Ribonucleoproteins, Small Nuclear

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  Subject Areas on Research

  • A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein. 
  • A human autoimmune protein associated with U1 RNA contains a region of homology that is cross-reactive with retroviral p30gag antigen. 
  • A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE. 
  • A specific 31-nucleotide domain of U1 RNA directly interacts with the 70K small nuclear ribonucleoprotein component. 
  • Anti-La antibody production by MRL-1pr/1pr mice. Analysis of fine specificity. 
  • Anti-Sm autoantibodies in MRL mice: analysis of precursor frequency. 
  • Anti-sm autoantibodies in systemic lupus target highly basic surface structures of complexed spliceosomal autoantigens. 
  • Antinuclear antibodies and nuclear antigens in NZB myeloma ascitic fluids. 
  • Characterization of a Drosophila U snRNP RNA-binding protein. 
  • Characterization of the human Snrpn minimal promoter and cis elements within it. 
  • Development of autoantibodies before the clinical onset of systemic lupus erythematosus. 
  • Expression of IgM and IgG autoantibodies in pediatric and adult systemic lupus erythematosus. 
  • Hfq structure, function and ligand binding. 
  • Hfq: a bacterial Sm-like protein that mediates RNA-RNA interaction. 
  • Identification of gemin5 as a novel 7-methylguanosine cap-binding protein. 
  • Idiotypic analysis of a monoclonal anti-Sm antibody. 
  • Idiotypic analysis of a monoclonal anti-Sm antibody. II. Strain distribution of a common idiotypic determinant and its relationship to anti-Sm expression. 
  • Idiotypic cross-reaction between MRL autoantibodies and a BALB/c myeloma. 
  • Idiotypic cross-reaction between MRL monoclonal autoantibodies with different antigen specificity. 
  • IgG antinuclear antibodies with cross-reactive rheumatoid factor activity. 
  • Immunization with the Sm nuclear antigen induces anti-Sm antibodies in normal and MRL mice. 
  • Independent expression of autoantibodies in systemic lupus erythematosus. 
  • Infectious mononucleosis patients temporarily recognize a unique, cross-reactive epitope of Epstein-Barr virus nuclear antigen-1. 
  • Leucine periodicity of U2 small nuclear ribonucleoprotein particle (snRNP) A' protein is implicated in snRNP assembly via protein-protein interactions. 
  • Lupus autoantibodies recognize the product of an alternative open reading frame of SmB/B'. 
  • Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds. 
  • Molecular composition of Ro small ribonucleoprotein complexes in human cells. Intracellular localization of the 60- and 52-kD proteins. 
  • Post-transcriptional regulation of myotube elongation and myogenesis by Hoi Polloi. 
  • Quantitative determination that one of two potential RNA-binding domains of the A protein component of the U1 small nuclear ribonucleoprotein complex binds with high affinity to stem-loop II of U1 RNA. 
  • RNA binding specificity of a Drosophila snRNP protein that shares sequence homology with mammalian U1-A and U2-B" proteins. 
  • RNA-binding domain of the A protein component of the U1 small nuclear ribonucleoprotein analyzed by NMR spectroscopy is structurally similar to ribosomal proteins. 
  • Rapid inhibition of processing and assembly of small nuclear ribonucleoproteins after infection with vesicular stomatitis virus. 
  • Recognition of U1 and U2 small nuclear RNAs can be altered by a 5-amino-acid segment in the U2 small nuclear ribonucleoprotein particle (snRNP) B" protein and through interactions with U2 snRNP-A' protein. 
  • Selective small antigenic structures are capable of inducing widespread autoimmunity which closely mimics the humoral fine specificity of human SLE. 
  • Side-chain specificities and molecular modelling of peptide determinants for two anti-Sm B/B' autoantibodies. 
  • Specificity and idiotypic analysis of a monoclonal anti-Sm antibody with anti-DNA activity. 
  • Spliceosomal immunophilins. 
  • The U1 RNA-binding site of the U1 small nuclear ribonucleoprotein (snRNP)-associated A protein suggests a similarity with U2 snRNPs. 
  • The U1 small nuclear ribonucleoprotein (snRNP) 70K protein is transported independently of U1 snRNP particles via a nuclear localization signal in the RNA-binding domain. 
  • The anti-La response of a single MRL/Mp-lpr/lpr mouse: specificity for DNA and VH gene usage. 
  • The fine specificity of monoclonal anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. 
  • The genetics of autoantibody production in MRL/lpr lupus mice. 
  • The mechanism of autoantibody production in an autoimmune MRL/lpr mouse. 
  • The mouse Snrpn minimal promoter and its human orthologue: activity and imprinting. 
  • U1-snRNP-A protein selects a ten nucleotide consensus sequence from a degenerate RNA pool presented in various structural contexts. 
  • V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr mice. 
  • Viral transcription is necessary and sufficient for vesicular stomatitis virus to inhibit maturation of small nuclear ribonucleoproteins.