Oxidants

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  Subject Areas on Research

  • A hot oxidant, 3-NO2Y122 radical, unmasks conformational gating in ribonucleotide reductase. 
  • A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression. 
  • Activation of NAD(P)H oxidase by lipid hydroperoxides: mechanism of oxidant-mediated smooth muscle cytotoxicity. 
  • Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl thiol oxidation in vascular smooth muscle cells. 
  • Altered pulmonary response to hyperoxia in Clara cell secretory protein deficient mice. 
  • Aminoguanidine inhibits reactive oxygen species formation, lipid peroxidation, and oxidant-induced apoptosis. 
  • An assay for oxidant regulation of protein tyrosine phosphatase activity. 
  • Anticancer therapeutic potential of Mn porphyrin/ascorbate system. 
  • Apolipoprotein E protects against oxidative stress in mixed neuronal-glial cell cultures by reducing glutamate toxicity. 
  • Biological assessments of a mixture of endocrine disruptors at environmentally relevant concentrations in water following UV/H2O2 oxidation. 
  • COPD: balancing oxidants and antioxidants. 
  • Carbon monoxide, oxidative stress, and mitochondrial permeability pore transition. 
  • Catalytic scavenging of peroxynitrite by isomeric Mn(III) N-methylpyridylporphyrins in the presence of reductants. 
  • Cells with pathogenic biallelic mutations in the human MUTYH gene are defective in DNA damage binding and repair. 
  • Cigarette smoke-related oxidants and the development of sub-RPE deposits in an experimental animal model of dry AMD. 
  • Clara cell secretory protein deficiency increases oxidant stress response in conducting airways. 
  • Cross influences of ozone and sulfate precursor emissions changes on air quality and climate. 
  • Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury. 
  • Differential susceptibility of fish and rat liver cells to oxidative stress and cytotoxicity upon exposure to prooxidants. 
  • Disruption of iron homeostasis in mesothelial cells after talc pleurodesis. 
  • Distinctive adaptive response to repeated exposure to hydrogen peroxide associated with upregulation of DNA repair genes and cell cycle arrest. 
  • Effects of TNFalpha on expression of ICAM-1 in human airway epithelial cells in vitro: oxidant-mediated pathways and transcription factors. 
  • Exploring the potential role of the oxidant-activated transcription factor aryl hydrocarbon receptor in the pathogenesis of AMD. 
  • Extracellular but not cytosolic superoxide dismutase protects against oxidant-mediated endothelial dysfunction. 
  • Generation of hydrogen peroxide and failure of antioxidative responses in pancreatic islets of male C57BL/6 mice are associated with diabetes induced by multiple low doses of streptozotocin. 
  • Glutamate mobilizes [Zn2+] through Ca2+ -dependent reactive oxygen species accumulation. 
  • Glutamine protects intestinal epithelial cells: role of inducible HSP70. 
  • H(2)O(2)-induced O(2) production by a non-phagocytic NAD(P)H oxidase causes oxidant injury. 
  • HEPATIC ALDEHYDE OXIDASE. II. DIFFERENTIAL INHIBITION OF ELECTRON TRANSFER TO VARIOUS ELECTRON ACCEPTORS. 
  • Haptoglobin alters oxygenation and oxidation of hemoglobin and decreases propagation of peroxide-induced oxidative reactions. 
  • How irritating: the role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways. 
  • Hydrogen Sulfide Prevents and Partially Reverses Ozone-Induced Features of Lung Inflammation and Emphysema in Mice. 
  • Identification of a negative feedback loop in biological oxidant formation fegulated by 4-hydroxy-2-(E)-nonenal. 
  • Improved blackwater disinfection using potentiodynamic methods with oxidized boron-doped diamond electrodes. 
  • In vivo accumulation of iron on crocidolite is associated with decrements in oxidant generation by the fiber. 
  • Involvement of reactive oxygen species in the electrochemical inhibition of barnacle (Amphibalanus amphitrite) settlement. 
  • Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes: selective catalysis by FMO3. 
  • Klotho, an antiaging molecule, attenuates oxidant-induced alveolar epithelial cell mtDNA damage and apoptosis. 
  • Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1. 
  • Manganese (III) meso-tetrakis N-ethylpyridinium-2-yl porphyrin acts as a pro-oxidant to inhibit electron transport chain proteins, modulate bioenergetics, and enhance the response to chemotherapy in lymphoma cells. 
  • Markers of oxidative status in a clinical model of oxidative assault: a pilot study in human blood following doxorubicin administration. 
  • Measurement of DNA damage using the comet assay. 
  • Methylglyoxal augments intracellular oxidative stress in human aortic endothelial cells. 
  • Mitochondrial oxidant production by a pollutant dust and NO-mediated apoptosis in human alveolar macrophage. 
  • Mitochondrial transcription factor A induction by redox activation of nuclear respiratory factor 1. 
  • Modulation of the GABA(A)-gated chloride channel by reactive oxygen species. 
  • NAD(P)H quinone oxidoreductase 1 is essential for ozone-induced oxidative stress in mice and humans. 
  • Nanotechnologies: tools for sustainability in a new wave of water treatment processes. 
  • Nitric oxide decreases oxidant-mediated hepatocyte injury. 
  • Nitrosative stress: activation of the transcription factor OxyR. 
  • Nonlethal oxidant injury to human retinal pigment epithelium cells causes cell membrane blebbing but decreased MMP-2 activity. 
  • Overlapping specificities of base excision repair, nucleotide excision repair, recombination, and translesion synthesis pathways for DNA base damage in Saccharomyces cerevisiae. 
  • Oxidant enhancement in martian dust devils and storms: storm electric fields and electron dissociative attachment. 
  • Oxidant generation promotes iron sequestration in BEAS-2B cells exposed to asbestos. 
  • Oxidant-induced cell death in retinal pigment epithelium cells mediated through the release of apoptosis-inducing factor. 
  • Oxidant-mediated Akt activation in human RPE cells. 
  • Oxidants and antioxidants in alveolar epithelial type II cells: in situ, freshly isolated, and cultured cells. 
  • Oxidants, antioxidants and the ischemic brain. 
  • Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice. 
  • Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina. 
  • PRDX6 attenuates oxidative stress- and TGFbeta-induced abnormalities of human trabecular meshwork cells. 
  • Possible cellular and molecular mechanisms for asbestos carcinogenicity. 
  • Priming of platelet alphaIIbbeta3 by oxidants is associated with tyrosine phosphorylation of beta3. 
  • Protection of perfused lung from oxidant injury by inhibitors of anion exchange. 
  • Protein synthesis inhibitors and the chemical chaperone TMAO reverse endoplasmic reticulum perturbation induced by overexpression of the iodide transporter pendrin. 
  • Pulmonary fibrosis and ferruginous bodies associated with exposure to synthetic fibers. 
  • Rapid mtDNA deletion by oxidants in rat liver mitochondria after hemin exposure. 
  • Rapid up-regulation of peptide elongation factor EF-1alpha protein levels is an immediate early event during oxidative stress-induced apoptosis. 
  • Redox regulation of human Rac1 stability by the proteasome in human aortic endothelial cells. 
  • Redox-based regulation of signal transduction: principles, pitfalls, and promises. 
  • Retinal pigment epithelium protection from oxidant-mediated loss of MMP-2 activation requires both MMP-14 and TIMP-2. 
  • Retinal pigment epithelium response to oxidant injury in the pathogenesis of early age-related macular degeneration. 
  • Role of quercetin on PCBs (Aroclor-1254) induced impairment of dopaminergic receptor mRNA expression in cerebral cortex of adult male rats. 
  • Sequestration of mitochondrial iron by silica particle initiates a biological effect. 
  • Soluble recombinant neutral endopeptidase (CD10) as a potential antiinflammatory agent. 
  • TRPA1 is a major oxidant sensor in murine airway sensory neurons. 
  • The importance of Bcl-xL in the survival of human RPE cells. 
  • The release of iron from different asbestos structures by hydrogen peroxide with concomitant O2 generation. 
  • The role of reactive oxygen and nitrogen species in airway epithelial gene expression. 
  • Thermodynamic analysis of protein-ligand interactions in complex biological mixtures using a shotgun proteomics approach. 
  • Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. 
  • Tumor necrosis factor increases mitochondrial oxidant production and induces expression of uncoupling protein-2 in the regenerating mice [correction of rat] liver. 
  • Yeast base excision repair: interconnections and networks. 
  • α-Hemoglobin stabilizing protein (AHSP) markedly decreases the redox potential and reactivity of α-subunits of human HbA with hydrogen peroxide. 
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  Keywords of People

  • De Caceres Bustos, Anabel, Research Scientist, Senior, Anesthesiology
  • Jordt, Sven Eric, Associate Professor in Anesthesiology, Pharmacology & Cancer Biology
  • Laskowitz, Daniel Todd, Professor of Neurology, Duke Innovation & Entrepreneurship
  • Shindell, Drew Todd, Nicholas Distinguished Professor of Earth Science, Earth and Ocean Sciences
  • Warner, David Samuel, Distinguished Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology