tau Proteins

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  Subject Areas on Research

  • 25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner. 
  • A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer's disease dementia. 
  • A novel Alzheimer disease locus located near the gene encoding tau protein. 
  • Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. 
  • Aggregated Tau Measured by Visual Interpretation of Flortaucipir Positron Emission Tomography and the Associated Risk of Clinical Progression of Mild Cognitive Impairment and Alzheimer Disease: Results From 2 Phase III Clinical Trials. 
  • Alpha-2 macroglobulin in Alzheimer's disease: a marker of neuronal injury through the RCAN1 pathway. 
  • Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: Relationship to neuroimaging and CSF biomarkers. 
  • Alzheimer disease pathology in cognitively healthy elderly: a genome-wide study. 
  • Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease. 
  • Anatomy of disturbed sleep in pallido-ponto-nigral degeneration. 
  • ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation. 
  • ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. 
  • Apolipoprotein E and Alzheimer disease. 
  • Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade. 
  • Apolipoprotein E is present in hippocampal neurons without neurofibrillary tangles in Alzheimer's disease and in age-matched controls. 
  • Association Between Polygenic Risk Score and the Progression from Mild Cognitive Impairment to Alzheimer's Disease. 
  • Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease. 
  • Associations of the APOE ε2 and ε4 alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer's disease biomarkers. 
  • CSF biomarker changes precede symptom onset of mild cognitive impairment. 
  • Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. 
  • Cerebrospinal fluid Aβ and tau level fluctuation in an older clinical cohort. 
  • Cerebrospinal fluid profiles and prospective course and outcome in patients with amnestic mild cognitive impairment. 
  • Circulating ethanolamine plasmalogen indices in Alzheimer's disease: Relation to diagnosis, cognition, and CSF tau. 
  • Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer's disease from normal cognitive aging. 
  • Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function. 
  • Corpora amylacea are associated with tau burden and cognitive status in Alzheimer's disease. 
  • Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins. 
  • E-4-hydroxy-2-nonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglial cultures. 
  • Early AGEing and Alzheimer's. 
  • Early role of vascular dysregulation on late-onset Alzheimer's disease based on multifactorial data-driven analysis. 
  • Enhanced capillary amyloid angiopathy-associated pathology in Tg-SwDI mice with deleted nitric oxide synthase 2. 
  • Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. 
  • Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease. 
  • From promiscuity to precision: protein phosphatases get a makeover. 
  • Function of tau protein in adult newborn neurons. 
  • Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. 
  • Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. 
  • Glial and neuronal tau pathology in tauopathies: characterization of disease-specific phenotypes and tau pathology progression. 
  • Higher CSF sTNFR1-related proteins associate with better prognosis in very early Alzheimer's disease. 
  • Hypothesis: microtubule instability and paired helical filament formation in the Alzheimer disease brain are related to apolipoprotein E genotype. 
  • Hypothetical Preclinical Alzheimer Disease Groups and Longitudinal Cognitive Change. 
  • Impaired thermoregulation and beneficial effects of thermoneutrality in the 3×Tg-AD model of Alzheimer's disease. 
  • In vitro polymerization of tau protein monitored by laser light scattering: method and application to the study of FTDP-17 mutants. 
  • Inhibition of Both Hsp70 Activity and Tau Aggregation in Vitro Best Predicts Tau Lowering Activity of Small Molecules. 
  • Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice. 
  • Intracerebral Expression of AAV-APOE4 Is Not Sufficient to Alter Tau Burden in Two Distinct Models of Tauopathy. 
  • Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease. 
  • Linkage disequilibrium and haplotype tagging polymorphisms in the Tau H1 haplotype. 
  • Lithium treatment of APPSwDI/NOS2-/- mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype. 
  • Longitudinal study of differential protein expression in an Alzheimer's mouse model lacking inducible nitric oxide synthase. 
  • Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease. 
  • MAPT rs242557 variant is associated with hippocampus tau uptake on 18F-AV-1451 PET in non-demented elders. 
  • Metabolic network failures in Alzheimer's disease: A biochemical road map. 
  • Metabolism-Based Gene Differences in Neurons Expressing Hyperphosphorylated AT8- Positive (AT8+) Tau in Alzheimer's Disease. 
  • Microglia are not exclusively associated with plaque-rich regions of the dentate gyrus in Alzheimer's disease. 
  • Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model. 
  • Microtubule-associated protein MAP1B showing a fetal phosphorylation pattern is present in sites of neurofibrillary degeneration in brains of Alzheimer's disease patients. 
  • Mild cognitive impairment and asymptomatic Alzheimer disease subjects: equivalent β-amyloid and tau loads with divergent cognitive outcomes. 
  • Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism. 
  • Multicenter cohort study on association of genotypes with prospective sports concussion: methods, lessons learned, and recommendations. 
  • NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease. 
  • Neuropathologic studies of the Baltimore Longitudinal Study of Aging (BLSA). 
  • Neuropathological features of frontotemporal dementia and parkinsonism linked to chromosome 17q21-22 (FTDP-17): Duke Family 1684. 
  • Novel Genetic Variants in TP37, PIK3R1, CALM1, and PLCG2 of the Neurotrophin Signaling Pathway Are Associated with the Progression from Mild Cognitive Impairment to Alzheimer's Disease. 
  • Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers. 
  • Prenatal and Early Postnatal Odorant Exposure Heightens Odor-Evoked Mitral Cell Responses in the Mouse Olfactory Bulb. 
  • Prevalence of Alzheimer's pathologic endophenotypes in asymptomatic and mildly impaired first-degree relatives. 
  • Relationship between cerebrospinal fluid biomarkers of Alzheimer's disease and cognition in cognitively normal older adults. 
  • Relationship of cognitive reserve and cerebrospinal fluid biomarkers to the emergence of clinical symptoms in preclinical Alzheimer's disease. 
  • Resistance to Alzheimer's pathology is associated with nuclear hypertrophy in neurons. 
  • Serum cleaved tau does not predict postconcussion syndrome after mild traumatic brain injury. 
  • Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins. 
  • Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau. 
  • Sex-specific genetic predictors of Alzheimer's disease biomarkers. 
  • Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline. 
  • Targeting Tau Mitigates Mitochondrial Fragmentation and Oxidative Stress in Amyotrophic Lateral Sclerosis. 
  • Tau deficiency leads to the upregulation of BAF-57, a protein involved in neuron-specific gene repression. 
  • Tau induces formation of α-synuclein filaments with distinct molecular conformations. 
  • Tau is essential to beta -amyloid-induced neurotoxicity. 
  • Tau protein binding forms a 1 nm thick layer along protofilaments without affecting the radial elasticity of microtubules. 
  • Tau protein is required for amyloid {beta}-induced impairment of hippocampal long-term potentiation. 
  • Tau--an inhibitor of deacetylase HDAC6 function. 
  • Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits. 
  • The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. 
  • The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease. 
  • The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory. 
  • The Effect of Propofol Versus Isoflurane Anesthesia on Human Cerebrospinal Fluid Markers of Alzheimer's Disease: Results of a Randomized Trial. 
  • The Q7R Saitohin gene polymorphism is not associated with Alzheimer disease. 
  • The apolipoprotein-E-mimetic COG112 protects amyloid precursor protein intracellular domain-overexpressing animals from Alzheimer's disease-like pathological features. 
  • The role of apolipoprotein E in the nervous system. 
  • The tau N279K exon 10 splicing mutation recapitulates frontotemporal dementia and parkinsonism linked to chromosome 17 tauopathy in a mouse model. 
  • The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates. 
  • Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic. 
  • Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative. 
  • Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: the Cache County Dementia Progression Study. 
  • Visualizing an olfactory sensory map. 
  • α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration.