 paralogues modulate Cryptococcus neoformans thermotolerance and morphogenesis under host physiological conditions. 
  • UNC-6 (netrin) orients the invasive membrane of the anchor cell in C. elegans. 
  • UNC-6 (netrin) stabilizes oscillatory clustering of the UNC-40 (DCC) receptor to orient polarity 
  • Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates. 
  • [Expression of presenilin 1 on the cell surface in motile polarized cells]. 
  • dishevelled and armadillo act in the wingless signalling pathway in Drosophila. 
  • miR-21 depletion in macrophages promotes tumoricidal polarization and enhances PD-1 immunotherapy. 
  • mirror controls planar polarity and equator formation through repression of fringe expression and through control of cell affinities. 
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  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology