Stromal Cells
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Subject Areas on Research
- A cell-intrinsic role for CaMKK2 in granulocyte lineage commitment and differentiation.
- A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer.
- A signature of epithelial-mesenchymal plasticity and stromal activation in primary tumor modulates late recurrence in breast cancer independent of disease subtype.
- Addressing cell-sourcing limitations with gene therapy.
- An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus.
- Angiomirs expression profiling in diffuse large B-Cell lymphoma.
- Bile ductules and stromal cells express hedgehog ligands and/or hedgehog target genes in primary biliary cirrhosis.
- Bioluminescence imaging of glucose in tissue surrounding polyurethane and glucose sensor implants.
- Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression.
- Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter.
- CD34+CD38-lin- cord blood cells develop into dendritic cells in human thymic stromal monolayers and thymic nodules.
- CD83 expression influences CD4+ T cell development in the thymus.
- CD90(+) stromal cells are the major source of IL-6, which supports cancer stem-like cells and inflammation in colorectal cancer.
- Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells.
- Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors.
- Characterization of neuronal/glial differentiation of murine adipose-derived adult stromal cells.
- Chemotherapy and the bone marrow stroma.
- Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo.
- Circulating Cancer-Associated Macrophage-Like Cells Differentiate Malignant Breast Cancer and Benign Breast Conditions.
- Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion.
- Clinical Insights Into the Biology and Treatment of Pancreatic Cancer.
- Comparative and functional evaluation of in vitro generated to ex vivo CD8 T cells.
- Cystic nephroma/mixed epithelial stromal tumor: a benign neoplasm with potential for recurrence.
- Cytogenetics and mechanisms of spontaneous abortions: increased apoptosis and decreased cell proliferation in chromosomally abnormal villi.
- Defective pericyte recruitment of villous stromal vessels as the possible etiologic cause of hydropic change in complete hydatidiform mole.
- Determination of estrogen receptor messenger ribonucleic acid (mRNA) and cytochrome P450 aromatase mRNA levels in adipocytes and adipose stromal cells by competitive polymerase chain reaction amplification.
- ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells.
- Embryonic germ cells are capable of adipogenic differentiation in vitro and in vivo.
- Epithelial repair of the uterine cervix: assessment of morphologic features and correlations with cytologic diagnosis.
- Epithelialization of hydrogels achieved by amine functionalization and co-culture with stromal cells.
- Establishment of a Novel Histopathological Classification of High-Grade Serous Ovarian Carcinoma Correlated with Prognostically Distinct Gene Expression Subtypes.
- Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
- Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone.
- Expression profiling of a transformed thymocyte cell line undergoing maturation in vitro identifies multiple genes involved in positive selection.
- FOXP3-positive regulatory T lymphocytes and epithelial FOXP3 expression in synchronous normal, ductal carcinoma in situ, and invasive cancer of the breast.
- Fine-needle aspiration of gastrointestinal stromal tumors.
- Flow cytometric analysis of intercellular adhesion between B-cell precursor acute lymphoblastic leukemic cells and bone marrow stromal cells.
- Galectin-1 accumulation in the ovary carcinoma peritumoral stroma is induced by ovary carcinoma cells and affects both cancer cell proliferation and adhesion to laminin-1 and fibronectin.
- Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus.
- Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation.
- Human bone marrow stromal cell contact and soluble factors have different effects on the survival and proliferation of paediatric B-lineage acute lymphoblastic leukaemic blasts.
- Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma.
- Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer.
- Hypoxia depletes contaminating CD45+ hematopoietic cells from murine bone marrow stromal cell (BMSC) cultures: Methods for BMSC culture purification.
- IFATS collection: Adipose-derived stromal cells improve the foreign body response.
- Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice.
- Increased production of sonic hedgehog by ballooned hepatocytes.
- Induced sensitization of tumor stroma leads to eradication of established cancer by T cells.
- Induction of cyclooxygenase-2 in human endometrial stromal cells by malignant endometrial epithelial cells: evidence for the involvement of extracellularly regulated kinases and CCAAT/enhancer binding proteins.
- Induction of ductal and stromal hyperplasia by basic fibroblast growth factor produced by human pancreatic carcinoma.
- Infection-induced thrombin production: a potential novel mechanism for preterm premature rupture of membranes (PPROM).
- Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression.
- Insights from a chimpanzee adipose stromal cell population: opportunities for adult stem cells to expand primate functional genomics.
- Interleukin-1beta elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinases 1 and 2.
- Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion.
- Isolation and characterization of a novel human prostatic stromal cell culture: DuK50.
- Isolation of Adipogenic and Fibro-Inflammatory Stromal Cell Subpopulations from Murine Intra-Abdominal Adipose Depots.
- KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin.
- LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.
- Late-outgrowth endothelial progenitors from patients with coronary artery disease: endothelialization of confluent stromal cell layers.
- Ligand binding and activation of PPARγ by Firemaster® 550: effects on adipogenesis and osteogenesis in vitro.
