Malaria, Falciparum

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  Subject Areas on Research

  • Plasmodium vivax Infections over 3 Years in Duffy Blood Group Negative Malians in Bandiagara, Mali. 
  • A Single Mutation in K13 Predominates in Southern China and Is Associated With Delayed Clearance of Plasmodium falciparum Following Artemisinin Treatment. 
  • A Thermal Exhaust Port on the Death Star of Plasmodium falciparum-Infected Erythrocytes. 
  • A comprehensive survey of polymorphisms conferring anti-malarial resistance in Plasmodium falciparum across Pakistan. 
  • A cross-sectional survey of Plasmodium falciparum pfcrt mutant haplotypes in the Democratic Republic of Congo. 
  • A deep sequencing approach to estimate Plasmodium falciparum complexity of infection (COI) and explore apical membrane antigen 1 diversity. 
  • A longitudinal cohort study of malaria exposure and changing serostatus in a malaria endemic area of rural Tanzania. 
  • A microarray platform and novel SNP calling algorithm to evaluate Plasmodium falciparum field samples of low DNA quantity. 
  • A molecular marker for chloroquine-resistant falciparum malaria. 
  • A network to monitor antimalarial drug resistance: a plan for moving forward. 
  • A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children. 
  • A role for fetal hemoglobin and maternal immune IgG in infant resistance to Plasmodium falciparum malaria. 
  • A set of microsatellite markers to differentiate Plasmodium falciparum progeny of four genetic crosses. 
  • A study of the TNF/LTA/LTB locus and susceptibility to severe malaria in highland papuan children and adults. 
  • A validated agent-based model to study the spatial and temporal heterogeneities of malaria incidence in the rainforest environment. 
  • Absence of Association Between Sickle Trait Hemoglobin and Placental Malaria Outcomes. 
  • Absence of putative artemisinin resistance mutations among Plasmodium falciparum in Sub-Saharan Africa: a molecular epidemiologic study. 
  • Adaptive evolution and fixation of drug-resistant Plasmodium falciparum genotypes in pregnancy-associated malaria: 9-year results from the QuEERPAM study. 
  • Age-related susceptibility to severe malaria associated with galectin-2 in highland Papuans. 
  • American society for apheresis guidelines support use of red cell exchange transfusion for severe malaria with high parasitemia. 
  • An intrinsic oscillator drives the blood stage cycle of the malaria parasite Plasmodium falciparum. 
  • Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing. 
  • Antenatal receipt of sulfadoxine-pyrimethamine does not exacerbate pregnancy-associated malaria despite the expansion of drug-resistant Plasmodium falciparum: clinical outcomes from the QuEERPAM study. 
  • Arginine, nitric oxide, carbon monoxide, and endothelial function in severe malaria. 
  • Artemisinin combination therapies and malaria parasite drug resistance: the game is afoot. 
  • Artemisinin resistance in Plasmodium falciparum malaria. 
  • Artemisinin resistance phenotypes and K13 inheritance in a Plasmodium falciparum cross and Aotus model. 
  • Association of HLA alleles with Plasmodium falciparum severity in Malian children. 
  • Association of intraleukocytic Plasmodium falciparum malaria pigment with disease severity, clinical manifestations, and prognosis in severe malaria. 
  • Asymptomatic Plasmodium falciparum malaria in pregnant women in the Chittagong Hill Districts of Bangladesh. 
  • Attenuated PfSPZ Vaccine induces strain-transcending T cells and durable protection against heterologous controlled human malaria infection. 
  • Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting. 
  • Blood mononuclear cell nitric oxide production and plasma cytokine levels in healthy gabonese children with prior mild or severe malaria. 
  • Born to sweet delight: Using natural models of malaria protection to understand and neutralize P. falciparum pathogenesis. 
  • Burden, pathology, and costs of malaria in pregnancy: new developments for an old problem. 
  • Changes in Malaria Epidemiology in Africa and New Challenges for Elimination. 
  • Changes in the levels of chemokines and cytokines in the placentas of women with Plasmodium falciparum malaria. 
  • Chloroquine-resistant malaria. 
  • Clinical determinants of early parasitological response to ACTs in African patients with uncomplicated falciparum malaria: a literature review and meta-analysis of individual patient data. 
  • Complexity of the msp2 locus and the severity of childhood malaria, in south-western Nigeria. 
  • Controlled human malaria infection of Tanzanians by intradermal injection of aseptic, purified, cryopreserved Plasmodium falciparum sporozoites. 
  • Decreased circulating macrophage migration inhibitory factor (MIF) protein and blood mononuclear cell MIF transcripts in children with Plasmodium falciparum malaria. 
  • Decreased endothelial nitric oxide bioavailability, impaired microvascular function, and increased tissue oxygen consumption in children with falciparum malaria. 
  • Defining the in vivo phenotype of artemisinin-resistant falciparum malaria: a modelling approach. 
  • Designing malaria vaccines to circumvent antigen variability. 
  • Developmental allometry and paediatric malaria. 
  • Differential regulation of beta-chemokines in children with Plasmodium falciparum malaria. 
  • Dimethylarginines: endogenous inhibitors of nitric oxide synthesis in children with falciparum malaria. 
  • Direct Detection of Unamplified Pathogen RNA in Blood Lysate using an Integrated Lab-in-a-Stick Device and Ultrabright SERS Nanorattles. 
  • Direct Estimation of Sensitivity of Plasmodium falciparum Rapid Diagnostic Test for Active Case Detection in a High-Transmission Community Setting. 
  • Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes. 
  • Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. 
  • Droplet microfluidics platform for highly sensitive and quantitative detection of malaria-causing Plasmodium parasites based on enzyme activity measurement. 
  • Early Endothelial Activation Precedes Glycocalyx Degradation and Microvascular Dysfunction in Experimentally Induced Plasmodium falciparum and Plasmodium vivax Infection. 
  • Early malaria infection, dysregulation of angiogenesis, metabolism and inflammation across pregnancy, and risk of preterm birth in Malawi: A cohort study. 
  • Effect of Plasmodium falciparum sulfadoxine-pyrimethamine resistance on the effectiveness of intermittent preventive therapy for malaria in pregnancy in Africa: a systematic review and meta-analysis. 
  • Effects of age and parasitemia on nitric oxide production/leukocyte nitric oxide synthase type 2 expression in asymptomatic, malaria-exposed children. 
  • Effects of concomitant Schistosoma haematobium infection on the serum cytokine levels elicited by acute Plasmodium falciparum malaria infection in Malian children. 
  • Efficacy of chloroquine on Plasmodium falciparum transmitted at Amani, eastern Usambara Mountains, north-east Tanzania: an area where malaria has recently become endemic. 
  • Efficacy of sulphadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy, Mansa, Zambia. 
  • Elevated nitric oxide production in children with malarial anemia: hemozoin-induced nitric oxide synthase type 2 transcripts and nitric oxide in blood mononuclear cells. 
  • Etiology of pediatric fever in western Kenya: a case-control study of falciparum malaria, respiratory viruses, and streptococcal pharyngitis. 
  • Exploring the lower thermal limits for development of the human malaria parasite, Plasmodium falciparum. 
  • Gametocytemia in Plasmodium vivax and Plasmodium falciparum infections. 
  • Genetic Evidence of Importation of Drug-Resistant Plasmodium falciparum to Guatemala from the Democratic Republic of the Congo. 
  • Genetic architecture of artemisinin-resistant Plasmodium falciparum. 
  • Genetic diversity of the msp-1 locus and symptomatic malaria in south-west Nigeria. 
  • Genomic epidemiology of artemisinin resistant malaria. 
  • Genotyping cognate Plasmodium falciparum in humans and mosquitoes to estimate onward transmission of asymptomatic infections. 
  • Glycocalyx Breakdown Is Associated With Severe Disease and Fatal Outcome in Plasmodium falciparum Malaria. 
