Lipoxygenase Inhibitors

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  Subject Areas on Research

  • 8(S)-hydroxyeicosatetraenoic acid is the lipoxygenase metabolite of arachidonic acid that regulates epithelial cell migration in the rat cornea. 
  • Deficiency of 5-lipoxygenase abolishes sex-related survival differences in MRL-lpr/lpr mice. 
  • Dicranin, an antimicrobial and 15-lipoxygenase inhibitor from the moss Dicranum scoparium. 
  • Effect of inhibitors of arachidonic acid metabolism on corneal reepithelialization in the rat. 
  • Effects of 9, 12, 15-octadecatrien-6-ynoic acid on the metabolism of arachidonic acid in platelets and on platelet aggregation. 
  • Effects of 9,12,15-octadecatrien-6-ynoic acid on the metabolism of arachidonic acid in platelets and on the platelet aggregation. 
  • Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203. 
  • Immunology of inflammatory bowel disease: summary of the proceedings of the Subcommittee on Immunosuppressive Use in IBD. 
  • Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases. 
  • Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats. 
  • Leukotrienes in renal transplant rejection in rats. Distinct roles for leukotriene B4 and peptidoleukotrienes in the pathogenesis of allograft injury. 
  • Lipoxygenase isozymes in higher plants: biochemical properties and physiological role. 
  • Mast cell modulation of immune responses to bacteria. 
  • Protection against platelet-activating factor-induced injury by interferon inducer in perfused rabbit lung. 
  • Substituted 1,3-Dihydro-2H-pyrrolo-[2,3-b]pyridin-2-ones as Potential Antiinflammatory Agents 
  • Substituted 2,2-bisaryl-bicycloheptanes as novel and potent inhibitors of 5-lipoxygenase activating protein. 
  • Substituted indoles as potent and orally active 5-lipoxygenase activating protein (FLAP) inhibitors. 
  • Substituted thiopyrano[2,3,4-c,d]indoles as potent, selective, and orally active inhibitors of 5-lipoxygenase. Synthesis and biological evaluation of L-691,816. 
  • Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid. 
  • Thiopyranol[2,3,4-c,d]indoles as inhibitors of 5-lipoxygenase, 5-lipoxygenase-activating protein, and leukotriene C4 synthase.