Drug Monitoring

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  Subject Areas on Research

  • "Blueprinting" thrombogenicity and antithrombotic drug response at the bedside in patients presenting emergently with symptoms of acute stroke. 
  • "Short course" bortezomib plus melphalan and prednisone as induction prior to transplant or as frontline therapy for nontransplant candidates in patients with previously untreated multiple myeloma. 
  • A 24-hour comparison of serum growth hormone concentrations in patients with heart failure versus healthy controls. 
  • A Phase I Clinical Trial of Guadecitabine and Carboplatin in Platinum-Resistant, Recurrent Ovarian Cancer: Clinical, Pharmacokinetic, and Pharmacodynamic Analyses. 
  • A Phase I, First-in-Human Study of AMG 780, an Angiopoietin-1 and -2 Inhibitor, in Patients with Advanced Solid Tumors. 
  • A Systematic Literature Review Approach to Estimate the Therapeutic Index of Selected Immunosuppressant Drugs After Renal Transplantation. 
  • A comparison of electronic monitoring vs. clinician rating of antipsychotic adherence in outpatients with schizophrenia. 
  • A longitudinal replicate study of immunosuppressive drugs: a College of American Pathologists study. 
  • A multi-dose pharmacokinetic study of dalteparin in haemodialysis patients. 
  • A phase Ib study of the combination regorafenib with PF-03446962 in patients with refractory metastatic colorectal cancer (REGAL-1 trial). 
  • A randomized, double-blind, placebo-controlled trial of pramipexole augmentation in treatment-resistant major depressive disorder. 
  • A structurally optimized FXR agonist, MET409, reduced liver fat content over 12 weeks in patients with non-alcoholic steatohepatitis. 
  • Accuracy of Patient-reported Adherence to Glaucoma Medications on a Visual Analog Scale Compared With Electronic Monitors. 
  • Achievement of dual low-density lipoprotein cholesterol and high-sensitivity C-reactive protein targets more frequent with the addition of ezetimibe to simvastatin and associated with better outcomes in IMPROVE-IT. 
  • Acute myeloid leukemia clinical practice guidelines in oncology. 
  • Adherence and persistence with oral adjuvant chemotherapy in older women with early-stage breast cancer in CALGB 49907: adherence companion study 60104. 
  • Alternative calculations of individual patient time in therapeutic range while taking warfarin: results from the ROCKET AF trial. 
  • An evaluation of analytic goals for assays of drugs: a College of American Pathologists Therapeutic Drug Monitoring Survey Study. 
  • An evaluation of patient self-testing competency of prothrombin time for managing anticoagulation: pre-randomization results of VA Cooperative Study #481--The Home INR Study (THINRS). 
  • Antiarrhythmic drugs-clinical use and clinical decision making: a consensus document from the European Heart Rhythm Association (EHRA) and European Society of Cardiology (ESC) Working Group on Cardiovascular Pharmacology, endorsed by the Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS) and International Society of Cardiovascular Pharmacotherapy (ISCP). 
  • Anticoagulants. 
  • Anticoagulation Monitoring with Activated Partial ThromboPlastin Time and Anti-Xa Activity in Intensive Care Unit Patients: Interest of Thrombin Generation Assay. 
  • Anticoagulation monitoring during pediatric extracorporeal membrane oxygenation. 
  • Anticoagulation: managing adverse events in patients receiving anticoagulation and perioperative care. 
  • Anticoagulation: monitoring of patients receiving anticoagulation. 
  • Antiplatelet drug resistance and variability in response: the role of antiplatelet therapy monitoring. 
  • Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis. 
  • Appropriate baseline laboratory testing following ACEI or ARB initiation by Medicare FFS beneficiaries. 
  • Assays for measuring rivaroxaban: their suitability and limitations. 
  • Assessment of oral antithrombotic therapy by platelet function testing. 
  • Association Between Warfarin Control Metrics and Atrial Fibrillation Outcomes in the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation. 
  • Association of Testosterone Levels With Anemia in Older Men: A Controlled Clinical Trial. 
  • Associations between model-predicted rivaroxaban exposure and patient characteristics and efficacy and safety outcomes in patients with non-valvular atrial fibrillation. 
  • At-Home Versus In-Clinic INR Monitoring: A Cost-Utility Analysis from The Home INR Study (THINRS). 
  • Biomarker guided therapy for heart failure: focus on natriuretic peptides. 
  • Biomarkers and personalised medicine in rheumatoid arthritis: a proposal for interactions between academia, industry and regulatory bodies. 
  • Blockade of tissue factor: treatment for organ injury in established sepsis. 
  • Blood pressure and heart rate over 10 years in the multimodal treatment study of children with ADHD. 
  • Caution about overinterpretation of symptom indexes in reflux monitoring for refractory gastroesophageal reflux disease. 
  • Challenges of development and implementation of point of care pharmacogenetic testing. 
  • Characterization of Mineralocorticoid Receptor Antagonist Therapy Initiation in High-Risk Patients With Heart Failure. 
  • Clinical assessment of medication adherence among HIV-infected children: examination of the Treatment Interview Protocol (TIP). 
  • Clinical use of the activated partial thromboplastin time and prothrombin time for screening: a review of the literature and current guidelines for testing. 
  • Clinically relevant bleeding in cancer patients treated for venous thromboembolism from the CATCH study. 
  • Comment: Decreased warfarin effect after initiation of high-protein, low-carbohydrate diets. 
  • Comparison of Assays for Therapeutic Monitoring of Infliximab and Adalimumab in Patients With Inflammatory Bowel Diseases. 
  • Comparison of morning vs bedtime administration of the combination of valsartan/amlodipine on nocturnal brachial and central blood pressure in patients with hypertension. 
  • Core Recommendations for Antifungal Stewardship: A Statement of the Mycoses Study Group Education and Research Consortium. 
  • Cryoprecipitate therapy. 
  • Daptomycin use in infants: report of two cases with peak and trough drug concentrations. 
  • Delivering clinical trials at home: protocol, design and implementation of a direct-to-family paediatric lupus trial. 
  • Determination of non-Vitamin K oral anticoagulant (NOAC) effects using a new-generation thrombelastography TEG 6s system. 
  • Direct measurement of peptide-specific CD8+ T cells using HLA-A2:Ig dimer for monitoring the in vivo immune response to a HER2/neu vaccine in breast and prostate cancer patients. 
  • Direct oral anticoagulants: new drugs and new concepts. 
  • Direct-to-patient expert system and home INR monitoring improves control of oral anticoagulation. 
  • Does distance modify the effect of self-testing in oral anticoagulation? 
  • Does switching to a new antipsychotic improve outcomes? Data from the CATIE Trial. 
  • Early diuretic strategies and the association with In-hospital and Post-discharge outcomes in acute heart failure. 
  • Economic evaluation of ART in resource-limited countries. 
  • Effect of Azithromycin on Venetoclax Pharmacokinetics in Healthy Volunteers: Implications for Dosing Venetoclax with P-gp Inhibitors. 
  • Effect of Intravenous Fentanyl on Ticagrelor Absorption and Platelet Inhibition Among Patients Undergoing Percutaneous Coronary Intervention: The PACIFY Randomized Clinical Trial (Platelet Aggregation With Ticagrelor Inhibition and Fentanyl). 
  • Effect of NGM282, an FGF19 analogue, in primary sclerosing cholangitis: A multicenter, randomized, double-blind, placebo-controlled phase II trial. 
  • Effect of a Practice-wide Anti-TNF Proactive Therapeutic Drug Monitoring Program on Outcomes in Pediatric Patients with Inflammatory Bowel Disease. 
  • Effect of cyclosporin pharmacokinetics on renal allograft outcome in African-Americans. 
  • Effect of home testing of international normalized ratio on clinical events. 
  • Effectiveness of clozapine versus olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia who did not respond to prior atypical antipsychotic treatment. 
  • Effects of pre-analytical variables on the anti-activated factor X chromogenic assay when monitoring unfractionated heparin and low molecular weight heparin anticoagulation. 
  • Electronic toxicity monitoring and patient-reported outcomes. 
  • Enabling social listening for cardiac safety monitoring: Proceedings from a drug information association-cardiac safety research consortium cosponsored think tank. 
  • Evaluation of tacrolimus abbreviated area-under-the-curve monitoring in renal transplant patients who are potentially at risk for adverse events. 
  • Evaluation of the dofetilide risk-management program. 
  • Every breath you take, we'll be watching you. 
  • Extracorporeal membrane oxygenation in the adult: a review of anticoagulation monitoring and transfusion. 
  • Factors associated with reduced infliximab exposure in the treatment of pediatric autoimmune disorders: a cross-sectional prospective convenience sampling study. 
  • Factors associated with therapeutic anticoagulation status in patients with ischemic stroke and atrial fibrillation. 
  • Fentanyl and Midazolam Are Ineffective in Reducing Episodic Intracranial Hypertension in Severe Pediatric Traumatic Brain Injury. 
  • Few Disparities in Baseline Laboratory Testing After the Diuretic or Digoxin Initiation by Medicare Fee-For-Service Beneficiaries. 
  • Gastrointestinal hemorrhage due to complicated gastroduodenal ulcer disease in liver transplant patients taking sirolimus. 
  • Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics. 
  • Growth patterns reflect response to antiretroviral therapy in HIV-positive infants: potential utility in resource-poor settings. 
  • Guidance on the emergent reversal of oral thrombin and factor Xa inhibitors. 
  • HIV and pregnancy: considerations for nursing practice. 
  • Heparin and low-molecular-weight heparin: mechanisms of action, pharmacokinetics, dosing considerations, monitoring, efficacy, and safety. 
  • High performance liquid chromatography-mass spectrometry assay for polymyxin B1 and B2 in human plasma. 
  • History of bleeding and outcomes with apixaban versus warfarin in patients with atrial fibrillation in the Apixaban for Reduction in Stroke and Other Thromboembolic Events in Atrial Fibrillation trial. 
  • Home monitoring of warfarin effects. 
  • Hypertension Control in Adults With Diabetes Mellitus and Recurrent Cardiovascular Events: Global Results From the Trial Evaluating Cardiovascular Outcomes With Sitagliptin. 
  • Impact of global geographic region on time in therapeutic range on warfarin anticoagulant therapy: data from the ROCKET AF clinical trial. 
  • Impact of prophylactic oseltamivir on INR in patients on stable warfarin therapy. 
  • Impact of the revised american academy of ophthalmology guidelines regarding hydroxychloroquine screening on actual practice. 
  • Improved glycemic control enhances the incretin effect in patients with type 2 diabetes. 
  • Improving care transitions: current practice and future opportunities for pharmacists. 
  • In-vitro evaluation of anti-factor IXa aptamer on thrombin generation, clotting time, and viscoelastometry. 
  • Infliximab and Adalimumab Concentrations May Vary Between the Enzyme-Linked Immunosorbent Assay and the Homogeneous Mobility Shift Assay in Patients With Inflammatory Bowel Disease: A Prospective Cross-Sectional Observational Study. 
  • Influence of parental health literacy and dosing responsibility on pediatric glaucoma medication adherence. 
  • Initial experience with factor-Xa inhibition in percutaneous coronary intervention: the XaNADU-PCI Pilot. 
  • Interaction between digoxin and dronedarone in the PALLAS trial. 
  • Is There a Role for Preoperative Platelet Function Testing in Patients Undergoing Cardiac Surgery During Antiplatelet Therapy? 
  • Is light transmittance aggregometry still a useful tool to assess pharmacodynamic effects of antiplatelet therapy? 
  • Issues in the utilization of low molecular weight heparins. 
  • Lansoprazole Is Associated with Worsening Asthma Control in Children with the CYP2C19 Poor Metabolizer Phenotype. 
  • Levosimendan in patients with left ventricular systolic dysfunction undergoing cardiac surgery on cardiopulmonary bypass: Rationale and study design of the Levosimendan in Patients with Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery Requiring Cardiopulmonary Bypass (LEVO-CTS) trial. 
  • Long-term cardiovascular toxicity in children, adolescents, and young adults who receive cancer therapy: pathophysiology, course, monitoring, management, prevention, and research directions: a scientific statement from the American Heart Association. 
  • Long-term electrocardiographic safety monitoring in clinical drug development: A report from the Cardiac Safety Research Consortium. 
  • Management of anticoagulation agents in trauma patients. 
  • Management of hepatitis C virus infection: the basics. 
  • Management of lepirudin therapy for a patient with antiphospholipid antibody syndrome using the whole blood ecarin clot time and activated partial thromboplastin time. 
  • Measurement of felbamate by wide-bore capillary gas chromatography and flame ionization detection. 
  • Mechanisms and monitoring of bypassing agent therapy. 
  • Medication monitoring and drug testing ethics project. 
  • Metabolomic Profiling to Identify Molecular Biomarkers of Cellular Response to Methotrexate In Vitro. 
  • Metformin for weight loss and metabolic control in overweight outpatients with schizophrenia and schizoaffective disorder. 
  • Molecular monitoring to improve outcomes in patients with chronic myeloid leukemia in chronic phase: importance of achieving treatment-free remission. 
  • Monitoring DOACs with a Novel Dielectric Microsensor: A Clinical Study. 
  • Monitoring guidance for patients with hypophosphatasia treated with asfotase alfa. 
  • Monitoring liver safety in drug development: the GSK experience. 
  • Non-invasive monitoring of intra-tumor drug concentration and therapeutic response using optical spectroscopy. 
  • On-treatment analysis of the Improved Reduction of Outcomes: Vytorin Efficacy International Trial (IMPROVE-IT). 
  • Ophthalmologist-patient communication, self-efficacy, and glaucoma medication adherence. 
  • Outcomes of discontinuing rivaroxaban compared with warfarin in patients with nonvalvular atrial fibrillation: analysis from the ROCKET AF trial (Rivaroxaban Once-Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation). 
  • Paradoxical reactions in children associated with midazolam use during endoscopy. 
  • Patterns of anticoagulation following bioprosthetic valve implantation: observations from ANSWER. 
  • Patterns of etanercept use in juvenile idiopathic arthritis in the Childhood Arthritis and Rheumatology Research Alliance Registry. 
  • Percutaneous coronary intervention and antiplatelet therapy in patients with atrial fibrillation receiving apixaban or warfarin: Insights from the ARISTOTLE trial. 
  • Perioperative management of patients receiving new oral anticoagulants: an international survey. 
  • Pharmacist-managed international normalized ratio patient self-testing is associated with increased time in therapeutic range in patients with left ventricular assist devices at an academic medical center. 
  • Pharmacodynamic Profile and Prevalence of Bleeding Episode in East Asian Patients with Acute Coronary Syndromes Treated with Prasugrel Standard-Dose versus De-escalation Strategy: A Randomized A-MATCH Trial. 
  • Pharmacokinetic, efficacy, and safety considerations for the use of antifungal drugs in the neonatal population. 
  • Pharmacokinetics of hydroxychloroquine in paediatric lupus: data from a novel, direct-to-family clinical trial. 
  • Pharmacology and safety of new oral anticoagulants: the challenge of bleeding persists. 
  • Pharmacy-based assessment of adherence to HAART predicts virologic and immunologic treatment response and clinical progression to AIDS and death. 
  • Phase 1 study of PSMA ADC, an antibody-drug conjugate targeting prostate-specific membrane antigen, in chemotherapy-refractory prostate cancer. 
  • Phase 1/2 multiple ascending dose trial of the prostate-specific membrane antigen-targeted antibody drug conjugate MLN2704 in metastatic castration-resistant prostate cancer. 
  • Phase I Study of the Investigational Aurora A Kinase Inhibitor Alisertib plus Rituximab or Rituximab/Vincristine in Relapsed/Refractory Aggressive B-cell Lymphoma. 
  • Plasma levels of factors II, VII and X and their relationship to the international normalized ratio during chronic warfarin therapy. 
  • Point-of-care testing of the international normalized ratio in patients with antiphospholipid antibodies. 
  • Population Analysis of Anidulafungin in Infants to Older Adults With Confirmed or Suspected Invasive Candidiasis. 
  • Population-based hepatitis C surveillance and treatment in a national managed care organization. 
  • Postdischarge international normalized ratio testing and long-term clinical outcomes of patients with heart failure receiving warfarin: findings from the ADHERE registry linked to Medicare claims. 
  • Practice bulletin no. 123: thromboembolism in pregnancy. 
  • Presence of neuroticism and antidepressant remission rates in late-life depression: results from the Neurobiology of Late-Life Depression (NBOLD) study. 
  • Primary care of HIV infection. 
  • Processed EEG (bispectral index) is not appropriate for characterizing opioid sedation. 
  • Quality of pharmacotherapy and outcomes for older veterans discharged from the emergency department. 
  • Quantifying Glaucoma Medication Adherence: The Relationship Between Self-Report, Electronic Monitoring, and Pharmacy Refill. 
  • Randomized Phase II and Biomarker Study of Pembrolizumab plus Bevacizumab versus Pembrolizumab Alone for Patients with Recurrent Glioblastoma. 
  • Randomized, double-blind trial of fluconazole versus voriconazole for prevention of invasive fungal infection after allogeneic hematopoietic cell transplantation. 
  • Reducing thrombotic complications in the perioperative setting: an update on heparin-induced thrombocytopenia. 
  • Relationship between time in therapeutic range and comparative treatment effect of rivaroxaban and warfarin: results from the ROCKET AF trial. 
  • Reversing targeted oral anticoagulants. 
  • Risks and benefits of triple oral anti-thrombotic therapies after acute coronary syndromes and percutaneous coronary intervention. 
  • Routine therapeutic monitoring of lamotrigine in epileptic patients using a simple and rapid high performance liquid chromatographic technique. 
  • Safety and Tolerability of Manual Push Administration of Subcutaneous IgPro20 at High Infusion Rates in Patients with Primary Immunodeficiency: Findings from the Manual Push Administration Cohort of the HILO Study. 
  • Safety monitoring of drugs receiving pediatric marketing exclusivity. 
  • Safety of 2 months of rifampin and pyrazinamide for treatment of latent tuberculosis. 
  • Safety of warfarin dosing in the intensive care unit following the Fontan procedure. 
  • Self-monitoring of oral anticoagulation: systematic review and meta-analysis of individual patient data. 
  • Simplified monitoring for hepatitis C virus treatment with glecaprevir plus pibrentasvir, a randomised non-inferiority trial. 
  • Sociodemographic, clinical, and treatment characteristics associated with worsened depression during treatment with citalopram: results of the NIMH STAR(*)D trial. 
  • Sources of variability: a College of American Pathologists Therapeutic Drug Monitoring study. 
  • Systolic Blood Pressure in Heart Failure With Preserved Ejection Fraction Treated With Sacubitril/Valsartan. 
  • Targeting Natriuretic Peptide Levels in Heart Failure with Therapy: Does "X" Really Mark the Spot? 
  • Tetany in a child with AIDS receiving intravenous tobramycin. 
  • The Brief Adherence Rating Scale (BARS) validated against electronic monitoring in assessing the antipsychotic medication adherence of outpatients with schizophrenia and schizoaffective disorder. 
  • The Impact of the Support, Educate, Empower Personalized Glaucoma Coaching Pilot Study on Glaucoma Medication Adherence. 
  • The effects of MDCO-2010, a serine protease inhibitor, on activated clotting time in blood obtained from volunteers and cardiac surgical patients. 
  • The health-related quality of life and survival of small-cell lung cancer patients: results of a companion study to CALGB 9033. 
  • The impact of bispectral index monitoring on rates of propofol administration. 
  • The impact of frequency of patient self-testing of prothrombin time on time in target range within VA Cooperative Study #481: The Home INR Study (THINRS), a randomized, controlled trial. 
  • The impact of patient self-testing of prothrombin time for managing anticoagulation: rationale and design of VA Cooperative Study #481--the Home INR Study (THINRS). 
  • The safety of warfarin therapy in the nursing home setting. 
  • Therapeutic Drug Monitoring, Electronic Health Records, and Pharmacokinetic Modeling to Evaluate Sirolimus Drug Exposure-Response Relationships in Renal Transplant Patients. 
  • Therapeutic Index Estimation of Antiepileptic Drugs: A Systematic Literature Review Approach. 
  • Therapeutic drug monitoring of antimycobacterial drugs in patients with both tuberculosis and advanced human immunodeficiency virus infection. 
  • Therapeutic monitoring of voriconazole in children less than three years of age: a case report and summary of voriconazole concentrations for ten children. 
  • Toward Solving the Sedation-Assessment Conundrum: Neurofunction Monitoring. 
  • Toward solving the sedation-assessment conundrum: bi-spectral index monitoring and sedation interruption. 
  • Transition of Patients with Opioid Use Disorder from Buprenorphine to Extended-Release Naltrexone: A Randomized Clinical Trial Assessing Two Transition Regimens. 
  • Two instruments to determine activated partial thromboplastin time: implications for heparin monitoring. 
  • Update of studies on drug-related problems in older adults. 
  • Use of Therapeutic Drug Monitoring, Electronic Health Record Data, and Pharmacokinetic Modeling to Determine the Therapeutic Index of Phenytoin and Lamotrigine. 
  • Using insulin to prevent hyperglycemia in surgical patients. 
  • Utility of thiopurine methyltransferase genotyping and phenotyping, and measurement of azathioprine metabolites in the management of patients with autoimmune hepatitis. 
  • Validity of electronically monitored medication adherence and conventional adherence measures in schizophrenia. 
  • Vorapaxar with or without clopidogrel after non-ST-segment elevation acute coronary syndromes: results from the thrombin receptor antagonist for clinical event reduction in acute coronary syndrome trial. 
  • Warfarin and acetaminophen interaction: a summary of the evidence and biologic plausibility. 
  • What clinicians should know about the QT interval. 
  • Wilson disease--penicillamine therapy and late presentation. 
  • Withdrawal severity and early response to treatment in the outpatient transition from opioid use to extended release naltrexone. 
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  Keywords of People

  • Cohen-Wolkowiez, Michael, Kiser-Arena Distinguished Professor, Pediatrics, Infectious Diseases
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma
  • O'Connor, Christopher Michael, Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology
  • Palmer, Gregory M., Associate Professor of Radiation Oncology, Radiation Oncology