Cyclooxygenase Inhibitors
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Subject Areas on Research
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3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility.
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A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors.
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A randomised, double blind, placebo controlled study of celecoxib, a selective cyclooxygenase 2 inhibitor, on duodenal polyposis in familial adenomatous polyposis.
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A randomized trial of a 6-week course of celecoxib on proteinuria in diabetic kidney disease.
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A selective inhibitor of cyclooxygenase-2 reverses endotoxin-induced pyretic responses in non-human primates.
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A voltage-gated calcium-selective channel encoded by a sodium channel-like gene.
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Acute urinary retention associated with the use of cyclooxygenase-2 inhibitors.
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Adsorption of clofibric acid and ketoprofen onto powdered activated carbon: effect of natural organic matter.
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Alternative activation of extracellular signal-regulated protein kinases in curcumin and arsenite-induced HSP70 gene expression in human colorectal carcinoma cells.
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Antiinflammatory activity of substituted 6-hydroxypyrimido[2,1-f]purine-2,4,8(1H,3H,9H)-triones. Atypical nonsteroidal antiinflammatory agents.
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Applying the neoadjuvant paradigm to ductal carcinoma in situ.
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Aspartate release from rat hippocampal synaptosomes.
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Aspirin and dry eye?
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Aspirin and reproductive outcomes.
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Aspirin for prophylaxis against cerebral aneurysm rupture.
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Aspirin in cardiovascular disorders. What is the optimum dose?
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Aspirin inhibits tumor necrosis factoralpha gene expression in murine tissue macrophages.
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Barrett's esophagus in 2008: an update.
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Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor.
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COX-2 inhibitors.
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COX-2-derived prostacyclin modulates vascular remodeling.
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Cardiopulmonary effects of tumor necrosis factor-alpha in the piglet: influence of cyclooxygenase inhibition.
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Celecoxib (celebrex) increases canine lower esophageal sphincter pressure.
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Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity.
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Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells.
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Central nervous system concentrations of cyclooxygenase-2 inhibitors in humans.
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Chemotherapeutic and biologic agents as radiosensitizers in rectal cancer.
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Clinical applications of antiplatelet therapy.
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Combined modality treatment for rectal cancer.
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Consequences of intra-articular bleeding in haemophilia: science to clinical practice and beyond.
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Covariation of changing patent ductus arteriosus management and preterm infant outcomes in Pediatrix neonatal intensive care units.
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Cyclooxygenase-1 and -2 knockout mice demonstrate increased cardiac ischemia/reperfusion injury but are protected by acute preconditioning.
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Cyclooxygenase-2 inhibitors and nonsteroidal anti-inflammatory drugs in the management of arthritis.
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Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor).
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Diagnostics for aspirin resistance.
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Differential Sex Response to Aspirin in Decreasing Aneurysm Rupture in Humans and Mice.
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Differential regulation of renin and Cox-2 expression in the renal cortex of C57Bl/6 mice.
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Do NSAIDs interfere with the cardioprotective effects of aspirin?
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E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation.
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Effect of cyclooxygenase and lipoxygenase products on pulmonary function in group B streptococcal sepsis.
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Effect of inhibitors of arachidonic acid metabolism on corneal reepithelialization in the rat.
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Effects of 9, 12, 15-octadecatrien-6-ynoic acid on the metabolism of arachidonic acid in platelets and on platelet aggregation.
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Effects of 9,12,15-octadecatrien-6-ynoic acid on the metabolism of arachidonic acid in platelets and on the platelet aggregation.
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Evaluation of dose-related effects of aspirin on platelet function: results from the Aspirin-Induced Platelet Effect (ASPECT) study.
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Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE₂.
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Host response to infection: the role of CpG DNA in induction of cyclooxygenase 2 and nitric oxide synthase 2 in murine macrophages.
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Impact of hypocapnia and cerebral perfusion on orthostatic tolerance.
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In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization.
