Treatment Failure

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  Subject Areas on Research

  • A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation. 
  • A comparison of the minimally invasive dual-incision versus posterolateral approach in total hip arthroplasty. 
  • A diagnostic for Cox regression with discrete failure-time models. 
  • A pharmacogenetic versus a clinical algorithm for warfarin dosing. 
  • A phase II trial of temsirolimus in men with castration-resistant metastatic prostate cancer. 
  • A placebo-controlled randomized trial of warfarin in idiopathic pulmonary fibrosis. 
  • A randomized trial of intravenous heparin in conjunction with anistreplase (anisoylated plasminogen streptokinase activator complex) in acute myocardial infarction: the Duke University Clinical Cardiology Study (DUCCS) 1. 
  • A randomized, double-blind, placebo-controlled trial of augmentation with an extended release formulation of methylphenidate in outpatients with treatment-resistant depression. 
  • A recurrent cerebral arteriovenous malformation in an adult. 
  • A safe and feasible "clock-face" duct-to-mucosa pancreaticojejunostomy with a very low incidence of anastomotic failure: A single center experience of 248 patients. 
  • A systematic review of syphilis serological treatment outcomes in HIV-infected and HIV-uninfected persons: rethinking the significance of serological non-responsiveness and the serofast state after therapy. 
  • Accessory veins in nonmaturing autogenous arteriovenous fistulae: analysis of anatomic features and impact on fistula maturation. 
  • Adalimumab for prevention of uveitic flare in patients with inactive non-infectious uveitis controlled by corticosteroids (VISUAL II): a multicentre, double-masked, randomised, placebo-controlled phase 3 trial. 
  • Adalimumab in Patients with Active Noninfectious Uveitis. 
  • Adjuvant radiotherapy for pathologic stage T3/4 adenocarcinoma of the prostate: ten-year update. 
  • Alteration of the tumor suppressor gene p53 in a high fraction of hormone refractory prostate cancer. 
  • An effective preoperative three-dimensional radiotherapy target volume for extremity soft tissue sarcoma and the effect of margin width on local control. 
  • Analysis of failures after vascularized fibular grafting in femoral head necrosis. 
  • Analysis of outcomes following failed endovascular treatment of chronic limb ischemia. 
  • Analysis of site performance in academic-based and community-based centers in the IDEAL Study. 
  • Ankle arthrodesis after failed total ankle replacement: a systematic review of the literature. 
  • Apical soft tissue biopsies predict biochemical failure in radical perineal prostatectomy patients with apical cancer involvement. 
  • Appendiceal carcinoma: patterns of failure following surgery and implications for adjuvant therapy. 
  • Application of a molecular marker for surveillance of chloroquine-resistant falciparum malaria. 
  • Association between the pharmacokinetics and in vivo therapeutic efficacy of sulfadoxine-pyrimethamine in Malawian children. 
  • Association of a Novel Mutation in the Plasmodium falciparum Chloroquine Resistance Transporter With Decreased Piperaquine Sensitivity. 
  • Atypical immunologic response in a patient with CRIM-negative Pompe disease. 
  • Autogenous tendon graft substitution for absent knee joint meniscus: a pilot study. 
  • B7-h1 as a biomarker for therapy failure in patients with favorable histology Wilms tumor. 
  • Benefits, risk, and uncertainty: preferences of antiretroviral-naïve African Americans for HIV treatments. 
  • Bevacizumab fails to treat temporal paraganglioma: discussion and case illustration. 
  • Biochemical modulation of 5-fluorouacil through dihydropyrimidine dehydrogenase inhibition: a Southwest Oncology Group phase II trial of eniluracil and 5-fluorouracil in advanced resistant colorectal cancer. 
  • Blood folate concentrations and in vivo sulfadoxine-pyrimethamine failure in Malawian children with uncomplicated Plasmodium falciparum malaria. 
  • Boceprevir for chronic HCV genotype 1 infection in patients with prior treatment failure to peginterferon/ribavirin, including prior null response. 
  • Bony Lateral Recess Stenosis and Other Radiographic Predictors of Failed Indirect Decompression via Extreme Lateral Interbody Fusion: Multi-Institutional Analysis of 101 Consecutive Spinal Levels. 
  • Bovine xenograft failures in pediatric foot reconstructive surgery. 
  • Brincidofovir for Asymptomatic Adenovirus Viremia in Pediatric and Adult Allogeneic Hematopoietic Cell Transplant Recipients: A Randomized Placebo-Controlled Phase II Trial. 
  • CALGB 80403 (Alliance)/E1206: A Randomized Phase II Study of Three Chemotherapy Regimens Plus Cetuximab in Metastatic Esophageal and Gastroesophageal Junction Cancers. 
  • Can we predict which patients with refractory dyspnea will respond to opioids? 
  • Carbapenems for surgical prophylaxis? 
  • Cerebrospinal fluid shunt survival and etiology of failures: a seven-year institutional experience. 
  • Change in Anterior Cruciate Ligament Graft Choice and Outcomes Over Time. 
  • Changes in plasma HIV RNA levels and CD4+ lymphocyte counts predict both response to antiretroviral therapy and therapeutic failure. VA Cooperative Study Group on AIDS. 
  • Characterization and predictors of prostate specific antigen progression rates after radical retropubic prostatectomy. 
  • Characterization of Death in Neonatal Encephalopathy in the Hypothermia Era. 
  • Characterization of alpha-toxin hla gene variants, alpha-toxin expression levels, and levels of antibody to alpha-toxin in hemodialysis and postsurgical patients with Staphylococcus aureus bacteremia. 
  • Chemoreirradiation for recurrent salivary gland malignancies. 
  • Chest wall invasive non-small cell lung cancer: patterns of failure and implications for a revised staging system. 
  • Clinical and angiographic efficacy of a self-expanding nitinol stent in saphenous vein graft atherosclerotic disease: the Stent Comparative Restenosis (SCORES) Saphenous Vein Graft Registry. 
  • Clinical risks and healthcare utilization of hematopoietic cell transplantation for sickle cell disease in the USA using merged databases. 
  • Clopidogrel efficacy and cigarette smoking status. 
  • Comparative effectiveness of second-line targeted therapies for metastatic renal cell carcinoma: synthesis of findings from two multi-practice chart reviews in the United States. 
  • Comparison of attachment site endoleak rates in Dacron versus native aorta landing zones after thoracic endovascular aortic repair. 
  • Comparison of transposed brachiobasilic fistulas to upper arm grafts and brachiocephalic fistulas. 
  • Complications and failures of subclavian-vein catheterization. 
  • Conservative Care in Lumbar Spine Surgery Trials: A Descriptive Literature Review. 
  • Constructing unit-specific empiric treatment guidelines for catheter-related and primary bacteremia by determining the likelihood of inadequate therapy. 
  • Continuous 12-lead ST-segment recovery analysis in the TAMI 7 study. Performance of a noninvasive method for real-time detection of failed myocardial reperfusion. 
  • Contrast enhancement on computed tomography after renal cryoablation: an evidence of treatment failure? 
  • Conversion to atorvastatin in patients intolerant or refractory to simvastatin therapy: the CAPISH study. 
  • Correlation of prostate-specific antigen nadir and biochemical failure after high-intensity focused ultrasound of localized prostate cancer based on the Stuttgart failure criteria - analysis from the @-Registry. 
  • Correlations between epicardial flow, microvascular reperfusion, infarct size and clinical outcomes in patients with anterior versus non-anterior myocardial infarction treated with primary or rescue angioplasty: analysis from the EMERALD trial. 
  • Cost-Effectiveness of Screening for Primary Aldosteronism and Subtype Diagnosis in the Resistant Hypertensive Patients. 
  • Cromolyn cream for recalcitrant idiopathic vulvar vestibulitis: results of a placebo controlled study. 
  • Current indication of a modified Sugiura procedure in the management of variceal bleeding. 
  • Current indications for hand and face allotransplantation. 
  • Daptomycin resistance in enterococci is associated with distinct alterations of cell membrane phospholipid content. 
  • Darapladib for preventing ischemic events in stable coronary heart disease. 
  • Definitive Management of Failure After Pyeloplasty. 
  • Detection of minor drug-resistant populations by parallel allele-specific sequencing. 
  • Determinants of peritoneal dialysis technique failure in incident US patients. 
  • Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis. 
  • Differential effects of donor-specific alloantibody. 
  • Docetaxel and dasatinib or placebo in men with metastatic castration-resistant prostate cancer (READY): a randomised, double-blind phase 3 trial. 
  • Drotrecogin alfa (activated) in adults with septic shock. 
  • Drug susceptibility and resistance mutations after first-line failure in resource limited settings. 
  • Duchenne muscular dystrophy and steroids: pharmacologic treatment in the absence of effective gene therapy. 
  • Durability and cost-effectiveness of transurethral needle ablation of the prostate as an alternative to transurethral resection of the prostate when alpha-adrenergic antagonist therapy fails. 
  • Durability of antiretroviral therapy and predictors of virologic failure among perinatally HIV-infected children in Tanzania: a four-year follow-up. 
  • ECT failure rate among specific devices. 
  • Early Caffeine Prophylaxis and Risk of Failure of Initial Continuous Positive Airway Pressure in Very Low Birth Weight Infants. 
  • Early failure of frontline rituximab-containing chemo-immunotherapy in diffuse large B cell lymphoma does not predict futility of autologous hematopoietic cell transplantation. 
  • Early postpartum endometritis. Randomized comparison of ampicillin/sulbactam vs. ampicillin, gentamicin and clindamycin. 
  • Early prostate cancer: prevention, treatment modalities, and quality of life issues. 
  • Early versus delayed hormonal therapy for prostate specific antigen only recurrence of prostate cancer after radical prostatectomy. 
  • Early versus delayed, provisional eptifibatide in acute coronary syndromes. 
  • Edatrexate (10-ethyl-deaza-aminopterin) (NSC #626715) with or without leucovorin rescue for malignant mesothelioma. Sequential phase II trials by the cancer and leukemia group B. 
  • Efavirenz Therapeutic Range in HIV-1 Treatment-Naive Participants. 
  • Effect of Depth and Duration of Cooling on Death or Disability at Age 18 Months Among Neonates With Hypoxic-Ischemic Encephalopathy: A Randomized Clinical Trial. 
  • Effect of Natriuretic Peptide-Guided Therapy on Hospitalization or Cardiovascular Mortality in High-Risk Patients With Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial. 
  • Effect of Uterosacral Ligament Suspension vs Sacrospinous Ligament Fixation With or Without Perioperative Behavioral Therapy for Pelvic Organ Vaginal Prolapse on Surgical Outcomes and Prolapse Symptoms at 5 Years in the OPTIMAL Randomized Clinical Trial. 
  • Effect of amifostine on survival among patients treated with radiotherapy: a meta-analysis of individual patient data. 
  • Effect of nateglinide on the incidence of diabetes and cardiovascular events. 
  • Effect of needle size on success of transarterial axillary block. 
  • Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial. 
  • Effectiveness and safety of abciximab after failed thrombolytic therapy. 
  • Effectiveness of early coronary angioplasty and abciximab for failed thrombolysis (reteplase or alteplase) during acute myocardial infarction (results from the GUSTO-III trial). Global Use of Strategies To Open occluded coronary arteries. 
  • Effectiveness of lurasidone in patients with schizophrenia or schizoaffective disorder switched from other antipsychotics: a randomized, 6-week, open-label study. 
  • Effectiveness of paliperidone palmitate vs haloperidol decanoate for maintenance treatment of schizophrenia: a randomized clinical trial. 
  • Effects of thrombolytic regimen, early catheterization, and predischarge angiographic variables on six-week left ventricular function. The TAMI Investigators. Thrombolysis and Angioplasty in Acute Myocardial Infarction. 
  • Effects of thrombolytic regimen, early catheterization, and predischarge angiographic variables on six-week left ventricular function. The TAMI Investigators. Thrombolysis and Angioplasty in Acute Myocardial Infarction. 
  • Efficacy of carboplatin-taxane combinations in the management of castration-resistant prostate cancer: a pooled analysis of seven prospective clinical trials. 
  • Efficacy of esomeprazole for treatment of poorly controlled asthma. 
  • Efficacy of human anodal trypsinogen for detection of rejection in clinical pancreas transplantation. 
  • Efficacy of peripheral androgen blockade in prostate cancer patients with biochemical failure after definitive local therapy: results of Cancer and Leukemia Group B (CALGB) 9782. 
  • Efficacy of sulphadoxine-pyrimethamine for intermittent preventive treatment of malaria in pregnancy, Mansa, Zambia. 
  • Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine. 
  • Elevated end-of-treatment serum INSL3 is associated with failure to completely suppress spermatogenesis in men receiving male hormonal contraception. 
  • Emerging therapeutic approaches in the management of metastatic castration-resistant prostate cancer. 
  • End points and trial design in geriatric oncology research: a joint European organisation for research and treatment of cancer--Alliance for Clinical Trials in Oncology--International Society Of Geriatric Oncology position article. 
  • Endocarditis caused by Staphylococcus aureus with reduced susceptibility to vancomycin. 
  • Etoposide (VP-16) and cisplatin at maximum tolerated dose in non-small cell lung carcinoma: a Cancer and Leukemia Group B study. 
  • Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease. 
  • Evaluation of failed and high blocks associated with spinal anesthesia for Cesarean delivery following inadequate labour epidural: a retrospective cohort study. 
  • Evidence of increased failure in the treatment of prostate carcinoma patients who have perineural invasion treated with three-dimensional conformal radiation therapy. 
  • Evolving standards in the treatment of docetaxel-refractory castration-resistant prostate cancer. 
  • Exercise therapy for depression in middle-aged and older adults: predictors of early dropout and treatment failure. 
  • External Validation of a Prognostic Model for Predicting Nonresponse Following Knee Arthroplasty. 
  • Factors associated with failed retrieval of the Günther Tulip inferior vena cava filter. 
  • Factors predicting the failure of Bernese periacetabular osteotomy: a meta-regression analysis. 
  • Failure of amphotericin B colloidal dispersion in the treatment of paracoccidioidomycosis. 
  • Failure of benzathine penicillin in a case of seronegative secondary syphilis in a patient with acquired immunodeficiency syndrome: case report and review of the literature. 
  • Failure of clopidogrel to reduce platelet reactivity and activation following standard dosing in elective stenting: implications for thrombotic events and restenosis. 
  • Failure of irrigation and débridement for early postoperative periprosthetic infection. 
  • Failure of metronidazole to prevent preterm delivery among pregnant women with asymptomatic Trichomonas vaginalis infection. 
  • Failure to rescue and pulmonary resection for lung cancer. 
  • Final results of a multicenter phase II study of the purine nucleoside phosphorylase (PNP) inhibitor forodesine in patients with advanced cutaneous T-cell lymphomas (CTCL) (Mycosis fungoides and Sézary syndrome). 
  • Free vascularized fibular grafting following failed core decompression for femoral head osteonecrosis. 
  • Frequency and Predictors of Internal Mammary Artery Graft Failure and Subsequent Clinical Outcomes: Insights From the Project of Ex-vivo Vein Graft Engineering via Transfection (PREVENT) IV Trial. 
  • Gastric surgical adjuvant radiotherapy consensus report: rationale and treatment implementation. 
  • Gene therapy and genomic strategies for cardiovascular surgery: The emerging field of surgiomics. 
  • Genotypic analysis of the V3 region of HIV from virologic nonresponders to maraviroc-containing regimens reveals distinct patterns of failure. 
  • Gentamicin-collagen sponge for infection prophylaxis in colorectal surgery. 
  • Glecaprevir and pibrentasvir yield high response rates in patients with HCV genotype 1-6 without cirrhosis. 
  • Graft loss due to recurrent focal segmental glomerulosclerosis in renal transplant recipients in the United States. 
  • Guideline adjudicated fibrinolytic failure: incidence, findings, and management in a contemporary clinical trial. 
  • HIV-1 drug resistance in antiretroviral-naive individuals with HIV-1-associated tuberculous meningitis initiating antiretroviral therapy in Vietnam. 
  • HLA antibodies and soluble CD30 are associated with poor renal graft outcome: updated results of a single-center cross-sectional study. 
  • Haemophilus influenzae type b meningitis in a fully immunized 2-year-old. 
  • Hematopoietic stem-cell transplantation for acute leukemia in relapse or primary induction failure. 
  • Hemilaryngectomy for glottic carcinoma after radiation therapy failure. 
  • High expression of nucleoside transporter protein hENT1 in Reed-Sternberg cells is associated with treatment failure in relapsed/refractory Hodgkin lymphoma patients treated with gemcitabine, vinorelbine and liposomal doxorubicin - a CALGB 59804 correlative study. 
  • High failure rate associated with 180 degrees selective laser trabeculoplasty. 
  • High prevalence of PI resistance in patients failing second-line ART in Vietnam. 
  • High risks for adverse outcomes after gastric bypass surgery following failed gastric banding: a population-based trend analysis of the United States. 
  • High-dose gemcitabine, busulfan, and melphalan for autologous stem-cell transplant in patients with relapsed or refractory myeloma: a phase 2 trial and matched-pair comparison with melphalan. 
  • High-intensity focused ultrasound for prostate cancer: comparative definitions of biochemical failure. 
  • Hip resurfacing after failed free vascularized fibular graft. 
  • Histopathological changes associated with dextranomer/hyaluronic acid injection for pediatric vesicoureteral reflux. 
  • Hormonal therapy options for biochemical recurrence of prostate cancer after local therapy. 
  • Hydrocortisone with or without mitoxantrone in men with hormone-refractory prostate cancer: results of the cancer and leukemia group B 9182 study. 
  • Immune reconstitution syndrome associated with opportunistic mycoses. 
  • Immunotherapeutic agents for the management of BCG refractory non-muscle invasive bladder cancer. 
  • Impact of a chemoresponse assay on treatment costs for recurrent ovarian cancer. 
  • Impact of extracardiac vascular disease on vein graft failure and outcomes after coronary artery bypass surgery. 
  • Impact of genotypic resistance testing on physician selection of antiretroviral therapy. 
  • Impact of postoperative prostate-specific antigen disease recurrence and the use of salvage therapy on the risk of death. 
  • Impairment of filgrastim-induced stem cell mobilization after prior lenalidomide in patients with multiple myeloma. 
  • Implications of early failure of superficial femoral artery endoluminal interventions. 
  • In vitro characteristics of Tenon's fibroblast lines derived from pediatric and adult eyes do not fully explain pediatric glaucoma surgery failure: a preliminary report. 
  • Incidence and risk factors for surgical intervention after uterine artery embolization. 
  • Increased baseline levels of platelet P-selectin, and platelet-endothelial cell adhesion molecule-1 in patients with acute myocardial infarction as predictors of unsuccessful thrombolysis. 
  • Influence of acetabular coverage on hip survival after free vascularized fibular grafting for femoral head osteonecrosis. 
  • Influence of obesity on surgical regional anesthesia in the ambulatory setting: an analysis of 9,038 blocks. 
  • Inhaled corticosteroid reduction and elimination in patients with persistent asthma receiving salmeterol: a randomized controlled trial. 
  • Initial experience with Crotalidae polyvalent immune Fab (ovine) antivenom in the treatment of copperhead snakebite. 
  • Initial nonfunction in cadaveric renal transplantation. 
  • Innovations in design and delivery of chemotherapy for brain tumors. 
  • Inoculum effect with cefazolin among clinical isolates of methicillin-susceptible Staphylococcus aureus: frequency and possible cause of cefazolin treatment failure. 
  • Intensified PEG-L-asparaginase and antimetabolite-based therapy for treatment of higher risk precursor-B acute lymphoblastic leukemia: a report from the Children's Oncology Group. 
  • Intermediate end point for prostate cancer-specific mortality following salvage hormonal therapy for prostate-specific antigen failure. 
  • Internal fixation of radiation-induced pathological fractures of the femur has a high rate of failure. 
  • Intrahepatic tumor recurrence after partial hepatectomy: value of percutaneous radiofrequency ablation. 
  • Intramedullary screw fixation of Jones fractures. Analysis of failure. 
  • Invasive mycoses: evolving challenges and opportunities in antifungal therapy (multimedia activity). 
  • Is Four Stage Management the Future of Univentricular Hearts? Destination Therapy in the Young. 
  • Is information the answer for hypertension control? 
  • Is prostate specific antigen of clinical importance in evaluating outcome after radical prostatectomy. 
  • Lack of effect of topical finasteride suggests an endocrine role for dihydrotestosterone. 
  • Lack of efficacy of postoperative chemotherapy and delayed radiation in very young children with pineoblastoma. Pediatric Oncology Group. 
  • Laparoscopic surgical treatment for refractory gastric antral vascular ectasia: a case report and review. 
  • Late intracytoplasmic sperm injection in unexpected failed fertilization in vitro: diagnostic or therapeutic? 
  • Levosimendan in Patients with Left Ventricular Dysfunction Undergoing Cardiac Surgery. 
  • Liver transplantation at the University of Wisconsin. 
  • Local failure and margin status in early-stage breast carcinoma treated with conservation surgery and radiation therapy. 
  • Local failure in resected N1 lung cancer: implications for adjuvant therapy. 
  • Local recurrence after surgery for early stage lung cancer: an 11-year experience with 975 patients. 
  • Locally advanced pancreatic cancer. 
  • Locoregional failure of postmastectomy patients with 1-3 positive axillary lymph nodes without adjuvant radiotherapy. 
  • Long-Term Effectiveness of Uterosacral Colpopexy and Minimally Invasive Sacral Colpopexy for Treatment of Pelvic Organ Prolapse. 
  • Long-term outcome of concurrent chemotherapy and reirradiation for recurrent and second primary head-and-neck squamous cell carcinoma. 
  • Long-term outcomes following abdominal sacrocolpopexy for pelvic organ prolapse. 
  • Long-term results of therapy for stage C neuroblastoma. 
  • Long-term survival of nasopharyngeal carcinoma following concomitant radiotherapy and chemotherapy. 
  • Lopinavir/ritonavir monotherapy after virologic failure of first-line antiretroviral therapy in resource-limited settings. 
  • Loss of nuclear localized and tyrosine phosphorylated Stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failure. 
  • Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers. 
  • Low-dose naloxone infusion for the treatment of intractable nausea and vomiting after intrathecal morphine in a parturient. 
  • Low-stage medulloblastoma: final analysis of trial comparing standard-dose with reduced-dose neuraxis irradiation. 
  • M6P/IGF2R loss of heterozygosity in head and neck cancer associated with poor patient prognosis. 
  • Malfunction of the liver after transplantation: an analysis of potential risk factors. 
  • Management of residual stones. 
  • Markers of Successful Extubation in Extremely Preterm Infants, and Morbidity After Failed Extubation. 
  • Maternal serum interleukin-6 levels predict impending funisitis in preterm premature rupture of membranes after completion of antibiotics. 
  • Methotrexate and cyclosporine for graft-vs.-host disease prevention: what length of therapy with cyclosporine? 
  • Metronomic chemotherapy with daily, oral etoposide plus bevacizumab for recurrent malignant glioma: a phase II study. 
  • Modifiable factors associated with failure to attain low-density lipoprotein cholesterol goal at 6 months after acute myocardial infarction. 
  • Molecular markers for failure of sulfadoxine-pyrimethamine and chlorproguanil-dapsone treatment of Plasmodium falciparum malaria. 
  • Mucosal melanoma of the female genitalia: a clinicopathologic study of forty-three cases at Duke University Medical Center. 
  • Multiagent concurrent chemoradiotherapy for locoregionally advanced squamous cell head and neck cancer: mature results from a single institution. 
  • Multicentre analysis of second-line antiretroviral treatment in HIV-infected children: adolescents at high risk of failure. 
  • Myeloablative intravenous busulfan/fludarabine conditioning does not facilitate reliable engraftment of dual umbilical cord blood grafts in adult recipients. 
  • National patterns in intensity and frequency of outpatient care for apparent treatment-resistant hypertension. 
  • Native coronary disease progression exceeds failed revascularization as cause of angina after five years in the Bypass Angioplasty Revascularization Investigation (BARI). 
  • Neonatal candidiasis among extremely low birth weight infants: risk factors, mortality rates, and neurodevelopmental outcomes at 18 to 22 months. 
  • No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trial. 
  • Non-parametric estimation for the difference or ratio of median failure times for paired observations. 
  • Noninvasive detection of reperfusion after thrombolysis based on serum creatine kinase MB changes and clinical variables. TAMI 7 Study Group. Thrombolysis and Angioplasty in Myocardial Infarction. 
  • Nonvascularized bone grafting defers joint arthroplasty in hip osteonecrosis. 
  • Olanzapine in refractory schizophrenia after failure of typical or atypical antipsychotic treatment: an open-label switch study. 
  • Older patients' understanding of emergency department discharge information and its relationship with adverse outcomes. 
  • Operative technique for converting a failed vertical banded gastroplasty to Roux-en-Y gastric bypass. 
  • Optic disc haemorrhages at baseline as a risk factor for poor outcome in the Idiopathic Intracranial Hypertension Treatment Trial. 
  • Oral Combination Therapies for Hepatitis C Virus Infection: Successes, Challenges, and Unmet Needs. 
  • Oral agent therapy in the treatment of type 2 diabetes. 
  • Oral antibiotics to prevent postoperative urinary tract infection: a randomized controlled trial. 
  • Organ and function preservation: the role of surgery as the optimal primary modality or as salvage after chemoradiation failure. 
  • Outcomes and predictors of failure of thrombolysis for iliofemoral deep venous thrombosis. 
  • Outcomes following bail-out abciximab administration during primary intervention in acute myocardial infarction (The CADILLAC Trial). 
  • Outcomes in surgical treatment of femoral neck fracture: analysis of failures secondary to osteonecrosis. 
  • Outcomes of bail-out stenting for suboptimal balloon angioplasty during primary intervention in acute myocardial infarction (The CADILLAC trial). 
  • Outcomes of transplantation of unrelated donor umbilical cord blood and bone marrow in children with acute leukaemia: a comparison study. 
  • PSA progression following radical prostatectomy and radiation therapy: new standards in the new Millennium. 
  • Paclitaxel for the treatment of progressive or recurrent childhood brain tumors: a pediatric oncology phase II study. 
  • Past and present treatment of pancreatic adenocarcinoma: chemotherapy as a standard treatment modality. 
  • Patient characteristics and management of dermal allograft extrusions. 
  • Patterns of Failure After Surgery for Non-Small-cell Lung Cancer Invading the Chest Wall. 
  • Patterns of disease failure after trimodality therapy of nonsmall cell lung carcinoma pathologic stage IIIA (N2). Analysis of Cancer and Leukemia Group B Protocol 8935. 
  • Patterns of failure after resection of non-small-cell lung cancer: implications for postoperative radiation therapy volumes. 
  • Patterns of recurrence after trimodality therapy for esophageal cancer. 
  • Pediatric antihypertensive trial failures: analysis of end points and dose range. 
  • Pegloticase failure and a possible solution: Immunosuppression to prevent intolerance and inefficacy in patients with gout. 
  • Percutaneous revascularization of chronic coronary occlusions: an overview. 
  • Persistence of Campylobacter fetus bacteremia associated with absence of opsonizing antibodies. 
  • Persistent eosinophilia and Strongyloides infection in Montagnard refugees after presumptive albendazole therapy. 
  • Phase II Study of Dasatinib in Previously Treated Patients with Advanced Non-Small Cell Lung Cancer. 
  • Phase II study of bortezomib in patients with previously treated advanced urothelial tract transitional cell carcinoma: CALGB 90207. 
  • Phase II study of cilengitide (EMD 121974, NSC 707544) in patients with non-metastatic castration resistant prostate cancer, NCI-6735. A study by the DOD/PCF prostate cancer clinical trials consortium. 
  • Phase II study of temozolomide and thalidomide in patients with metastatic melanoma in the brain: high rate of thromboembolic events (CALGB 500102). 
  • Phase II study on the effect of disease sites, age, and prior therapy on response to iodine-131-metaiodobenzylguanidine therapy in refractory neuroblastoma. 
  • Phase III trial of concurrent thoracic radiotherapy with either first- or third-cycle chemotherapy for limited-disease small-cell lung cancer. 
  • Phase III, randomized, placebo-controlled study of docetaxel in combination with zibotentan in patients with metastatic castration-resistant prostate cancer. 
  • Platelet inhibition with cangrelor in patients undergoing PCI. 
  • Poor drug distribution as a possible explanation for the results of the PRECISE trial. 
  • Positive Blood Cultures in Periprosthetic Joint Infection Decrease Rate of Treatment Success. 
  • Post-coronary intervention recurrent ischemia in the presence of adequate platelet inhibition by dual antiplatelet therapy: what are we overlooking? 
  • Postoperative chemotherapy and delayed radiation in infants and very young children with choroid plexus carcinomas. The Pediatric Oncology Group. 
  • Postoperative prostate-specific antigen as a prognostic indicator in patients with margin-positive prostate cancer, undergoing adjuvant radiotherapy after radical prostatectomy. 
  • Posttransplant lymphoproliferative disorders and Epstein-Barr virus prophylaxis. 
  • Predicting virologic failure among HIV-1-infected children receiving antiretroviral therapy in Tanzania: a cross-sectional study. 
  • Preexposure prophylaxis for HIV infection among African women. 
  • Preoperative and postoperative combination chemotherapy for potentially resectable gastric carcinoma. 
  • Preoperative chemo-radiation for carcinoma of the vulva with N2/N3 nodes: a gynecologic oncology group study. 
  • Preoperative chemoradiation for adenocarcinoma of the pancreas: excessive toxicity of prophylactic hepatic irradiation. 
  • Preoperative statin therapy does not reduce cognitive dysfunction after cardiopulmonary bypass. 
  • Pretreatment anemia is correlated with the reduced effectiveness of radiation and concurrent chemotherapy in advanced head and neck cancer. 
  • Problems in psychotherapy with suicidal patients. 
  • Prognostic significance of parapharyngeal space venous plexus and marrow involvement: potential landmarks of dissemination for stage I-III nasopharyngeal carcinoma. 
  • Progression of renal tumors after laparoscopic radiofrequency ablation. 
  • Prolonged CD4+ cell/virus load discordance during treatment with protease inhibitor-based highly active antiretroviral therapy: immune response and viral control. 
  • Prostate-specific antigen-based serial screening may decrease prostate cancer-specific mortality. 
  • Pulmonary vein isolation for the treatment of drug-refractory atrial fibrillation in adults with congenital heart disease. 
  • Quality of life and disability in patients with treatment-failure gout. 
  • Quantitative evaluation of acute renal transplant dysfunction with low-dose three-dimensional MR renography. 
  • Radiation dose selection in Hodgkin's disease patients with large mediastinal adenopathy treated with combined modality therapy. 
  • Radiation plus local hyperthermia versus radiation plus the combination of local and whole-body hyperthermia in canine sarcomas. 
  • Radical perineal prostatectomy: oncological outcome during a 20-year period. 
  • Radiographic evaluation of anterior cruciate ligament graft failure with special reference to tibial tunnel placement. 
  • Radiologic appearance of the irradiated larynx. Part II. Primary site response. 
  • Randomized phase II comparison of dose-intense gemcitabine: thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma. 
  • Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia. 
  • Randomized trial of acetylcysteine in idiopathic pulmonary fibrosis. 
  • Randomized trial of aspirin, sibrafiban, or both for secondary prevention after acute coronary syndromes. 
  • Randomized, multicenter trial of inhaled nitric oxide and high-frequency oscillatory ventilation in severe, persistent pulmonary hypertension of the newborn. 
  • Recombinant interferon-alpha2b added to oral cyclophosphamide either as induction or maintenance in treatment-naive follicular lymphoma: final analysis of CALGB 8691. 
  • Refractory calculation-induced idiopathic generalized epilepsy: a case report and review of the literature. 
  • Refractory gout: what is it and what to do about it? 
  • Relationship between vein graft failure and subsequent clinical outcomes after coronary artery bypass surgery. 
  • Renal osteodystrophy: neurosurgical considerations and challenges. 
  • Resected pancreatic neuroendocrine tumors: patterns of failure and disease-related outcomes with or without radiotherapy. 
  • Resistance to antiplatelet drugs: what progress has been made? 
  • Resistant hypertension. 
  • Results of allogeneic hematopoietic stem cell transplantation for chronic myelogenous leukemia patients who failed tyrosine kinase inhibitors after developing BCR-ABL1 kinase domain mutations. 
  • Results of trabeculectomy with 0.3 mg/ml mitomycin C titrating exposure times based on risk factors for failure. 
  • Rising PSA after local therapy failure: immediate vs deferred treatment. 
  • Rising PSA in nonmetastatic prostate cancer. 
  • Risk factors associated with failure 1 year after retropubic or transobturator midurethral slings. 
  • Risk factors for early failure of surgical amputations: an analysis of 8,878 isolated lower extremity amputation procedures. 
  • Risk factors for ineffective therapy in patients with bloodstream infection. 
  • Rituximab versus cyclophosphamide for ANCA-associated vasculitis with renal involvement. 
  • Rolofylline, an adenosine A1-receptor antagonist, in acute heart failure. 
  • Rotationplasty after failed limb-sparing tumor surgery: a report of two cases. 
  • Sacral neuromodulation for the treatment of refractory urinary urge incontinence after stress incontinence surgery. 
  • Safety and efficacy of stereotactic radiosurgery and adjuvant bevacizumab in patients with recurrent malignant gliomas. 
  • Salpingectomy improves the pregnancy rate in in-vitro fertilization patients with hydrosalpinx. 
  • Salvage Radiation Therapy Dose Response for Biochemical Failure of Prostate Cancer After Prostatectomy-A Multi-Institutional Observational Study. 
  • Salvage high-intensity focused ultrasound (HIFU) for locally recurrent prostate cancer after failed radiation therapy: Multi-institutional analysis of 418 patients. 
  • Salvage radiation in men after prostate-specific antigen failure and the risk of death. 
  • Saphenous vein graft failure after coronary artery bypass surgery: pathophysiology, management, and future directions. 
  • Short-term intravenous milrinone for acute exacerbation of chronic heart failure: a randomized controlled trial. 
  • Shortcuts in arthroscopic knot tying: do they affect knot and loop security? 
  • Single agent bortezomib in the treatment of relapsed and refractory Hodgkin lymphoma: cancer and leukemia Group B protocol 50206. 
  • Single-agent lapatinib for HER2-overexpressing advanced or metastatic breast cancer that progressed on first- or second-line trastuzumab-containing regimens. 
  • Soft Tissue Reconstruction After Total Ankle Arthroplasty. 
  • Sonographically guided compression repair of pseudoaneurysms: further experience from a single institution. 
  • Spinal anesthesia for orthopedic surgery: a detailed video assessment of quality. 
  • Spontaneous delayed migration/shortening of the pipeline embolization device: report of 5 cases. 
  • Steatosis is an independent predictor of relapse following rapid virologic response in patients with HCV genotype 3. 
  • Stent thrombosis: role of compliance and nonresponsiveness to antiplatelet therapy. 
  • Strategy for reoperative free flaps after failure of a first flap. 
  • Successful Re-treatment of Hepatitis C Virus in Patients Coinfected With HIV Who Relapsed After 12 Weeks of Ledipasvir/Sofosbuvir. 
  • Successful treatment of refractory childhood pemphgus vulgaris with anti-CD20 monoclonal antibody (rituximab). 
  • Supplemental transscleral diode laser cyclophotocoagulation after aqueous shunt placement in refractory glaucoma. 
  • Surgical Treatment of Prosthetic Joint Infections of the Hip and Knee: Changing Paradigms? 
  • Surgical aspects and biological considerations of arteriovenous fistula placement. 
  • Surgically placed left ventricular leads provide similar outcomes to percutaneous leads in patients with failed coronary sinus lead placement. 
  • Systematic biopsies: do they add prognostic information in men with clinically localized prostate cancer treated with radiation therapy alone? 
  • Systemic strategies for prostate cancer. 
  • T4 rectal cancer treated with preoperative chemoradiation to the posterior pelvis followed by multivisceral resection: patterns of failure and limitations of treatment. 
  • TGF-beta, radiation-induced pulmonary injury and lung cancer. 
  • Technical and patient-related characteristics associated with challenging retrieval of inferior vena cava filters. 
  • Telaprevir for previously treated chronic HCV infection. 
  • The COMPARE Registry: design and baseline patterns of care for men with biochemical failure after definitive treatment of localized prostate cancer. 
  • The Development of Intermediate Clinical Endpoints in Cancer of the Prostate (ICECaP). 
  • The ODD score: an opportunity to develop a definitive measure for assessing endoscopic outcomes. 
  • The association between radiographic response and overall survival in men with metastatic castration-resistant prostate cancer receiving chemotherapy. 
  • The concept of crosstalk-directed embryological target mining and its application to essential hypertension treatment failures. 
  • The effectiveness of rescue antiemetics after failure of prophylaxis with ondansetron or droperidol: a preliminary report. 
  • The failed total ankle. 
  • The failure of orally administered glycoprotein IIb/IIIa inhibitors to prevent recurrent cardiac events. 
  • The high failure rate of biologic resurfacing of the glenoid in young patients with glenohumeral arthritis. 
  • The role of angioplasty after failed thrombolysis for acute myocardial infarction. 
  • The role of dynamic indocyanine green angiography in the diagnosis and treatment of retinal angiomatous proliferation. 
  • The role of the perfusion balloon catheter after an initially unsuccessful coronary intervention. 
  • The treatment of high-grade soft tissue sarcomas with preoperative thermoradiotherapy. 
  • The undesirable influence of reconstructive procedures on the symmetry of the nasolabial folds. 
  • The use of GTX as second-line and later chemotherapy for metastatic pancreatic cancer: a retrospective analysis. 
  • Therapy of circadian rhythm disorders in chronic fatigue syndrome: no symptomatic improvement with melatonin or phototherapy. 
  • Thoracoscopic resection of the left atrial appendage after failed focal atrial tachycardia ablation. 
  • Thromboelastography detects inadequate response to abciximab therapy during stent-assisted cerebral aneurysm coil embolization complicated by stroke. 
  • Timing and patterns of recurrences and deaths from prostate cancer following adjuvant pelvic radiotherapy for pathologic stage T3/4 adenocarcinoma of the prostate. 
  • Timing of local and distant failure in resected lung cancer: implications for reported rates of local failure. 
  • Treatment Failures and Excess Mortality Among HIV-Exposed, Uninfected Children With Pneumonia. 
  • Treatment of acute postoperative hypertension in cardiac surgery patients: an efficacy study of clevidipine assessing its postoperative antihypertensive effect in cardiac surgery-2 (ESCAPE-2), a randomized, double-blind, placebo-controlled trial. 
  • Treatment of anemia with darbepoetin alfa in systolic heart failure. 
  • Treatment of sudden sensorineural hearing loss with systemic steroids and valacyclovir. 
  • Treatment selection in metastatic renal cell carcinoma: more confusion or a path forward? 
  • Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck. 
  • Two-Year Outcomes of Surgical Treatment of Severe Ischemic Mitral Regurgitation. 
  • Unicameral bone cyst: a retrospective study of three surgical treatments. 
  • Unrecognized dislocation of the medial portion of the triceps: another cause of failed ulnar nerve transposition. 
  • Unrelated umbilical cord blood stem cell transplant after failure of haploidentical or matched unrelated donor hematopoietic stem cell transplant. 
  • Update: Acute coronary syndromes (V). Personalized antiplatelet therapy. 
  • Ureteral stents for impassable ureteroscopy. 
  • Uricase and other novel agents for the management of patients with treatment-failure gout. 
  • Use of emergency department transcranial Doppler assessment of reperfusion after intravenous tPA for ischemic stroke. 
  • Use of vancomycin or first-generation cephalosporins for the treatment of hemodialysis-dependent patients with methicillin-susceptible Staphylococcus aureus bacteremia. 
  • Utility of remote wireless pressure sensing for endovascular leak detection after endovascular thoracic aneurysm repair. 
  • Uveal melanoma treated with iodine-125 episcleral plaque: an analysis of dose on disease control and visual outcomes. 
  • Variation in the definition of biochemical recurrence in patients treated for localized prostate cancer: the American Urological Association Prostate Guidelines for Localized Prostate Cancer Update Panel report and recommendations for a standard in the reporting of surgical outcomes. 
  • Virologic failure in first-line human immunodeficiency virus therapy with a CCR5 entry inhibitor, aplaviroc, plus a fixed-dose combination of lamivudine-zidovudine: nucleoside reverse transcriptase inhibitor resistance regardless of envelope tropism. 
  • Virologic failure in therapy-naive subjects on aplaviroc plus lopinavir-ritonavir: detection of aplaviroc resistance requires clonal analysis of envelope. 
  • Voriconazole in the treatment of aspergillosis, scedosporiosis and other invasive fungal infections in children. 
  • What Is the Mid-term Failure Rate of Revision ACL Reconstruction? A Systematic Review. 
  • When primary antifungal therapy fails. 
  • Why John wasn't healed by prayer: perspectives across disciplines. 
  • Wire-reinforced ureteral stents to rescue from nephrostomy tube in extrinsic ureteral obstruction. 
  • Work productivity loss due to flares in patients with chronic gout refractory to conventional therapy. 
  • p53 immunohistochemical and genetic alterations are associated at high incidence with post-irradiated locally persistent prostate carcinoma. 
  • pN collagen type III within tendon grafts used for anterior cruciate ligament reconstruction. 
• 

  Keywords of People

  • Alexander, John Hunter Peel, Professor of Medicine, Medicine, Cardiology
  • Bennett, Vann, George B. Geller Professor for Research in Molecular Biology in the School of Medicine, Duke Cancer Institute
  • Esclamado, Ramon Mitra, Richard Hall Chaney,Sr. Professor of Otolaryngology, Head & Neck Surgery, in the School of Medicine, Surgery, Head and Neck Surgery and Communication Sciences
  • Ferrari, Guido, Associate Professor of Surgery, Molecular Genetics and Microbiology
  • Halabi, Susan, Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Sampson, John Howard, Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine, Immunology
  • Stinnett, Sandra Sue, Associate Professor of Biostatistics and Bioinformatics, Biostatistics & Bioinformatics