In Situ Hybridization

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  Subject Areas on Research

  • A Drosophila CREB/CREM homolog encodes multiple isoforms, including a cyclic AMP-dependent protein kinase-responsive transcriptional activator and antagonist. 
  • A binding site for Pax proteins regulates expression of the gene for the neural cell adhesion molecule in the embryonic spinal cord. 
  • A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF. 
  • A candidate taste receptor gene near a sweet taste locus. 
  • A microRNA signature profile in EBV+ diffuse large B-cell lymphoma of the elderly. 
  • A model for optimizing adenoviral delivery in human cancer gene therapy trials. 
  • A multigene family encoding a diverse array of putative pheromone receptors in mammals. 
  • A phase I/II trial of intratumoral endoscopic ultrasound injection of ONYX-015 with intravenous gemcitabine in unresectable pancreatic carcinoma. 
  • A quantitative method for measuring gene expression magnitude and volume delivered by gene therapy vectors. 
  • A standardized definition of placental infection by SARS-CoV-2, a consensus statement from the National Institutes of Health/Eunice Kennedy Shriver National Institute of Child Health and Human Development SARS-CoV-2 Placental Infection Workshop. 
  • AMH induces mesonephric cell migration in XX gonads. 
  • Ablation of the secondary heart field leads to tetralogy of Fallot and pulmonary atresia. 
  • Age cutoff for Epstein-Barr virus-positive diffuse large B-cell lymphoma--is it necessary? 
  • Alpha-adrenergic mRNA subtype expression in the human nasal turbinate. 
  • Alpha1-adrenergic receptors in human spinal cord: specific localized expression of mRNA encoding alpha1-adrenergic receptor subtypes at four distinct levels. 
  • Alteration of Caenorhabditis elegans gene expression by targeted transformation. 
  • An approach for treating the hepatobiliary disease of cystic fibrosis by somatic gene transfer. 
  • An env gene derived from a primary human immunodeficiency virus type 1 isolate confers high in vivo replicative capacity to a chimeric simian/human immunodeficiency virus in rhesus monkeys. 
  • Analysis of messenger ribonucleic acid and protein for the ligands and receptors of the platelet-derived growth factor signaling pathway in the placenta, extraembryonic membranes, and uterus during the latter half of murine gestation. 
  • Aneuploidy of chromosome 9 and the tumor suppressor genes p16(INK4) and p15(INK4B) detected by in situ hybridization in locally advanced prostate cancer. 
  • Angiotensin converting enzyme in renal ontogeny: hypothesis for multiple roles. 
  • Angiotensinogen gene null-mutant mice lack homeostatic regulation of glomerular filtration and tubular reabsorption. 
  • Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter. 
  • Antiretroviral monotherapy in early stage human immunodeficiency virus disease has no detectable effect on virus load in peripheral blood and lymph nodes. 
  • Apolipoprotein J/clusterin induction in myocarditis: A localized response gene to myocardial injury. 
  • Aromatic hydrocarbon receptor polymorphism: development of new methods to correlate genotype with phenotype. 
  • Ascorbic acid modulates collagen type I gene expression by cells from an eye tissue--trabecular meshwork. 
  • Assignment of the human beta-adducin gene (ADD2) to 2p13-p14 by in situ hybridization. 
  • Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling. 
  • Automated annotation of gene expression image sequences via non-parametric factor analysis and conditional random fields. 
  • BMP antagonism by Noggin is required in presumptive notochord cells for mammalian foregut morphogenesis. 
  • BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning. 
  • BMP signaling in the development of the mouse esophagus and forestomach. 
  • BMPs induce dermal markers and ectopic feather tracts. 
  • Balloon catheterization induced arterial expression of embryonic fibronectins. 
  • Beta heavy-spectrin has a restricted tissue and subcellular distribution during Drosophila embryogenesis. 
  • Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway. 
  • Bmp and Fgf signaling are essential for liver specification in zebrafish. 
  • Bmp7 regulates germ cell proliferation in mouse fetal gonads. 
  • Bombesin and [Leu8]phyllolitorin promote fetal mouse lung branching morphogenesis via a receptor-mediated mechanism. 
  • Bombesin-like peptide and receptors in lung injury models: diverse gene expression, similar function. 
  • Bombesin-like peptide receptor gene expression, regulation, and function in fetal murine lung. 
  • Bombesin-like peptides and receptors in normal fetal baboon lung: roles in lung growth and maturation. 
  • Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. 
  • Brain gene regulation by territorial singing behavior in freely ranging songbirds. 
  • CD10/neutral endopeptidase 24.11 in developing human fetal lung. Patterns of expression and modulation of peptide-mediated proliferation. 
  • CD19 maps to a region of conservation between human chromosome 16 and mouse chromosome 7. 
  • Cadherin-11 expressed in association with mesenchymal morphogenesis in the head, somite, and limb bud of early mouse embryos. 
  • Calcitonin driven v-Ha-ras induces multilineage pulmonary epithelial hyperplasias and neoplasms. 
  • Calreticulin chaperones regulate functional expression of vomeronasal type 2 pheromone receptors. 
  • Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation. 
  • Cellular interactions implicated in the mechanism of photoreceptor degeneration in transgenic mice expressing a mutant rhodopsin gene. 
  • Cellular patterns of insulin-like growth factor system gene expression in murine chondrogenesis and osteogenesis. 
  • Central and peripheral expression of galanin in response to inflammation. 
  • Cftr controls lumen expansion and function of Kupffer's vesicle in zebrafish. 
  • Characterization of skin cytokines in bullous pemphigoid and pemphigus vulgaris. 
  • Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression. 
  • Chemokine ligand and receptor expression in the pregnant uterus: reciprocal patterns in complementary cell subsets suggest functional roles. 
  • Clarification of subtle reciprocal rearrangements using fluorescence in situ hybridization. 
  • Classical Hodgkin lymphoma arising in the setting of iatrogenic immunodeficiency: a clinicopathologic study of 10 cases. 
  • Cloning and characterization of SLP3: a novel member of the stomatin family expressed by olfactory receptor neurons. 
  • Cloning of zebrafish vsx1: expression of a paired-like homeobox gene during CNS development. 
  • Cloning, characterization, and chromosomal localization of rec1.3, a member of the G-protein-coupled receptor family highly expressed in brain. 
  • Co-expression of urokinase with haptoglobin in human carcinomas. 
  • Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta. 
  • Composite lymphoid neoplasm of B-cell and T-cell origins: a pathologic study of 14 cases. 
  • Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. 
  • Continuous contractile activity induces fiber type specific expression of HSP70 in skeletal muscle. 
  • Contribution of hedgehog signaling to the establishment of left-right asymmetry in the sea urchin. 
  • Coordinated activation of corneal wound response genes in vivo as observed by in situ hybridization. 
  • Cortical glutamic acid decarboxylase 67 deficiency results in lower cannabinoid 1 receptor messenger RNA expression: implications for schizophrenia. 
  • Dax1 regulates testis cord organization during gonadal differentiation. 
  • Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway. 
  • Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis. 
  • Detection of Epstein-Barr virus in transformations of low-grade B-cell lymphomas after fludarabine treatment. 
  • Detection of human papillomavirus in the prostate by polymerase chain reaction and in situ hybridization. 
  • Developmental expression of renal angiotensin II receptor genes in the mouse. 
  • Diagnostic accuracy of serum antibodies to human papillomavirus type 16 early antigens in the detection of human papillomavirus-related oropharyngeal cancer. 
  • Differences in apolipoprotein E3/3 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease. 
  • Differences in the anatomic distribution of immediate-early gene expression in amygdala and angular bundle kindling development. 
  • Different patterns of angiogenesis in sarcomas and carcinomas. 
  • Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. 
  • Differential expression of plasminogen activators and their inhibitors in an organotypic skin coculture system. 
  • Differential localization of allograft nitric oxide synthesis: comparison of liver and heart transplantation in the rat model. 
  • Differential localization of placental extracellular superoxide dismutase as pregnancy progresses. 
  • Differentiating pancreatic lesions by microarray and QPCR analysis of pancreatic juice RNAs. 
  • Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability. 
  • Disruption of Gen1 Causes Congenital Anomalies of the Kidney and Urinary Tract in Mice. 
  • Disruption of PAX6 function in mice homozygous for the Pax6Sey-1Neu mutation produces abnormalities in the early development and regionalization of the diencephalon. 
  • Disruption of testis cords by cyclopamine or forskolin reveals independent cellular pathways in testis organogenesis. 
  • Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice. 
  • Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. 
  • Distribution of GABAA receptors in the limbic system of alcohol-preferring and non-preferring rats: in situ hybridisation histochemistry and receptor autoradiography. 
  • Distribution of alpha 2-adrenergic receptor subtype gene expression in rat brain. 
  • Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis. 
  • Distribution of opioid peptide gene expression in the limbic system of Fawn-Hooded (alcohol-preferring) and Wistar-Kyoto (alcohol-non-preferring) rats. 
  • Divergent vascular mechanisms downstream of Sry establish the arterial system in the XY gonad. 
  • Effect of INS37217, a P2Y(2) receptor agonist, on experimental retinal detachment and electroretinogram in adult rabbits. 
  • Effect of complement consumption by cobra venom factor on the course of primary infection with simian immunodeficiency virus in rhesus monkeys. 
  • Effect of growth factors on substance P mRNA expression in axotomized dorsal root ganglia. 
  • Effects of fasting, refeeding, and intraluminal triglyceride on proglucagon expression in jejunum and ileum. 
  • Embryonic expression and steroid regulation of brain aromatase cyp19a1b in zebrafish (Danio rerio). 
  • Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad. 
  • Enhanced central response to dehydration in mice lacking angiotensin AT(1a) receptors. 
  • Epithelial cells are an important source of tenascin in normal and malignant human breast tissue. 
  • Epstein-Barr virus DNA is abundant and monoclonal in the Reed-Sternberg cells of Hodgkin's disease: association with mixed cellularity subtype and Hispanic American ethnicity. 
  • Epstein-Barr virus-associated lymphoproliferative disorder following autologous bone marrow transplantation for non-Hodgkin's lymphoma. 
  • Epstein-Barr virus-associated smooth muscle tumors are distinctive mesenchymal tumors reflecting multiple infection events: a clinicopathologic and molecular analysis of 29 tumors from 19 patients. 
  • Epstein-Barr virus-positive nodular lymphocyte predominant Hodgkin lymphoma. 
  • Epstein-Barr virus-related posttransplantation lymphoproliferative disorder involving pancreas allografts: histological differential diagnosis from acute allograft rejection. 
  • Estrogen receptor beta protects against in vivo injury in RPE cells. 
  • Evidence for the involvement of the Gli gene family in embryonic mouse lung development. 
  • Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse. 
  • Expression microarray identifies novel markers of free flap failure in a rat model. 
  • Expression of Ca(2+)/calmodulin-dependent protein kinase IV (caMKIV) messenger RNA during murine embryogenesis. 
  • Expression of E-selectin messenger RNA and protein in rheumatoid arthritis. 
  • Expression of EGFR, VEGF, and NOTCH1 suggest differences in tumor angiogenesis in HPV-positive and HPV-negative head and neck squamous cell carcinoma. 
  • Expression of TERT in early premalignant lesions and a subset of cells in normal tissues. 
  • Expression of TIMP in fetal and adult mouse tissues studied by in situ hybridization. 
  • Expression of bone morphogenetic protein-4 (BMP-4), bone morphogenetic protein-7 (BMP-7), fibroblast growth factor-8 (FGF-8) and sonic hedgehog (SHH) during branchial arch development in the chick. 
  • Expression of cadherin-11 delineates boundaries, neuromeres, and nuclei in the developing mouse brain. 
  • Expression of cyp26b1 during zebrafish early development. 
  • Expression of neuropeptide Y and neuropeptide Y (Y1) receptor mRNA in rat spinal cord and dorsal root ganglia following peripheral tissue inflammation. 
  • Expression of non-N-methyl-D-aspartate glutamate receptor subunits in the olfactory epithelium. 
  • Expression of peptides, nitric oxide synthase and NPY receptor in trigeminal and nodose ganglia after nerve lesions. 
  • Expression of pituitary adenylate cyclase-activating polypeptide in dorsal root ganglia following axotomy: time course and coexistence. 
  • Expression of plasminogen activator enzymes in psoriatic epidermis. 
  • Expression of plasminogen activator inhibitor type 2 in normal and psoriatic epidermis. 
  • Expression of plasminogen activators in basal cell carcinoma. 
  • Expression of telomerase reverse transcriptase (TERT) in malignant mesotheliomas. 
  • Expression of the 71 kDa dystrophin isoform (Dp71) evaluated by gene targeting. 
  • Expression of transforming growth factor beta 2 RNA during murine embryogenesis. 
  • Expression of transforming growth factor-beta receptors during hyperoxia-induced lung injury and repair. 
  • Expression of transforming growth factor-beta type II receptor in rat lung is regulated during development. 
  • Expression profile of an androgen regulated prostate specific homeobox gene NKX3.1 in primary prostate cancer. 
  • Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer. 
  • FGF signaling regulates rod photoreceptor cell maintenance and regeneration in zebrafish. 
  • Factors regulating islet regeneration in the post-insulinoma NEDH rat. 
  • Fasting prevents experimental murine colitis produced by dextran sulfate sodium and decreases interleukin-1 beta and insulin-like growth factor I messenger ribonucleic acid. 
  • Fgf8 is required for anterior heart field development. 
  • Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. 
  • Fgfs control homeostatic regeneration in adult zebrafish fins. 
  • Fibroblast growth factors regulate calcitonin gene-related peptide mRNA expression in rat motoneurons after lesion and in culture. 
  • Fibrolamellar carcinoma of the liver exhibits immunohistochemical evidence of both hepatocyte and bile duct differentiation. 
  • Formation of Rathke's pouch requires dual induction from the diencephalon. 
  • FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain. 
  • FoxP2 expression in avian vocal learners and non-learners. 
  • Functional and molecular adaptations in skeletal muscle of myoglobin-mutant mice. 
  • GABAA alpha 2 mRNA levels are decreased following induction of spontaneous epileptiform discharges in hippocampal-entorhinal cortical slices. 
  • Galectin-1 accumulation in the ovary carcinoma peritumoral stroma is induced by ovary carcinoma cells and affects both cancer cell proliferation and adhesion to laminin-1 and fibronectin. 
  • Gastrin-releasing peptide gene expression in small cell and large cell undifferentiated lung carcinomas. 
  • Genes for apolipoprotein B and microsomal triglyceride transfer protein are expressed in the heart: evidence that the heart has the capacity to synthesize and secrete lipoproteins. 
  • Genetic control of single lumen formation in the zebrafish gut. 
  • Genomic alterations in head and neck squamous cell carcinoma determined by cancer gene-targeted sequencing. 
  • Glioblastoma-related gene mutations and over-expression of functional epidermal growth factor receptors in SKMG-3 glioma cells. 
  • Glucose-dependent insulinotropic peptide (GIP) gene expression in the rat salivary gland. 
  • Glutamate receptor activation regulates mRNA at both transcriptional and posttranscriptional levels. 
  • Gradients of transgene expression directed by the human myoglobin promoter in the developing mouse heart. 
  • HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. 
  • HNF-3 beta as a regulator of floor plate development. 
  • Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration. 
  • Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development. 
  • Histopathology and vascular endothelial growth factor in untreated and diode laser-treated retinopathy of prematurity. 
  • Human cystic fibrosis transmembrane conductance regulator directed to respiratory epithelial cells of transgenic mice. 
  • Human placental cytotrophoblasts attract monocytes and CD56(bright) natural killer cells via the actions of monocyte inflammatory protein 1alpha. 
  • Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of function. 
  • Hypothalamic CaMKK2 contributes to the regulation of energy balance. 
  • Hypothermic treatment restores glucose regulated protein 78 (GRP78) expression in ischemic brain. 
  • Identification and characterization of a Drosophila nuclear receptor with the ability to inhibit the ecdysone response. 
  • Identification and characterization of a functional zebrafish smrt corepressor (ncor2). 
  • Identification and characterization of genes involved in the carcinogenesis of human squamous cell cervical carcinoma. 
  • Identification of E2F target genes that are rate limiting for dE2F1-dependent cell proliferation. 
  • Identification of aberrantly regulated genes in diseased skin using the cDNA differential display technique. 
  • Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. 
  • Identification of molecular markers for the early detection of human squamous cell carcinoma of the uterine cervix. 
  • Identification of novel cellular targets in biliary tract cancers using global gene expression technology. 
  • Identification of tumor angiogenesis-related genes by subtractive hybridization. 
  • Identification, quantification, and localization of mRNA for three distinct alpha 1 adrenergic receptor subtypes in human prostate. 
  • Immunophenotypic Shifts in Primary Cutaneous γδ T-Cell Lymphoma Suggest Antigenic Modulation: A Study of Sequential Biopsy Specimens. 
  • In situ detection of Epstein-Barr virus in non-small cell lung carcinomas. 
  • In situ hybridization of adrenergic receptor mRNA in brain. 
  • In situ hybridization: identification of rare mRNAs in human tissues. 
  • Increased expression of galanin in the rat superior cervical ganglion after pre- and postganglionic nerve lesions. 
  • Increased expression of transforming growth factor-beta1 and thrombospondin-1 in congenital hepatic fibrosis: possible role of the hepatic stellate cell. 
  • Indian hedgehog as a progesterone-responsive factor mediating epithelial-mesenchymal interactions in the mouse uterus. 
  • Induction of CB1 cannabinoid receptor by inflammation in primary afferent neurons facilitates antihyperalgesic effect of peripheral CB1 agonist. 
  • Induction of c-fos expression in the rostral medulla of rats following electroacupuncture stimulation. 
  • Induction of c-fos mRNA by kindled seizures: complex relationship with neuronal burst firing. 
  • Induction of ductal and stromal hyperplasia by basic fibroblast growth factor produced by human pancreatic carcinoma. 
  • Induction of tenascin in rat lungs undergoing bleomycin-induced pulmonary fibrosis. 
  • Infectious disease pathology. 
  • Inhibition of adaptive immune responses leads to a fatal clinical outcome in SIV-infected pigtailed macaques but not vervet African green monkeys. 
  • Insulin receptor substrate-1 (IRS-1) expression in rat brain. 
  • Insulin-like growth factor-I gene expression in the tibial epiphyseal growth plate of growth hormone-treated uremic rats. 
  • Interaction between PKD1L3 and PKD2L1 through their transmembrane domains is required for localization of PKD2L1 at taste pores in taste cells of circumvallate and foliate papillae. 
  • Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. 
  • Intrarenal and subcellular localization of rat CLC5. 
  • Involvement of Sonic hedgehog (Shh) in mouse embryonic lung growth and morphogenesis. 
  • Ionotropic glutamate receptor subtypes activate c-fos transcription by distinct calcium-requiring intracellular signaling pathways. 
  • Isoflurane-induced neuronal degeneration: an evaluation in organotypic hippocampal slice cultures. 
  • Isolation and characterization of cDNA clones encoding pig gastric mucin. 
  • Isolation of song-regulated genes in the brain of songbirds. 
  • Kif7 promotes hedgehog signaling in growth plate chondrocytes by restricting the inhibitory function of Sufu. 
  • Kindling produces long-lasting and selective changes in gene expression of hippocampal neurons. 
  • Lateralized activation of Cluster N in the brains of migratory songbirds. 
  • Localization of Parkinson's disease-associated LRRK2 in normal and pathological human brain. 
  • Localization of S1 and elongation factor-1 alpha mRNA in rat brain and liver by non-radioactive in situ hybridization. 
  • Localization of heparin cofactor II in injured human skin: a potential role in wound healing. 
  • Long-distance regulation of fetal V(δ) gene segment TRDV4 by the Tcrd enhancer. 
  • Long-lasting reduction of inhibitory function and gamma-aminobutyric acid type A receptor subunit mRNA expression in a model of temporal lobe epilepsy. 
  • Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice. 
  • Loss of cftr function leads to pancreatic destruction in larval zebrafish. 
  • Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations. 
  • Loss of p16/CDKN2A tumor suppressor protein in gastric adenocarcinoma is associated with Epstein-Barr virus and anatomic location in the body of the stomach. 
  • Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. 
  • MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group. 
  • Major histocompatibility complex class I expression on neurons in subacute sclerosing panencephalitis and experimental subacute measles encephalitis. 
  • Malignant transformation of the human endometrium is associated with overexpression of lactoferrin messenger RNA and protein. 
  • Maternal microchimerism in Hirschsprung's disease. 
  • Maturation of coordinated immediate early gene expression by cocaine during adolescence. 
  • Mechanism of shortened bones in mucopolysaccharidosis VII. 
  • Meiotic germ cells antagonize mesonephric cell migration and testis cord formation in mouse gonads. 
  • Melastatin expression and prognosis in cutaneous malignant melanoma. 
  • Mesonephric cell migration induces testis cord formation and Sertoli cell differentiation in the mammalian gonad. 
  • Microarray gene expression profiling during the segmentation phase of zebrafish development. 
  • Microbial colonization induces dynamic temporal and spatial patterns of NF-κB activation in the zebrafish digestive tract. 
  • Molecular analysis of the SCARECROW gene in maize reveals a common basis for radial patterning in diverse meristems. 
  • Molecular profiling of activated olfactory neurons identifies odorant receptors for odors in vivo. 
  • Molecular taxonomy of major neuronal classes in the adult mouse forebrain. 
  • Multilocular thymic cysts in children with human immunodeficiency virus infection: clinical and pathologic aspects. 
  • Multiple tissue-specific requirements for the BMP antagonist Noggin in development of the mammalian craniofacial skeleton. 
  • Murine forkhead/winged helix genes Foxc1 (Mf1) and Foxc2 (Mfh1) are required for the early organogenesis of the kidney and urinary tract. 
  • Mutational analysis of endothelin receptor b1 (rose) during neural crest and pigment pattern development in the zebrafish Danio rerio. 
  • Myocardial NF-κB activation is essential for zebrafish heart regeneration. 
  • NFκB expression is a feature of both activated B-cell-like and germinal center B-cell-like subtypes of diffuse large B-cell lymphoma. 
  • NK-1 receptor gene expression is related to pain in chronic pancreatitis. 
  • NPY and galanin in a hibernator: hypothalamic gene expression and effects on feeding. 
  • Nasopharyngeal carcinomas frequently lack the p16/MTS1 tumor suppressor protein but consistently express the retinoblastoma gene product. 
  • Neural induction and patterning in the mouse in the absence of the node and its derivatives. 
  • Neuregulin-1 enhances depolarization-induced GABA release. 
  • Neuron specific alpha-adrenergic receptor expression in human cerebellum: implications for emerging cerebellar roles in neurologic disease. 
  • Neuron-specific Sumo1-3 knockdown in mice impairs episodic and fear memories. 
  • Neuronal expression of the Ccm2 gene in a new mouse model of cerebral cavernous malformations. 
  • Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity. 
  • Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation. 
  • Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation. 
  • Notch/Delta expression in the developing mouse lung. 
  • Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesis. 
  • Nuclear beta-catenin-dependent Wnt8 signaling in vegetal cells of the early sea urchin embryo regulates gastrulation and differentiation of endoderm and mesodermal cell lineages. 
  • Ontogeny and localization of TGF-beta type I receptor expression during lung development. 
  • Oral and extraoral plasmablastic lymphoma: similarities and differences in clinicopathologic characteristics. 
  • Pdgfr-alpha mediates testis cord organization and fetal Leydig cell development in the XY gonad. 
  • Peripheral axonal injury results in reduced mu opioid receptor pre- and post-synaptic action in the spinal cord. 
  • Plasticity in the adult human oligodendrocyte lineage. 
  • Platelet-derived growth factor in fibrous musculoskeletal disorders: a study of pathologic tissue sections and in vitro primary cell cultures. 
  • Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathy. 
  • Polycystic kidney disease in SBM transgenic mice: role of c-myc in disease induction and progression. 
  • Positional cloning of a temperature-sensitive mutant emmental reveals a role for sly1 during cell proliferation in zebrafish fin regeneration. 
  • Post-transcriptional regulation of myotube elongation and myogenesis by Hoi Polloi. 
  • Postnatal development and plasticity of specialized muscle fiber characteristics in the hindlimb. 
  • Posttransplant lymphoproliferative disorder following nonmyeloablative allogeneic stem cell transplantation. 
  • Production of cytokines around loosened cemented acetabular components. Analysis with immunohistochemical techniques and in situ hybridization. 
  • Prominent expression of bFGF in dorsal root ganglia after axotomy. 
  • Prominent expression of mRNA for proinflammatory cytokines in synovium in patients with juvenile rheumatoid arthritis or chronic Lyme arthritis. 
  • Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model. 
  • Protein C inhibitor (plasminogen activator inhibitor-3) expression in the CWR22 prostate cancer xenograft. 
  • Protein kinase C activity, translocation, and conventional isoforms in aging rat brain. 
  • Quantitative expression profile of PSGR in prostate cancer. 
  • RK2, a glial-specific homeodomain protein required for embryonic nerve cord condensation and viability in Drosophila. 
  • RacGap50C negatively regulates wingless pathway activity during Drosophila embryonic development. 
  • Radioactive in situ hybridization for detecting diverse gene expression patterns in tissue. 
  • Rapid behavioral and genomic responses to social opportunity. 
  • Rapid decline of GABAA receptor subunit mRNA expression in hippocampus following transient cerebral ischemia in the gerbil. 
  • Reaper is regulated by IAP-mediated ubiquitination. 
  • Receptors for bitter and sweet taste. 
  • Recurrent demyelinating myelitis associated with hepatitis C viral infection. 
  • Regulation of flt-1 expression during mouse embryogenesis suggests a role in the establishment of vascular endothelium. 
  • Regulation of intrahepatic biliary duct morphogenesis by Claudin 15-like b. 
  • Reiterative roles for FGF signaling in the establishment of size and proportion of the zebrafish heart. 
  • Relative expression of E-cadherin and type IV collagenase genes predicts disease outcome in patients with resectable pancreatic carcinoma. 
  • Renal epithelium is a previously unrecognized site of HIV-1 infection. 
  • Repression of mesodermal fate by foxa, a key endoderm regulator of the sea urchin embryo. 
  • Restricted expression of WT1 messenger ribonucleic acid in immature ovarian follicles: uniformity in mammalian and avian species and maintenance during reproductive senescence. 
  • Restriction of hepatic competence by Fgf signaling. 
  • Retina-specifically expressed novel subtypes of bovine cyclophilin. 
  • Retinoid signaling and the generation of regional and cellular diversity in the embryonic mouse spinal cord. 
  • Retrograde BMP signaling regulates trigeminal sensory neuron identities and the formation of precise face maps. 
  • Retrograde influence of muscle fibers on their innervation revealed by a novel marker for slow motoneurons. 
  • Reverse genetics of Drosophila RNA polymerase II: identification and characterization of RpII140, the genomic locus for the second-largest subunit. 
  • RoBo-1, a novel member of the urokinase plasminogen activator receptor/CD59/Ly-6/snake toxin family selectively expressed in rat bone and growth plate cartilage. 
  • Role for ETS domain transcription factors Pea3/Erm in mouse lung development. 
  • Role of glutamic acid decarboxylase 67 in regulating cortical parvalbumin and GABA membrane transporter 1 expression: implications for schizophrenia. 
  • Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses. 
  • Role of the GLT-1 subtype of glutamate transporter in glutamate homeostasis: the GLT-1-preferring inhibitor WAY-855 produces marginal neurotoxicity in the rat hippocampus. 
  • Role of the angiotensin type 2 receptor gene in congenital anomalies of the kidney and urinary tract, CAKUT, of mice and men. 
  • Role of the midbrain dopaminergic system in modulation of vocal brain activation by social context. 
  • Secondary heart field contributes myocardium and smooth muscle to the arterial pole of the developing heart. 
  • Sensitive detection of human cytomegalovirus in tumors and peripheral blood of patients diagnosed with glioblastoma. 
  • Sequence and expression of zebrafish foxc1a and foxc1b, encoding conserved forkhead/winged helix transcription factors. 
  • Signaling activities of the Drosophila wingless gene are separately mutable and appear to be transduced at the cell surface. 
  • Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. 
  • Simultaneous labeling of mast cell proteases and protease mRNAs at the bone-implant interface of aseptically loosened hip implants. 
  • Single-target molecule detection with nonbleaching multicolor optical immunolabels. 
  • Socioeconomic characteristics of patients with oropharyngeal carcinoma according to tumor HPV status, patient smoking status, and sexual behavior. 
  • Sour taste responses in mice lacking PKD channels. 
  • Sox8 is expressed at similar levels in gonads of both sexes during the sex determining period in turtles. 
  • Stage-specific expression of B cell translocation gene 1 in rat testis. 
  • Stall encodes an ADAMTS metalloprotease and interacts genetically with Delta in Drosophila ovarian follicle formation. 
  • Steroidogenic factor 1 and Dax-1 colocalize in multiple cell lineages: potential links in endocrine development. 
  • Subcellular partitioning of MRP RNA assessed by ultrastructural and biochemical analysis. 
  • Submucosal glands are the predominant site of CFTR expression in the human bronchus. 
  • Survival analysis of presumptive prognostic markers among oligodendrogliomas. 
  • Syndecan-1 expression is up-regulated in pancreatic but not in other gastrointestinal cancers. 
  • T-cell and T/natural killer-cell lymphomas involving ocular and ocular adnexal tissues: a clinicopathologic, immunohistochemical, and molecular study of seven cases. 
  • TBX5 is required for embryonic cardiac cell cycle progression. 
  • Targeted disruption of the estrogen receptor-alpha gene in female mice: characterization of ovarian responses and phenotype in the adult. 
  • Tenascin in rat lung development: in situ localization and cellular sources. 
  • The 70-kDa heat shock cognate protein (Hsc73) gene is enhanced by ovarian hormones in the ventromedial hypothalamus. 
  • The EJC component Magoh regulates proliferation and expansion of neural crest-derived melanocytes. 
  • The GRAS gene family in Arabidopsis: sequence characterization and basic expression analysis of the SCARECROW-LIKE genes. 
  • The Mammalian-Specific Protein Armcx1 Regulates Mitochondrial Transport during Axon Regeneration. 
  • The Ter mutation in the dead end gene causes germ cell loss and testicular germ cell tumours. 
  • The alpha 1C-adrenoceptor in human prostate: cloning, functional expression, and localization to specific prostatic cell types. 
  • The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development. 
  • The cloning of GRK7, a candidate cone opsin kinase, from cone- and rod-dominant mammalian retinas. 
  • The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system. 
  • The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8). 
  • The expression of platelet-derived growth-factor gene in Dupuytren contracture. 
  • The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate. 
  • The gene encoding the glutamate receptor subunit GluR5 is located on human chromosome 21q21.1-22.1 in the vicinity of the gene for familial amyotrophic lateral sclerosis. 
  • The gene encoding vitamin K-dependent anticoagulant protein C is expressed in human male reproductive tissues. 
  • The gene encoding vitamin K-dependent anticoagulant protein S is expressed in multiple rabbit organs as demonstrated by northern blotting, in situ hybridization, and immunohistochemistry. 
  • The mammalian twisted gastrulation gene functions in foregut and craniofacial development. 
  • The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development. 
  • The role of HOM-C genes in segmental transformations: reexamination of the Drosophila Sex combs reduced embryonic phenotype. 
  • The role of Smad3 in mediating mouse hepatic stellate cell activation. 
  • The role of the forkhead transcription factor, Foxc1, in the development of the mouse lacrimal gland. 
  • The vesicular glutamate transporter 1 (xVGlut1) is expressed in discrete regions of the developing Xenopus laevis nervous system. 
  • Thrombin expression in prostate: a novel finding. 
  • Thymopoiesis in HIV-infected adults after highly active antiretroviral therapy. 
  • Tissue expression studies on the mouse acyl-CoA: cholesterol acyltransferase gene (Acact): findings supporting the existence of multiple cholesterol esterification enzymes in mice. 
  • Tissue response to particulate polymethylmethacrylate in mice with various immune deficiencies. 
  • Tissue transglutaminase expression in human breast cancer. 
  • Transcription factor short stature homeobox 2 is required for proper development of tropomyosin-related kinase B-expressing mechanosensory neurons. 
  • Transcriptional response to hypoxia in human tumors. 
  • Transcriptome profiling of genes involved in neural tube closure during human embryonic development using long serial analysis of gene expression (long-SAGE). 
  • Transforming growth factors beta 1, beta 2, and beta 3 messenger RNA and protein expression in mouse uterus and vagina during estrogen-induced growth: a comparison to other estrogen-regulated genes. 
  • Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. 
  • Twist is an essential regulator of the skeletogenic gene regulatory network in the sea urchin embryo 
  • Ultrabithorax function in butterfly wings and the evolution of insect wing patterns. 
  • Use of in situ hybridization to detect human papillomavirus in head and neck squamous cell carcinoma patients without a history of alcohol or tobacco use. 
  • Using whole mount in situ hybridization to examine thyroid hormone deiodinase expression in embryonic and larval zebrafish: a tool for examining OH-BDE toxicity to early life stages. 
  • Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. 
  • Visual cortex is rescued from the effects of dark rearing by overexpression of BDNF. 
  • Visualizing an olfactory sensory map. 
  • Visualizing mechanosensory endings of TrkC-expressing neurons in HS3ST-2-hPLAP mice. 
  • Vitamin K-dependent protein S in Leydig cells of human testis. 
  • Whole Mount In Situ Hybridization in Murine Tissues. 
  • Whole-mount in situ hybridization on murine skeletogenic tissues. 
  • Y353/B: a candidate multiple-copy spermiogenesis gene on the mouse Y chromosome. 
  • Yantar, a conserved arginine-rich protein is involved in Drosophila hemocyte development. 
  • Zfp36l3, a rodent X chromosome gene encoding a placenta-specific member of the Tristetraprolin family of CCCH tandem zinc finger proteins. 
  • [A study of E-cadherin and beta-catenin expression and their correlation with prognosis of nonsmall cell lung carcinoma]. 
  • [Electroacupuncture enhances enkephalin mRNA expression in the spinal cord and medulla, an in situ hybridization study]. 
  • alpha 2-Adrenergic receptors in human spinal cord: specific localized expression of mRNA encoding alpha 2-adrenergic receptor subtypes at four distinct levels. 
  • ePAD, an oocyte and early embryo-abundant peptidylarginine deiminase-like protein that localizes to egg cytoplasmic sheets. 
  • p38 MAPK is essential for secondary axis specification and patterning in sea urchin embryos. 
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  Keywords of People

  • Bejsovec, Amy, Associate Professor of Biology, Biology
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Gunn, Michael Dee, Professor of Medicine, Integrative Immunobiology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Integrative Immunobiology