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Increased formation of thromboxane in vivo in humans with mastocytosis.
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Inhibition of haematogenous metastasis of colon cancer in mice by a selective COX-2 inhibitor, JTE-522.
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Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases.
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Interleukin-1, tumor necrosis factor alpha, and interleukin-17 synergistically up-regulate nitric oxide and prostaglandin E2 production in explants of human osteoarthritic knee menisci.
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Intraoperative ketorolac and eye pain after viteoretinal surgery: a prospective, randomized, placebo-controlled study.
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Ionotropic glutamate receptor subtypes activate c-fos transcription by distinct calcium-requiring intracellular signaling pathways.
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Mast cells are critical for protection against peptic ulcers induced by the NSAID piroxicam.
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Microparticles stimulate the synthesis of prostaglandin E(2) via induction of cyclooxygenase 2 and microsomal prostaglandin E synthase 1.
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Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes.
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New treatments for rheumatoid arthritis.
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Nonsteroidal antiinflammatory drug use among patients with GI bleeding.
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Novel therapies for pancreatic adenocarcinoma.
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Perioperative COX-2 inhibitors: knowledge and challenges.
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Potentiation of calcium levels by extracellular arachidonic acid in nuclei isolated from macrophages stimulated with receptor-recognized forms of alpha(2)-macroglobulin.
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Prostacyclin protects against elevated blood pressure and cardiac fibrosis.
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Prostaglandin E2-mediated regulation of immunoglobulin G2 via interferon gamma.
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Pulmonary vascular and airway responses to endothelin-1 are mediated by different mechanisms in the cat.
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Pyridazinones as selective cyclooxygenase-2 inhibitors.
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Racial/ethnic variations in non-steroidal anti-inflammatory drug (NSAID) use among patients with osteoarthritis.
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Reduced spontaneous relaxation in immature guinea pig airway smooth muscle is associated with increased prostanoid release.
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Reduction of spinal PGE2 concentrations prevents swim stress-induced thermal hyperalgesia.
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Relaxation of guinea pig trachealis during electrical field stimulation increases with age.
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Results of a pilot study of the effects of celecoxib on cancer cachexia in patients with cancer of the head, neck, and gastrointestinal tract.
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Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.
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Role of prostacyclin in the cardiovascular response to thromboxane A2.
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Role of thromboxane A2 in the induction of apoptosis of immature thymocytes by lipopolysaccharide.
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Salt restriction leads to activation of adult renal mesenchymal stromal cell-like cells via prostaglandin E2 and E-prostanoid receptor 4.
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Simultaneous assessment of drug interactions with low- and high-extraction opioids: application to parecoxib effects on the pharmacokinetics and pharmacodynamics of fentanyl and alfentanil.
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Substituted 1,3-Dihydro-2H-pyrrolo-[2,3-b]pyridin-2-ones as Potential Antiinflammatory Agents
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Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors.
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Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx).
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The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.
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The effect of active site-inhibited factor VIIa on tissue factor-initiated coagulation using platelets before and after aspirin administration.
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The effect of aspirin on endothelial progenitor cell biology: preliminary investigation of novel properties.
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The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis.
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The effects of physician specialty and patient comorbidities on the use and discontinuation of coxibs.
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The in vitro reversal of histamine-induced vasodilation in the human internal mammary artery.
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The use of analgesics in the management of pain in rheumatic diseases.
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Therapy of rheumatoid arthritis: new developments and trends.
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Tolfenamic acid and pancreatic cancer growth, angiogenesis, and Sp protein degradation.
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Understanding the Pathophysiology, Implications, and Treatment Options of Patent Ductus Arteriosus in the Neonatal Population.
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Urinary concentrating function in mice lacking EP3receptors for prostaglandin E2.
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Valdecoxib-associated acute generalized exanthematous pustulosis.
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Will we be able to repair osteoarthritic joints? New drugs and surgical techniques for cartilage problems.