Viral Nonstructural Proteins

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  Subject Areas on Research

  • A Fluorescent Cell-Based System for Imaging Zika Virus Infection in Real-Time. 
  • A physical interaction network of dengue virus and human proteins. 
  • Characterization of SARS2 Nsp15 nuclease activity reveals it's mad about U. 
  • Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo. 
  • Control of innate immune signaling and membrane targeting by the Hepatitis C virus NS3/4A protease are governed by the NS3 helix α0. 
  • Convergent evolution of escape from hepaciviral antagonism in primates. 
  • Cooperation between the Hepatitis C Virus p7 and NS5B Proteins Enhances Virion Infectivity. 
  • Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics. 
  • Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis. 
  • Development and use of SIV-based Integrase defective lentiviral vector for immunization. 
  • Development of CRISPR as an Antiviral Strategy to Combat SARS-CoV-2 and Influenza. 
  • Development of a Fluorescence-Based, High-Throughput SARS-CoV-2 3CLpro Reporter Assay. 
  • Emerging therapies in hepatitis C: dawn of the era of the direct-acting antivirals. 
  • Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infection. 
  • Expression of a murine cytomegalovirus early-late protein in "latently" infected mice. 
  • Flipped over U: structural basis for dsRNA cleavage by the SARS-CoV-2 endoribonuclease. 
  • Genetic adaptation to untranslated region-mediated enterovirus growth deficits by mutations in the nonstructural proteins 3AB and 3CD. 
  • Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins. 
  • Hepatitis C Virus Infection Is Inhibited by a Noncanonical Antiviral Signaling Pathway Targeted by NS3-NS4A. 
  • Hepatitis C virus NS5B polymerase: QM/MM calculations show the important role of the internal energy in ligand binding. 
  • Hepatitis C virus directly acting antivirals: current developments with NS3/4A HCV serine protease inhibitors. 
  • IL28B polymorphism is not associated with HCV protease diversity in patients co-infected with HIV and HCV treated with pegylated interferon and ribavirin. 
  • Induction of primary, human antigen-specific cytotoxic T lymphocytes in vitro using dendritic cells pulsed with peptides. 
  • Inhibition of translation and induction of apoptosis by Bunyaviral nonstructural proteins bearing sequence similarity to reaper. 
  • Interferon and ribavirin therapy does not select for resistance mutations in hepatitis C virus polymerase. 
  • Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection. 
  • Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus. 
  • Molecular mechanisms of receptor desensitization using the beta-adrenergic receptor-coupled adenylate cyclase system as a model. 
  • RSV-encoded NS2 promotes epithelial cell shedding and distal airway obstruction. 
  • Sofosbuvir and Velpatasvir for HCV Genotype 2 and 3 Infection. 
  • Sofosbuvir and Velpatasvir for HCV in Patients with Decompensated Cirrhosis. 
  • Synonymous codon usage analysis of hand, foot and mouth disease viruses: A comparative study on coxsackievirus A6, A10, A16, and enterovirus 71 from 2008 to 2015. 
  • Telaprevir for the treatment of chronic hepatitis C infection. 
  • The acidic domain of the hepatitis C virus NS4A protein is required for viral assembly and envelopment through interactions with the viral E1 glycoprotein. 
  • The sequences of reovirus serotype 3 genome segments M1 and M3 encoding the minor protein mu 2 and the major nonstructural protein mu NS, respectively. 
  • Treatment of chronic hepatitis C in blacks and non-Hispanic whites. 
  • Virome Analysis of Transfusion Recipients Reveals a Novel Human Virus That Shares Genomic Features with Hepaciviruses and Pegiviruses. 
  • ZIKV-Specific NS1 Epitopes as Serological Markers of Acute Zika Virus Infection. 
  • Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors.