Sequence Analysis

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  Subject Areas on Research

  • Analysis of genes coding for small-subunit rRNA sequences in studying phylogenetics of dematiaceous fungal pathogens. 
  • Analysis of intercurrent human immunodeficiency virus type 1 infections in phase I and II trials of candidate AIDS vaccines. AIDS Vaccine Evaluation Group, and the Correlates of HIV Immune Protection Group. 
  • Antibodies to endometrial transferrin and alpha 2-Heremans Schmidt (HS) glycoprotein in patients with endometriosis. 
  • Biochemical role of the Cryptococcus neoformans ADE2 protein in fungal de novo purine biosynthesis. 
  • Biosynthesis of bikunin proteins in the human carcinoma cell line HepG2 and in primary human hepatocytes. Polypeptide assembly by glycosaminoglycan. 
  • Can three incongruence tests predict when data should be combined? 
  • Cell surface annexin II is a high affinity receptor for the alternatively spliced segment of tenascin-C. 
  • Circular polymerase extension cloning. 
  • Cloning, sequencing, and recombinant expression of the porcine inhibitor of carbonic anhydrase: a novel member of the transferrin family. 
  • Comparative analysis of Homo sapiens and Mus musculus cyclin-dependent kinase (CDK) inhibitor genes p16 (MTS1) and p15 (MTS2). 
  • Comprehensive analysis of the chromatin landscape in Drosophila melanogaster. 
  • Conserved nucleosome positioning defines replication origins. 
  • Decoupling of genome size and sequence divergence in a symbiotic bacterium. 
  • Diagnostic exome sequencing: a new paradigm in neurology. 
  • Direct atomic force microscope imaging of EcoRI endonuclease site specifically bound to plasmid DNA molecules. 
  • Genetic and phenotypic changes accompanying the emergence of epizootic subtype IC Venezuelan equine encephalitis viruses from an enzootic subtype ID progenitor. 
  • Genetic variation in yellow fever virus: duplication in the 3' noncoding region of strains from Africa. 
  • Genomic approaches for understanding the genetics of complex disease. 
  • Human DNA-activated protein kinase (DNA-PK) is homologous to phosphatidylinositol kinases. 
  • Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation. 
  • Identification of aberrantly regulated genes in diseased skin using the cDNA differential display technique. 
  • Identification of antigens on porcine pulmonary microvascular endothelial cells recognized by human xenoreactive natural antibodies. 
  • Identification of cis-acting repressor activity within human immunodeficiency virus type 1 protease sequences. 
  • Identification of five hemoglobins in B6C3F1 mice by mass spectrometry and sequence analysis. 
  • Immunogen sequence: the fourth tier of AIDS vaccine design. 
  • Isolation and characterization of fibronectin-alpha 1-microglobulin complex in rat plasma. 
  • Isolation and characterization of the gene encoding the type 5 mouse (Mus musculus) somatostatin receptor (msst5). 
  • Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures. 
  • Mitotic crossovers between diverged sequences are regulated by mismatch repair proteins in Saccaromyces cerevisiae. 
  • Molecular cloning, chromosomal mapping, and characterization of the human cardiac-specific homeobox gene hCsx. 
  • Not the End of the Odyssey: Parental Perceptions of Whole Exome Sequencing (WES) in Pediatric Undiagnosed Disorders. 
  • Overlapping epitopes in human immunodeficiency virus type 1 gp120 presented by HLA A, B, and C molecules: effects of viral variation on cytotoxic T-lymphocyte recognition. 
  • Preparation and electron paramagnetic resonance characterization of spin labeled monoderivatives of horse cytochrome c. 
  • Preparative isoelectric focusing and preparative electrophoresis of hydrophobic Candida albicans cell wall proteins with in-line transfer to polyvinylidene difluoride membranes for sequencing. 
  • Purification and characterization of a 60-kDa protein from oat, formerly known as a TCP1-related chaperone. 
  • Purification and partial sequencing of the XL-I form of xenobiotic-metabolizing medium chain fatty acid:CoA ligase from bovine liver mitochondria, and its homology with the essential hypertension protein. 
  • Purification, amino acid sequence, synthesis, and receptor selectivity of alligator gastrin. 
  • Randomization and selection of RNA to identify targets for RRM RNA-binding proteins and antibodies. 
  • Ribonucleotides in DNA: hidden in plain sight. 
  • Sequencing and characterization of oligosaccharides using infrared multiphoton dissociation and boronic acid derivatization in a quadrupole ion trap. 
  • Structural features of nephritogenic lupus autoantibodies. 
  • The C-terminal domain of the adenine-DNA glycosylase MutY confers specificity for 8-oxoguanine.adenine mispairs and may have evolved from MutT, an 8-oxo-dGTPase. 
  • The Gene Ontology (GO) project in 2006. 
  • The Gene Ontology project in 2008. 
  • The North Carolina Experience with Mucopolysaccharidosis Type I Newborn Screening. 
  • The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor. 
  • The expression of a functional, secreted human lysyl hydroxylase in a baculovirus system. 
  • The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator. 
  • The heterosexual human immunodeficiency virus type 1 epidemic in Thailand is caused by an intersubtype (A/E) recombinant of African origin. 
  • Whole Exome Sequencing Identifies Frequent Somatic Mutations in Cell-Cell Adhesion Genes in Chinese Patients with Lung Squamous Cell Carcinoma. 
  • Whole genome analysis: experimental access to all genome sequenced segments through larger-scale efficient oligonucleotide synthesis and PCR. 
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  Keywords of People

  • Erickson, Harold Paul, James B. Duke Distinguished Professor of Cell Biology, Cell Biology
  • Wernegreen, Jennifer Jo, Lee Hill Snowdon Associate Professor, Environmental Sciences and Policy