Gram-Negative Bacterial Infections

• 

  Subject Areas on Research

  • 10 x '20 Progress--development of new drugs active against gram-negative bacilli: an update from the Infectious Diseases Society of America. 
  • A CRISPR-Cas system enhances envelope integrity mediating antibiotic resistance and inflammasome evasion. 
  • A comparison of neonatal Gram-negative rod and Gram-positive cocci meningitis. 
  • A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized, controlled trial. The E5 Sepsis Study Group. 
  • Association of Follow-up Blood Cultures With Mortality in Patients With Gram-Negative Bloodstream Infections: A Systematic Review and Meta-analysis. 
  • Azithromycin--spectrum of activity, pharmacokinetics, and clinical applications. 
  • Bacterial outer membrane vesicles and the host-pathogen interaction. 
  • Bacterial priming increases lung injury in gram-negative sepsis. 
  • Blood transcriptomes reveal novel parasitic zoonoses circulating in Madagascar's lemurs. 
  • Bloodstream infections in community hospitals in the 21st century: a multicenter cohort study. 
  • Capnocytophagia canimorsus sepsis in an asplenic heart transplant candidate with a left ventricular assist system. 
  • Caspase-11 protects against bacteria that escape the vacuole. 
  • Cefepime and Ceftazidime Safety in Hospitalized Infants. 
  • Ceftaroline for complicated skin and skin-structure infections. 
  • Characterization of the interleukin 1 receptor-associated kinase 4 (IRAK4)-encoding gene in salmonid fish: the functional copy is rearranged in Oncorhynchus mykiss and that factor can impair TLR signaling in mammalian cells. 
  • Clinical Outcomes and Healthcare Utilization Related to Multidrug-Resistant Gram-Negative Infections in Community Hospitals. 
  • Clinical and Molecular Analyses of Recurrent Gram-Negative Bloodstream Infections. 
  • Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC. 
  • Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock. 
  • Delays in appropriate antibiotic therapy for gram-negative bloodstream infections: a multicenter, community hospital study. 
  • Direct-from-blood RNA sequencing identifies the cause of post-bronchoscopy fever. 
  • E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomized controlled trial. E5 Study Investigators. 
  • Early and late onset sepsis in late preterm infants. 
  • Effect of Intrawound Vancomycin Powder in Operatively Treated High-risk Tibia Fractures: A Randomized Clinical Trial. 
  • Emerging evidence for seasonality of gram-negative bacterial infections. 
  • Environmentally controlled bacterial vesicle-mediated export. 
  • Epidemiology, pathophysiology and clinical presentation of gram-negative sepsis. 
  • Fever, bacterial zoonoses, and One Health in sub-Saharan Africa. 
  • Fluoroquinolone resistance during 2000-2005: an observational study. 
  • Glutamine administration reduces Gram-negative bacteremia in severely burned patients: a prospective, randomized, double-blind trial versus isonitrogenous control. 
  • Gram-Negative Bacterial Infections: Research Priorities, Accomplishments, and Future Directions of the Antibacterial Resistance Leadership Group. 
  • History of antibiotics: from fluoroquinolones to daptomycin (Part 2). 
  • Hyperkeratotic rim of gram-negative toe web infections. 
  • Implementation of antibiotic rotation protocol improves antibiotic susceptibility profile in a surgical intensive care unit. 
  • Increased Costs Associated with Bloodstream Infections Caused by Multidrug-Resistant Gram-Negative Bacteria Are Due Primarily to Patients with Hospital-Acquired Infections. 
  • Infections in patients with cystic fibrosis following lung transplantation. 
  • Infectious Loss of Tissue Expanders in Breast Reconstruction: Are We Treating the Right Organisms? 
  • Infectious complications after pulsatile-flow and continuous-flow left ventricular assist device implantation. 
  • Inhibition of lipid A biosynthesis as the primary mechanism of CHIR-090 antibiotic activity in Escherichia coli. 
  • Late-onset bloodstream infections in hospitalized term infants. 
  • Leptotrichia sanguinegens sp. nov., a new agent of postpartum and neonatal bacteremia. 
  • Low-Avidity Autoantibodies against Bactericidal/Permeability-Increasing Protein Occur in Gram-Negative and Gram-Positive Bacteremia. 
  • Mast cell modulation of immune responses to bacteria. 
  • Measuring the effect of inappropriate initial antibiotic therapy on outcomes of patients with Gram-negative sepsis: An imprecise science. 
  • Methylobacterium mesophilica as a cause of persistent bacteremia in a child with lymphoma. 
  • Multicountry Distribution and Characterization of Extended-spectrum β-Lactamase-associated Gram-negative Bacteria From Bloodstream Infections in Sub-Saharan Africa. 
  • Non-HACEK gram-negative bacillus endocarditis. 
  • Outcome of Pediatric Gastroenterology Outpatients With Fever and Central Line. 
  • Patient-level interventions to prevent the acquisition of resistant gram-negative bacteria in critically ill patients: a systematic review. 
  • Phylogenetic, genomic, and biogeographic characterization of a novel and ubiquitous marine invertebrate-associated Rickettsiales parasite, Candidatus Aquarickettsia rohweri, gen. nov., sp. nov. 
  • Positive follow-up blood cultures identify high mortality risk among patients with Gram-negative bacteraemia. 
  • Predictive value of cerebrospinal fluid parameters in neonates with intraventricular drainage devices. 
  • Proposed primary endpoints for use in clinical trials that compare treatment options for bloodstream infection in adults: a consensus definition. 
  • Recent Advances in Lipopolysaccharide Recognition Systems. 
  • Risk factors for gram-negative bacterial surgical site infection: do allergies to antibiotics increase risk? 
  • Risk of intravascular cardiac device infections in patients with bacteraemia: impact on device removal. 
  • Seasonal Variation of Common Surgical Site Infections: Does Season Matter? 
  • Selective decontamination of digestive tract in intensive care. 
  • Sepsis in young infants with congenital heart disease. 
  • Sepsis, multiple organ failure, and death due to Pandoraea pnomenusa infection after lung transplantation. 
  • Successful treatment of Edwardsiella tarda prosthetic valve endocarditis in a patient with AIDS. 
  • TLR4-initiated and cAMP-mediated abrogation of bacterial invasion of the bladder. 
  • Telavancin hospital-acquired pneumonia trials: impact of Gram-negative infections and inadequate Gram-negative coverage on clinical efficacy and all-cause mortality. 
  • Temporal Trends in Blood Stream Infection Isolates from Surgical Patients. 
  • The Impact of 2015 NHSN Catheter-associated Urinary Tract Infection (CAUTI) Definition Change on Central Line-associated Bloodstream Infection (CLABSI) Rates and CLABSI Prevention Efforts at an Academic Medical Center. 
  • The association of third-generation cephalosporin use and invasive candidiasis in extremely low birth-weight infants. 
  • The effect of povidone-iodine solutions used as surgical preparations on the bacterial flora of the skin. 
  • The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. 
  • The tripartite associations between bacteriophage, Wolbachia, and arthropods. 
  • Tick-borne disease. 
  • Treatment of multidrug-resistant gram-negative bacilli after solid organ transplant: Outcomes and complications. 
  • Type III protein secretion mechanism in mammalian and plant pathogens. 
  • Variability in oral antibiotic step-down therapy in the management of Gram-negative bloodstream infections. 
  • Very low birth weight preterm infants with early onset neonatal sepsis: the predominance of gram-negative infections continues in the National Institute of Child Health and Human Development Neonatal Research Network, 2002-2003. 
  • Virulence and immunomodulatory roles of bacterial outer membrane vesicles. 
• 

  Keywords of People

  • Cohen-Wolkowiez, Michael, Kiser-Arena Distinguished Professor, Pediatrics, Infectious Diseases
  • Kuehn, Margarethe Joanna, Associate Professor of Biochemistry, Cell Biology
  • Moehring, Rebekah, Associate Professor of Medicine, Medicine, Infectious Diseases