Pain Threshold

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  Subject Areas on Research

  • A comparison of laboratory measures of escape and avoidance behavior. 
  • A greater role for the norepinephrine transporter than the serotonin transporter in murine nociception. 
  • A systematic literature review of 10 years of research on sex/gender and experimental pain perception - part 1: are there really differences between women and men? 
  • A systematic literature review of 10 years of research on sex/gender and pain perception - part 2: do biopsychosocial factors alter pain sensitivity differently in women and men? 
  • Activation of peripheral nerve fibers by electrical stimulation in the sole of the foot. 
  • Age Group Comparisons of TENS Response Among Individuals With Chronic Axial Low Back Pain. 
  • An evaluation of remifentanil-sevoflurane response surface models in patients emerging from anesthesia: model improvement using effect-site sevoflurane concentrations. 
  • Assessing potential functionality of catechol-O-methyltransferase (COMT) polymorphisms associated with pain sensitivity and temporomandibular joint disorders. 
  • Association between physical activity and pain processing in adults with chronic low back pain compared to pain-free controls. 
  • Association of systolic blood pressure at time of myocardial ischemia with angina pectoris during exercise testing. 
  • Associations among four modalities of experimental pain in women. 
  • Associations between pressure-pain threshold, symptoms, and radiographic knee and hip osteoarthritis. 
  • Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury. 
  • Biology and therapy of fibromyalgia. Functional magnetic resonance imaging findings in fibromyalgia. 
  • Blood pressure-related hypoalgesia in bulimia nervosa. 
  • Brain mechanisms supporting the modulation of pain by mindfulness meditation. 
  • CACNG2 polymorphisms associate with chronic pain after mastectomy. 
  • COMT gene locus: new functional variants. 
  • Catastrophizing predicts changes in thermal pain responses after resolution of acute dental pain. 
  • Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. 
  • Catechol-O-methyltransferase genotype predicts pain severity in hospitalized burn patients. 
  • Catechol-O-methyltransferase inhibition increases pain sensitivity through activation of both beta2- and beta3-adrenergic receptors. 
  • Cathodal and anodal left prefrontal tDCS and the perception of control over pain. 
  • Central processing of noxious somatic stimuli in patients with irritable bowel syndrome compared with healthy controls. 
  • Changes in pain from a repetitive thermal stimulus: the roles of adaptation and sensitization. 
  • Changes in pain sensitivity following spinal manipulation: a systematic review and meta-analysis. 
  • Comparison of 2 Lumbar Manual Therapies on Temporal Summation of Pain in Healthy Volunteers. 
  • Comparison of clinical and evoked pain measures in fibromyalgia. 
  • Comt1 genotype and expression predicts anxiety and nociceptive sensitivity in inbred strains of mice. 
  • Content validity of an acupuncture sensation questionnaire. 
  • Coping strategies and laboratory pain in children with sickle cell disease. 
  • Development of responder definitions for fibromyalgia clinical trials. 
  • Differences in unpleasantness induced by experimental pressure pain between patients with fibromyalgia and healthy controls. 
  • Differential effects of experimental central sensitization on the time-course and magnitude of offset analgesia. 
  • Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice. 
  • Dolorimetry performed at 3 paired tender points highly predicts overall tenderness. 
  • Dynamic, but not static, pain sensitivity predicts exercise-induced muscle pain: covariation of temporal sensory summation and pain intensity. 
  • Effect of catechol-O-methyltransferase polymorphism on response to propranolol therapy in chronic musculoskeletal pain: a randomized, double-blind, placebo-controlled, crossover pilot study. 
  • Effect of estrogen depletion on pain sensitivity in aromatase inhibitor-treated women with early-stage breast cancer. 
  • Effects of a brief coping skills training intervention on nociceptive flexion reflex threshold in patients having osteoarthritic knee pain: a preliminary laboratory study of sex differences. 
  • Effects of gender and acute dental pain on thermal pain responses. 
  • Effects of spinal manipulation on trunk proprioception in subjects with chronic low back pain during symptom remission. 
  • Effects of transcutaneous electrical nerve stimulation on pain, pain sensitivity, and function in people with knee osteoarthritis: a randomized controlled trial. 
  • Elimination of GRK2 from cholinergic neurons reduces behavioral sensitivity to muscarinic receptor activation. 
  • Enhanced central thermal nociception in mildly depressed nonpatients and transiently sad healthy subjects. 
  • Enhanced morphine analgesia in mice lacking beta-arrestin 2. 
  • Establishing a link between heart rate and pain in healthy subjects: a gender effect. 
  • Evidence of augmented central pain processing in idiopathic chronic low back pain. 
  • Excitatory and inhibitory pain mechanisms during the menstrual cycle in healthy women. 
  • Exercise-induced pain intensity predicted by pre-exercise fear of pain and pain sensitivity. 
  • Experimental and model-based analysis of differences in perception of cutaneous electrical stimulation across the sole of the foot. 
  • Experimental pain responses support peripheral and central sensitization in patients with unilateral shoulder pain. 
  • Fear of pain, pain catastrophizing, and acute pain perception: relative prediction and timing of assessment. 
  • Fear-avoidance beliefs and temporal summation of evoked thermal pain influence self-report of disability in patients with chronic low back pain. 
  • Follow-up of coping skills training in adults with sickle cell disease: analysis of daily pain and coping practice diaries. 
  • From peripheral to central: the role of ERK signaling pathway in acupuncture analgesia. 
  • Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. 
  • Group differences in pain modulation: pain-free women compared to pain-free men and to women with TMD. 
  • Heightened pain sensitivity in individuals with signs and symptoms of carpal tunnel syndrome and the relationship to clinical outcomes following a manual therapy intervention. 
  • Hope against the cold: individual differences in trait hope and acute pain tolerance on the cold pressor task. 
  • Immediate changes after manual therapy in resting-state functional connectivity as measured by functional magnetic resonance imaging in participants with induced low back pain. 
  • Immediate reduction in temporal sensory summation after thoracic spinal manipulation. 
  • Immobilisation stress induced analgesia in diabetic rats. 
  • Impact of human CA8 on thermal antinociception in relation to morphine equivalence in mice. 
  • In vivo luminescence imaging of NF-κB activity and serum cytokine levels predict pain sensitivities in a rodent model of osteoarthritis. 
  • In vivo luminescent imaging of NF-κB activity and NF-κB-related serum cytokine levels predict pain sensitivities in a rodent model of peripheral neuropathy. 
  • Increased perception of post-ischemic paresthesias in depressed subjects. 
  • Influence and stability of pain scale anchors for an investigation of cold pressor pain tolerance. 
  • Investigating dynamic pain sensitivity in the context of the fear-avoidance model. 
  • Investigation of central pain processing in shoulder pain: converging results from 2 musculoskeletal pain models. 
  • Is endogenous D-serine in the rostral anterior cingulate cortex necessary for pain-related negative affect? 
  • Ischemic but not thermal pain sensitivity varies across the menstrual cycle. 
  • JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. 
  • Janus molecule I: dichotomous effects of COMT in neuropathic vs nociceptive pain modalities. 
  • Laboratory pain perception and clinical pain in post-menopausal women and age-matched men with osteoarthritis: relationship to pain coping and hormonal status. 
  • Lack of evidence for ectopic sprouting of genetically labeled Aβ touch afferents in inflammatory and neuropathic trigeminal pain. 
  • Low enzymatic activity haplotypes of the human catechol-O-methyltransferase gene: enrichment for marker SNPs. 
  • Low hot pain threshold predicts shorter time to exercise-induced angina: results from the psychophysiological investigations of myocardial ischemia (PIMI) study. 
  • Lumbar plexus and sciatic nerve block for knee arthroplasty: comparison of ropivacaine and bupivacaine. 
  • Mechanical hyperalgesia and reduced quality of life occur in people with mild knee osteoarthritis pain. 
  • Mechanical sensation and pain thresholds in patients with chronic arthropathies. 
  • Melanocortin-1 receptor gene variants affect pain and mu-opioid analgesia in mice and humans. 
  • Menstrual cycle, beta-endorphins, and pain sensitivity in premenstrual dysphoric disorder. 
  • Modification of COMT-dependent pain sensitivity by psychological stress and sex. 
  • Modulation of activity and conduction in single dorsal column axons by kilohertz-frequency spinal cord stimulation. 
  • Multifactorial assessment of measurement errors affecting intraoral quantitative sensory testing reliability. 
  • Multisystem dysregulation in painful temporomandibular disorders. 
  • New directions in research on pain and ethnicity: a comment on Riley, Wade, Myers, Sheffield, Pappas, and Price (2002). 
  • Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. 
  • Optimism and pain: a positive move forward. 
  • PD-L1 inhibits acute and chronic pain by suppressing nociceptive neuron activity via PD-1. 
  • Pain Sensitivity and Pain Catastrophizing Are Associated With Persistent Pain and Disability After Lumbar Spine Surgery. 
  • Pain catastrophizing predicts pain intensity during a neurodynamic test for the median nerve in healthy participants. 
  • Pain is associated with short leukocyte telomere length in women with fibromyalgia. 
  • Pain modality- and sex-specific effects of COMT genetic functional variants. 
  • Pain perception is altered by a nucleotide polymorphism in SCN9A. 
  • Pain sensitivity and autonomic factors associated with development of TMD: the OPPERA prospective cohort study. 
  • Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction. 
  • Pain sensitivity as a correlate of clinical status in individuals with chronic low back pain. 
  • Pain sensitivity in patients with temporomandibular disorders: relationship to clinical and psychosocial factors. 
  • Pain sensitivity is inversely related to regional grey matter density in the brain. 
  • Pain sensitivity subgroups in individuals with spine pain: potential relevance to short-term clinical outcome. 
  • Parents' worries about recurrent abdominal pain in children. 
  • Peripheral axonal injury results in reduced mu opioid receptor pre- and post-synaptic action in the spinal cord. 
  • Persistent smoking after a diagnosis of lung cancer is associated with higher reported pain levels. 
  • Potential neurobiological benefits of exercise in chronic pain and posttraumatic stress disorder: Pilot study. 
  • Potentiated opioid analgesia in norepinephrine transporter knock-out mice. 
  • Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines. 
  • Pressure pain thresholds fluctuate with, but do not usefully predict, the clinical course of painful temporomandibular disorder. 
  • Pronociceptive actions of dynorphin maintain chronic neuropathic pain. 
  • Psychologic influence on experimental pain sensitivity and clinical pain intensity for patients with shoulder pain. 
  • Psychophysical responses to a speech stressor: correlation of plasma beta-endorphin levels at rest and after psychological stress with thermally measured pain threshold in patients with coronary artery disease. 
  • Pulse Width Affects Scalp Sensation of Transcranial Magnetic Stimulation. 
  • Race and sex differences in cutaneous pain perception. 
  • Reduced GABA neurotransmission underlies hyperalgesia induced by repeated forced swimming stress. 
  • Reduced tolerance and cardiovascular response to ischemic pain in minor depression. 
  • Regional brain activation in response to rectal distension in patients with irritable bowel syndrome and the effect of a history of abuse. 
  • Relationship between pain sensitivity and resting arterial blood pressure in patients with painful temporomandibular disorders. 
  • Relationship between temporomandibular disorders, widespread palpation tenderness, and multiple pain conditions: a case-control study. 
  • Relationship of intersession variation in negative pain-related affect and responses to thermally-evoked pain. 
  • Relax, you won't feel the pain. 
  • Reliability and reproducibility of novel methodology for assessment of pressure pain sensitivity in pelvis. 
  • Resting blood pressure and thermal pain responses among females: effects on pain unpleasantness but not pain intensity. 
  • Role of mu-opioid and NMDA receptors in the development and maintenance of repeated swim stress-induced thermal hyperalgesia. 
  • Role of the CX3CR1/p38 MAPK pathway in spinal microglia for the development of neuropathic pain following nerve injury-induced cleavage of fractalkine. 
  • Screening for pain phenotypes: analysis of three congenic mouse strains on a battery of nine nociceptive assays. 
  • Selective activation of cannabinoid CB(2) receptors suppresses spinal fos protein expression and pain behavior in a rat model of inflammation. 
  • Selective role for TRPV4 ion channels in visceral sensory pathways. 
  • Sensitivity of patients with painful temporomandibular disorders to experimentally evoked pain. 
  • Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activity. 
  • Sex differences in chest pain in patients with documented coronary artery disease and exercise-induced ischemia: Results from the PIMI study. 
  • Sex differences in experimental and clinical pain sensitivity for patients with shoulder pain. 
  • Sex differences in temporal summation but not sensory-discriminative processing of thermal pain. 
  • Sex differences in the associations among psychological factors and pain report: a novel psychophysical study of patients with chronic low back pain. 
  • Sexual and physical abuse history in subjects with temporomandibular disorders: relationship to clinical variables, pain sensitivity, and psychologic factors. 
  • Short small-interfering RNAs produce interferon-α-mediated analgesia. 
  • Somatic Awareness and Tender Points in a Community Sample. 
  • Southampton needle sensation questionnaire: development and validation of a measure to gauge acupuncture needle sensation. 
  • Spinal injection of TNF-α-activated astrocytes produces persistent pain symptom mechanical allodynia by releasing monocyte chemoattractant protein-1. 
  • Spinal manipulative therapy has an immediate effect on thermal pain sensitivity in people with low back pain: a randomized controlled trial. 
  • Spinal manipulative therapy-specific changes in pain sensitivity in individuals with low back pain (NCT01168999). 
  • Subgrouping of fibromyalgia patients on the basis of pressure-pain thresholds and psychological factors. 
  • Suprathreshold heat pain response is associated with clinical pain intensity for patients with shoulder pain. 
  • Suprathreshold heat pain response predicts activity-related pain, but not rest-related pain, in an exercise-induced injury model. 
  • Targeting CYP2J to reduce paclitaxel-induced peripheral neuropathic pain. 
  • Temporal summation of second pain: variability in responses to a fixed protocol. 
  • Temporomandibular disorder and optimism: relationships to ischemic pain sensitivity and interleukin-6. 
  • Testing Assumptions in Human Pain Models: Psychophysical Differences Between First and Second Pain. 
  • The James A. Rand Young Investigator's Award: Battling the Opioid Epidemic with Prospective Pain Threshold Measurement. 
  • The beta3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test. 
  • The comparative effects of spinal and peripheral thrust manipulation and exercise on pain sensitivity and the relation to clinical outcome: a mechanistic trial using a shoulder pain model. 
  • The effect of past-injury on pain threshold and tolerance. 
  • The influence of expectation on spinal manipulation induced hypoalgesia: an experimental study in normal subjects. 
  • The influence of resting blood pressure and gender on pain responses. 
  • The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure. 
  • The relationship between chief complaint and comparable sign in patients with spinal pain: An exploratory study. 
  • The relationship of the audible pop to hypoalgesia associated with high-velocity, low-amplitude thrust manipulation: a secondary analysis of an experimental study in pain-free participants. 
  • Thermal and pressure pain sensitivity in patients with unilateral shoulder pain: comparison of involved and uninvolved sides. 
  • Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states. 
  • Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms. 
  • Variable sensitivity to noxious heat is mediated by differential expression of the CGRP gene. 
  • Voltage-gated ion channels in nociceptors: modulation by cGMP. 
  • White cancer patients' perception of gender and ethnic differences in pain experience. 
  • Widespread somatosensory sensitivity in naturally occurring canine model of osteoarthritis. 
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  Keywords of People

  • Clewley, Derek James, Assistant Professor of Orthopaedic Surgery, Orthopaedics, Physical Therapy
  • Nackley, Andrea Gail, Associate Professor in Anesthesiology, Pharmacology & Cancer Biology