Exercise Tolerance

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  Subject Areas on Research

  • A 20-yr longitudinal study of Olympic oarsmen. 
  • A Multicenter Randomized Controlled Trial of Zephyr Endobronchial Valve Treatment in Heterogeneous Emphysema (LIBERATE). 
  • A Novel Rehabilitation Intervention for Older Patients With Acute Decompensated Heart Failure: The REHAB-HF Pilot Study. 
  • A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation. 
  • A comparison of quality of life scores in patients with angina pectoris after angioplasty compared with after medical therapy. Outcomes of a randomized clinical trial. Veterans Affairs Study of Angioplasty Compared to Medical Therapy Investigators. 
  • A pilot study of high-intensity interval training in older adults with treatment naïve chronic lymphocytic leukemia. 
  • ACC/AHA 2002 guideline update for exercise testing: summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1997 Exercise Testing Guidelines). 
  • Alteration in angiogenic and anti-angiogenic forms of vascular endothelial growth factor-A in skeletal muscle of patients with intermittent claudication following exercise training. 
  • Altered expression of myosin heavy chain in human skeletal muscle in chronic heart failure. 
  • Altered expression of myosin heavy chain in the vastus lateralis muscle in patients with COPD. 
  • American Thoracic Society/European Respiratory Society statement on pulmonary rehabilitation. 
  • An official European Respiratory Society/American Thoracic Society technical standard: field walking tests in chronic respiratory disease. 
  • An official systematic review of the European Respiratory Society/American Thoracic Society: measurement properties of field walking tests in chronic respiratory disease. 
  • An overview of risk assessment in coronary artery disease. 
  • An unexpected echocardiographic image in a patient with dyspnea. 
  • Another surprise from the mitochondrial genome. 
  • Are We Approaching Chronotropy (In)competently? 
  • Arrhythmias in children having a single left superior vena cava and minimal structural heart disease. 
  • Assessment of functional capacity before major non-cardiac surgery: an international, prospective cohort study. 
  • Association between exercise capacity and left ventricular geometry in overweight patients with mild systemic hypertension. 
  • Association of preoperative anaemia with cardiopulmonary exercise capacity and postoperative outcomes in noncardiac surgery: a substudy of the Measurement of Exercise Tolerance before Surgery (METS) Study. 
  • Autologous CD34+ cell therapy improves exercise capacity, angina frequency and reduces mortality in no-option refractory angina: a patient-level pooled analysis of randomized double-blinded trials. 
  • Beet the Best? 
  • CYP3A4 genotype is associated with sildenafil concentrations in patients with heart failure with preserved ejection fraction. 
  • Capillary density of skeletal muscle: a contributing mechanism for exercise intolerance in class II-III chronic heart failure independent of other peripheral alterations. 
  • Cardiac Rehabilitation in Older Adults with Heart Failure: Fitting a Square Peg in a Round Hole. 
  • Cardiac rehabilitation as secondary prevention. Cardiac Rehabilitation Guideline Panel. 
  • Cardiorespiratory coupling is associated with exercise capacity in patients with chronic obstructive pulmonary disease. 
  • Carotid body resection for sympathetic modulation in systolic heart failure: results from first-in-man study. 
  • Characterization of the Obese Phenotype of Heart Failure With Preserved Ejection Fraction: A RELAX Trial Ancillary Study. 
  • Circulating long chain acylcarnitines and outcomes in diabetic heart failure: an HF-ACTION clinical trial substudy. 
  • Clinical Outcomes and Quality of Life With an Ambulatory Counterpulsation Pump in Advanced Heart Failure Patients: Results of the Multicenter Feasibility Trial. 
  • Clinical and Radiologic Disease in Smokers With Normal Spirometry. 
  • Commentary: The heart of the matter: Close clinical follow-up and exercise capacity in Fontan circulation. 
  • Congenital heart disease and pulmonary hypertension. 
  • Correlations between physician-perceived functional status, patient-perceived health status, and cardiopulmonary exercise results in hypertrophic cardiomyopathy. 
  • Counting Steps: A New Way to Monitor Patients with Pulmonary Arterial Hypertension. 
  • Deconditioning fails to explain peripheral skeletal muscle alterations in men with chronic heart failure. 
  • Defining and refining heart failure risk stratification to optimize patient selection for cardiac transplantation. 
  • Developments in Exercise Capacity Assessment in Heart Failure Clinical Trials and the Rationale for the Design of METEORIC-HF. 
  • Diet and Exercise for Obese Patients With Heart Failure--Reply. 
  • Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. 
  • Differential effects of exercise training in men and women with chronic heart failure. 
  • Disruption of STIM1-mediated Ca2+ sensing and energy metabolism in adult skeletal muscle compromises exercise tolerance, proteostasis, and lean mass. 
  • Effect of Caloric Restriction or Aerobic Exercise Training on Peak Oxygen Consumption and Quality of Life in Obese Older Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial. 
  • Effect of Endobronchial Coils vs Usual Care on Exercise Tolerance in Patients With Severe Emphysema: The RENEW Randomized Clinical Trial. 
  • Effect of Heart Rate Reserve on Exercise Capacity in Patients Treated with a Continuous Left Ventricular Assist Device. 
  • Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction: The INDIE-HFpEF Randomized Clinical Trial. 
  • Effect of Mavacamten on Echocardiographic Features in Symptomatic Patients With Obstructive Hypertrophic Cardiomyopathy. 
  • Effect of Omecamtiv Mecarbil on Exercise Capacity in Chronic Heart Failure With Reduced Ejection Fraction: The METEORIC-HF Randomized Clinical Trial. 
  • Effect of Oral Iron Repletion on Exercise Capacity in Patients With Heart Failure With Reduced Ejection Fraction and Iron Deficiency: The IRONOUT HF Randomized Clinical Trial. 
  • Effect of Spironolactone on Exercise Tolerance and Arterial Function in Older Adults with Heart Failure with Preserved Ejection Fraction. 
  • Effect of Vericiguat vs Placebo on Quality of Life in Patients With Heart Failure and Preserved Ejection Fraction: The VITALITY-HFpEF Randomized Clinical Trial. 
  • Effect of Zephyr Endobronchial Valves on Dyspnea, Activity Levels, and Quality of Life at One Year. Results from a Randomized Clinical Trial. 
  • Effect of inadequate cardiac output reserve on exercise tolerance in patients with moderate mitral stenosis. 
  • Effect of phosphodiesterase-5 inhibition on exercise capacity and clinical status in heart failure with preserved ejection fraction: a randomized clinical trial. 
  • Effect of recombinant human growth hormone on exercise capacity in patients with HIV-associated wasting on HAART. 
  • Effective training for patients with intermittent claudication. 
  • Effects of Exercise Restriction on Patients With Anomalous Aortic Origin of a Coronary Artery. 
  • Effects of Xanthine Oxidase Inhibition in Hyperuricemic Heart Failure Patients: The Xanthine Oxidase Inhibition for Hyperuricemic Heart Failure Patients (EXACT-HF) Study. 
  • Effects of a 12-week mHealth program on peak VO2 and physical activity patterns after completing cardiac rehabilitation: A randomized controlled trial. 
  • Effects of hybrid comprehensive telerehabilitation on cardiopulmonary capacity in heart failure patients depending on diabetes mellitus: subanalysis of the TELEREH-HF randomized clinical trial. 
  • Effects of the Novel Long-Acting GLP-1 Agonist, Albiglutide, on Cardiac Function, Cardiac Metabolism, and Exercise Capacity in Patients With Chronic Heart Failure and Reduced Ejection Fraction. 
  • Endothelial Progenitor Cell Levels Predict Future Physical Function: An Exploratory Analysis From the VA Enhanced Fitness Study. 
  • Epicardial delivery of XC001 gene therapy for refractory angina coronary treatment (The EXACT Trial): Rationale, design, and clinical considerations. 
  • Exercise Capacity and Predictors of Performance After Fontan: Results from the Pediatric Heart Network Fontan 3 Study. 
  • Exercise Intolerance in Older Adults With Heart Failure With Preserved Ejection Fraction: JACC State-of-the-Art Review. 
  • Exercise Training in Patients With Chronic Heart Failure and Atrial Fibrillation. 
  • Exercise blood pressure response during assisted circulatory support: comparison of the total artificial [corrected] heart with a left ventricular assist device during rehabilitation. 
  • Exercise capacity and mortality in patients with ischemic left ventricular dysfunction randomized to coronary artery bypass graft surgery or medical therapy: an analysis from the STICH trial (Surgical Treatment for Ischemic Heart Failure). 
  • Exercise capacity: the prognostic variable that doesn't get enough respect. 
  • Exercise echocardiographic comparison of pulmonary autograft and aortic homograft replacements for aortic valve disease in adults. 
  • Exercise has a disproportionate role in the pathogenesis of arrhythmogenic right ventricular dysplasia/cardiomyopathy in patients without desmosomal mutations. 
  • Exercise outcomes after pulmonary rehabilitation depend on the initial mechanism of exercise limitation among non-oxygen-dependent COPD patients. 
  • Exercise restriction is not associated with increasing body mass index over time in patients with anomalous aortic origin of the coronary arteries. 
  • Exercise training as therapy for heart failure: current status and future directions. 
  • Extracardiac Abnormalities of Preload Reserve: Mechanisms Underlying Exercise Limitation in Heart Failure with Preserved Ejection Fraction, Autonomic Dysfunction, and Liver Disease. 
  • Fatigability, Exercise Intolerance, and Abnormal Skeletal Muscle Energetics in Heart Failure. 
  • Fibroblast Growth Factor 23 and Exercise Capacity in Heart Failure with Preserved Ejection Fraction. 
  • Function Follows Form. 
  • Functional and Symptomatic Clinical Trial Endpoints: The HFC-ARC Scientific Expert Panel. 
  • Functional capacity in men and women following cardiac rehabilitation. 
  • Functional status in left ventricular assist device-supported patients: a literature review. 
  • Galectin-3 in heart failure with preserved ejection fraction. A RELAX trial substudy (Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure). 
  • Gas exchange and exercise capacity affect neurocognitive performance in patients with lung disease. 
  • INDIE-HFpEF (Inorganic Nitrite Delivery to Improve Exercise Capacity in Heart Failure With Preserved Ejection Fraction): Rationale and Design. 
  • Identifying responders to oral iron supplementation in heart failure with a reduced ejection fraction: a post-hoc analysis of the IRONOUT-HF trial. 
  • Impact of Exercise Rehabilitation on Exercise Capacity and Quality-of-Life in Heart Failure: Individual Participant Meta-Analysis. 
  • Impact of atrial fibrillation on exercise capacity in heart failure with preserved ejection fraction: a RELAX trial ancillary study. 
  • Impaired left ventricular global longitudinal strain in patients with heart failure with preserved ejection fraction: insights from the RELAX trial. 
  • Improvements in Functional Exercise Capacity after a Residential Behavioural Change, Diet and Fitness Program for Obese Adults. 
  • Inactivity, exercise training and detraining, and plasma lipoproteins. STRRIDE: a randomized, controlled study of exercise intensity and amount. 
  • Increased myocardial contractility and enhanced exercise function in transgenic mice overexpressing either adenylyl cyclase 5 or 8. 
  • Incremental and independent value of cardiopulmonary exercise test measures and the Seattle Heart Failure Model for prediction of risk in patients with heart failure. 
  • Influence of change in aerobic fitness and weight on prevalence of metabolic syndrome. 
  • Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption. 
  • Inspiratory Muscle Rehabilitation Training in Pediatrics: What Is the Evidence? 
  • Interleukin-1 Blockade in Recently Decompensated Systolic Heart Failure: Results From REDHART (Recently Decompensated Heart Failure Anakinra Response Trial). 
  • Intramyocardial, autologous CD34+ cell therapy for refractory angina. 
  • Iodine-123 MIBG imaging before treatment of heart failure with carvedilol to predict improvement of left ventricular function and exercise capacity. 
  • Isosorbide Mononitrate in Heart Failure with Preserved Ejection Fraction. 
  • Laboratory measures of exercise capacity and ventricular characteristics and function are weakly associated with functional health status after Fontan procedure. 
  • Left Atrial Stiffness Index Independently Predicts Exercise Intolerance and Quality of Life in Older, Obese Patients With Heart Failure With Preserved Ejection Fraction. 
  • Left ventricular diastolic dysfunction and exercise intolerance in obese heart failure with preserved ejection fraction. 
  • Loop diuretic adjustments in patients with chronic heart failure: Insights from HF-ACTION. 
  • Low income as a determinant of exercise capacity in COPD. 
  • Lower levels of circulating progenitor cells are associated with low physical function and performance in elderly men with impaired glucose tolerance: a pilot substudy from the VA Enhanced Fitness trial. 
  • Magnitude of spinal muscle damage is not statistically associated with exercise-induced low back pain intensity. 
  • Making Cardiopulmonary Exercise Testing Interpretable for Clinicians. 
  • Mavacamten Treatment for Obstructive Hypertrophic Cardiomyopathy: A Clinical Trial. 
  • Mavacamten for treatment of symptomatic obstructive hypertrophic cardiomyopathy (EXPLORER-HCM): a randomised, double-blind, placebo-controlled, phase 3 trial. 
  • Measurement of Exercise Tolerance before Surgery (METS) study: a protocol for an international multicentre prospective cohort study of cardiopulmonary exercise testing prior to major non-cardiac surgery. 
  • Modest increase in peak VO2 is related to better clinical outcomes in chronic heart failure patients: results from heart failure and a controlled trial to investigate outcomes of exercise training. 
  • Muscle Oxygen Dynamics During Cycling Exercise in Angina Pectoris Patients. 
  • Myocardial Lipin 1 knockout in mice approximates cardiac effects of human LPIN1 mutations. 
  • Myocardial perfusion, function, and dyssynchrony in patients with heart failure: baseline results from the single-photon emission computed tomography imaging ancillary study of the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION) Trial. 
  • N-terminal pro-brain natriuretic peptide and exercise capacity in chronic heart failure: data from the Heart Failure and a Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION) study. 
  • New Concepts in an Old Disease: Exercise Intolerance in Moderate Mitral Stenosis. 
  • New York Heart Association functional class predicts exercise parameters in the current era. 
  • Nitrate's effect on activity tolerance in heart failure with preserved ejection fraction trial: rationale and design. 
  • Non-emphysematous chronic obstructive pulmonary disease is associated with diabetes mellitus. 
  • Normal skeletal muscle Na(+)-K(+) pump concentration in patients with chronic heart failure. 
  • Novel Methods for Reporting of Exercise Dose and Adherence: An Exploratory Analysis. 
  • Oral Iron Therapy for Heart Failure With Reduced Ejection Fraction: Design and Rationale for Oral Iron Repletion Effects on Oxygen Uptake in Heart Failure. 
  • Outcomes, health policy, and managed care: relationships between patient-reported outcome measures and clinical measures in outpatients with heart failure. 
  • Patient and Caregiver Attitudes and Practices of Exercise in Candidates Listed for Liver Transplantation. 
  • Patient and program outcome assessment in pulmonary rehabilitation: an AACVPR statement. 
  • Patterns and predictors of recovery from exhaustion in older adults: the cardiovascular health study. 
  • PhosphdiesteRasE-5 Inhibition to Improve CLinical Status and EXercise Capacity in Diastolic Heart Failure (RELAX) trial: rationale and design. 
  • Physical Activity, Quality of Life, and Biomarkers in Atrial Fibrillation and Heart Failure With Preserved Ejection Fraction (from the NEAT-HFpEF Trial). 
  • Prognostic validation of the body mass index, airflow obstruction, dyspnea, and exercise capacity (BODE) index in inoperable non-small-cell lung cancer. 
  • Provoked exercise desaturation in patent foramen ovale and impact of percutaneous closure. 
  • Psychosocial Factors, Exercise Adherence, and Outcomes in Heart Failure Patients: Insights From Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION). 
  • Pump speed modulations and sub-maximal exercise tolerance in left ventricular assist device recipients: A double-blind, randomized trial. 
  • Quality of life in heart failure with preserved ejection fraction: importance of obesity, functional capacity, and physical inactivity. 
  • Randomized double-blind trial of darbepoetin alfa in patients with symptomatic heart failure and anemia. 
  • Rationale and Design of the VITALITY-HFpEF Trial. 
  • Regional Adipose Distribution and its Relationship to Exercise Intolerance in Older Obese Patients Who Have Heart Failure With Preserved Ejection Fraction. 
  • Relation between coronary artery stenosis assessed by visual, caliper, and computer methods and exercise capacity in patients with single-vessel coronary artery disease. The Veterans Affairs ACME Investigators. 
  • Relation of Angina Pectoris to Outcomes, Quality of Life, and Response to Exercise Training in Patients With Chronic Heart Failure (from HF-ACTION). 
  • Relation of depression to severity of illness in heart failure (from Heart Failure And a Controlled Trial Investigating Outcomes of Exercise Training [HF-ACTION]). 
  • Relation of left atrial function with exercise capacity and muscle endurance in patients with heart failure. 
  • Relation of size of secondary ventricles to exercise performance in children after fontan operation. 
  • Relationship of age and exercise performance in patients with heart failure: the HF-ACTION study. 
  • Relationships of cardiac, pulmonary, and muscle reserves and frailty to exercise capacity in older women. 
  • Residual functional SYNTAX score by quantitative flow ratio and improvement of exercise capacity after revascularization. 
  • Response to Exercise Training and Outcomes in Patients With Heart Failure and Diabetes Mellitus: Insights From the HF-ACTION Trial. 
  • Resting ventricular-vascular function and exercise capacity in heart failure with preserved ejection fraction: a RELAX trial ancillary study. 
  • Risk Assessment and Comparative Effectiveness of Left Ventricular Assist Device and Medical Management in Ambulatory Heart Failure Patients: The ROADMAP Study 2-Year Results. 
  • Role of Diastolic Function in Preserved Exercise Capacity in Patients with Reduced Ejection Fractions. 
  • Role of noninvasive testing in the clinical evaluation of women with suspected ischemic heart disease: a consensus statement from the American Heart Association. 
  • Safety and Utility of Cardiopulmonary Exercise Testing in Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia. 
  • Sarcopenic obesity and the pathogenesis of exercise intolerance in heart failure with preserved ejection fraction. 
  • Sex differences in the associations among psychological factors and pain report: a novel psychophysical study of patients with chronic low back pain. 
  • Sham trials: benefits and risks for cardiovascular research and patients. 
  • Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort. 
  • Six-minute-walk distance and accelerometry predict outcomes in chronic obstructive pulmonary disease independent of Global Initiative for Chronic Obstructive Lung Disease 2011 Group. 
  • Skeletal muscle abnormalities and exercise intolerance in older patients with heart failure and preserved ejection fraction. 
  • Skeletal muscle abnormalities in heart failure with preserved ejection fraction. 
  • Skeletal muscle capillary density is related to anaerobic threshold and claudication in peripheral artery disease. 
  • Socioeconomic and partner status in chronic heart failure: Relationship to exercise capacity, quality of life, and clinical outcomes. 
  • Splanchnic Nerve Block for Chronic Heart Failure. 
  • Statins and Exercise Training Response in Heart Failure Patients: Insights From HF-ACTION. 
  • Strength training, walking, and social activity improve sleep in nursing home and assisted living residents: randomized controlled trial. 
  • Study Design and Rationale of EXPLORER-HCM: Evaluation of Mavacamten in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy. 
  • Suppression of Tumorigenicity 2 in Heart Failure With Preserved Ejection Fraction. 
  • Surrogate end points in heart failure trials. 
  • Synchronized diaphragmatic stimulation: a case report of a novel extra-cardiac intervention for chronic heart failure. 
  • Testosterone supplementation in heart failure: a meta-analysis. 
  • The RENEW Trial: Efficacy and Safety of Intramyocardial Autologous CD34(+) Cell Administration in Patients With Refractory Angina. 
  • The effect of Aliskiren on exercise capacity in older patients with heart failure and preserved ejection fraction: A randomized, placebo-controlled, double-blind trial. 
  • The effect of beta-adrenergic blockers on the prognostic value of peak exercise oxygen uptake in patients with heart failure. 
  • The effect of progressive resistance training on leg strength, aerobic capacity and functional tasks of daily living in persons with Down syndrome. 
  • The influence of adjuvant therapy on cardiorespiratory fitness in early-stage breast cancer seven years after diagnosis: the Cooper Center Longitudinal Study. 
  • The multicenter study of enhanced external counterpulsation (MUST-EECP): effect of EECP on exercise-induced myocardial ischemia and anginal episodes. 
  • The renin-angiotensin system and prevention of age-related functional decline: where are we now? 
  • The utility of 6-minute walk distance in predicting waitlist mortality for lung transplant candidates. 
  • The utility of preoperative six-minute-walk distance in lung transplantation. 
  • Trajectories of leg strength and gait speed among sedentary older adults: longitudinal pattern of dose response. 
  • Treatment of Chronic Thromboembolic Pulmonary Hypertension: The Role of Medical Therapy and Balloon Pulmonary Angioplasty. 
  • Use of Six-Minute Walk Test to Measure Functional Capacity After Liver Transplantation. 
  • Use of the 6-min walk distance to identify variations in treatment benefits from implantable cardioverter-defibrillator and amiodarone: results from the SCD-HeFT (Sudden Cardiac Death in Heart Failure Trial). 
  • Using the 6-minute walk test to predict disability-free survival after major surgery. 
  • Where does fitness fit in? 
  • l-Citrulline supplementation improves glucose and exercise tolerance in obese male mice. 
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  Keywords of People

  • O'Connor, Christopher Michael, Adjunct Professor in the Department of Medicine, Medicine, Clinical Pharmacology