Ion Transport

• 

  Subject Areas on Research

  • 17beta-Estradiol inhibits Ca2+-dependent homeostasis of airway surface liquid volume in human cystic fibrosis airway epithelia. 
  • A new face of the Rhesus antigen. 
  • A primary role for K+ and Na+ efflux in the activation of apoptosis. 
  • APOL1 Nephrotoxicity: What Does Ion Transport Have to Do With It? 
  • APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases. 
  • Accessory subunit KChIP2 modulates the cardiac L-type calcium current. 
  • Adenosine triphosphate activates ion permeabilities in biliary epithelial cells. 
  • Agonist-induced coordinated trafficking of functionally related transport proteins for water and ions in cholangiocytes. 
  • An Additional Ca2+ Binding Site Allosterically Controls TMEM16A Activation. 
  • An archaeal histone-like protein regulates gene expression in response to salt stress. 
  • Ankyrin-based cardiac arrhythmias: a new class of channelopathies due to loss of cellular targeting. 
  • Aquaporins and ion conductance. 
  • Asteropsin A: an unusual cystine-crosslinked peptide from porifera enhances neuronal Ca2+ influx. 
  • Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site. 
  • Characterization of Fe(III) sequestration by an analog of the cytotoxic siderophore brasilibactin A: implications for the iron transport mechanism in mycobacteria. 
  • Cl- and K+ transport in human biliary cell lines. 
  • Control of voltage-gated potassium channel Kv2.2 expression by pyruvate-isocitrate cycling regulates glucose-stimulated insulin secretion. 
  • Coupling diurnal cytosolic Ca2+ oscillations to the CAS-IP3 pathway in Arabidopsis. 
  • Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3. 
  • Cystic fibrosis gene mutations and pancreatitis risk: relation to epithelial ion transport and trypsin inhibitor gene mutations. 
  • Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. 
  • Dopamine neuronal transport kinetics and effects of amphetamine. 
  • Drosophila Subdued is a moonlighting transmembrane protein 16 (TMEM16) that transports ions and phospholipids. 
  • Electrocardiographic Early Repolarization: A Scientific Statement From the American Heart Association. 
  • Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells. 
  • FbpA--a bacterial transferrin with more to offer. 
  • Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone. 
  • Genetic control of single lumen formation in the zebrafish gut. 
  • Hepcidin expression in human airway epithelial cells is regulated by interferon-γ. 
  • Human trabecular meshwork cell volume regulation. 
  • Idealization and simulation of single ion channel data. 
  • Identification of a regulated Na/K/Cl cotransport system in a distal nephron cell line. 
  • Inactivation of Mechanically Activated Piezo1 Ion Channels Is Determined by the C-Terminal Extracellular Domain and the Inner Pore Helix. 
  • Involvement of Transient Receptor Potential Cation Channel Member A1 activation in the irritation and pain response elicited by skin-lightening reagent hydroquinone. 
  • Ion-exchange gel regulates neurotransmitter release through the exocytotic fusion pore. 
  • Iron accumulation in bronchial epithelial cells is dependent on concurrent sodium transport. 
  • Mechanism and specificity of lanthanide series cation transport by ionophores A23187, 4-BrA23187, and ionomycin. 
  • Molecular basis of PIP2-dependent regulation of the Ca2+-activated chloride channel TMEM16A. 
  • Molecular underpinning of intracellular pH regulation on TMEM16F. 
  • Muscarinic inhibition of substance P induced ion secretion in piglet jejunum. 
  • NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes. 
  • Potassium is a critical regulator of apoptotic enzymes in vitro and in vivo. 
  • Potassium recycling pathways in the human cochlea. 
  • Regulation of ion transport by the NHERF family of PDZ proteins. 
  • Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney. 
  • TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour. 
  • The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity. 
  • The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae. 
  • The kinetics of dimethylhydroxypyridinone interactions with iron(iii) and the catalysis of iron(iii) ligand exchange reactions: implications for bacterial iron transport and combination chelation therapies. 
  • gamma-Aminobutyric acid(A) neurotransmission and cerebral ischemia. 
  • pH dependence of the Slc4a11-mediated H⁺ conductance is influenced by intracellular lysine residues and modified by disease-linked mutations. 
• 

  Keywords of People

  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology