Stromal Cells

• 

  Subject Areas on Research

  • A cell-intrinsic role for CaMKK2 in granulocyte lineage commitment and differentiation. 
  • A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. 
  • A signature of epithelial-mesenchymal plasticity and stromal activation in primary tumor modulates late recurrence in breast cancer independent of disease subtype. 
  • Addressing cell-sourcing limitations with gene therapy. 
  • An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus. 
  • Bile ductules and stromal cells express hedgehog ligands and/or hedgehog target genes in primary biliary cirrhosis. 
  • Bioluminescence imaging of glucose in tissue surrounding polyurethane and glucose sensor implants. 
  • Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression. 
  • Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter. 
  • CD34+CD38-lin- cord blood cells develop into dendritic cells in human thymic stromal monolayers and thymic nodules. 
  • CD83 expression influences CD4+ T cell development in the thymus. 
  • CD90(+) stromal cells are the major source of IL-6, which supports cancer stem-like cells and inflammation in colorectal cancer. 
  • Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells. 
  • Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors. 
  • Characterization of neuronal/glial differentiation of murine adipose-derived adult stromal cells. 
  • Chemotherapy and the bone marrow stroma. 
  • Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo. 
  • Circulating Cancer-Associated Macrophage-Like Cells Differentiate Malignant Breast Cancer and Benign Breast Conditions. 
  • Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion. 
  • Clinical Insights Into the Biology and Treatment of Pancreatic Cancer. 
  • Comparative and functional evaluation of in vitro generated to ex vivo CD8 T cells. 
  • Correspondence Re: Demarchi LMMF, Reis MM, Palomina SAP, Farhat C, Takagaki TY, Beyruti R, et al. Prognostic values of stromal proportion and PCNA, Ki-67, and p53 proteins in patients with resected adenocarcinoma of the lung. MOD Pathol 2000; 13:511-20. 
  • Cytogenetics and mechanisms of spontaneous abortions: increased apoptosis and decreased cell proliferation in chromosomally abnormal villi. 
  • Defective pericyte recruitment of villous stromal vessels as the possible etiologic cause of hydropic change in complete hydatidiform mole. 
  • Determination of estrogen receptor messenger ribonucleic acid (mRNA) and cytochrome P450 aromatase mRNA levels in adipocytes and adipose stromal cells by competitive polymerase chain reaction amplification. 
  • ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells. 
  • Embryonic germ cells are capable of adipogenic differentiation in vitro and in vivo. 
  • Epithelial repair of the uterine cervix: assessment of morphologic features and correlations with cytologic diagnosis. 
  • Epithelialization of hydrogels achieved by amine functionalization and co-culture with stromal cells. 
  • Establishment of a Novel Histopathological Classification of High-Grade Serous Ovarian Carcinoma Correlated with Prognostically Distinct Gene Expression Subtypes. 
  • Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot". 
  • Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone. 
  • Expression of androgen and estrogen related proteins in normal weight and obese prostate cancer patients. 
  • Expression profiling of a transformed thymocyte cell line undergoing maturation in vitro identifies multiple genes involved in positive selection. 
  • FOXP3-positive regulatory T lymphocytes and epithelial FOXP3 expression in synchronous normal, ductal carcinoma in situ, and invasive cancer of the breast. 
  • Fine-needle aspiration of gastrointestinal stromal tumors. 
  • Flow cytometric analysis of intercellular adhesion between B-cell precursor acute lymphoblastic leukemic cells and bone marrow stromal cells. 
  • Functional analysis of two distinct bronchiolar progenitors during lung injury and repair. 
  • Galectin-1 accumulation in the ovary carcinoma peritumoral stroma is induced by ovary carcinoma cells and affects both cancer cell proliferation and adhesion to laminin-1 and fibronectin. 
  • Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation. 
  • Human bone marrow stromal cell contact and soluble factors have different effects on the survival and proliferation of paediatric B-lineage acute lymphoblastic leukaemic blasts. 
  • Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma. 
  • Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer. 
  • IFATS collection: Adipose-derived stromal cells improve the foreign body response. 
  • Increased production of sonic hedgehog by ballooned hepatocytes. 
  • Induced sensitization of tumor stroma leads to eradication of established cancer by T cells. 
  • Induction of cyclooxygenase-2 in human endometrial stromal cells by malignant endometrial epithelial cells: evidence for the involvement of extracellularly regulated kinases and CCAAT/enhancer binding proteins. 
  • Induction of ductal and stromal hyperplasia by basic fibroblast growth factor produced by human pancreatic carcinoma. 
  • Infection-induced thrombin production: a potential novel mechanism for preterm premature rupture of membranes (PPROM). 
  • Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression. 
  • Insight into the molecular pathophysiology of myelodysplastic syndromes: targets for novel therapy. 
  • Insights from a chimpanzee adipose stromal cell population: opportunities for adult stem cells to expand primate functional genomics. 
  • Interleukin-1beta elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinases 1 and 2. 
  • Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion. 
  • Isolation and characterization of a novel human prostatic stromal cell culture: DuK50. 
  • KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin. 
  • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. 
  • Late-outgrowth endothelial progenitors from patients with coronary artery disease: endothelialization of confluent stromal cell layers. 
  • Ligand binding and activation of PPARγ by Firemaster® 550: effects on adipogenesis and osteogenesis in vitro. 
  • Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice. 
  • Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions. 
  • Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta. 
  • Marrow cell transplantation for infantile hypophosphatasia. 
  • Measurement of the growth parameters of precursor B-acute lymphoblastic leukaemic cells in co-culture with bone marrow stromal cells; detection of two cd10 positive populations with different proliferative capacities and survival. 
  • Menstrual cyclic change of metastin/GPR54 in endometrium. 
  • Mesenchymal stromal cells alone or expressing interferon-beta suppress pancreatic tumors in vivo, an effect countered by anti-inflammatory treatment. 
  • Metabolic landscape of the tumor microenvironment at single cell resolution. 
  • Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition. 
  • NOTCH signaling in skeletal progenitors is critical for fracture repair. 
  • NOTCH-Mediated Maintenance and Expansion of Human Bone Marrow Stromal/Stem Cells: A Technology Designed for Orthopedic Regenerative Medicine. 
  • Neurogenic differentiation of murine and human adipose-derived stromal cells. 
  • Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation. 
  • Optimization of a widefield structured illumination microscope for non-destructive assessment and quantification of nuclear features in tumor margins of a primary mouse model of sarcoma. 
  • Osteopontin promotes CCL5-mesenchymal stromal cell-mediated breast cancer metastasis. 
  • PDGF-AA mediates mesenchymal stromal cell chemotaxis to the head and neck squamous cell carcinoma tumor microenvironment. 
  • PDGFRα + pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo. 
  • Peritoneal and subperitoneal stroma may facilitate regional spread of ovarian cancer. 
  • Polymorphisms in stromal genes and susceptibility to serous epithelial ovarian cancer: a report from the Ovarian Cancer Association Consortium. 
  • Rapid healing of femoral defects in rats with low dose sustained BMP2 expression from PEGDA hydrogel microspheres. 
  • Rational basis for Trk inhibition therapy for prostate cancer. 
  • Reduced MFAP5 expression in stroma of gallbladder adenocarcinoma and its potential diagnostic utility. 
  • Relationship between adipose stromal-vascular cells and adipocytes in human adipose tissue. 
  • Repair-related activation of hedgehog signaling in stromal cells promotes intrahepatic hypothyroidism. 
  • Requirement of estrogen receptor alpha DNA-binding domain for HPV oncogene-induced cervical carcinogenesis in mice. 
  • Role of aromatase in endometrial disease. 
  • Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer. 
  • Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts. 
  • Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones. 
  • Stromal complement receptor CD21/35 facilitates lymphoid prion colonization and pathogenesis. 
  • Stromal gene signatures in large-B-cell lymphomas. 
  • Stromal heparan sulfate differentiates neuroblasts to suppress neuroblastoma growth. 
  • Stromelysin-3 is overexpressed by stromal elements in primary non-small cell lung cancers and regulated by retinoic acid in pulmonary fibroblasts. 
  • Surface protein characterization of human adipose tissue-derived stromal cells. 
  • Synergistic enhancement of human bone marrow stromal cell proliferation and osteogenic differentiation on BMP-2-derived and RGD peptide concentration gradients. 
  • Targeting eNOS in pancreatic cancer. 
  • Telomere dysfunction causes alveolar stem cell failure. 
  • Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad. 
  • Tenascin and microvessel stromal changes in patients with non-Hodgkin's lymphoma are isolated to the sites of disease and vary in correlation to disease activity. 
  • The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease. 
  • The dynamics of bone marrow stromal cells in the proliferation of multipotent hematopoietic progenitors by substance P: an understanding of the effects of a neurotransmitter on the differentiating hematopoietic stem cell. 
  • The effect of alpha1-adrenergic receptor antagonist tamsulosin (Flomax) on iris dilator smooth muscle anatomy. 
  • The type III transforming growth factor-β receptor inhibits proliferation, migration, and adhesion in human myeloma cells. 
  • Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression. 
  • Type 2 alveolar cells are stem cells in adult lung. 
  • Up-regulation of cyclooxygenase-2 expression and prostaglandin synthesis in endometrial stromal cells by malignant endometrial epithelial cells. A paracrine effect mediated by prostaglandin E2 and nuclear factor-kappa B. 
  • Vasoactive intestinal peptide (VIP) inhibits the proliferation of bone marrow progenitors through the VPAC1 receptor. 
  • Viable bone marrow stromal cells are required for the in vitro survival of B-cell precursor acute lymphoblastic leukemic cells. 
  • Vulvar vascular tumors: a clinicopathologic study of 85 patients. 
  • WT1 and DAX-1 inhibit aromatase P450 expression in human endometrial and endometriotic stromal cells. 
  • miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis. 
• 

  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Ciofani, Maria, Associate Professor of Immunology, Immunology
  • Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology
  • Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Immunology
  • McCall, Shannon Jones, Associate Professor of Pathology, Pathology
  • Pang, Herbert, Adjunct Assistant Professor in the Department of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
  • Wray, Gregory Allan, Professor of Biology, Duke Innovation & Entrepreneurship