Cell Death

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  Subject Areas on Research

  • 2'Fluoro Modification Differentially Modulates the Ability of RNAs to Activate Pattern Recognition Receptors. 
  • A Fluorescent Cell-Based System for Imaging Zika Virus Infection in Real-Time. 
  • A bioenergetic profile of non-transformed fibroblasts uncovers a link between death-resistance and enhanced spare respiratory capacity. 
  • A biotin switch-based proteomics approach identifies 14-3-3ζ as a target of Sirt1 in the metabolic regulation of caspase-2. 
  • A genome-wide RNAi screen reveals multiple regulators of caspase activation. 
  • A genomic approach to identify molecular pathways associated with chemotherapy resistance. 
  • A high-throughput histoarray for quantitative molecular profiling of multiple, uniformly oriented medaka (Oryzias latipes) embryos. 
  • A noncanonical function of cGAMP in inflammasome priming and activation. 
  • A novel classification of lung cancer into molecular subtypes. 
  • A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLO. 
  • A plant genetic network for preventing dysbiosis in the phyllosphere. 
  • A role for Rac3 GTPase in the regulation of autophagy. 
  • A sphingosine kinase inhibitor induces cell death in temozolomide resistant glioblastoma cells. 
  • APOL1 Nephrotoxicity: What Does Ion Transport Have to Do With It? 
  • APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases. 
  • Acid potentiation of the capsaicin receptor determined by a key extracellular site. 
  • Activation of metabotropic glutamate receptor subtype mGluR1 contributes to post-traumatic neuronal injury. 
  • Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase. 
  • Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death. 
  • Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. 
  • All-trans-retinal sensitizes human RPE cells to alternative complement pathway-induced cell death. 
  • Allospecific CD4(+) effector memory T cells do not induce graft-versus-host disease in mice. 
  • Altered morphology of hippocampal dentate granule cell presynaptic and postsynaptic terminals following conditional deletion of TrkB. 
  • Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors. 
  • Amino acid sequence requirements of peptides that inhibit polyglutamine-protein aggregation and cell death. 
  • An efficient targeted radiotherapy/gene therapy strategy utilising human telomerase promoters and radioastatine and harnessing radiation-mediated bystander effects. 
  • An oxidative stress-based mechanism of doxorubicin cytotoxicity suggests new therapeutic strategies in ABC-DLBCL. 
  • Angiostatin is directly cytotoxic to tumor cells at low extracellular pH: a mechanism dependent on cell surface-associated ATP synthase. 
  • Antioxidant and cytotoxic tocopheryl quinones in normal and cancer cells. 
  • ApoE mimetic ameliorates motor deficit and tissue damage in rat spinal cord injury. 
  • Apolipoprotein E and neurological disease: therapeutic potential and pharmacogenomic interactions. 
  • Apolipoprotein E protects against NMDA excitotoxicity. 
  • Apoptosis in human retinal degenerations. 
  • Apoptosis leads to photoreceptor degeneration in inherited retinal dystrophy of RCS rats. 
  • Apoptotic cell death in disease-Current understanding of the NCCD 2023. 
  • Aptamer-mediated delivery of chemotherapy to pancreatic cancer cells. 
  • Are all nonproliferating cells similar? 
  • Autophagy protects against aminochrome-induced cell death in substantia nigra-derived cell line. 
  • BAX-mediated cell death affects early germ cell loss and incidence of testicular teratomas in Dnd1(Ter/Ter) mice. 
  • BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV. 
  • BMP antagonism by Noggin is required in presumptive notochord cells for mammalian foregut morphogenesis. 
  • Biochemical identification of apoptosis (programmed cell death) in granulosa cells: evidence for a potential mechanism underlying follicular atresia. 
  • Biological Principles of Stereotactic Body Radiation Therapy (SBRT) and Stereotactic Radiation Surgery (SRS): Indirect Cell Death. 
  • Biological basis of bone formation, remodeling, and repair-part II: extracellular matrix. 
  • CD4 T follicular helper cell dynamics during SIV infection. 
  • CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis. 
  • Ca2+-dependent demethylation of phosphatase PP2Ac promotes glucose deprivation-induced cell death independently of inhibiting glycolysis. 
  • Camptothecin and Fas receptor agonists synergistically induce medulloblastoma cell death: ROS-dependent mechanisms. 
  • Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy. 
  • Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension. 
  • Caspase-1-induced pyroptotic cell death. 
  • Caspase-11 protects against bacteria that escape the vacuole. 
  • Caspase-3 activation in rat frontal cortex following treatment with typical and atypical antipsychotics. 
  • Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. 
  • Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer. 
  • Cell cycle-independent death of prostate adenocarcinoma is induced by the trk tyrosine kinase inhibitor CEP-751 (KT6587). 
  • Cell death in age-related macular degeneration. 
  • Cell death in cortical development: How much? Why? So what? 
  • Cell death in the oligodendrocyte lineage. 
  • Cell division, growth and death. Cell growth: live and let die. 
  • Cell type-specific changes in retinal ganglion cell function induced by rod death and cone reorganization in rats. 
  • Changes in Neuroimmune and Neuronal Death Markers after Adolescent Alcohol Exposure in Rats are Reversed by Donepezil. 
  • Changes in sphingomyelinases, ceramide, Bax, Bcl(2), and caspase-3 during and after experimental status epilepticus. 
  • Changes in the expression of transcription factors ATF-2 and Fra-2 after axotomy and during regeneration in rat retinal ganglion cells. 
  • Characterization of a recovery global cerebral ischemia model in the mouse. 
  • Characterization of the cell death promoter, Bad, in the developing rat retina and forebrain. 
  • Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. 
  • Chemotherapy enriches for an invasive triple-negative breast tumor cell subpopulation expressing a precursor form of N-cadherin on the cell surface. 
  • Chloroform inhalation exposure conditions necessary to initiate liver toxicity in female B6C3F1 mice. 
  • Chromium genotoxicity: A double-edged sword. 
  • Chronic ethanol exposure potentiates lipopolysaccharide liver injury despite inhibiting Jun N-terminal kinase and caspase 3 activation. 
  • Clusterin: an enigmatic protein recruited by diverse stimuli. 
  • Comparative toxicity of C60 aggregates toward mammalian cells: role of tetrahydrofuran (THF) decomposition. 
  • Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. 
  • Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a prodeath factor. 
  • Control of fibroblast senescence and activation of programmed cell death. 
  • Control of lens epithelial cell survival. 
  • Controlled targeting of liposomal doxorubicin via the folate receptor in vitro. 
  • Core N-Glycan Structures Are Critical for the Pathogenicity of Cryptococcus neoformans by Modulating Host Cell Death. 
  • Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors. 
  • Creatine and phosphocreatine analogs: anticancer activity and enzymatic analysis. 
  • Critical periods for the role of oxidative stress in the developmental neurotoxicity of chlorpyrifos and terbutaline, alone or in combination. 
  • Cytotoxicity of oxidized LDL to porcine aortic smooth muscle cells is associated with the oxysterols 7-ketocholesterol and 7-hydroxycholesterol. 
  • DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. 
  • Death waits for no man--does it wait for a virus? How enteroviruses induce and control cell death. 
  • Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. 
  • Designer monotransregulators provide a basis for a transcriptional therapy for de novo endocrine-resistant breast cancer. 
  • Development of a simplified spinal cord ischemia model in mice. 
  • Differences in Reperfusion-Induced Mitochondrial Oxidative Stress and Cell Death Between Hippocampal CA1 and CA3 Subfields Are Due to the Mitochondrial Thioredoxin System. 
  • Differential Induction of Immunogenic Cell Death and Interferon Expression in Cancer Cells by Structured ssRNAs. 
  • Differential effects of toll-like receptor stimulation on mRNA-driven myogenic conversion of human and mouse fibroblasts. 
  • Digital microfluidic chips for chemical and biological applications. 
  • Direct Observation of Low Strain, High Rate Deformation of Cultured Brain Tissue During Primary Blast. 
  • Disrupted spermine homeostasis: a novel mechanism in polyglutamine-mediated aggregation and cell death. 
  • Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss. 
  • Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary. 
  • Distinct Responses of Stem Cells to Telomere Uncapping-A Potential Strategy to Improve the Safety of Cell Therapy. 
  • Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors. 
  • Distributing a fixed amount of cyclic loading to tendon explants over longer periods induces greater cellular and mechanical responses. 
  • Diverse mechanisms of resistance to Pseudomonas syringae in a thousand natural accessions of Arabidopsis thaliana. 
  • Dying glioma cells establish a proangiogenic microenvironment through a caspase 3 dependent mechanism. 
  • Dysregulated cholesterol homeostasis results in resistance to ferroptosis increasing tumorigenicity and metastasis in cancer. 
  • Effect of lipophilicity of Mn (III) ortho N-alkylpyridyl- and diortho N, N'-diethylimidazolylporphyrins in two in-vitro models of oxygen and glucose deprivation-induced neuronal death. 
  • Effects of glutamine, glucose, and oxygen concentration on the metabolism and proliferation of rabbit adipose-derived stem cells. 
  • Effects of isoflurane versus fentanyl-nitrous oxide anesthesia on long-term outcome from severe forebrain ischemia in the rat. 
  • Effects of myocardial infarction on the distribution and transport of nutrients and oxygen in porcine myocardium. 
  • EndoU is a novel regulator of AICD during peripheral B cell selection. 
  • Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor. 
  • Evaluation of the role of nitric oxide in acid sensing ion channel mediated cell death. 
  • Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis. 
  • Experience with subzonal insemination (SUZI) and intracytoplasmic sperm injection (ICSI) on unfertilized aged human oocytes. 
  • Expression of functional domains of beta G-spectrin disrupts epithelial morphology in cultured cells. 
  • Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury. 
  • Fabrication and testing of a device capable of reducing the incidence of ventricular shunt promoted metastasis. 
  • Fas(t) balls and Lou Gehrig disease. A clue to selective vulnerability of motor neurons? 
  • Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death. 
  • Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair. 
  • Fumonisin inhibition of de novo sphingolipid biosynthesis and cytotoxicity are correlated in LLC-PK1 cells. 
  • Fumonisin toxicity and sphingolipid biosynthesis. 
  • Functional characterization of a mitochondrial Ser/Thr protein phosphatase in cell death regulation. 
  • Functional diversity of mammalian type 2C protein phosphatase isoforms: new tales from an old family. 
  • G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program. 
  • Genetic and pharmacologic identification of Akt as a mediator of brain-derived neurotrophic factor/TrkB rescue of neuroblastoma cells from chemotherapy-induced cell death. 
  • Global re-wiring of p53 transcription regulation by the hepatitis B virus X protein. 
  • GluR3 autoantibodies destroy neural cells in a complement-dependent manner modulated by complement regulatory proteins. 
  • Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation. 
  • Glutamate receptor GluR3 antibodies and death of cortical cells. 
  • Glutamine attenuation of cell death and inducible nitric oxide synthase expression following inflammatory cytokine-induced injury is dependent on heat shock factor-1 expression. 
  • Going up in flames: necrotic cell injury and inflammatory diseases. 
  • Gq-dependent signaling upregulates COX2 in glomerular podocytes. 
  • Group VIA Ca2+-independent phospholipase A2 (iPLA2beta) and its role in beta-cell programmed cell death. 
  • Growth inhibition of human Tenon's capsule fibroblasts and rabbit dermal fibroblasts with non-carcinogenic N-alkylated anthracyclines. 
  • Growth signaling at the nexus of stem cell life and death. 
  • Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. 
  • HMGB1 and microparticles as mediators of the immune response to cell death. 
  • Hydrolyzed fumonisins HFB1 and HFB2 are acylated in vitro and in vivo by ceramide synthase to form cytotoxic N-acyl-metabolites. 
  • Hypothermic treatment restores glucose regulated protein 78 (GRP78) expression in ischemic brain. 
  • Hypoxia modulates nitric oxide-induced regulation of NMDA receptor currents and neuronal cell death. 
  • Hypoxic cell death is reduced by pH buffering in a model of engineered heart tissue. 
  • IL-7 enhances the survival and maintains the size of naive T cells. 
  • Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death. 
  • Imaging of Nanoparticle Distribution to Assess Treatments That Alter Delivery. 
  • Immunotherapy Gone Viral: Bortezomib and oHSV Enhance Antitumor NK-Cell Activity. 
  • Impaired volume regulation is the mechanism of excitotoxic sensitization to complement. 
  • Importance of the stress kinase p38alpha in mediating the direct cytotoxic effects of the thalidomide analogue, CPS49, in cancer cells and endothelial cells. 
  • In Vivo Assessment of Ferroptosis and Ferroptotic Stress in Mice. 
  • In utero exposure to nicotine and chlorpyrifos alone, and in combination produces persistent sensorimotor deficits and Purkinje neuron loss in the cerebellum of adult offspring rats. 
  • In vitro toxicology of fumonisins and the mechanistic implications. 
  • Increased resistance of tumor cells to hyperthermia mediated by integrin-linked kinase. 
  • Indirect Tumor Cell Death After High-Dose Hypofractionated Irradiation: Implications for Stereotactic Body Radiation Therapy and Stereotactic Radiation Surgery. 
  • Inflammasome-mediated pyroptotic and apoptotic cell death, and defense against infection. 
  • Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium. 
  • Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis. 
  • Inhibition of polyglutamine protein aggregation and cell death by novel peptides identified by phage display screening. 
  • Inhibition of telomerase is related to the life span and tumorigenicity of human prostate cancer cells. 
  • Innate Sensors Trigger Regulated Cell Death to Combat Intracellular Infection. 
  • Intracellular trafficking of histone deacetylase 4 regulates neuronal cell death. 
  • Investigation of HIFU-induced anti-tumor immunity in a murine tumor model. 
  • Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest. 
  • Isoflurane-induced neuronal degeneration: an evaluation in organotypic hippocampal slice cultures. 
  • Isolated Primary Blast Inhibits Long-Term Potentiation in Organotypic Hippocampal Slice Cultures. 
  • Isolated primary blast alters neuronal function with minimal cell death in organotypic hippocampal slice cultures. 
  • JAK-STAT activation contributes to cytotoxic T cell-mediated basal cell death in human chronic lung allograft dysfunction. 
  • Keto acid metabolites of branched-chain amino acids inhibit oxidative stress-induced necrosis and attenuate myocardial ischemia-reperfusion injury. 
  • LRRK2 in Parkinson's disease: function in cells and neurodegeneration. 
  • Large-scale death of retinal astrocytes during normal development is non-apoptotic and implemented by microglia. 
  • Lateral Root Initiation: The Emergence of New Primordia Following Cell Death. 
  • Life, death, and the metabolically controlled protein acetylome. 
  • Life-or-death decisions in plant immunity. 
  • Light uncages a copper complex to induce nonapoptotic cell death. 
  • Limitations of an ex vivo breast cancer model for studying the mechanism of action of the anticancer drug paclitaxel. 
  • Long-term effects of acute and of chronic hypoxia on behavior and on hippocampal histology in the developing brain. 
  • Long-term neuroprotection by benzodiazepine full versus partial agonists after transient cerebral ischemia in the gerbil [corrected]. 
  • Loss of BMI1 in mature olfactory sensory neurons leads to increased olfactory basal cell proliferation. 
  • Loss of basal cells precedes bronchiolitis obliterans-like pathological changes in a murine model of chlorine gas inhalation. 
  • MLKL Requires the Inositol Phosphate Code to Execute Necroptosis. 
  • Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl(-) channel disruption. 
