Gene Deletion

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  Subject Areas on Research

  • A bifunctional dihydrofolate synthetase--folylpolyglutamate synthetase in Plasmodium falciparum identified by functional complementation in yeast and bacteria. 
  • A cis-acting sequence homologous to the yeast filamentation and invasion response element regulates expression of a pectinase gene from the bean pathogen Colletotrichum lindemuthianum. 
  • A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets. 
  • A contiguous deletion syndrome of X-linked agammaglobulinemia and sensorineural deafness. 
  • A deletion unit on chromosome 17q in epithelial ovarian tumors distal to the familial breast/ovarian cancer locus. 
  • A heterochromatin barrier partitions the fission yeast centromere into discrete chromatin domains. 
  • A novel role for copper in Ras/mitogen-activated protein kinase signaling. 
  • A tenascin knockout with a phenotype. 
  • ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory. 
  • Aberrant splicing of the TSG101 tumor suppressor gene in human breast and ovarian cancers. 
  • Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. 
  • AglQ is a novel component of the Haloferax volcanii N-glycosylation pathway. 
  • Allelotype analysis of uterine leiomyoma: localization of a potential tumor suppressor gene to a 4-cM region of chromosome 7q. 
  • Alterations of the TP53 gene in human gliomas. 
  • Alternative translation of osteopontin generates intracellular and secreted isoforms that mediate distinct biological activities in dendritic cells. 
  • An alpha-2-macroglobulin insertion-deletion polymorphism in Alzheimer disease. 
  • An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation. 
  • An integrated physical map of 8q22-q24: use in positional cloning and deletion analysis of Langer-Giedion syndrome. 
  • Analysis of a gene conversion gradient at the HIS4 locus in Saccharomyces cerevisiae. 
  • Analysis of genetic alterations in uterine leiomyomas and leiomyosarcomas by comparative genomic hybridization. 
  • Angiotensin-converting enzyme gene insertion/deletion polymorphism and cardiovascular disease: identifying the guideposts for navigating the genetics landscape. 
  • Anti-tumor immunotherapy despite immunity to adenovirus using a novel adenoviral vector Ad5 [E1-, E2b-]-CEA. 
  • Aquaporin expression and freeze tolerance in Candida albicans. 
  • Aquaporins in Saccharomyces. Genetic and functional distinctions between laboratory and wild-type strains. 
  • Are sequence family variants useful for identifying deletions in the human Y chromosome? 
  • Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. 
  • Assembly dynamics of FtsZ rings in Bacillus subtilis and Escherichia coli and effects of FtsZ-regulating proteins. 
  • Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium. 
  • Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways. 
  • Avid binding of beta A amyloid peptide to its own precursor. 
  • Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome. 
  • CASP8 polymorphisms contribute to cancer susceptibility: evidence from a meta-analysis of 23 publications with 55 individual studies. 
  • CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice. 
  • CRISPR/Cas9 Editing of Murine Induced Pluripotent Stem Cells for Engineering Inflammation-Resistant Tissues. 
  • CX3CR1 deficiency accelerates the development of retinopathy in a rodent model of type 1 diabetes. 
  • Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides. 
  • Cardiomyopathy is associated with ribosomal protein gene haplo-insufficiency in Drosophila melanogaster. 
  • Caspofungin exposure alters the core septin AspB interactome of Aspergillus fumigatus. 
  • Cell cycle progression in G1 and S phases is CCR4 dependent following ionizing radiation or replication stress in Saccharomyces cerevisiae. 
  • Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. 
  • Characterization of frequently deleted 6q locus in prostate cancer. 
  • Characterization of the FKBP12-Encoding Genes in Aspergillus fumigatus. 
  • Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis. 
  • Chromosomal microarray analysis in clinical evaluation of neurodevelopmental disorders-reporting a novel deletion of SETDB1 and illustration of counseling challenge. 
  • Clinical and functional findings in choroideremia due to complete deletion of the CHM gene. 
  • Clinical and pathological features of an Alzheimer's disease patient with the MAPT Delta K280 mutation. 
  • Clinical evidence of decreased olfaction in Bardet-Biedl syndrome caused by a deletion in the BBS4 gene. 
  • Comparative genome-wide screening identifies a conserved doxorubicin repair network that is diploid specific in Saccharomyces cerevisiae. 
  • Comparative genomic hybridization studies in hydatidiform moles and choriocarcinoma: amplification of 7q21-q31 and loss of 8p12-p21 in choriocarcinoma. 
  • Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. 
  • Complex genetic interactions in a quantitative trait locus. 
  • Comprehensive DNA copy number profiling of meningioma using a chromosome 1 tiling path microarray identifies novel candidate tumor suppressor loci. 
  • Conditional deletion of TrkC does not modify limbic epileptogenesis. 
  • Construction of a Recyclable Genetic Marker and Serial Gene Deletions in the Human Pathogenic Mucorales Mucor circinelloides. 
  • Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. 
  • Convergent evolution of chicken Z and human X chromosomes by expansion and gene acquisition. 
  • Correlates of Prenatal and Early-Life Tobacco Smoke Exposure and Frequency of Common Gene Deletions in Childhood Acute Lymphoblastic Leukemia. 
  • Coxiella burnetii effector proteins that localize to the parasitophorous vacuole membrane promote intracellular replication. 
  • Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses. 
  • Cryptococcus neoformans methionine synthase: expression analysis and requirement for virulence. 
  • Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host. 
  • Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor production in two varieties of the fungal pathogen Cryptococcus neoformans. 
  • Cytochrome c peroxidase contributes to the antioxidant defense of Cryptococcus neoformans. 
  • De Novo Disruption of the Proteasome Regulatory Subunit PSMD12 Causes a Syndromic Neurodevelopmental Disorder. 
  • Decreased meiotic intergenic recombination and increased meiosis I nondisjunction in exo1 mutants of Saccharomyces cerevisiae. 
  • Deletion of CFHR3 and CFHR1 genes in age-related macular degeneration. 
  • Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass. 
  • Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway. 
  • Deletion of Siah-interacting protein gene in Drosophila causes cardiomyopathy. 
  • Deletion of V335 from the L2 domain of the insulin receptor results in a conformationally abnormal receptor that is unable to bind insulin and causes Donohue's syndrome in a human subject. 
  • Deletion of a splicing enhancer disrupts PLP1/DM20 ratio and myelin stability. 
  • Deletion of cyclin-dependent kinase 4 inhibitor genes P15 and P16 in non-Hodgkin's lymphoma. 
  • Deletion of p16 and p15 genes in brain tumors. 
  • Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration. 
  • Deletion of the essential gene 24 from the bacteriophage T4 genome. 
  • Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle. 
  • Deletions and rearrangements inactivate the p16INK4 gene in human glioma cells. 
  • Detailed analysis of gene expression during development of T cell lineages in the thymus. 
  • Dhh1 regulates the G1/S-checkpoint following DNA damage or BRCA1 expression in yeast. 
  • Dicer1 functions as a haploinsufficient tumor suppressor. 
  • Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes. 
  • Differential inactivation of CDKN2 and Rb protein in non-small-cell and small-cell lung cancer cell lines. 
  • Direct allelic variation scanning of the yeast genome. 
  • Discrimination of tRNALeu isoacceptors by the insertion mutant of Escherichia coli leucyl-tRNA synthetase. 
  • Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus. 
  • Distinct and redundant roles of exonucleases in Cryptococcus neoformans: implications for virulence and mating. 
  • Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria. 
  • Distinct gene expression phenotypes of cells lacking Rb and Rb family members. 
  • Dopamine enhances motor and neuropathological consequences of polyglutamine expanded huntingtin. 
  • Dynamic ubiquitination of the mitogen-activated protein kinase kinase (MAPKK) Ste7 determines mitogen-activated protein kinase (MAPK) specificity. 
  • Dysregulation of multiple facets of glycogen metabolism in a murine model of Pompe disease. 
  • Effect of mutations in genes affecting homologous recombination on restriction enzyme-mediated and illegitimate recombination in Saccharomyces cerevisiae. 
  • Effects of neuronal PIK3C3/Vps34 deletion on autophagy and beyond. 
  • Efficacy and safety of live attenuated persistent and rapidly cleared Mycobacterium tuberculosis vaccine candidates in non-human primates. 
  • Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. 
  • Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. 
  • Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. 
  • Evidence of mRNA-mediated intron loss in the human-pathogenic fungus Cryptococcus neoformans. 
  • Expanding CEP290 mutational spectrum in ciliopathies. 
  • Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas. 
  • Extracellular cAMP is sufficient to restore developmental gene expression and morphogenesis in Dictyostelium cells lacking the aggregation adenylyl cyclase (ACA). 
  • Fibroblast growth factor receptor 2 regulates proliferation and Sertoli differentiation during male sex determination. 
  • Flightin is essential for thick filament assembly and sarcomere stability in Drosophila flight muscles. 
  • Fragile X phenotype in a patient with a large de novo deletion in Xq27-q28. 
  • Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. 
  • Functional hyperdopaminergia in dopamine transporter knock-out mice. 
  • G-protein-coupled receptor (GPCR) kinase phosphorylation and beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR. 
  • GALC deletions increase the risk of primary open-angle glaucoma: the role of Mendelian variants in complex disease. 
  • Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand. 
  • Gene deletions in Mycobacterium bovis BCG stimulate increased CD8+ T cell responses. 
  • Gene disruption by biolistic transformation in serotype D strains of Cryptococcus neoformans. 
  • Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation. 
  • Gene loss and parallel evolution contribute to species difference in flower color. 
  • Gene-dose dependent effects of methamphetamine on interval timing in dopamine-transporter knockout mice. 
  • Genetic Deletion of β-Arrestin-2 and the Mitigation of Established Airway Hyperresponsiveness in a Murine Asthma Model. 
  • Genetic architecture of reciprocal CNVs. 
  • Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor). 
  • Genetically stable picornavirus expression vectors with recombinant internal ribosomal entry sites. 
  • Genome sequence of Blochmannia pennsylvanicus indicates parallel evolutionary trends among bacterial mutualists of insects. 
  • Genomic deletions and point mutations induced in Saccharomyces cerevisiae by the trinucleotide repeats (GAA·TTC) associated with Friedreich's ataxia. 
  • Genomic instability and endoreduplication triggered by RAD17 deletion. 
  • Genomic signatures of near-extinction and rebirth of the crested ibis and other endangered bird species. 
  • Genotype-phenotype study in an FSHD family with a proximal deletion encompassing p13E-11 and D4Z4. 
  • Gigantic splenomegaly in a 27-year-old male of South-East Asian descent with concurrent diagnosis of myeloproliferative neoplasm and hemoglobin H disease. 
  • Glioblastoma multiforme and the epidermal growth factor receptor. 
  • Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis. 
  • Gq signaling causes glomerular injury by activating TRPC6. 
  • Growth-Phase-Specific Modulation of Cell Morphology and Gene Expression by an Archaeal Histone Protein. 
  • Haem oxygenase-1 prevents cell death by regulating cellular iron. 
  • Haploidization in Saccharomyces cerevisiae induced by a deficiency in homologous recombination. 
  • Heat shock protein 90 is required for conidiation and cell wall integrity in Aspergillus fumigatus. 
  • Hepatic β-arrestin 2 is essential for maintaining euglycemia. 
  • Heritable resistance to tyrosine kinase inhibitors. 
  • High levels of human gamma-globin gene expression in adult mice carrying a transgene of deletion-type hereditary persistence of fetal hemoglobin. 
  • Hyperosmotic stress stimulates promoter activity and regulates cellular utilization of the serum- and glucocorticoid-inducible protein kinase (Sgk) by a p38 MAPK-dependent pathway. 
  • IKK mediates ischemia-induced neuronal death. 
  • Identification and characterization of an essential family of inositol polyphosphate 5-phosphatases (INP51, INP52 and INP53 gene products) in the yeast Saccharomyces cerevisiae. 
  • Identification of 28 novel mutations in the Bardet-Biedl syndrome genes: the burden of private mutations in an extensively heterogeneous disease. 
  • Identification of S-nitroso-CoA reductases that regulate protein S-nitrosylation. 
  • Identification of two novel mutations in families with X-linked ocular albinism. 
  • Immunogenicity study of glycoprotein-deficient rabies virus expressing simian/human immunodeficiency virus SHIV89.6P envelope in a rhesus macaque. 
  • Immunohistochemical [corrected] detection of the alternate INK4a-encoded tumor suppressor protein p14(ARF) in archival human cancers and cell lines using commercial antibodies: correlation with p16(INK4a) expression. 
  • Immunohistochemical p16INK4a analysis of archival tumors with deletion, hypermethylation, or mutation of the CDKN2/MTS1 gene. A comparison of four commercial antibodies. 
  • Increased glutamine catabolism mediates bone anabolism in response to WNT signaling. 
  • Increased rates of genomic deletions generated by mutations in the yeast gene encoding DNA polymerase delta or by decreases in the cellular levels of DNA polymerase delta. 
  • Independent and cooperative roles of adaptor molecules in proximal signaling during FcepsilonRI-mediated mast cell activation. 
  • Inefficient dystrophin expression after cord blood transplantation in Duchenne muscular dystrophy. 
  • Intra-arterial administration of a replication-selective adenovirus (dl1520) in patients with colorectal carcinoma metastatic to the liver: a phase I trial. 
  • Intronic deletions in the SLC34A3 gene cause hereditary hypophosphatemic rickets with hypercalciuria. 
  • Involvement of the S-layer proteins Hpi and SlpA in the maintenance of cell envelope integrity in Deinococcus radiodurans R1. 
  • Isolated sulfite oxidase deficiency: mutation analysis and DNA-based prenatal diagnosis. 
  • Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation. 
  • LETM1, a gene deleted in Wolf-Hirschhorn syndrome, encodes an evolutionarily conserved mitochondrial protein. 
  • Linkage to a known gene but no mutation identified: comprehensive reanalysis of SPG4 HSP pedigrees reveals large deletions as the sole cause. 
  • Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis. 
  • Localization and activity of the calcineurin catalytic and regulatory subunit complex at the septum is essential for hyphal elongation and proper septation in Aspergillus fumigatus. 
  • Loss of Wnt5a disrupts second heart field cell deployment and may contribute to OFT malformations in DiGeorge syndrome. 
  • Loss of atm radiosensitizes multiple p53 null tissues. 
  • Loss of autoreceptor functions in mice lacking the dopamine transporter. 
  • Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo. 
  • Loss of p53 in benzene-induced thymic lymphomas in p53+/- mice: evidence of chromosomal recombination. 
  • Lower incidence of deletions in the survival of motor neuron gene and the neuronal apoptosis inhibitory protein gene in children with spinal muscular atrophy from Serbia. 
  • Mcl-1 promotes survival of thymocytes by inhibition of Bak in a pathway separate from Bcl-2. 
  • Mechanism of inactivation of CDKN2 and MTS2 in non-small cell lung cancer and association with advanced stage. 
  • Mechanism of silver nanoparticle toxicity is dependent on dissolved silver and surface coating in Caenorhabditis elegans. 
  • Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis. 
  • Metabolic Alterations Contribute to Enhanced Inflammatory Cytokine Production in Irgm1-deficient Macrophages. 
  • Metabolic adaptation in Cryptococcus neoformans during early murine pulmonary infection. 
  • Mice lacking Homer 1 exhibit a skeletal myopathy characterized by abnormal transient receptor potential channel activity. 
  • Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. 
  • Mice with a deletion in the gene for CCAAT/enhancer-binding protein beta are protected against diet-induced obesity. 
  • Mice with duplications and deletions at the Tme locus have altered MnSOD activity. 
  • MicroRNA-16 suppresses metastasis in an orthotopic, but not autochthonous, mouse model of soft tissue sarcoma. 
  • MicroRNA-182 drives metastasis of primary sarcomas by targeting multiple genes. 
  • Mitochondrial DNA deletions/rearrangements in parkinson disease and related neurodegenerative disorders. 
  • Modeling Sjögren's syndrome with Id3 conditional knockout mice. 
  • Modulation of bacterial outer membrane vesicle production by envelope structure and content. 
  • Molecular analysis of P16(Ink4)/CDKN2 and P15(INK4B)/MTS2 genes in primary human testicular germ cell tumors. 
  • Molecular markers of prognosis in astrocytic tumors. 
  • Molecular pathogenesis of malignant gliomas. 
  • Mosaicism for an FMR1 gene deletion in a fragile X female. 
  • Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophy. 
  • Multi-agent chemotherapy overcomes glucocorticoid resistance conferred by a BIM deletion polymorphism in pediatric acute lymphoblastic leukemia. 
  • Multifactor dimensionality reduction reveals gene-gene interactions associated with multiple sclerosis susceptibility in African Americans. 
  • Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy. 
  • Multiprotein HIV type 1 clade B DNA and MVA vaccines: construction, expression, and immunogenicity in rodents of the MVA component. 
  • Mutation analysis in nephronophthisis using a combined approach of homozygosity mapping, CEL I endonuclease cleavage, and direct sequencing. 
  • Mutation analysis of 24 known cancer genes in the NCI-60 cell line set. 
  • Mutation analysis of IL2RG in human X-linked severe combined immunodeficiency. 
  • Mutation analysis of the THRA1 gene in breast cancer: deletion/fusion of the gene to a novel sequence on 17q in the BT474 cell line. 
  • Mutation of TBCE causes hypoparathyroidism-retardation-dysmorphism and autosomal recessive Kenny-Caffey syndrome. 
  • Mutational analysis of the Drosophila DNA repair and recombination gene mei-9. 
  • Mutational analysis of the PTEN gene in human uterine sarcomas. 
  • Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma. 
  • Mutations in MKKS cause obesity, retinal dystrophy and renal malformations associated with Bardet-Biedl syndrome. 
  • Mutations in a novel CLN6-encoded transmembrane protein cause variant neuronal ceroid lipofuscinosis in man and mouse. 
  • Mutations of the E-cadherin gene in human gynecologic cancers. 
  • Myocardium and BMP signaling are required for endocardial differentiation. 
  • NF1 deletion generates multiple subtypes of soft-tissue sarcoma that respond to MEK inhibition. 
  • NKG2D is required for NK cell activation and function in response to E1-deleted adenovirus. 
  • NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease. 
  • Neutralizing and infection-enhancing antibody responses do not correlate with the differential pathogenicity of SIVmac239delta3 in adult and infant rhesus monkeys. 
  • Ninety-six haploid yeast strains with individual disruptions of open reading frames between YOR097C and YOR192C, constructed for the Saccharomyces genome deletion project, have an additional mutation in the mismatch repair gene MSH3. 
  • NlpI-mediated modulation of outer membrane vesicle production through peptidoglycan dynamics in Escherichia coli. 
  • Normal neutrophil function in cathepsin G-deficient mice. 
  • Norrie disease gene sequence variants in an ethnically diverse population with retinopathy of prematurity. 
  • Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. 
  • Novel suppressor loci on chromosome 14q in primary bladder cancer. 
  • Oncolytic viruses for cancer therapy II. Cell-internal factors for conditional growth in neoplastic cells. 
  • Optimization of vaccine responses with an E1, E2b and E3-deleted Ad5 vector circumvents pre-existing anti-vector immunity. 
  • Outer membrane vesicle production by Escherichia coli is independent of membrane instability. 
  • Oxygen-induced mitochondrial biogenesis in the rat hippocampus. 
  • PCR identification of Mycobacterium bovis BCG. 
  • PTEN/MMAC1 mutations in endometrial cancers. 
  • Partial resistance to infection by R5X4 primary HIV type 1 isolates in an exposed-uninfected individual homozygous for CCR5 32-base pair deletion. 
  • Pharmacologic disruption of TRPV1-expressing primary sensory neurons but not genetic deletion of TRPV1 protects mice against pancreatitis. 
  • Phosphoproteome analysis in yeast. 
  • Plasmid models for bacteriophage T4 DNA replication: requirements for fork proteins. 
  • Plasminogen activator inhibitor-1 (PAI-1) modifies the formation of aggressive fibromatosis (desmoid tumor). 
  • Pleiotropic effects of deubiquitinating enzyme Ubp5 on growth and pathogenesis of Cryptococcus neoformans. 
  • Postlipopolysaccharide oxidative damage of mitochondrial DNA. 
  • Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. 
  • Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice. 
  • Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance. 
  • Probing the domain structure of FtsZ by random truncation and insertion of GFP. 
  • Production and characterization of improved adenovirus vectors with the E1, E2b, and E3 genes deleted. 
  • Profound neuronal plasticity in response to inactivation of the dopamine transporter. 
  • Prolactin induction of insulin gene transcription: roles of glucose and signal transducer and activator of transcription 5. 
  • Protection by live, attenuated simian immunodeficiency virus against heterologous challenge. 
  • Protection from nitrosative stress by yeast flavohemoglobin. 
  • RNA-Seq and ChIP-Seq reveal SQSTM1/p62 as a key mediator of JunB suppression of NF-κB-dependent inflammation. 
  • Ras1 and Ras2 contribute shared and unique roles in physiology and virulence of Cryptococcus neoformans. 
  • Recapitulation of the sexual cycle of the primary fungal pathogen Cryptococcus neoformans var. gattii: implications for an outbreak on Vancouver Island, Canada. 
  • Recombination between palindromes P5 and P1 on the human Y chromosome causes massive deletions and spermatogenic failure. 
  • Reduced levels of DNA polymerase delta induce chromosome fragile site instability in yeast. 
  • Reg1p targets protein phosphatase 1 to dephosphorylate hexokinase II in Saccharomyces cerevisiae: characterizing the effects of a phosphatase subunit on the yeast proteome. 
  • Region-specific impairments in striatal synaptic transmission and impaired instrumental learning in a mouse model of Angelman syndrome. 
  • Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment. 
  • Relations between deletion polymorphism of the angiotensin-converting enzyme gene and insulin resistance, glucose intolerance, hyperinsulinemia, and dyslipidemia. 
  • Remarkably little variation in proteins encoded by the Y chromosome's single-copy genes, implying effective purifying selection. 
  • Resistance of Yersinia pestis to complement-dependent killing is mediated by the Ail outer membrane protein. 
  • Rim Pathway-Mediated Alterations in the Fungal Cell Wall Influence Immune Recognition and Inflammation. 
  • Role of recombinational repair in sensitivity to an antitumour agent that inhibits bacteriophage T4 type II DNA topoisomerase. 
  • Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. 
  • SCRIB and PUF60 are primary drivers of the multisystemic phenotypes of the 8q24.3 copy-number variant. 
  • Sample type bias in the analysis of cancer genomes. 
  • Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation. 
  • Septin ring assembly involves cycles of GTP loading and hydrolysis by Cdc42p. 
  • Severe fetal and neonatal hemolytic anemia due to a 198 kb deletion removing the complete β-globin gene cluster. 
  • Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. 
  • Sirt3 regulates metabolic flexibility of skeletal muscle through reversible enzymatic deacetylation. 
  • Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells. 
  • Strict evolutionary conservation followed rapid gene loss on human and rhesus Y chromosomes. 
  • Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts. 
  • Substrate Selectivity of Lysophospholipid Transporter LplT Involved in Membrane Phospholipid Remodeling in Escherichia coli. 
  • Superoxide enhances interleukin 1beta-mediated transcription of the hepatocyte-inducible nitric oxide synthase gene. 
  • Suppression of food intake by glucagon-like peptide-1 receptor agonists: relative potencies and role of dipeptidyl peptidase-4. 
  • Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells. 
  • Survival defects of Cryptococcus neoformans mutants exposed to human cerebrospinal fluid result in attenuated virulence in an experimental model of meningitis. 
  • TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages. 
  • TWEAK/Fn14 signaling is required for liver regeneration after partial hepatectomy in mice. 
  • Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage. 
  • Targeted deletion of GD3 synthase protects against MPTP-induced neurodegeneration. 
  • Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide. 
  • Targeted gene disruption in endocrine research--the case of glucagon-like peptide-1 and neuroendocrine function. 
  • Targeted overexpression of an inactive calmodulin that binds Ca2+ to the mouse pancreatic beta-cell results in impaired secretion and chronic hyperglycemia. 
  • Targeting β-arrestin2 in the treatment of L-DOPA-induced dyskinesia in Parkinson's disease. 
  • Tau proteins-enhanced Ca2+/calmodulin (CaM)-dependent phosphorylation by the brain supernatant of diisopropyl phosphorofluoridate (DFP)-treated hen: tau mutants indicate phosphorylation of more amino acids in tau by CaM kinase II. 
  • Telomere dysfunction causes alveolar stem cell failure. 
  • Temporal analyses of virus replication, immune responses, and efficacy in rhesus macaques immunized with a live, attenuated simian immunodeficiency virus vaccine. 
  • The Aspergillus fumigatus septins play pleiotropic roles in septation, conidiation, and cell wall stress, but are dispensable for virulence. 
  • The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia. 
  • The E6-Ap ubiquitin-protein ligase (UBE3A) gene is localized within a narrowed Angelman syndrome critical region. 
  • The EJC component Magoh regulates proliferation and expansion of neural crest-derived melanocytes. 
  • The GO system prevents ROS-induced mutagenesis and killing in Pseudomonas aeruginosa. 
  • The MicroRNA miR-191 Supports T Cell Survival Following Common γ Chain Signaling. 
  • The PDZ motif of the α1C subunit is not required for surface trafficking and adrenergic modulation of CaV1.2 channel in the heart. 
  • The RAM1 gene encoding a protein-farnesyltransferase beta-subunit homologue is essential in Cryptococcus neoformans. 
  • The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration. 
  • The Transient Inactivation of the Master Cell Cycle Phosphatase Cdc14 Causes Genomic Instability in Diploid Cells of Saccharomyces cerevisiae. 
  • The alpha-specific cell identity factor Sxi1alpha is not required for virulence of Cryptococcus neoformans. 
  • The binding site of human adenosine deaminase for CD26/Dipeptidyl peptidase IV: the Arg142Gln mutation impairs binding to cd26 but does not cause immune deficiency. 
  • The cell surface glycosphingolipids SSEA-3 and SSEA-4 are not essential for human ESC pluripotency. 
  • The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. 
  • The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP. 
  • The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage. 
  • The evolving picture of microdeletion/microduplication syndromes in the age of microarray analysis: variable expressivity and genomic complexity. 
  • The forkhead/winged-helix gene, Mf1, is necessary for the normal development of the cornea and formation of the anterior chamber in the mouse eye. 
  • The generation and characterization of novel Col1a1FRT-Cre-ER-T2-FRT and Col1a1FRT-STOP-FRT-Cre-ER-T2 mice for sequential mutagenesis. 
  • The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms. 
  • The multifunctional Ca²⁺/calmodulin-dependent kinase IIδ (CaMKIIδ) regulates arteriogenesis in a mouse model of flow-mediated remodeling. 
  • The role of melanin-concentrating hormone in conditioned reward learning. 
  • The role of the LAT-PLC-gamma1 interaction in T regulatory cell function. 
  • The role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding. 
  • The role of the supernumerary subunit of Rhodobacter sphaeroides cytochrome bc1 complex. 
  • The roles of placental growth hormone and placental lactogen in the regulation of human fetal growth and development. 
  • The trehalose synthesis pathway is an integral part of the virulence composite for Cryptococcus gattii. 
  • Thirteen novel NPHS1 mutations in a large cohort of children with congenital nephrotic syndrome. 
  • Three new dominant drug resistance cassettes for gene disruption in Saccharomyces cerevisiae. 
  • Three phosphatidylglycerol-phosphate phosphatases in the inner membrane of Escherichia coli. 
  • Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors. 
  • Tiling path resolution mapping of constitutional 1p36 deletions by array-CGH: contiguous gene deletion or "deletion with positional effect" syndrome? 
  • Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as an in vitro assay system to show TLR4-independent signaling of Bacteroides fragilis lipopolysaccharide. 
  • Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells. 
  • Topoisomerase I plays a critical role in suppressing genome instability at a highly transcribed G-quadruplex-forming sequence. 
  • Transcriptional regulation of chitin synthases by calcineurin controls paradoxical growth of Aspergillus fumigatus in response to caspofungin. 
  • Transformation of Saccharomyces cerevisiae with nonhomologous DNA: illegitimate integration of transforming DNA into yeast chromosomes and in vivo ligation of transforming DNA to mitochondrial DNA sequences. 
  • Two distinct genes encode small isoproteolipids affecting plasma membrane H(+)-ATPase activity of Saccharomyces cerevisiae. 
  • Two transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon. 
  • Two-dimensional gel analysis of rolling circle replication in the presence and absence of bacteriophage T4 primase. 
  • Unprecedented loss of ammonia assimilation capability in a urease-encoding bacterial mutualist. 
  • Urease expression by Cryptococcus neoformans promotes microvascular sequestration, thereby enhancing central nervous system invasion. 
  • VEGF is essential for hypoxia-inducible factor-mediated neovascularization but dispensable for endothelial sprouting. 
  • Vasomotor instability in neonates with chromosome 22q11 deletion syndrome. 
  • Virulence factors identified by Cryptococcus neoformans mutant screen differentially modulate lung immune responses and brain dissemination. 
  • Whole genome genetic-typing in yeast using high-density oligonucleotide arrays. 
  • [GIPC: a new target for therapy in pancreatic adenocarcinoma?]. 
  • p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. 
  • p53 functions in endothelial cells to prevent radiation-induced myocardial injury in mice. 
  • β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Buckley, Rebecca Hatcher, James Buren Sidbury Professor of Pediatrics, in the School of Medicine, Immunology
  • Carbrey, Jennifer Mehlman, Assistant Research Professor of Cell Biology, Cell Biology
  • Ciofani, Maria, Assistant Professor of Immunology, Immunology
  • Davis, Erica Ellen, Associate Professor of Pediatrics, Cell Biology
  • Erickson, Harold Paul, James B. Duke Professor of Cell Biology, Biomedical Engineering
  • Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology
  • Guan, Ziqiang, Research Professor in Biochemistry, Biochemistry
  • Gunn, Michael Dee, Professor of Medicine, Immunology
  • Hogan, Brigid L. M., George Barth Geller Professor, Cell Biology
  • Hsu-Kim, Heileen, Mary Milus Yoh and Harold L. Yoh, Jr. Associate Professor of Civil and Environmental Engineering, Civil and Environmental Engineering
  • Juvvadi, Praveen Rao, Assistant Professor in Pediatrics, Pediatrics, Infectious Diseases
  • Liu, Yutao, Adjunct Assistant Professor in the Department of Medicine, Medicine, Medical Genetics
  • McCall, Shannon Jones, Associate Professor of Pathology, Pathology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Schmid, Amy K., Associate Professor of Biology, Duke University Energy Initiative
  • Shinohara, Mari L., Associate Professor of Immunology, Immunology
  • Silver, Debra Lynn, Associate Professor of Molecular Genetics and Microbiology, Duke Science & Society
  • Soderling, Scott Haydn, Professor in Cell Biology, Cell Biology
  • Steinbach, William J., Professor of Pediatrics, Molecular Genetics and Microbiology
  • Yan, Hai, Henry S. Friedman Professor of Neuro-Oncology in the School of Medicine, Pathology
  • Yang, Yiping, Professor of Medicine, Immunology