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Subject Areas on Research
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A cell-intrinsic role for CaMKK2 in granulocyte lineage commitment and differentiation.
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A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer.
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A signature of epithelial-mesenchymal plasticity and stromal activation in primary tumor modulates late recurrence in breast cancer independent of disease subtype.
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Addressing cell-sourcing limitations with gene therapy.
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An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus.
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Bile ductules and stromal cells express hedgehog ligands and/or hedgehog target genes in primary biliary cirrhosis.
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Bioluminescence imaging of glucose in tissue surrounding polyurethane and glucose sensor implants.
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Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression.
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Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter.
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CD34+CD38-lin- cord blood cells develop into dendritic cells in human thymic stromal monolayers and thymic nodules.
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CD83 expression influences CD4+ T cell development in the thymus.
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CD90(+) stromal cells are the major source of IL-6, which supports cancer stem-like cells and inflammation in colorectal cancer.
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Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells.
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Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors.
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Characterization of neuronal/glial differentiation of murine adipose-derived adult stromal cells.
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Chemotherapy and the bone marrow stroma.
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Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo.
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Circulating Cancer-Associated Macrophage-Like Cells Differentiate Malignant Breast Cancer and Benign Breast Conditions.
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Clinical Insights Into the Biology and Treatment of Pancreatic Cancer.
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Comparative and functional evaluation of in vitro generated to ex vivo CD8 T cells.
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Correspondence Re: Demarchi LMMF, Reis MM, Palomina SAP, Farhat C, Takagaki TY, Beyruti R, et al. Prognostic values of stromal proportion and PCNA, Ki-67, and p53 proteins in patients with resected adenocarcinoma of the lung. MOD Pathol 2000; 13:511-20.
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Cytogenetics and mechanisms of spontaneous abortions: increased apoptosis and decreased cell proliferation in chromosomally abnormal villi.
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Defective pericyte recruitment of villous stromal vessels as the possible etiologic cause of hydropic change in complete hydatidiform mole.
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Determination of estrogen receptor messenger ribonucleic acid (mRNA) and cytochrome P450 aromatase mRNA levels in adipocytes and adipose stromal cells by competitive polymerase chain reaction amplification.
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ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells.
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Embryonic germ cells are capable of adipogenic differentiation in vitro and in vivo.
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Epithelial repair of the uterine cervix: assessment of morphologic features and correlations with cytologic diagnosis.
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Epithelialization of hydrogels achieved by amine functionalization and co-culture with stromal cells.
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Establishment of a Novel Histopathological Classification of High-Grade Serous Ovarian Carcinoma Correlated with Prognostically Distinct Gene Expression Subtypes.
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Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
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Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone.
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Expression of androgen and estrogen related proteins in normal weight and obese prostate cancer patients.
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Expression profiling of a transformed thymocyte cell line undergoing maturation in vitro identifies multiple genes involved in positive selection.
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FOXP3-positive regulatory T lymphocytes and epithelial FOXP3 expression in synchronous normal, ductal carcinoma in situ, and invasive cancer of the breast.
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Fine-needle aspiration of gastrointestinal stromal tumors.
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Flow cytometric analysis of intercellular adhesion between B-cell precursor acute lymphoblastic leukemic cells and bone marrow stromal cells.
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Functional analysis of two distinct bronchiolar progenitors during lung injury and repair.
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Galectin-1 accumulation in the ovary carcinoma peritumoral stroma is induced by ovary carcinoma cells and affects both cancer cell proliferation and adhesion to laminin-1 and fibronectin.
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Glucocorticoid-induced osteogenesis is negatively regulated by Runx2/Cbfa1 serine phosphorylation.
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Human bone marrow stromal cell contact and soluble factors have different effects on the survival and proliferation of paediatric B-lineage acute lymphoblastic leukaemic blasts.
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Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma.
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Hypermethylation of 14-3-3 sigma (stratifin) is an early event in breast cancer.
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IFATS collection: Adipose-derived stromal cells improve the foreign body response.
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Increased production of sonic hedgehog by ballooned hepatocytes.
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Induced sensitization of tumor stroma leads to eradication of established cancer by T cells.
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Induction of cyclooxygenase-2 in human endometrial stromal cells by malignant endometrial epithelial cells: evidence for the involvement of extracellularly regulated kinases and CCAAT/enhancer binding proteins.
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Induction of ductal and stromal hyperplasia by basic fibroblast growth factor produced by human pancreatic carcinoma.
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Infection-induced thrombin production: a potential novel mechanism for preterm premature rupture of membranes (PPROM).
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Inflammation controls B lymphopoiesis by regulating chemokine CXCL12 expression.
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Insight into the molecular pathophysiology of myelodysplastic syndromes: targets for novel therapy.
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Insights from a chimpanzee adipose stromal cell population: opportunities for adult stem cells to expand primate functional genomics.
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Interleukin-1beta elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinases 1 and 2.
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Intrathecal bone marrow stromal cells inhibit neuropathic pain via TGF-β secretion.
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Isolation and characterization of a novel human prostatic stromal cell culture: DuK50.
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KRAS2 mutations in human pancreatic acinar-ductal metaplastic lesions are limited to those with PanIN: implications for the human pancreatic cancer cell of origin.
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LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.
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Late-outgrowth endothelial progenitors from patients with coronary artery disease: endothelialization of confluent stromal cell layers.
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Ligand binding and activation of PPARγ by Firemaster® 550: effects on adipogenesis and osteogenesis in vitro.
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Macrophage cells secrete factors including LRP1 that orchestrate the rejuvenation of bone repair in mice.
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Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions.
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Malignant breast epithelial cells stimulate aromatase expression via promoter II in human adipose fibroblasts: an epithelial-stromal interaction in breast tumors mediated by CCAAT/enhancer binding protein beta.
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Marrow cell transplantation for infantile hypophosphatasia.
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Measurement of the growth parameters of precursor B-acute lymphoblastic leukaemic cells in co-culture with bone marrow stromal cells; detection of two cd10 positive populations with different proliferative capacities and survival.
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Menstrual cyclic change of metastin/GPR54 in endometrium.
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Mesenchymal stromal cells alone or expressing interferon-beta suppress pancreatic tumors in vivo, an effect countered by anti-inflammatory treatment.
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Metabolic landscape of the tumor microenvironment at single cell resolution.
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Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition.
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NOTCH signaling in skeletal progenitors is critical for fracture repair.
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NOTCH-Mediated Maintenance and Expansion of Human Bone Marrow Stromal/Stem Cells: A Technology Designed for Orthopedic Regenerative Medicine.
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Neurogenic differentiation of murine and human adipose-derived stromal cells.
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Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation.
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Optimization of a widefield structured illumination microscope for non-destructive assessment and quantification of nuclear features in tumor margins of a primary mouse model of sarcoma.
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Osteopontin promotes CCL5-mesenchymal stromal cell-mediated breast cancer metastasis.
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PDGF-AA mediates mesenchymal stromal cell chemotaxis to the head and neck squamous cell carcinoma tumor microenvironment.
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PDGFRα
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pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo.
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Peritoneal and subperitoneal stroma may facilitate regional spread of ovarian cancer.
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Polymorphisms in stromal genes and susceptibility to serous epithelial ovarian cancer: a report from the Ovarian Cancer Association Consortium.
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Rapid healing of femoral defects in rats with low dose sustained BMP2 expression from PEGDA hydrogel microspheres.
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Rational basis for Trk inhibition therapy for prostate cancer.
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Relationship between adipose stromal-vascular cells and adipocytes in human adipose tissue.
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Repair-related activation of hedgehog signaling in stromal cells promotes intrahepatic hypothyroidism.
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Requirement of estrogen receptor alpha DNA-binding domain for HPV oncogene-induced cervical carcinogenesis in mice.
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Role of aromatase in endometrial disease.
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Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer.
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Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts.
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Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones.
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Stromal complement receptor CD21/35 facilitates lymphoid prion colonization and pathogenesis.
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Stromal cues regulate the pancreatic cancer epigenome and metabolome.
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Stromal gene signatures in large-B-cell lymphomas.
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Stromal heparan sulfate differentiates neuroblasts to suppress neuroblastoma growth.
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Stromelysin-3 is overexpressed by stromal elements in primary non-small cell lung cancers and regulated by retinoic acid in pulmonary fibroblasts.
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Surface protein characterization of human adipose tissue-derived stromal cells.
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Synergistic enhancement of human bone marrow stromal cell proliferation and osteogenic differentiation on BMP-2-derived and RGD peptide concentration gradients.
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Targeting eNOS in pancreatic cancer.
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Telomere dysfunction causes alveolar stem cell failure.
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Temporal transcriptional profiling of somatic and germ cells reveals biased lineage priming of sexual fate in the fetal mouse gonad.
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Tenascin and microvessel stromal changes in patients with non-Hodgkin's lymphoma are isolated to the sites of disease and vary in correlation to disease activity.
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The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease.
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The dynamics of bone marrow stromal cells in the proliferation of multipotent hematopoietic progenitors by substance P: an understanding of the effects of a neurotransmitter on the differentiating hematopoietic stem cell.
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The effect of alpha1-adrenergic receptor antagonist tamsulosin (Flomax) on iris dilator smooth muscle anatomy.
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The type III transforming growth factor-β receptor inhibits proliferation, migration, and adhesion in human myeloma cells.
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Type 2 alveolar cells are stem cells in adult lung.
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Up-regulation of cyclooxygenase-2 expression and prostaglandin synthesis in endometrial stromal cells by malignant endometrial epithelial cells. A paracrine effect mediated by prostaglandin E2 and nuclear factor-kappa B.
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Vasoactive intestinal peptide (VIP) inhibits the proliferation of bone marrow progenitors through the VPAC1 receptor.
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Viable bone marrow stromal cells are required for the in vitro survival of B-cell precursor acute lymphoblastic leukemic cells.
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Vulvar vascular tumors: a clinicopathologic study of 85 patients.
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WT1 and DAX-1 inhibit aromatase P450 expression in human endometrial and endometriotic stromal cells.
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miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis.
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Ciofani, Maria,
Associate Professor of Immunology,
Immunology
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Hogan, Brigid L. M.,
George Barth Geller Distinguished Professor for Research in Molecular Biology,
Cell Biology
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Kelsoe, Garnett H.,
James B. Duke Distinguished Professor of Immunology,
Immunology
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McCall, Shannon Jones,
Associate Professor of Pathology,
Pathology
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Pang, Herbert,
Adjunct Assistant Professor in the Department of Biostatistics and Bioinformatics,
Biostatistics & Bioinformatics
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Wray, Gregory Allan,
Professor of Biology,
Duke Innovation & Entrepreneurship