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Subject Areas on Research
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A hot oxidant, 3-NO2Y122 radical, unmasks conformational gating in ribonucleotide reductase.
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A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression.
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Activation of NAD(P)H oxidase by lipid hydroperoxides: mechanism of oxidant-mediated smooth muscle cytotoxicity.
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Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl thiol oxidation in vascular smooth muscle cells.
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Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation, and oxidant-induced apoptosis.
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An endothelial TLR4-VEGFR2 pathway mediates lung protection against oxidant-induced injury.
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Anticancer therapeutic potential of Mn porphyrin/ascorbate system.
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Apolipoprotein E protects against oxidative stress in mixed neuronal-glial cell cultures by reducing glutamate toxicity.
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Assessment of the oxidant tolerance of Methanosarcina acetivorans.
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Biological assessments of a mixture of endocrine disruptors at environmentally relevant concentrations in water following UV/H2O2 oxidation.
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COPD: balancing oxidants and antioxidants.
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Carbon monoxide, oxidative stress, and mitochondrial permeability pore transition.
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Catalytic scavenging of peroxynitrite by isomeric Mn(III) N-methylpyridylporphyrins in the presence of reductants.
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Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair.
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Cigarette smoke-related oxidants and the development of sub-RPE deposits in an experimental animal model of dry AMD.
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Cross influences of ozone and sulfate precursor emissions changes on air quality and climate.
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Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury.
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Differential susceptibility of fish and rat liver cells to oxidative stress and cytotoxicity upon exposure to prooxidants
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Disruption of iron homeostasis in mesothelial cells after talc pleurodesis.
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Distinctive adaptive response to repeated exposure to hydrogen peroxide associated with upregulation of DNA repair genes and cell cycle arrest.
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Effects of TNFalpha on expression of ICAM-1 in human airway epithelial cells in vitro: oxidant-mediated pathways and transcription factors.
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Endothelial PINK1 mediates the protective effects of NLRP3 deficiency during lethal oxidant injury.
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Endothelial Stanniocalcin 1 Maintains Mitochondrial Bioenergetics and Prevents Oxidant-Induced Lung Injury via Toll-Like Receptor 4.
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Exploring the potential role of the oxidant-activated transcription factor aryl hydrocarbon receptor in the pathogenesis of AMD.
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Extracellular but not cytosolic superoxide dismutase protects against oxidant-mediated endothelial dysfunction.
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Generation of hydrogen peroxide and failure of antioxidative responses in pancreatic islets of male C57BL/6 mice are associated with diabetes induced by multiple low doses of streptozotocin.
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Glutamate mobilizes [Zn2+] through Ca2+ -dependent reactive oxygen species accumulation.
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Glutamine protects intestinal epithelial cells: role of inducible HSP70.
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H(2)O(2)-induced O(2) production by a non-phagocytic NAD(P)H oxidase causes oxidant injury.
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HEPATIC ALDEHYDE OXIDASE. II. DIFFERENTIAL INHIBITION OF ELECTRON TRANSFER TO VARIOUS ELECTRON ACCEPTORS.
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Haptoglobin alters oxygenation and oxidation of hemoglobin and decreases propagation of peroxide-induced oxidative reactions.
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How irritating: the role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways.
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Hydrogen Sulfide Prevents and Partially Reverses Ozone-Induced Features of Lung Inflammation and Emphysema in Mice.
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Identification of a negative feedback loop in biological oxidant formation fegulated by 4-hydroxy-2-(E)-nonenal.
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Improved blackwater disinfection using potentiodynamic methods with oxidized boron-doped diamond electrodes.
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In vivo accumulation of iron on crocidolite is associated with decrements in oxidant generation by the fiber.
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Involvement of reactive oxygen species in the electrochemical inhibition of barnacle (Amphibalanus amphitrite) settlement
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Klotho, an antiaging molecule, attenuates oxidant-induced alveolar epithelial cell mtDNA damage and apoptosis.
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Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1.
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Manganese (III) meso-tetrakis N-ethylpyridinium-2-yl porphyrin acts as a pro-oxidant to inhibit electron transport chain proteins, modulate bioenergetics, and enhance the response to chemotherapy in lymphoma cells.
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Markers of oxidative status in a clinical model of oxidative assault: a pilot study in human blood following doxorubicin administration.
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Methylglyoxal augments intracellular oxidative stress in human aortic endothelial cells.
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Mitochondrial DNA, oxidants, and innate immunity.
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Mitochondrial oxidant production by a pollutant dust and NO-mediated apoptosis in human alveolar macrophage.
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Mitochondrial transcription factor A induction by redox activation of nuclear respiratory factor 1.
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Modulation of the GABA(A)-gated chloride channel by reactive oxygen species.
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NAD(P)H quinone oxidoreductase 1 is essential for ozone-induced oxidative stress in mice and humans.
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Nanotechnologies: tools for sustainability in a new wave of water treatment processes.
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Nitric oxide decreases oxidant-mediated hepatocyte injury.
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Nonlethal oxidant injury to human retinal pigment epithelium cells causes cell membrane blebbing but decreased MMP-2 activity.
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Overlapping specificities of base excision repair, nucleotide excision repair, recombination, and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae.
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Oxidant enhancement in martian dust devils and storms: storm electric fields and electron dissociative attachment.
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Oxidant generation promotes iron sequestration in BEAS-2B cells exposed to asbestos.
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Oxidant-induced cell death in retinal pigment epithelium cells mediated through the release of apoptosis-inducing factor.
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Oxidant-mediated Akt activation in human RPE cells.
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Oxidants and antioxidants in alveolar epithelial type II cells: in situ, freshly isolated, and cultured cells.
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Oxidants, antioxidants and the ischemic brain.
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Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice.
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Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina.
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PRDX6 attenuates oxidative stress- and TGFbeta-induced abnormalities of human trabecular meshwork cells.
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Possible cellular and molecular mechanisms for asbestos carcinogenicity.
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Protection of perfused lung from oxidant injury by inhibitors of anion exchange.
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Protein synthesis inhibitors and the chemical chaperone TMAO reverse endoplasmic reticulum perturbation induced by overexpression of the iodide transporter pendrin.
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Pulmonary fibrosis and ferruginous bodies associated with exposure to synthetic fibers.
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Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure.
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Rapid up-regulation of peptide elongation factor EF-1alpha protein levels is an immediate early event during oxidative stress-induced apoptosis.
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Retinal pigment epithelium protection from oxidant-mediated loss of MMP-2 activation requires both MMP-14 and TIMP-2.
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Retinal pigment epithelium response to oxidant injury in the pathogenesis of early age-related macular degeneration.
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Sequestration of mitochondrial iron by silica particle initiates a biological effect.
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Soluble recombinant neutral endopeptidase (CD10) as a potential antiinflammatory agent.
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TRPA1 is a major oxidant sensor in murine airway sensory neurons.
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The importance of Bcl-xL in the survival of human RPE cells.
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The release of iron from different asbestos structures by hydrogen peroxide with concomitant O2 generation.
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Thermodynamic analysis of protein-ligand interactions in complex biological mixtures using a shotgun proteomics approach.
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Thiol peroxidase is critical for virulence and resistance to nitric oxide and peroxide in the fungal pathogen, Cryptococcus neoformans.
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Toll-like receptor 4 deficiency causes pulmonary emphysema.
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Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases.
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Tumor necrosis factor increases mitochondrial oxidant production and induces expression of uncoupling protein-2 in the regenerating mice [correction of rat] liver.
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Yeast base excision repair: interconnections and networks.
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α-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of α-subunits of human HbA with hydrogen peroxide.
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Keywords of People
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De Caceres Bustos, Anabel,
Research Scientist, Senior,
Anesthesiology
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Jordt, Sven Eric,
Associate Professor in Anesthesiology,
Pharmacology & Cancer Biology
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Laskowitz, Daniel Todd,
Professor of Neurology,
Duke Science & Society
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Shindell, Drew Todd,
Nicholas Distinguished Professor of Earth Science,
Duke Science & Society