  • Mechanical injury to neuronal/glial cultures in microplates: role of NMDA receptors and pH in secondary neuronal cell death. 
  • Mechanisms and methods in glucose metabolism and cell death. 
  • Mechanisms of Disease: the role of high-mobility group protein 1 in the pathogenesis of inflammatory arthritis. 
  • Mechanisms of cell death governed by the balance between nitrosative and oxidative stress. 
  • Mechanistic insights into cancer cell killing through interaction of phosphodiesterase 3A and schlafen family member 12. 
  • Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function. 
  • Metabolic and functional characterization of human adipose-derived stem cells in tissue engineering. 
  • Metabolomic profiling reveals a role for caspase-2 in lipoapoptosis. 
  • Microarray analysis of gene expression in adult retinal ganglion cells. 
  • Microdosimetric and Biological Effects of Photon Irradiation at Different Energies in Bone Marrow. 
  • Mitochondrial DNA damage induced autophagy, cell death, and disease. 
  • Mitochondrial hTERT exacerbates free-radical-mediated mtDNA damage. 
  • Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes. 
  • Mitochondrial quality-control dysregulation in conditional HO-1-/- mice. 
  • Mobilization of peripheral blood progenitor cells by hematopoietic growth factors. 
  • Modeling killing and repopulation kinetics of subclinical cancer: direct calculations from clinical data. 
  • Modeling nuclear molecule release during in vitro cell death. 
  • Modelling the effects of age-related mtDNA mutation accumulation; complex I deficiency, superoxide and cell death. 
  • Modulation of melphalan resistance in glioma cells with a peripheral benzodiazepine receptor ligand-melphalan conjugate. 
  • Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. 
  • Molecular therapies for vascular diseases. 
  • Morphometric analysis for early detection of changes in cellular structure in a toxicological experiment. 
  • Mouse models of retinal ganglion cell death and glaucoma. 
  • Multifunctional nanocarriers for mammographic quantification of tumor dosing and prognosis of breast cancer therapy. 
  • Multiple activities of the plant pathogen type III effector proteins WtsE and AvrE require WxxxE motifs. 
  • N-(4-Hydroxyphenyl)retinamide increases dihydroceramide and synergizes with dimethylsphingosine to enhance cancer cell killing. 
  • NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling. 
  • NMDA and glutamate evoke excitotoxicity at distinct cellular locations in rat cortical neurons in vitro. 
  • NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism. 
  • Necroptosis at a glance. 
  • Necroptosis of infiltrated macrophages drives Yersinia pestis dispersal within buboes. 
  • Neuronal cell death in Huntington's disease: a potential role for dopamine. 
  • Neuronal cell death in a rat model of mesial temporal lobe epilepsy is induced by the initial status epilepticus and not by later repeated spontaneous seizures. 
  • Neuroprotective effects of group III mGluR in traumatic neuronal injury. 
  • Neuroprotective effects of reactive oxygen species mediated by BDNF-independent activation of TrkB. 
  • New in vitro model of traumatic neuronal injury: evaluation of secondary injury and glutamate receptor-mediated neurotoxicity. 
  • Nicotine evokes cell death in embryonic rat brain during neurulation. 
  • Nitric oxide and prostaglandin E2 participate in lipopolysaccharide/interferon-gamma-induced heme oxygenase 1 and prevent RAW264.7 macrophages from UV-irradiation-induced cell death. 
  • Nitric oxide production and regulation of neuronal NOS in tyrosine hydroxylase containing neurons. 
  • Nonalcoholic Steatohepatitis. 
  • Notch promotes radioresistance of glioma stem cells. 
  • Novel ceramide analogs as potential chemotherapeutic agents in breast cancer. 
  • Nrf2-mediated protection against 6-hydroxydopamine. 
  • Nucleotide metabolism is linked to cysteine availability. 
  • Numb regulates somatic cell lineage commitment during early gonadogenesis in mice. 
  • Over-pressure suppresses ultrasonic-induced drug uptake. 
  • Overexpression of VMAT-2 and DT-diaphorase protects substantia nigra-derived cells against aminochrome neurotoxicity. 
  • Oxidant-induced cell death in retinal pigment epithelium cells mediated through the release of apoptosis-inducing factor. 
  • Oxidative DNA damage and DNA repair enzyme expression are inversely related in murine models of fatty liver disease. 
  • Oxidative damage is a potential cause of cone cell death in retinitis pigmentosa. 
  • PLANT NATRIURETIC PEPTIDE A and Its Putative Receptor PNP-R2 Antagonize Salicylic Acid-Mediated Signaling and Cell Death. 
  • Paracrine mechanisms in adult stem cell signaling and therapy. 
  • Peripapillary chorioretinal atrophy: Bruch's membrane changes and photoreceptor loss. 
  • Pharmacologic purging of malignant T cells from human bone marrow using 9-beta-D-arabinofuranosylguanine. 
  • Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death. 
  • Phosphatidylinositol ether lipid analogues induce AMP-activated protein kinase-dependent death in LKB1-mutant non small cell lung cancer cells. 
  • Phosphodiesterase-4 inhibition restored hippocampal long term potentiation after primary blast. 
  • Photoinactivation of lymphohemopoietic cells: studies in transfusion medicine and bone marrow transplantation. 
  • Photoreceptor apoptosis in animal models. Implications for retinitis pigmentosa research. 
  • Plant "helper" immune receptors are Ca²⁺ -permeable nonselective cation channels. 
  • Platelet-derived growth factor-BB pretreatment attenuates excitotoxic death in cultured hippocampal neurons. 
  • Polymorphisms of FAS and FAS ligand genes involved in the death pathway and risk and progression of squamous cell carcinoma of the head and neck. 
  • Polyploidy and Mitotic Cell Death Are Two Distinct HIV-1 Vpr-Driven Outcomes in Renal Tubule Epithelial Cells. 
  • Post-illumination cellular effects of photodynamic treatment. 
  • Postischemic inhibition of GABA reuptake by tiagabine slows neuronal death in the gerbil hippocampus. 
  • Pre- and postmortem diffusion coefficients in rat neural and muscle tissues. 
  • Preparation, cytotoxicity, and in vivo antitumor efficacy of 111In-labeled modular nanotransporters. 
  • Prochelator BHAPI protects cells against paraquat-induced damage by ROS-triggered iron chelation. 
  • Prochelators triggered by hydrogen peroxide provide hexadentate iron coordination to impede oxidative stress. 
  • Progesterone protects fetal chorion and maternal decidua cells from calcium-induced death. 
  • Programmed cell death as a defence against infection. 
  • Programmed cell death in the lithium pilocarpine model: evidence for NMDA receptor and ceramide-mediated mechanisms. 
  • Programmed necrosis in the cross talk of cell death and inflammation. 
  • Proliferation and differentiation defects during lung development in corticotropin-releasing hormone-deficient mice. 
  • Protein serine/threonine phosphatases: life, death, and sleeping. 
  • Proton-gated ion channels in mouse bone marrow stromal cells. 
  • Quantification of normal cell death in the rat retina: implications for clone composition in cell lineage analysis. 
  • Quantitative morphological assessment reveals neuronal and glial deficits in hippocampus after a brief subtoxic exposure to chlorpyrifos in neonatal rats. 
  • REST and stress resistance in ageing and Alzheimer's disease. 
  • RIPK1 and PGAM5 Control Leishmania Replication through Distinct Mechanisms. 
  • RIPK3 Slams the Brake on Leukemogenesis. 
  • ROCK1 phosphorylates and activates zipper-interacting protein kinase. 
  • Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. 
  • Re-setting the biologic rationale for thermal therapy. 
  • Reciprocal control of Forkhead box O 3a and c-Myc via the phosphatidylinositol 3-kinase pathway coordinately regulates p27Kip1 levels. 
  • Regulation of RIPK3- and RHIM-dependent Necroptosis by the Proteasome. 
  • Regulation of mast cell survival and function by tuberous sclerosis complex 1. 
  • Regulation of tumor necrosis factor cytotoxicity by calcineurin. 
  • Regulatory mechanisms of RIPK1 in cell death and inflammation. 
  • Renal cryoablation and radio frequency ablation: an evaluation of worst case scenarios in a porcine model. 
  • Requirement for superoxide in excitotoxic cell death. 
  • Retinal pigment epithelial cell death by the alternative complement cascade: role of membrane regulatory proteins, calcium, PKC, and oxidative stress. 
  • Rhodopsin transgenic pigs as a model for human retinitis pigmentosa. 
  • Role of Toll-like receptors in HMGB1 release from macrophages. 
  • Role of macrophages in the generation of circulating blood nucleosomes from dead and dying cells. 
  • Role of the GLT-1 subtype of glutamate transporter in glutamate homeostasis: the GLT-1-preferring inhibitor WAY-855 produces marginal neurotoxicity in the rat hippocampus. 
  • Role of tumor suppressor TSC1 in regulating antigen-specific primary and memory CD8 T cell responses to bacterial infection. 
  • SHP-2 is required for the maintenance of cardiac progenitors. 
  • Seeing stars: Development and function of retinal astrocytes. 
  • Seizures, cell death, and mossy fiber sprouting in kainic acid-treated organotypic hippocampal cultures. 
  • Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival. 
  • Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity. 
  • Selective killing of cancer cells harboring mutant RAS by concomitant inhibition of NADPH oxidase and glutathione biosynthesis. 
  • Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved. 
  • Sertraline-induced potentiation of the CYP3A4-dependent neurotoxicity of carbamazepine: an in vitro study. 
  • Signal transduction. Three paths to stress relief. 
  • Similarities and differences in the pathogenesis of alcoholic and nonalcoholic steatohepatitis. 
  • Sonic hedgehog is required for cardiac outflow tract and neural crest cell development. 
  • Stage 2 combination testing of rapamycin with cytotoxic agents by the Pediatric Preclinical Testing Program. 
  • Staying alive: cell death in antiviral immunity. 
  • Suppression of the c-Jun N-terminal kinase pathway by 17beta-estradiol can preserve human islet functional mass from proinflammatory cytokine-induced destruction. 
  • Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death. 
  • Synergistic antitumor effects of 9.2.27-PE38KDEL and ABT-737 in primary and metastatic brain tumors. 
  • Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers. 
  • TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation. 
  • TRPing into excitotoxic neuronal death. 
  • Targeting YAP-mediated HSC death susceptibility and senescence for treatment of liver fibrosis. 
  • The Alarmin Properties of DNA and DNA-associated Nuclear Proteins. 
  • The B cell death function of obinutuzumab-HDEL produced in plant (Nicotiana benthamiana L.) is equivalent to obinutuzumab produced in CHO cells. 
  • The Chlamydia protease CPAF regulates host and bacterial proteins to maintain pathogen vacuole integrity and promote virulence. 
  • The Chlamydia trachomatis Inclusion Membrane Protein CpoS Counteracts STING-Mediated Cellular Surveillance and Suicide Programs. 
  • The MicroRNA miR-191 Supports T Cell Survival Following Common γ Chain Signaling. 
  • The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons. 
  • The Survival of Cone Photoreceptors in Retinitis Pigmentosa. 
  • The autophagy gene ATG5 plays an essential role in B lymphocyte development. 
  • The cell and molecular biology of glaucoma: common neurodegenerative pathways and relevance to glaucoma. 
  • The central effectors of cell death in the immune system. 
  • The control of growth. 
  • The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies. 
  • The death-inducing activity of RIPK1 is regulated by the pH environment. 
  • The development of posttraumatic arthritis after articular fracture. 
  • The effect of hyperbranched polyglycerol coatings on drug delivery using degradable polymer nanoparticles. 
  • The effects of aprotinin on outcome from cerebral ischemia in the rat. 
  • The engine driving the ship: metabolic steering of cell proliferation and death. 
  • The expression of HMGB1 on microparticles released during cell activation and cell death in vitro and in vivo. 
  • The functional age of hearing loss in a mouse model of presbycusis. II. Neuroanatomical correlates. 
  • The generation of extracellular DNA in SLE: the role of death and sex. 
  • The genomic underpinnings of apoptosis in Strongylocentrotus purpuratus. 
  • The immune response to cell death in SLE. 
  • The injured cochlea as a target for inflammatory processes, initiation of cell death pathways and application of related otoprotectives strategies. 
  • The mode of death of pig kidney cells infected with cowpox virus is governed by the expression of the crmA gene. 
  • The oral iron chelator deferiprone protects against iron overload-induced retinal degeneration. 
  • The protein hSnm1B is stabilized when bound to the telomere-binding protein TRF2. 
  • The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion. 
  • The release of microparticles and mitochondria from RAW 264.7 murine macrophage cells undergoing necroptotic cell death in vitro. 
  • The role of cytokines in posttraumatic arthritis. 
  • The role of macrophages in the in vitro generation of extracellular DNA from apoptotic and necrotic cells. 
  • The synergistic combination of the farnesyl transferase inhibitor lonafarnib and paclitaxel enhances tubulin acetylation and requires a functional tubulin deacetylase. 
  • The translocation of nuclear molecules during inflammation and cell death. 
  • The urinary proteome infers dysregulation of mitochondrial, lysosomal, and protein reabsorption processes in chronic kidney disease of unknown etiology (CKDu). 
  • Thresholds for thermal damage to normal tissues: an update. 
  • Toxicity of oxidized low density lipoproteins for vascular smooth muscle cells and partial protection by antioxidants. 
  • Tumor cells, but not endothelial cells, mediate eradication of primary sarcomas by stereotactic body radiation therapy. 
  • Tumor initiating cells in esophageal squamous cell carcinomas express high levels of CD44. 
  • Tumor-intrinsic and immune modulatory roles of receptor-interacting protein kinases. 
  • Use of 1,25α dihydroxyvitamin D3 as a cryosensitizing agent in a murine prostate cancer model. 
  • VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation. 
  • Virally induced lytic cell death elicits the release of immunogenic GRP94/gp96. 
  • Viruses for the treatment of malignant glioma. 
  • Vitamin D(3) cryosensitization increases prostate cancer susceptibility to cryoablation via mitochondrial-mediated apoptosis and necrosis. 
  • Wing morphogenesis in Lepidoptera. 
  • [Synthesis and anti-influenza virus activities of heteropoly compounds containing rare earth elements]. 
  • c-Jun N-terminal kinase activation mediates downregulation of connexin43 in cardiomyocytes. 
  • hBub1 negatively regulates p53 mediated early cell death upon mitotic checkpoint activation. 
  • mGluR modulation of post-traumatic neuronal death: role of NMDA receptors. 
  • p53 and ATM: cell cycle, cell death, and cancer. 
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  Keywords of People

  • Allori, Alexander C, Associate Professor of Surgery, Surgery, Plastic, Maxillofacial, and Oral Surgery
  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Bowes Rickman, Catherine, George and Geneva Boguslavsky Distinguished Professor of Eye Research, Cell Biology
  • Chen, Jun, Professor of Medicine, Duke Cancer Institute
  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Ciofani, Maria, Associate Professor of Integrative Immunobiology, Cell Biology
  • Ferreira, Paulo Alexandre, Associate Professor in Ophthalmology, Pathology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • Miao, Edward A., Professor of Integrative Immunobiology, Cell Biology
  • Olson, Steven Arthur, Goldner Jones Distinguished Professor of Orthopaedic Surgery, Orthopaedic Surgery
  • Tourian, Ara Y., Associate Professor Emeritus of Medicine, Neurology
  • West, Andrew Bradley, Professor of Pharmacology and Cancer Biology, Cell Biology
  • Zhong, Xiaoping, Professor of Pediatrics, Integrative Immunobiology