Cyclic AMP Response Element-Binding Protein
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Subject Areas on Research
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A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans.
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A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist.
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A c-Fos- and E1A-interacting component of the tissue factor basal promoter complex mediates synergistic activation of transcription by transforming growth factor-beta1.
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A cAMP response element in the beta 2-adrenergic receptor gene confers transcriptional autoregulation by cAMP.
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A role for repressive histone methylation in cocaine-induced vulnerability to stress.
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A signaling complex of Ca2+-calmodulin-dependent protein kinase IV and protein phosphatase 2A.
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Activated cAMP-response element-binding protein regulates neuronal expression of presenilin-1.
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Activation of Akt/PDK signaling in macrophages upon binding of receptor-recognized forms of alpha2-macroglobulin to its cellular receptor: effect of silencing the CREB gene.
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Activation of protein kinases in chronically hypoxic infant human and rabbit hearts: role in cardioprotection.
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Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility.
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Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients.
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Analysis of the structural properties of cAMP-responsive element-binding protein (CREB) and phosphorylated CREB.
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Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway.
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Aspartate release and signalling in the hippocampus.
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CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability.
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CREB coactivators CRTC2 and CRTC3 modulate bone marrow hematopoiesis.
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Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression.
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Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells.
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Case-control association study of 14 variants of CREB1, CREBBP and CREM on diagnosis and treatment outcome in major depressive disorder and bipolar disorder.
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Cell survival promoted by the Ras-MAPK signaling pathway by transcription-dependent and -independent mechanisms.
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Cerebellar defects in Ca2+/calmodulin kinase IV-deficient mice.
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Changes in the expression of transcription factors ATF-2 and Fra-2 after axotomy and during regeneration in rat retinal ganglion cells.
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Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation.
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Chronic fluoxetine increases extra-hippocampal neurogenesis in adult mice.
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Chronic very low dose naltrexone administration attenuates opioid withdrawal expression.
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Co-regulation of nuclear respiratory factor-1 by NFkappaB and CREB links LPS-induced inflammation to mitochondrial biogenesis.
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Context-dependent activation kinetics elicited by soluble versus outer membrane vesicle-associated heat-labile enterotoxin.
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Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation.
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Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation.
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Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord.
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Defective signaling in a subpopulation of CD4(+) T cells in the absence of Ca(2+)/calmodulin-dependent protein kinase IV.
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Defective survival and activation of thymocytes in transgenic mice expressing a catalytically inactive form of Ca2+/calmodulin-dependent protein kinase IV.
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Definition of a lipopolysaccharide-responsive element in the 5'-flanking regions of MuRantes and crg-2.
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Developmental activation of the TCR alpha enhancer requires functional collaboration among proteins bound inside and outside the core enhancer.
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Differential regulation of c-jun and CREB by acrolein and 4-hydroxynonenal.
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Distinct nuclear proteins competing for an overlapping sequence of cyclic adenosine monophosphate and negative regulatory elements regulate tissue-specific mouse renin gene expression.
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Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease.
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Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia.
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Engineered leucine zippers show that hemiphosphorylated CREB complexes are transcriptionally active.
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Enhancement of dopaminergic properties and protection mediated by neuronal activation of Ras in mouse ventral mesencephalic neurones.
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Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy.
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Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway.
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Expression of a peptide inhibitor of protein phosphatase 1 increases phosphorylation and activity of CREB in NIH 3T3 fibroblasts.
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Generation of silent synapses by acute in vivo expression of CaMKIV and CREB.
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High glucose stimulates angiotensinogen gene expression and cell hypertrophy via activation of the hexosamine biosynthesis pathway in rat kidney proximal tubular cells.
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Human T-cell leukemia virus type 1 Tax activates cyclin-dependent kinase inhibitor p21/Waf1/Cip1 expression through a p53-independent mechanism: Inhibition of cdk2.
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Implications of hypoxia on mucosal barrier function.
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In vitro selection of DNA elements highly responsive to the human T-cell lymphotropic virus type I transcriptional activator, Tax.
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Inhibition of betaARK1 restores impaired biochemical beta-adrenergic receptor responsiveness but does not rescue CREB(A133) induced cardiomyopathy.
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Inhibition of the cAMP/PKA/CREB Pathway Contributes to the Analgesic Effects of Electroacupuncture in the Anterior Cingulate Cortex in a Rat Pain Memory Model.
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Intracellular CMTM2 negatively regulates human immunodeficiency virus type-1 transcription through targeting the transcription factors AP-1 and CREB.