  • Glycocalyx breakdown is increased in African children with cerebral and uncomplicated falciparum malaria. 
  • Griseofulvin impairs intraerythrocytic growth of Plasmodium falciparum through ferrochelatase inhibition but lacks activity in an experimental human infection study. 
  • Haemoglobinopathies and the clinical epidemiology of malaria: a systematic review and meta-analysis. 
  • Hemoglobinopathies: slicing the Gordian knot of Plasmodium falciparum malaria pathogenesis. 
  • High numerical aperture Fourier ptychography: principle, implementation and characterization. 
  • Higher production of peripheral blood macrophage migration inhibitory factor in healthy children with a history of mild malaria relative to children with a history of severe malaria. 
  • Host iron status and iron supplementation mediate susceptibility to erythrocytic stage Plasmodium falciparum. 
  • Hyperendemic malaria transmission in areas of occupation-related travel in the Peruvian Amazon. 
  • Immunity to malaria after administration of ultra-low doses of red cells infected with Plasmodium falciparum. 
  • Impact of intermittent screening and treatment for malaria among school children in Kenya: a cluster randomised trial. 
  • Impaired nitric oxide bioavailability and L-arginine reversible endothelial dysfunction in adults with falciparum malaria. 
  • Impaired systemic tetrahydrobiopterin bioavailability and increased dihydrobiopterin in adult falciparum malaria: association with disease severity, impaired microvascular function and increased endothelial activation. 
  • Impaired systemic tetrahydrobiopterin bioavailability and increased oxidized biopterins in pediatric falciparum malaria: association with disease severity. 
  • In silico Screening and Evaluation of Plasmodium falciparum Protein Kinase 5 (PK5) Inhibitors. 
  • Increased Susceptibility to Plasmodium falciparum in Infants is associated with Low, not High, Placental Malaria Parasitemia. 
  • Increased asymmetric dimethylarginine in severe falciparum malaria: association with impaired nitric oxide bioavailability and fatal outcome. 
  • Increased prevalence of dhfr and dhps mutants at delivery in Malawian pregnant women receiving intermittent preventive treatment for malaria. 
  • Increased risk of low birth weight in women with placental malaria associated with P. falciparum VAR2CSA clade. 
  • Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in Southeast Asia. 
  • Independent lineages of highly sulfadoxine-resistant Plasmodium falciparum haplotypes, eastern Africa. 
  • Interaction between acute diarrhoea and falciparum malaria in Nigerian children. 
  • Interactions Between Antenatal Sulfadoxine-Pyrimethamine, Drug-Resistant Plasmodium falciparum Parasites, and Delivery Outcomes in Malawi. 
  • Intermittent preventive malaria treatment in Tanzanian infants. 
  • Intermittent preventive treatment for malaria in infants: moving forward, cautiously. 
  • Intraleucocytic malaria pigment and clinical severity of malaria in children. 
  • Inverse relationship of plasma prostaglandin E2 and blood mononuclear cell cyclooxygenase-2 with disease severity in children with Plasmodium falciparum malaria. 
  • Kenyan Plasmodium falciparum field isolates: correlation between pyrimethamine and chlorcycloguanil activity in vitro and point mutations in the dihydrofolate reductase domain. 
  • Kinetic and Cross-Sectional Studies on the Genesis of Hypoargininemia in Severe Pediatric Plasmodium falciparum Malaria. 
  • Lack of an association between antibodies to Plasmodium falciparum glycosylphosphatidylinositols and malaria-associated placental changes in Cameroonian women with preterm and full-term deliveries. 
  • Lack of association between falciparum malaria parasitemia and acute diarrhea in Nigerian children. 
  • Liver-stage malaria parasites vulnerable to diverse chemical scaffolds. 
  • Longitudinal studies of Plasmodium falciparum malaria in pregnant women living in a rural Cameroonian village with high perennial transmission. 
  • Low interleukin-12 activity in severe Plasmodium falciparum malaria. 
  • Malaria infection during pregnancy: intrauterine growth retardation and preterm delivery in Malawi. 
  • Malaria vaccine trials in pregnant women: An imperative without precedent. 
  • Malaria: a rising incidence in the United States. 
  • Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum. 
  • Minimal Impact by Antenatal Subpatent Plasmodium falciparum Infections on Delivery Outcomes in Malawian Women: A Cohort Study. 
  • Modelling the incremental benefit of introducing malaria screening strategies to antenatal care in Africa. 
  • Molecular basis of allele-specific efficacy of a blood-stage malaria vaccine: vaccine development implications. 
  • Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria. 
  • Monocyte polarization in children with falciparum malaria: relationship to nitric oxide insufficiency and disease severity. 
  • Multicenter Pivotal Clinical Trial of Urine Malaria Test for Rapid Diagnosis of Plasmodium falciparum Malaria. 
  • Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia. 
  • Multiplex assay for simultaneous measurement of antibodies to multiple Plasmodium falciparum antigens. 
  • Nitric oxide synthase type 2 promoter polymorphisms, nitric oxide production, and disease severity in Tanzanian children with malaria. 
  • Overlap Extension Barcoding for the Next Generation Sequencing and Genotyping of Plasmodium falciparum in Individual Patients in Western Kenya. 
  • Parasite prevalence: a static measure of dynamic infections. 
  • Permethrin-impregnated bed nets for malaria control in northern Guatemala: epidemiologic impact and community acceptance. 
  • Plasma interleukin-12 in malaria-tolerant papua new guineans: inverse correlation with Plasmodium falciparum parasitemia and peripheral blood mononuclear cell nitric oxide synthase activity. 
  • Plasmodium falciparum malaria challenge by the bite of aseptic Anopheles stephensi mosquitoes: results of a randomized infectivity trial. 
  • Plasmodium falciparum malaria in south-west Nigerian children: is the polymorphism of ICAM-1 and E-selectin genes contributing to the clinical severity of malaria? 
  • Plasmodium falciparum parasitaemia in the first half of pregnancy, uterine and umbilical artery blood flow, and foetal growth: a longitudinal Doppler ultrasound study. 
  • Plasmodium falciparum sulfadoxine resistance is geographically and genetically clustered within the DR Congo. 
  • Plasmodium falciparum, anaemia and cognitive and educational performance among school children in an area of moderate malaria transmission: baseline results of a cluster randomized trial on the coast of Kenya. 
  • Plasmodium falciparum-infected erythrocytes adhere both in the intervillous space and on the villous surface of human placenta by binding to the low-sulfated chondroitin sulfate proteoglycan receptor. 
  • Platelet factor 4 and Duffy antigen required for platelet killing of Plasmodium falciparum. 
  • Polymerase chain reaction adjustment in antimalarial trials: molecular malarkey? 
  • Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. 
  • Pooled deep sequencing of Plasmodium falciparum isolates: an efficient and scalable tool to quantify prevailing malaria drug-resistance genotypes. 
  • Predicting mortality for paediatric inpatients where malaria is uncommon. 
  • Protection against malaria at 1 year and immune correlates following PfSPZ vaccination. 
  • Providing lipid-based nutrient supplement during pregnancy does not reduce the risk of maternal P falciparum parasitaemia and reproductive tract infections: a randomised controlled trial. 
  • Pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: what next? 
  • Qualified Biolayer Interferometry Avidity Measurements Distinguish the Heterogeneity of Antibody Interactions with Plasmodium falciparum Circumsporozoite Protein Antigens. 
  • Quantification of the burden and consequences of pregnancy-associated malaria in the Democratic Republic of the Congo. 
  • Rapid Diagnostic Test Performance Assessed Using Latent Class Analysis for the Diagnosis of Plasmodium falciparum Placental Malaria. 
  • Rapid increases in parasitemia following red cell exchange for malaria. 
  • Recovery of endothelial function in severe falciparum malaria: relationship with improvement in plasma L-arginine and blood lactate concentrations. 
  • Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites. 
  • Reduced interleukin-12 and transforming growth factor-beta1 in severe childhood malaria: relationship of cytokine balance with disease severity. 
  • Reduced peripheral PGE2 biosynthesis in Plasmodium falciparum malaria occurs through hemozoin-induced suppression of blood mononuclear cell cyclooxygenase-2 gene expression via an interleukin-10-independent mechanism. 
  • Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi. 
  • Relationship of cell-free hemoglobin to impaired endothelial nitric oxide bioavailability and perfusion in severe falciparum malaria. 
  • Reply to Harrington et al. 
  • Return of chloroquine antimalarial efficacy in Malawi. 
  • Return of chloroquine-susceptible falciparum malaria in Malawi was a reexpansion of diverse susceptible parasites. 
  • Return of widespread chloroquine-sensitive Plasmodium falciparum to Malawi. 
  • Safety and immunogenicity of an AMA-1 malaria vaccine in Malian adults: results of a phase 1 randomized controlled trial. 
  • Safety and immunogenicity of an AMA1 malaria vaccine in Malian children: results of a phase 1 randomized controlled trial. 
  • Safety profile of L-arginine infusion in moderately severe falciparum malaria. 
  • Serum levels of the proinflammatory cytokines interleukin-1 beta (IL-1beta), IL-6, IL-8, IL-10, tumor necrosis factor alpha, and IL-12(p70) in Malian children with severe Plasmodium falciparum malaria and matched uncomplicated malaria or healthy controls. 
  • Shared features in the pathobiology of babesiosis and malaria. 
  • Sickle hemoglobin (HbS) allele and sickle cell disease: a HuGE review. 
  • Sources of variability in determining malaria parasite density by microscopy. 
  • Spread of artemisinin resistance in Plasmodium falciparum malaria. 
  • Strain-specific Plasmodium falciparum growth inhibition among Malian children immunized with a blood-stage malaria vaccine. 
  • Suppression of prostaglandin E2 by malaria parasite products and antipyretics promotes overproduction of tumor necrosis factor-alpha: association with the pathogenesis of childhood malarial anemia. 
  • Systematic comparison of two methods to measure parasite density from malaria blood smears. 
  • The A581G Mutation in the Gene Encoding Plasmodium falciparum Dihydropteroate Synthetase Reduces the Effectiveness of Sulfadoxine-Pyrimethamine Preventive Therapy in Malawian Pregnant Women. 
  • The changing landscape of Plasmodium falciparum drug resistance in the Democratic Republic of Congo. 
  • The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. 
  • The diagnosis of Plasmodium falciparum infection using a new antigen detection system. 
  • The effect of Plasmodium falciparum malaria on HIV-1 RNA blood plasma concentration. 
  • The geography of malaria genetics in the Democratic Republic of Congo: A complex and fragmented landscape. 
  • The influence of individual preventive measures on the clinical severity of malaria among Nigerian children. 
  • The practice of jhum cultivation and its relationship to Plasmodium falciparum infection in the Chittagong Hill Districts of Bangladesh. 
  • Trans-kingdom small RNA transfer during host-pathogen interactions: The case of P. falciparum and erythrocytes. 
  • Translocation of sickle cell erythrocyte microRNAs into Plasmodium falciparum inhibits parasite translation and contributes to malaria resistance. 
  • Treatment of erythrocytes with the 2-cys peroxiredoxin inhibitor, Conoidin A, prevents the growth of Plasmodium falciparum and enhances parasite sensitivity to chloroquine. 
  • Variation in the circumsporozoite protein of Plasmodium falciparum: vaccine development implications. 
  • White blood cell counts and malaria. 
  • [Epidemiology of chemoresistant Plasmodium falciparum]. 
  • [LMP-420, a new therapeutic approach for cerebral malaria?]. 
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  Keywords of People

  • O'Meara, Wendy P, Associate Professor of Medicine, Medicine, Infectious Diseases