Complement Factor H

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  Subject Areas on Research

  • A 32 kb critical region excluding Y402H in CFH mediates risk for age-related macular degeneration. 
  • A Therapeutic Antibody for Cancer, Derived from Single Human B Cells. 
  • A rare penetrant mutation in CFH confers high risk of age-related macular degeneration. 
  • Adrenomedullin signaling pathway polymorphisms and adverse pregnancy outcomes. 
  • C3b covalently bound to IgG demonstrates a reduced rate of inactivation by factors H and I. 
  • C3b generation is affected by the structure of the O-antigen polysaccharide in lipopolysaccharide from salmonellae. 
  • CFH and VIPR2 as susceptibility loci in choroidal thickness and pachychoroid disease central serous chorioretinopathy. 
  • Cigarette smoking strongly modifies the association of LOC387715 and age-related macular degeneration. 
  • Complement Factor H Antibodies from Lung Cancer Patients Induce Complement-Dependent Lysis of Tumor Cells, Suggesting a Novel Immunotherapeutic Strategy. 
  • Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation. 
  • Complement factor H autoantibodies are associated with early stage NSCLC. 
  • Complement factor H in AMD: Bridging genetic associations and pathobiology. 
  • Complement factor H increases risk for atrophic age-related macular degeneration. 
  • Complement factor H variant increases the risk of age-related macular degeneration. 
  • Enhanced CDC of B cell chronic lymphocytic leukemia cells mediated by rituximab combined with a novel anti-complement factor H antibody. 
  • Ethnic variation in early age-related macular degeneration lesions between white Australians and Singaporean Asians. 
  • Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice. 
  • Factor I co-factor activity of CR1 overcomes the protective effect of IgG on covalently bound C3b residues. 
  • Genetic Polymorphisms of CFH and ARMS2 Do Not Predict Response to Antioxidants and Zinc in Patients with Age-Related Macular Degeneration: Independent Statistical Evaluations of Data from the Age-Related Eye Disease Study. 
  • Genetic determinants of age-related macular degeneration in diverse populations from the PAGE study. 
  • Haplotypes spanning the complement factor H gene are protective against age-related macular degeneration. 
  • Heparan sulfate, including that in Bruch's membrane, inhibits the complement alternative pathway: implications for age-related macular degeneration. 
  • Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in mice. 
  • Incidence of Age-Related Macular Degeneration in a Multi-Ethnic United States Population: The Multi-Ethnic Study of Atherosclerosis. 
  • Independent effects of complement factor H Y402H polymorphism and cigarette smoking on risk of age-related macular degeneration. 
  • Inflammation, complement factor h, and age-related macular degeneration: the Multi-ethnic Study of Atherosclerosis. 
  • Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis. 
  • LOC387715/HTRA1 and complement factor H variants in patients with age-related macular degeneration seen at the mayo clinic. 
  • Lens status influences the association between CFH polymorphisms and age-related macular degeneration: findings from two population-based studies in Singapore. 
  • Molecular medicine: Defence against oxidative damage. 
  • Neovascular age-related macular degeneration and its association with LOC387715 and complement factor H polymorphism. 
  • Pentraxin 3 recruits complement factor H to protect against oxidative stress-induced complement and inflammasome overactivation. 
  • Peripheral reticular pigmentary change is associated with complement factor H polymorphism (Y402H) in age-related macular degeneration. 
  • Rapid and sensitive method for detection of Y402, H402, I62, and V62 variants of complement factor H in human plasma samples using mass spectrometry. 
  • Regulation of age-related macular degeneration-like pathology by complement factor H. 
  • Shared genetic variants for polypoidal choroidal vasculopathy and typical neovascular age-related macular degeneration in East Asians. 
  • Single-Nucleotide Polymorphisms Associated With Age-Related Macular Degeneration and Lesion Phenotypes in the Comparison of Age-Related Macular Degeneration Treatments Trials. 
  • The ARMS2 A69S variant and bilateral advanced age-related macular degeneration. 
  • The discovery and early validation of novel plasma biomarkers in mild-to-moderate Alzheimer's disease patients responding to treatment with rosiglitazone. 
  • The interaction of C3b bound to pneumococci with factor H (beta 1H globulin), factor I (C3b/C4b inactivator), and properdin factor B of the human complement system. 
  • The role of complement dysregulation in AMD mouse models.