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Ionotropic and metabotropic receptors, protein kinase A, protein kinase C, and Src contribute to C-fiber-induced ERK activation and cAMP response element-binding protein phosphorylation in dorsal horn neurons, leading to central sensitization.
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LXRalpha functions as a cAMP-responsive transcriptional regulator of gene expression.
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MeCP2 enforces Foxp3 expression to promote regulatory T cells' resilience to inflammation.
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Modulatory function of CREB.CREM alpha heterodimers depends upon CREM alpha phosphorylation.
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Molecular dissection of the miR-17-92 cluster's critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation.
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Molecular mechanism of tissue-specific regulation of mouse renin gene expression by cAMP. Identification of an inhibitory protein that binds nuclear transcriptional factor.
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Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal.
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Nuclear protein CBP is a coactivator for the transcription factor CREB.
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Opposing roles for endogenous BDNF and NT-3 in regulating cortical dendritic growth.
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Organization and analysis of the complete rat calmodulin-dependent protein kinase IV gene.
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Orphan Adhesion GPCR GPR64/ADGRG2 Is Overexpressed in Parathyroid Tumors and Attenuates Calcium-Sensing Receptor-Mediated Signaling.
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Phosphorylation of transcription factor CREB in rat spinal cord after formalin-induced hyperalgesia: relationship to c-fos induction.
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Physiological roles of the Ca2+/CaM-dependent protein kinase cascade in health and disease.
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Possible influence of CREB1, CREBBP and CREM variants on diagnosis and treatment outcome in patients with schizophrenia.
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Potentiation of signal transduction mitogenesis and cellular proliferation upon binding of receptor-recognized forms of alpha2-macroglobulin to 1-LN prostate cancer cells.
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Prenatal choline supplementation advances hippocampal development and enhances MAPK and CREB activation.
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Recruitment of CREB binding protein is sufficient for CREB-mediated gene activation.
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Regulation and function of the calcium/calmodulin-dependent protein kinase IV/protein serine/threonine phosphatase 2A signaling complex.
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Regulation of cytosolic phospholipase A2 activity in macrophages stimulated with receptor-recognized forms of alpha 2-macroglobulin: role in mitogenesis and cell proliferation.
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Secondary structure creates mismatched base pairs required for high-affinity binding of cAMP response element-binding protein to the human enkephalin enhancer.
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Sequences that direct rat tyrosine hydroxylase gene expression.
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Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression.
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Serotonin- and training-induced dynamic regulation of CREB2 in Aplysia.
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Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia.
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Specific agrin isoforms induce cAMP response element binding protein phosphorylation in hippocampal neurons.
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Suppression of the c-Jun N-terminal kinase pathway by 17beta-estradiol can preserve human islet functional mass from proinflammatory cytokine-induced destruction.
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T-lymphocyte CREB as a potential biomarker of response to antidepressant drugs.
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Targeting CREB Pathway Suppresses Small Cell Lung Cancer.
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The CREB/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation.
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The cyclic AMP response element directs tyrosine hydroxylase expression in catecholaminergic central and peripheral nervous system cell lines from transgenic mice.
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The dopamine metabolite 3-methoxytyramine is a neuromodulator.
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The human T-cell leukemia virus-1 transcriptional activator Tax enhances cAMP-responsive element-binding protein (CREB) binding activity through interactions with the DNA minor groove.
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The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions.
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The role of cAMP-dependent signaling in receptor-recognized forms of alpha 2-macroglobulin-induced cellular proliferation.
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The structure of a CREB bZIP.somatostatin CRE complex reveals the basis for selective dimerization and divalent cation-enhanced DNA binding.
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Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet.
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Tobacco Carcinogen-Induced Production of GM-CSF Activates CREB to Promote Pancreatic Cancer.
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Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB.
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Transcriptional regulation of N-acetylglutamate synthase.
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Tyrosine hydroxylase transcription depends primarily on cAMP response element activity, regardless of the type of inducing stimulus.
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Upregulation of AKT1 protein expression in forskolin-stimulated macrophage: evidence from ChIP analysis that CREB binds to and activates the AKT1 promoter.
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Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex.
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c-Jun enhancement of cyclic adenosine 3',5'-monophosphate response element-dependent transcription induced by transforming growth factor-beta is independent of c-Jun binding to DNA.
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cAMP response element-binding protein 1 feedback loop is necessary for consolidation of long-term synaptic facilitation in Aplysia.
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p38 Mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis.