Spliceosomes
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Subject Areas on Research
- 5' exon replacement and repair by spliceosome-mediated RNA trans-splicing.
- A mammalian activity required for the second step of pre-messenger RNA splicing.
- A mutational analysis of the polypyrimidine tract of introns. Effects of sequence differences in pyrimidine tracts on splicing.
- An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses.
- Anti-sm autoantibodies in systemic lupus target highly basic surface structures of complexed spliceosomal autoantigens.
- Both phosphorylation and dephosphorylation of ASF/SF2 are required for pre-mRNA splicing in vitro.
- Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6.
- Comparative genomic analysis of fungal genomes reveals intron-rich ancestors.
- Comprehensive RNA Polymerase II Interactomes Reveal Distinct and Varied Roles for Each Phospho-CTD Residue.
- Correction of tau mis-splicing caused by FTDP-17 MAPT mutations by spliceosome-mediated RNA trans-splicing.
- Early history of circular RNAs, children of splicing.
- Identification of the cellular targets of the transcription factor TCERG1 reveals a prevalent role in mRNA processing.
- Messenger RNA repair and restoration of protein function by spliceosome-mediated RNA trans-splicing.
- Messenger RNA reprogramming by spliceosome-mediated RNA trans-splicing.
- Partial correction of endogenous DeltaF508 CFTR in human cystic fibrosis airway epithelia by spliceosome-mediated RNA trans-splicing.
- Phenotype correction of hemophilia A mice by spliceosome-mediated RNA trans-splicing.
- Prespliceosome and spliceosome isolation and analysis.
- Proximity-dependent and proximity-independent trans-splicing in mammalian cells.
- RECQ5 helicase associates with the C-terminal repeat domain of RNA polymerase II during productive elongation phase of transcription.
- Repair of CFTR mRNA by spliceosome-mediated RNA trans-splicing.
- Reprogramming of tau alternative splicing by spliceosome-mediated RNA trans-splicing: implications for tauopathies.
- SR proteins escort the U4/U6.U5 tri-snRNP to the spliceosome.
- Selective small antigenic structures are capable of inducing widespread autoimmunity which closely mimics the humoral fine specificity of human SLE.
- Spliceosome-mediated RNA trans-splicing as a tool for gene therapy.
- Structural availability influences the capacity of autoantigenic epitopes to induce a widespread lupus-like autoimmune response.
- Trans-splicing into highly abundant albumin transcripts for production of therapeutic proteins in vivo.
- U1 snRNP-ASF/SF2 interaction and 5' splice site recognition: characterization of required elements.
- Using 5'-PTMs to repair mutant beta-globin transcripts.
- Widespread occurrence of spliceosomal introns in the rDNA genes of ascomycetes.