Protein Tyrosine Phosphatases
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Subject Areas on Research
- A protein microarray-based analysis of S-nitrosylation.
- AKT1 mediates bypass of the G1/S checkpoint after genotoxic stress in normal human cells.
- Abnormal protein tyrosine phosphorylation in fibroblasts from hyperapobetalipoproteinemia subjects.
- Analysis of functional domains of angiotensin II type 2 receptor involved in apoptosis.
- Analytical trapping: extraction of time-independent structures from time-dependent crystallographic data.
- Angiotensin II type 2 receptor mediates programmed cell death.
- Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosis.
- Assessment and application of the biotin switch technique for examining protein S-nitrosylation under conditions of pharmacologically induced oxidative stress.
- Bypass of hexavalent chromium-induced growth arrest by a protein tyrosine phosphatase inhibitor: enhanced survival and mutagenesis.
- Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: a descriptive study.
- Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis.
- Conformation-assisted inhibition of protein-tyrosine phosphatase-1B elicits inhibitor selectivity over T-cell protein-tyrosine phosphatase.
- DNA replication and progression through the cell cycle.
- Deletion of PTEN in a patient with Bannayan-Riley-Ruvalcaba syndrome suggests allelism with Cowden disease.
- Differential susceptibility of yeast S and M phase CDK complexes to inhibitory tyrosine phosphorylation.
- Disruption of Gen1 Causes Congenital Anomalies of the Kidney and Urinary Tract in Mice.
- Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells.
- Effects of valsartan and valeryl 4-hydroxy valsartan on human platelets: a possible additional mechanism for clinical benefits.
- Engagement of the adhesion receptor CD22 triggers a potent stimulatory signal for B cells and blocking CD22/CD22L interactions impairs T-cell proliferation.
- Expression of genes and proteins of the pax-six-eya-dach network in the metamorphic sea urchin: Insights into development of the enigmatic echinoderm body plan and sensory structures.
- Expression of the protein tyrosine phosphatase, phosphatase of regenerating liver 1, in the outer segments of primate cone photoreceptors.
- Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration.
- Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy.
- Genetic diagnosis in Lafora disease: genotype-phenotype correlations and diagnostic pitfalls.
- Genotypic analysis of tumor suppressor genes PTEN/MMAC1 and p53 in head and neck squamous cell carcinomas.
- Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation.
- HCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity.
- Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1.
- Involvement of a mitochondrial phosphatase in the regulation of ATP production and insulin secretion in pancreatic beta cells.
- Knock-down of LAR protein tyrosine phosphatase induces insulin resistance.
- Localization of the VHR phosphatase gene and its analysis as a candidate for BRCA1.
- Meeting report: targeting protein phosphatases-medicines for the new millenium.
- Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
- Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis.
- Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop.
- Molecular and cellular mechanism of angiotensin II-mediated apoptosis.
- Molecular basis of T cell inactivation by CTLA-4.
- Mutation of the PTEN tumor suppressor gene in endometrial hyperplasias.
- Mutation of the PTEN tumor suppressor gene is not a feature of ovarian cancers.
- Mutational analysis of the tyrosine phosphatome in colorectal cancers.
- NHERF1/EBP50 is an organizer of polarity structures and a diagnostic marker in ependymoma.
- Nucleocytoplasmic trafficking of G2/M regulators in yeast.
- Overexpression of the protein tyrosine phosphatase PTP1B in human breast cancer: association with p185c-erbB-2 protein expression.
- Overexpression of the tyrosine phosphatase PTP1B is associated with human ovarian carcinomas.
- Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina.
- PTEN as an effector in the signaling of antimigratory G protein-coupled receptor.
- PTP mu-dependent growth cone rearrangement is regulated by Cdc42.
- Platelet activation after stenting with heparin-coated versus noncoated stents.
- Polo-like kinase 1 enhances survival and mutagenesis after genotoxic stress in normal cells through cell cycle checkpoint bypass.
- Posttranslational control of Cdc25 degradation terminates Drosophila's early cell-cycle program.
- Protein kinase C delta (PKCdelta) is required for protein tyrosine phosphatase mu (PTPmu)-dependent neurite outgrowth.
- Protein tyrosine phosphatase (PTP) inhibition enhances chromosomal stability after genotoxic stress: decreased chromosomal instability (CIN) at the expense of enhanced genomic instability (GIN)?
- Protein tyrosine phosphatase 1B antagonizes signalling by oncoprotein tyrosine kinase p210 bcr-abl in vivo.
- Reciprocal signaling between the transcriptional co-factor Eya2 and specific members of the Galphai family.
- Refinement of the PARK3 locus on chromosome 2p13 and the analysis of 14 candidate genes.
- Regulation of the Saccharomyces cerevisiae Slt2 kinase pathway by the stress-inducible Sdp1 dual specificity phosphatase.
- Regulation of the platelet-derived growth factor receptor-beta by G protein-coupled receptor kinase-5 in vascular smooth muscle cells involves the phosphatase Shp2.
- SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function.
- Salmonella typhimurium impedes innate immunity with a mast-cell-suppressing protein tyrosine phosphatase, SptP.
- Self-antigen-presenting cells expressing diabetes-associated autoantigens exist in both thymus and peripheral lymphoid organs.
- Six1 and Six1 cofactor expression is altered during early skeletal muscle overload in mice.
- Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase.
- Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors.
- Susceptibility to vascular neoplasms but no increased susceptibility to renal carcinogenesis in Vhl knockout mice.
- Synthesis of a novel peptidic photoaffinity probe for the PTP-1B enzyme.
- The Rho-GAP Bem2p plays a GAP-independent role in the morphogenesis checkpoint.
- The Transient Inactivation of the Master Cell Cycle Phosphatase Cdc14 Causes Genomic Instability in Diploid Cells of Saccharomyces cerevisiae.
- The exon A (C77G) mutation is a common cause of abnormal CD45 splicing in humans.
- The receptor protein tyrosine phosphatase mu, PTPmu, regulates histogenesis of the chick retina.
- The structural basis for the selectivity of benzotriazole inhibitors of PTP1B.
- Tyrosine phosphorylation at a site highly conserved in the L1 family of cell adhesion molecules abolishes ankyrin binding and increases lateral mobility of neurofascin.
- Use of protein phosphatase inhibitors.
- VCP is essential for mitochondrial quality control by PINK1/Parkin and this function is impaired by VCP mutations.
- ¹H, ¹³C and ¹⁵N backbone and side-chain resonance assignments of Drosophila melanogaster Ssu72.
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Keywords of People
- Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
- O'Connor, Christopher Michael, Richard Sean Stack, M.D. / Guidant Foundation Distinguished Professor of Cardiology, Medicine, Clinical Pharmacology
- Yan, Hai, Henry S. Friedman Distinguished Professor of Neuro-Oncology in the School of Medicine, Pathology