Genes, Protozoan

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  Subject Areas on Research

  • A bifunctional dihydrofolate synthetase--folylpolyglutamate synthetase in Plasmodium falciparum identified by functional complementation in yeast and bacteria. 
  • A developmental mutation (npfL1) resulting in cell death in Physarum polycephalum. 
  • A linking function for the cellulose-binding protein SP85 in the spore coat of Dictyostelium discoideum. 
  • Cellular and molecular analysis of plasmodium development in Physarum. 
  • Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia. 
  • Discovery of a novel Toxoplasma gondii conoid-associated protein important for parasite resistance to reactive nitrogen intermediates. 
  • Limited geographical origin and global spread of sulfadoxine-resistant dhps alleles in Plasmodium falciparum populations. 
  • Molecular diagnosis of resistance to antimalarial drugs during epidemics and in war zones. 
  • Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia. 
  • Point mutations in dihydrofolate reductase and dihydropteroate synthase genes of Plasmodium falciparum isolates from Venezuela. 
  • Polymorphisms in the K13-propeller gene in artemisinin-susceptible Plasmodium falciparum parasites from Bougoula-Hameau and Bandiagara, Mali. 
  • dictyBase--a Dictyostelium bioinformatics resource update.