RNA Editing

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  Subject Areas on Research

  • ADAR-Mediated RNA Editing Predicts Progression and Prognosis of Gastric Cancer. 
  • Acute spinal cord injury persistently reduces R/G RNA editing of AMPA receptors. 
  • Cas9 loosens its grip on off-target sites. 
  • Characterization of Staphylococcus aureus Cas9: a smaller Cas9 for all-in-one adeno-associated virus delivery and paired nickase applications. 
  • Correction of dystrophin expression in cells from Duchenne muscular dystrophy patients through genomic excision of exon 51 by zinc finger nucleases. 
  • Disproportionate relationship between APOBEC-1 expression and apolipoprotein B mRNA editing activity. 
  • Dynamic landscape and regulation of RNA editing in mammals. 
  • Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers. 
  • Ethanol increases apolipoprotein B mRNA editing in rat primary hepatocytes and McArdle cells. 
  • Examination of Endogenous Rotund Expression and Function in Developing Drosophila Olfactory System Using CRISPR-Cas9-Mediated Protein Tagging. 
  • Identification of the yeast cytidine deaminase CDD1 as an orphan C-->U RNA editase. 
  • In vivo RNA editing of point mutations via RNA-guided adenosine deaminases. 
  • Inherited variants affecting RNA editing may contribute to ovarian cancer susceptibility: results from a large-scale collaboration. 
  • Inhibition of alpharetrovirus replication by a range of human APOBEC3 proteins. 
  • Insect sodium channels and insecticide resistance. 
  • Kappa editing rescues autoreactive B cells destined for deletion in mice transgenic for a dual specific anti-laminin Ig. 
  • Know thyself. 
  • Molecular and functional characterization of voltage-gated sodium channel variants from Drosophila melanogaster. 
  • Molecular biology of insect sodium channels and pyrethroid resistance. 
  • Molecular characterization and functional expression of the DSC1 channel. 
  • Novel RNA modifications in the nervous system: form and function. 
  • Optical Control of CRISPR/Cas9 Gene Editing. 
  • Persistent tetrodotoxin-sensitive sodium current resulting from U-to-C RNA editing of an insect sodium channel. 
  • Posttranscriptional m(6)A Editing of HIV-1 mRNAs Enhances Viral Gene Expression. 
  • RGEN Editing of RNA and DNA: The Long and Winding Road from Catalytic RNAs to CRISPR to the Clinic. 
  • RNA editing generates tissue-specific sodium channels with distinct gating properties. 
  • RNA editing induces variation in desensitization and trafficking of 5-hydroxytryptamine 2c receptor isoforms. 
  • RNA repair: a novel approach to gene therapy. 
  • RNA-guided gene activation by CRISPR-Cas9-based transcription factors. 
  • Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene. 
  • Role and mechanism of action of the APOBEC3 family of antiretroviral resistance factors. 
  • Structure and function of the native and recombinant mitochondrial MRP1/MRP2 complex from Trypanosoma brucei. 
  • Structure of the Trypanosoma brucei p22 protein, a cytochrome oxidase subunit II-specific RNA-editing accessory factor. 
  • Structures of the T. brucei kRNA editing factor MRB1590 reveal unique RNA-binding pore motif contained within an ABC-ATPase fold. 
  • The Development of TALE Nucleases for Biotechnology. 
  • The RRM of the kRNA-editing protein TbRGG2 uses multiple surfaces to bind and remodel RNA. 
  • The intrinsic antiretroviral factor APOBEC3B contains two enzymatically active cytidine deaminase domains. 
  • The nicotinic acetylcholine receptor gene family of the silkworm, Bombyx mori. 
  • Variation in frequency of plastid RNA editing within Adiantum implies rapid evolution in fern plastomes. 
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  Keywords of People

  • Meyer, Kathryn, Assistant Professor of Biochemistry, Neurobiology
  • Reddy, Timothy E, Associate Professor of Biostatistics & Bioinformatics, Molecular Genetics and Microbiology