- Limited Reporting of Histopathologic Details in a Multi-Institutional Academic Cohort of Phyllodes Tumors: Time for Standardization.
- Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice.
- Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions.
- Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta.
- Marrow cell transplantation for infantile hypophosphatasia.
- Measurement of the growth parameters of precursor B-acute lymphoblastic leukaemic cells in co-culture with bone marrow stromal cells; detection of two cd10 positive populations with different proliferative capacities and survival.
- Menstrual cyclic change of metastin/GPR54 in endometrium.
- Mesenchymal stromal cells alone or expressing interferon-beta suppress pancreatic tumors in vivo, an effect countered by anti-inflammatory treatment.
- Metabolic landscape of the tumor microenvironment at single cell resolution.
- Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition.
- NOTCH signaling in skeletal progenitors is critical for fracture repair.
- NOTCH-Mediated Maintenance and Expansion of Human Bone Marrow Stromal/Stem Cells: A Technology Designed for Orthopedic Regenerative Medicine.
- Neurogenic differentiation of murine and human adipose-derived stromal cells.
- Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation.
- Optimization of a widefield structured illumination microscope for non-destructive assessment and quantification of nuclear features in tumor margins of a primary mouse model of sarcoma.
- Osteopontin promotes CCL5-mesenchymal stromal cell-mediated breast cancer metastasis.
- PDGF-AA mediates mesenchymal stromal cell chemotaxis to the head and neck squamous cell carcinoma tumor microenvironment.
- PDGFRα+ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo.
- Peritoneal and subperitoneal stroma may facilitate regional spread of ovarian cancer.
- Polymorphisms in stromal genes and susceptibility to serous epithelial ovarian cancer: a report from the Ovarian Cancer Association Consortium.
- Rapid healing of femoral defects in rats with low dose sustained BMP2 expression from PEGDA hydrogel microspheres.
- Rational basis for Trk inhibition therapy for prostate cancer.
- Recurrent PDGFRB mutations in unicentric Castleman disease.
- Reduced MFAP5 expression in stroma of gallbladder adenocarcinoma and its potential diagnostic utility.
- Relationship between adipose stromal-vascular cells and adipocytes in human adipose tissue.
- Repair-related activation of hedgehog signaling in stromal cells promotes intrahepatic hypothyroidism.
- Requirement of estrogen receptor alpha DNA-binding domain for HPV oncogene-induced cervical carcinogenesis in mice.
- Role of aromatase in endometrial disease.
- Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer.
- Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts.
- Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones.
- Stromal complement receptor CD21/35 facilitates lymphoid prion colonization and pathogenesis.
- Stromal epigenetic dysregulation is sufficient to initiate mouse prostate cancer via paracrine Wnt signaling.
- Stromal gene signatures in large-B-cell lymphomas.
- Stromal heparan sulfate differentiates neuroblasts to suppress neuroblastoma growth.
- Stromelysin-3 is overexpressed by stromal elements in primary non-small cell lung cancers and regulated by retinoic acid in pulmonary fibroblasts.
- Surface protein characterization of human adipose tissue-derived stromal cells.
- Synergistic enhancement of human bone marrow stromal cell proliferation and osteogenic differentiation on BMP-2-derived and RGD peptide concentration gradients.
- Targeting eNOS in pancreatic cancer.
- Telomere dysfunction causes alveolar stem cell failure.
- Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad.
- Tenascin and microvessel stromal changes in patients with non-Hodgkin's lymphoma are isolated to the sites of disease and vary in correlation to disease activity.
- The dynamics of bone marrow stromal cells in the proliferation of multipotent hematopoietic progenitors by substance P: an understanding of the effects of a neurotransmitter on the differentiating hematopoietic stem cell.
- The effect of alpha1-adrenergic receptor antagonist tamsulosin (Flomax) on iris dilator smooth muscle anatomy.
- The type III transforming growth factor-β receptor inhibits proliferation, migration, and adhesion in human myeloma cells.
- Thrombin expression in prostate: a novel finding.
- Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth.
- Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma.
- Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression.
- Type 2 alveolar cells are stem cells in adult lung.
- Up-regulation of cyclooxygenase-2 expression and prostaglandin synthesis in endometrial stromal cells by malignant endometrial epithelial cells. A paracrine effect mediated by prostaglandin E2 and nuclear factor-kappa B.
- Vasoactive intestinal peptide (VIP) inhibits the proliferation of bone marrow progenitors through the VPAC1 receptor.
- Viable bone marrow stromal cells are required for the in vitro survival of B-cell precursor acute lymphoblastic leukemic cells.
- Vulvar vascular tumors: a clinicopathologic study of 85 patients.
- WT1 and DAX-1 inhibit aromatase P450 expression in human endometrial and endometriotic stromal cells.
- miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.
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Keywords of People
- Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
- Ciofani, Maria, Associate Professor of Immunology, Immunology
- Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology
- Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Immunology
- McCall, Shannon Jones, Associate Professor of Pathology, Pathology
- Pang, Herbert, Adjunct Assistant Professor in the Department of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics
- Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology