Protein Structure, Tertiary

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  Subject Areas on Research

  • 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition. 
  • A Bayesian approach for determining protein side-chain rotamer conformations using unassigned NOE data. 
  • A bacterial selection for the directed evolution of pyruvate aldolases. 
  • A barrier-type insulator forms a boundary between active and inactive chromatin at the murine TCRβ locus. 
  • A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon. 
  • A comparison of the genes coding for canonical TRP channels and their M, V and P relatives. 
  • A conserved acidic patch in the Myb domain is required for activation of an endogenous target gene and for chromatin binding. 
  • A conserved family of enzymes that phosphorylate inositol hexakisphosphate. 
  • A core-weighted fitting method for docking atomic structures into low-resolution maps: application to cryo-electron microscopy. 
  • A dimerized coiled-coil domain and an adjoining part of geminin interact with two sites on Cdt1 for replication inhibition. 
  • A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling. 
  • A fusion intermediate gp41 immunogen elicits neutralizing antibodies to HIV-1. 
  • A galactosylceramide binding domain is involved in trafficking of CLN3 from Golgi to rafts via recycling endosomes. 
  • A graphical method for analyzing distance restraints using residual dipolar couplings for structure determination of symmetric protein homo-oligomers. 
  • A high frequency of activating extracellular domain ERBB2 (HER2) mutation in micropapillary urothelial carcinoma. 
  • A methylation-dependent electrostatic switch controls DNA repair and transcriptional activation by E. coli ada. 
  • A minimal TrpRS catalytic domain supports sense/antisense ancestry of class I and II aminoacyl-tRNA synthetases. 
  • A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice. 
  • A negative charge in transmembrane segment 1 of domain II of the cockroach sodium channel is critical for channel gating and action of pyrethroid insecticides. 
  • A new activity of doublecortin in recognition of the phospho-FIGQY tyrosine in the cytoplasmic domain of neurofascin. 
  • A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1. 
  • A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation. 
  • A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC. 
  • A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLO. 
  • A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic speckles. 
  • A rationally-designed chimeric KDM1A/KDM1B histone demethylase tower domain deletion mutant retaining enzymatic activity. 
  • A signature in HIV-1 envelope leader peptide associated with transition from acute to chronic infection impacts envelope processing and infectivity. 
  • A single amino acid defines cross-species reactivity of tree shrew (Tupaia belangeri) CD1d to human invariant natural killer T (iNKT) cells. 
  • A small molecule inhibitor of isoprenylcysteine carboxymethyltransferase induces autophagic cell death in PC3 prostate cancer cells. 
  • A solubility-enhancement tag (SET) for NMR studies of poorly behaving proteins. 
  • A specific domain of Gialpha required for the transactivation of Gialpha by tubulin is implicated in the organization of cellular microtubules. 
  • A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain. 
  • A truncated isoform of c-Mpl with an essential C-terminal peptide targets the full-length receptor for degradation. 
  • ADA-SCID with 'WAZA-ARI' mutations that synergistically abolished ADA protein stability. 
  • ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein. 
  • ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration. 
  • ATP hydrolysis by a CFTR domain: pharmacology and effects of G551D mutation. 
  • Ab initio based calculations of electron-transfer rates in metalloproteins. 
  • Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels. 
  • Accessory subunit KChIP2 modulates the cardiac L-type calcium current. 
  • Act globally, think locally: systems biology addresses the PDZ domain. 
  • Activation and signaling of the Abl tyrosine kinase: bidirectional link with phosphoinositide signaling. 
  • Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway. 
  • Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains. 
  • Activation-dependent conformational changes in {beta}-arrestin 2. 
  • Adding a positive charge at residue 46 of Drosophila alcohol dehydrogenase increases cofactor specificity for NADP+. 
  • Adducin: structure, function and regulation. 
  • Adeno-associated virus type 2 contains an integrin alpha5beta1 binding domain essential for viral cell entry. 
  • Adenosine nucleotides and the regulation of GRP94-client protein interactions. 
  • Adenovirus F protein as a delivery vehicle for botulinum B. 
  • Adenylyl cyclase-associated protein Aca1 regulates virulence and differentiation of Cryptococcus neoformans via the cyclic AMP-protein kinase A cascade. 
  • Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains. 
  • Alleles of the yeast Pms1 mismatch-repair gene that differentially affect recombination- and replication-related processes. 
  • Allosteric actuation of inverse phase transition of a stimulus-responsive fusion polypeptide by ligand binding. 
  • Alternative translation of osteopontin generates intracellular and secreted isoforms that mediate distinct biological activities in dendritic cells. 
  • Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors. 
  • Amino acid sequence requirements of peptides that inhibit polyglutamine-protein aggregation and cell death. 
  • Amino acids important in enzyme activity and dimer stability for Drosophila alcohol dehydrogenase. 
  • An alanine in segment 3 of domain III (IIIS3) of the cockroach sodium channel contributes to the low pyrethroid sensitivity of an alternative splice variant. 
  • An algorithm for smoothly tessellating beta-sheet structures in proteins. 
  • An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution. 
  • An image-based RNAi screen identifies SH3BP1 as a key effector of Semaphorin 3E-PlexinD1 signaling. 
  • An inhibitory region of the DNA-binding domain of thyroid hormone receptor blocks hormone-dependent transactivation. 
  • An insulin-like growth factor II (IGF-II) affinity-enhancing domain localized within extracytoplasmic repeat 13 of the IGF-II/mannose 6-phosphate receptor. 
  • An investigation of hemopexin redox properties by spectroelectrochemistry: biological relevance for heme uptake. 
  • Anabolic effects of a G protein-coupled receptor kinase inhibitor expressed in osteoblasts. 
  • Analysis of V2 antibody responses induced in vaccinees in the ALVAC/AIDSVAX HIV-1 vaccine efficacy trial. 
  • Analysis of the glycoproteome of Toxoplasma gondii using lectin affinity chromatography and tandem mass spectrometry. 
  • Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. 
  • Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells 
  • Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes. 
  • Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos. 
  • Antiangiogenic treatment with three thrombospondin-1 type 1 repeats versus gemcitabine in an orthotopic human pancreatic cancer model. 
  • Antibodies in sera of patients with late-onset myasthenia gravis recognize the PEVK domain of titin. 
  • Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization. 
  • Antibody binding to a conformation-dependent epitope induces L-selectin association with the detergent-resistant cytoskeleton. 
  • Apoptosis and B cell tolerance. 
  • Aquaporin 6 binds calmodulin in a calcium-dependent manner. 
  • Assembly and molecular activities of the MutS tetramer. 
  • Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domain. 
  • Association of CD8(+) T lymphocyte repertoire spreading with the severity of DRESS syndrome. 
  • Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function. 
  • Association with endoplasmic reticulum promotes proteasomal degradation of GADD34 protein. 
  • Atomic force microscopy captures folded ribosome bound nascent chains. 
  • Atomic structures of tubulin and FtsZ. 
  • Atomistic basis of force generation, translocation, and coordination in a viral genome packaging motor. 
  • Automated identification of elemental ions in macromolecular crystal structures. 
  • Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities. 
  • Axl2 integrates polarity establishment, maintenance, and environmental stress response in the filamentous fungus Ashbya gossypii. 
  • BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation. 
  • Backbone dynamics of homologous fibronectin type III cell adhesion domains from fibronectin and tenascin. 
  • Bacteriophage T4 helicase loader protein gp59 functions as gatekeeper in origin-dependent replication in vivo. 
  • Base-pairing potential identified by in vitro selection predicts the kinked RNA backbone observed in the crystal structure of the alfalfa mosaic virus RNA-coat protein complex. 
  • Basic residues in the nucleocapsid domain of Gag are critical for late events of HIV-1 budding. 
  • Bcr-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release. 
  • Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling. 
  • Beta-arrestin-2 regulates the development of allergic asthma. 
  • Beta2-glycoprotein I-dependent anticardiolipin antibodies preferentially bind the amino terminal domain of beta2-glycoprotein I. 
  • Beyond the E-Value: Stratified Statistics for Protein Domain Prediction. 
  • Binding of factor VIII inhibitors to discrete regions of the factor VIII C2 domain disrupt phospholipid binding. 
  • Binding of the beta2 adrenergic receptor to N-ethylmaleimide-sensitive factor regulates receptor recycling. 
  • Binding site on human immunoglobulin G for the affinity ligand HWRGWV. 
  • Biochemical properties of recombinant human and mouse N-acetylglutamate synthase. 
  • Biochemistry. Exciting structures. 
  • Biology and functions of the RGS9 isoforms. 
  • Borg proteins control septin organization and are negatively regulated by Cdc42. 
  • Both heptad repeats of human respiratory syncytial virus fusion protein are potent inhibitors of viral fusion. 
  • Broad and potent neutralization of HIV-1 by a gp41-specific human antibody. 
  • C-terminal opening mimics 'inside-out' activation of integrin alpha5beta1. 
  • C-terminal regions of the human telomerase catalytic subunit essential for in vivo enzyme activity. 
  • CODAS syndrome is associated with mutations of LONP1, encoding mitochondrial AAA+ Lon protease. 
  • COMMD proteins, a novel family of structural and functional homologs of MURR1. 
  • Ca2+ channel nanodomains boost local Ca2+ amplitude. 
  • Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites. 
  • CaMKII tethers to L-type Ca2+ channels, establishing a local and dedicated integrator of Ca2+ signals for facilitation. 
  • Calbindin D28K interacts with Ran-binding protein M: identification of interacting domains by NMR spectroscopy. 
  • Calcineurin plays key roles in the dimorphic transition and virulence of the human pathogenic zygomycete Mucor circinelloides. 
  • Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission. 
  • Calcium channel function regulated by the SH3-GK module in beta subunits. 
  • Can you tBID on it? 
  • Capturing the mechanical unfolding pathway of a large protein with coiled-coil probes. 
  • Cardiac hypertrophy and altered beta-adrenergic signaling in transgenic mice that express the amino terminus of beta-ARK1. 
  • Casein kinase 2beta as a novel enhancer of activin-like receptor-1 signaling. 
  • Caspase-3 cleavage links delta-catenin to the novel nuclear protein ZIFCAT. 
  • Caspase-dependent cleavage of carbamoyl phosphate synthetase II during apoptosis. 
  • Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis. 
  • Cdc37/Hsp90 protein-mediated regulation of IRE1α protein activity in endoplasmic reticulum stress response and insulin synthesis in INS-1 cells. 
  • Cell adhesion molecule L1 in folded (horseshoe) and extended conformations. 
  • Cell cycle dependence of group VIA calcium-independent phospholipase A2 activity. 
  • Centromere round-up at the heterochromatin corral. 
  • Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin. 
  • Chaperones rescue luciferase folding by separating its domains. 
  • Characterization of a Large Panel of Rabbit Monoclonal Antibodies against HIV-1 gp120 and Isolation of Novel Neutralizing Antibodies against the V3 Loop. 
  • Characterization of a new family of protein kinases from Arabidopsis containing phosphoinositide 3/4-kinase and ubiquitin-like domains. 
  • Characterization of key residues in the subdomain encoded by exons 8 and 9 of human inducible nitric oxide synthase: a critical role for Asp-280 in substrate binding and subunit interactions. 
  • Characterization of the PC4 binding domain and its interactions with HNF4alpha. 
  • Characterization of transcriptional activation and DNA-binding functions in the hinge region of the vitamin D receptor. 
  • Charting the landscape of tandem BRCT domain-mediated protein interactions. 
  • Chemical Regulation of the Protein Quality Control E3 Ubiquitin Ligase C-Terminus of Hsc70 Interacting Protein (CHIP). 
  • Chemoinformatic identification of novel inhibitors against Mycobacterium tuberculosis L-aspartate α-decarboxylase. 
  • Chikungunya virus neutralization antigens and direct cell-to-cell transmission are revealed by human antibody-escape mutants. 
  • Chromatin-associated HMG-17 is a major regulator of homeodomain transcription factor activity modulated by Wnt/beta-catenin signaling. 
  • Chromophore conformation and the evolution of tertiary structural changes in photoactive yellow protein. 
  • Circulating and binding characteristics of wild-type factor IX and certain Gla domain mutants in vivo. 
  • Circulating tumor cells in HER-2 positive metastatic breast cancer patients treated with trastuzumab and chemotherapy. 
  • Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases. 
  • Cloning and expression of a novel, truncated, progesterone receptor. 
  • Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. 
  • Co-evolving motions at protein-protein interfaces of two-component signaling systems identified by covariance analysis. 
  • Coarse-grained modeling of allosteric regulation in protein receptors. 
  • Coiled-coil targeting of myocilin to intracellular membranes. 
  • Collision-induced dissociative chemical cross-linking reagents and methodology: Applications to protein structural characterization using tandem mass spectrometry analysis. 
  • Comparative analysis of the ATP-binding sites of Hsp90 by nucleotide affinity cleavage: a distinct nucleotide specificity of the C-terminal ATP-binding site. 
  • Comparative immunogenicity of HIV-1 gp160, gp140 and gp120 expressed by live attenuated newcastle disease virus vector. 
  • Compartmentalized NRG signaling and PDZ domain-containing proteins in synapse structure and function. 
  • Comprehensive genomic characterization defines human glioblastoma genes and core pathways. 
  • Computational approaches for inferring 3D conformations of chromatin from chromosome conformation capture data. 
  • Condensin and cohesin display different arm conformations with characteristic hinge angles. 
  • Conformational dynamics of amyloid beta-protein assembly probed using intrinsic fluorescence. 
  • Conformational plasticity of the coiled-coil domain of BmrR is required for bmr operator binding: the structure of unliganded BmrR. 
  • Conformationally distinct five-coordinate heme-NO complexes of soluble guanylate cyclase elucidated by multifrequency electron paramagnetic resonance (EPR). 
  • Conserved organization of centromeric chromatin in flies and humans. 
  • Constitutive activation of the N-methyl-D-aspartate receptor via cleft-spanning disulfide bonds. 
  • Constitutive proteasome-mediated turnover of Bfl-1/A1 and its processing in response to TNF receptor activation in FL5.12 pro-B cells convert it into a prodeath factor. 
  • Construction and phenotypic characterization of HIV type 1 functional envelope clones of subtypes G and F. 
  • Construction of a family of Cys2His2 zinc binding sites in the hydrophobic core of thioredoxin by structure-based design. 
  • Contributions of Asn2198, Met2199, and Phe2200 in the factor VIII C2 domain to cofactor activity, phospholipid-binding, and von Willebrand factor-binding. 
  • Control elements within the PWS/AS imprinting box and their function in the imprinting process. 
  • Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC. 
  • Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation. 
  • Cordon-bleu is an actin nucleation factor and controls neuronal morphology. 
  • Coronary artery disease and the thrombospondin single nucleotide polymorphisms. 
  • Cotranscriptional association of mRNA export factor Yra1 with C-terminal domain of RNA polymerase II. 
  • Counteracting signaling activities in lipid rafts associated with the invasion of lung epithelial cells by Pseudomonas aeruginosa. 
  • Coupling of proton binding in extracellular domain to channel gating in acid-sensing ion channel. 
  • Crossover interference on nucleolus organizing region-bearing chromosomes in Arabidopsis. 
  • Crucial role for the VWF A1 domain in binding to type IV collagen. 
  • Crucial role of copper in detection of metal-coordinating odorants. 
  • Crustacean peptide and peptide-like pheromones and kairomones. 
  • Crystal structure of MtaN, a global multidrug transporter gene activator. 
  • Crystal structure of Streptococcus pyogenes sortase A: implications for sortase mechanism. 
  • Crystal structure of a pol alpha family DNA polymerase from the hyperthermophilic archaeon Thermococcus sp. 9 degrees N-7. 
  • Crystal structure of a thermostable Bacillus DNA polymerase I large fragment at 2.1 A resolution. 
  • Crystal structure of alkaline phosphatase from the Antarctic bacterium TAB5. 
  • Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue. 
  • Crystal structure of human type III collagen Gly991-Gly1032 cystine knot-containing peptide shows both 7/2 and 10/3 triple helical symmetries. 
  • Crystal structure of the Bacillus subtilis anti-alpha, global transcriptional regulator, Spx, in complex with the alpha C-terminal domain of RNA polymerase. 
  • Crystal structure of the human LRH-1 DBD-DNA complex reveals Ftz-F1 domain positioning is required for receptor activity. 
  • Crystal structure of the phage T4 recombinase UvsX and its functional interaction with the T4 SF2 helicase UvsW. 
  • Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin. 
  • Crystal structures of QacR-diamidine complexes reveal additional multidrug-binding modes and a novel mechanism of drug charge neutralization. 
  • Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding. 
  • Crystal structures of Toxoplasma gondii adenosine kinase reveal a novel catalytic mechanism and prodrug binding. 
  • Crystal structures of apocalmodulin and an apocalmodulin/SK potassium channel gating domain complex. 
  • Crystal structures of the Klenow fragment of DNA polymerase I complexed with deoxynucleoside triphosphate and pyrophosphate. 
  • Crystal structures of the fungal pathogen Aspergillus fumigatus protein farnesyltransferase complexed with substrates and inhibitors reveal features for antifungal drug design. 
  • Crystal structures of the membrane-binding C2 domain of human coagulation factor V. 
  • Crystallization of a fragment of human fibronectin: introduction of methionine by site-directed mutagenesis to allow phasing via selenomethionine. 
  • Cyclic AMP mediated GSTP1 gene activation in tumor cells involves the interaction of activated CREB-1 with the GSTP1 CRE: a novel mechanism of cellular GSTP1 gene regulation. 
  • Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor production in two varieties of the fungal pathogen Cryptococcus neoformans. 
  • Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. 
  • D-dimer antigen: current concepts and future prospects. 
  • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. 
  • DNA-XPA interactions: a (31)P NMR and molecular modeling study of dCCAATAACC association with the minimal DNA-binding domain (M98-F219) of the nucleotide excision repair protein XPA. 
  • Deencryption of cellular tissue factor is independent of its cytoplasmic domain. 
  • Defects in ankyrin-based cellular pathways in metazoan physiology. 
  • Deficiency in SLC25A1, encoding the mitochondrial citrate carrier, causes combined D-2- and L-2-hydroxyglutaric aciduria. 
  • Defining a two-pronged structural model for PB1 (Phox/Bem1p) domain interaction in plant auxin responses. 
  • Definition of the molecular basis for estrogen receptor-related receptor-alpha-cofactor interactions. 
  • Deletion of V335 from the L2 domain of the insulin receptor results in a conformationally abnormal receptor that is unable to bind insulin and causes Donohue's syndrome in a human subject. 
  • Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology. 
  • Deletion of the Tail Domain of the Kinesin-5 Cin8 Affects Its Directionality. 
  • Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization. 
  • Depletion of catalytic and regulatory subunits of protein kinase CK2 by antisense oligonucleotide treatment of neuroblastoma cells. 
  • Design and characterization of a peptide mimotope of the HIV-1 gp120 bridging sheet. 
  • Design of a calcium-binding protein with desired structure in a cell adhesion molecule. 
  • Design, expression, and immunogenicity of a soluble HIV trimeric envelope fragment adopting a prefusion gp41 configuration. 
  • Designing an extracellular matrix protein with enhanced mechanical stability. 
  • Detection of amino-terminal extracellular domain of somatostatin receptor 2 by specific monoclonal antibodies and quantification of receptor density in medulloblastoma. 
  • Development of human protein reference database as an initial platform for approaching systems biology in humans. 
  • Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis. 
  • Differential mapping of the amino acids mediating agonist and antagonist coordination with the human thromboxane A2 receptor protein. 
  • Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites. 
  • Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1. 
  • Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6. 
  • Direct evidence for methyl group coordination by carbon-oxygen hydrogen bonds in the lysine methyltransferase SET7/9. 
  • Direct interaction of Gas11 with microtubules: implications for the dynein regulatory complex. 
  • Dissociation of nitric oxide from soluble guanylate cyclase and heme-nitric oxide/oxygen binding domain constructs. 
  • Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage. 
  • Distinct phosphorylation sites on the β(2)-adrenergic receptor establish a barcode that encodes differential functions of β-arrestin. 
  • Distinct roles of Rho1, Cdc42, and Cyk3 in septum formation and abscission during yeast cytokinesis. 
  • Distinct stress responses of two functional laccases in Cryptococcus neoformans are revealed in the absence of the thiol-specific antioxidant Tsa1. 
  • Disulfide-mediated dimerization of L1 Ig domains. 
  • Domain 3 of hepatitis C virus core protein is sufficient for intracellular lipid accumulation. 
  • Domain structure and DNA binding regions of beta protein from bacteriophage lambda. 
  • Domain unfolding plays a role in superfibronectin formation. 
  • Domain-specific antibodies reveal multiple-site topology of Nup153 within the nuclear pore complex. 
  • Domain-specific effector interactions within the central cavity of human adult hemoglobin in solution and in porous sol-gel matrices: evidence for long-range communication pathways. 
  • Domains of the parathyroid hormone (PTH) receptor required for regulation by G protein-coupled receptor kinases (GRKs). 
  • Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPases. 
  • Drosophila crinkled, mutations of which disrupt morphogenesis and cause lethality, encodes fly myosin VIIA. 
  • Drosophila stretchin-MLCK is a novel member of the Titin/Myosin light chain kinase family. 
  • Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity. 
  • Dynamic regulation of the translation initiation helicase complex by mitogenic signal transduction to eukaryotic translation initiation factor 4G. 
  • Dynamics of backbone conformational heterogeneity in Bacillus subtilis ribonuclease P protein. 
  • EP24.15 interacts with the angiotensin II type I receptor and bradykinin B2 receptor. 
  • ERAP75 functions as a coactivator to enhance estrogen receptor alpha transactivation in prostate stromal cells. 
  • Effect of heterologous factor V heavy chain sequences on the secretion of recombinant human factor VIII. 
  • Efficiency, selectivity, and robustness of nucleocytoplasmic transport. 
  • Electrostatic Energetics of Bacillus subtilis Ribonuclease P Protein Determined by Nuclear Magnetic Resonance-Based Histidine pKa Measurements. 
  • Elite Control, Gut CD4 T Cell Sparing, and Enhanced Mucosal T Cell Responses in Macaca nemestrina Infected by a Simian Immunodeficiency Virus Lacking a gp41 Trafficking Motif. 
  • Emergence of SARS-CoV-2 through recombination and strong purifying selection. 
  • Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt. 
  • Endovascular infections caused by methicillin-resistant Staphylococcus aureus are linked to clonal complex-specific alterations in binding and invasion domains of fibronectin-binding protein A as well as the occurrence of fnbB. 
  • Enhanced HIV-1 neutralization by a CD4-VH3-IgG1 fusion protein. 
  • Enhanced MyoD-induced transdifferentiation to a myogenic lineage by fusion to a potent transactivation domain. 
  • Enhanced cytoprotective effects of the inhibitor of apoptosis protein cellular IAP1 through stabilization with TRAF2. 
  • Enhanced sensitivity to cytochrome c-induced apoptosis mediated by PHAPI in breast cancer cells. 
  • Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle. 
  • Epitope mapping of the U1 small nuclear ribonucleoprotein particle in patients with systemic lupus erythematosus and mixed connective tissue disease. 
  • Erbin is a protein concentrated at postsynaptic membranes that interacts with PSD-95. 
  • Erythropoietin hypersensitivity in primary familial and congenital polycythemia: role of tyrosines Y285 and Y344 in erythropoietin receptor cytoplasmic domain. 
  • Erythropoietin structure-function relationships. Mutant proteins that test a model of tertiary structure. 
  • Escherichia coli purine repressor: key residues for the allosteric transition between active and inactive conformations and for interdomain signaling. 
  • Essential light chain of Drosophila nonmuscle myosin II. 
  • EuroPhenome: a repository for high-throughput mouse phenotyping data. 
  • Evidence for Dual Binding Sites for 1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) in Insect Sodium Channels. 
  • Evidence of Fe3+ interaction with the plug domain of the outer membrane transferrin receptor protein of Neisseria gonorrhoeae: implications for Fe transport. 
  • Evolution of budding yeast prion-determinant sequences across diverse fungi. 
  • Evolution of the tenascin family--implications for function of the C-terminal fibrinogen-like domain. 
  • Evolutionary genomics and adaptive evolution of the Hedgehog gene family (Shh, Ihh and Dhh) in vertebrates. 
  • Expanding the functional repertoire of CTD kinase I and RNA polymerase II: novel phosphoCTD-associating proteins in the yeast proteome. 
  • Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation. 
  • Expression and trans-specific polymorphism of self-incompatibility RNases in coffea (Rubiaceae). 
  • Expression, purification and primary crystallographic study of human androgen receptor in complex with DNA and coactivator motifs. 
  • Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex. 
  • Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells. 
  • FBW2 targets GCMa to the ubiquitin-proteasome degradation system. 
  • Fast and faster: a designed variant of the B-domain of protein A folds in 3 microsec. 
  • FbpA--a bacterial transferrin with more to offer. 
  • Fibronectin aggregation and assembly: the unfolding of the second fibronectin type III domain. 
  • Filamentous fungal-specific septin AspE is phosphorylated in vivo and interacts with actin, tubulin and other septins in the human pathogen Aspergillus fumigatus. 
  • Fine mapping of inhibitory anti-factor V antibodies using factor V C2 domain mutants. Identification of two antigenic epitopes involved in phospholipid binding. 
  • Fission yeast Cyk3p is a transglutaminase-like protein that participates in cytokinesis and cell morphogenesis. 
  • Flipping of the ribosomal A-site adenines provides a basis for tRNA selection. 
  • Folding mechanism of a multiple independently-folding domain protein: double B domain of protein A. 
  • Frequent IGF2/H19 domain epigenetic alterations and elevated IGF2 expression in epithelial ovarian cancer. 
  • FtsZ filament capping by MciZ, a developmental regulator of bacterial division. 
  • FtsZ from divergent foreign bacteria can function for cell division in Escherichia coli. 
  • Functional Analysis of the Bacteriophage T4 Rad50 Homolog (gp46) Coiled-coil Domain. 
  • Functional domains of the ubiquitous chromatin protein DEK. 
  • Functional equivalence of an evolutionarily conserved RNA binding module. 
  • Functional expression of Mammalian odorant receptors. 
  • Functional polymorphisms of matrix metalloproteinase-9 are associated with risk of occurrence and metastasis of lung cancer. 
  • Functional roles of the two domains of phosducin and phosducin-like protein. 
  • Fusions of elastin-like polypeptides to pharmaceutical proteins. 
  • G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95. 
  • G-protein-coupled receptor (GPCR) kinase phosphorylation and beta-arrestin recruitment regulate the constitutive signaling activity of the human cytomegalovirus US28 GPCR. 
  • GIPC interacts with the beta1-adrenergic receptor and regulates beta1-adrenergic receptor-mediated ERK activation. 
  • Gain-of-function RAF1 mutations cause Noonan and LEOPARD syndromes with hypertrophic cardiomyopathy. 
  • Generalized reconstruction of n-D NMR spectra from multiple projections: application to the 5-D HACACONH spectrum of protein G B1 domain. 
  • Generation of high curvature membranes mediated by direct endophilin bilayer interactions. 
  • Genetic analysis demonstrates a direct link between rho signaling and nonmuscle myosin function during Drosophila morphogenesis. 
  • Genetic characterization and functional analysis of the GID1 gibberellin receptors in Arabidopsis. 
  • Genetic organization, length conservation, and evolution of RNA polymerase II carboxyl-terminal domain. 
  • Genetically and epidemiologically related "non-syncytium-inducing" isolates of HIV-1 display heterogeneous growth patterns in macrophages. 
  • Genome engineering: the next genomic revolution. 
  • Genome-wide detection and characterization of positive selection in human populations. 
  • Genome-wide survey and expression analysis of the OSCA gene family in rice. 
  • Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene. 
  • Getting a grip on the CTD of Pol II. 
  • Giant ankyrin-G: a critical innovation in vertebrate evolution of fast and integrated neuronal signaling. 
  • Gibberellin-induced DELLA recognition by the gibberellin receptor GID1. 
  • Grab your partner with both hands: cytoskeletal remodeling by Arp2/3 signaling. 
  • HDAC6 and Ubp-M BUZ domains recognize specific C-terminal sequences of proteins. 
  • HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes. 
  • HLA class II genes modulate vaccine-induced antibody responses to affect HIV-1 acquisition. 
  • HLA polymorphisms in African Americans with idiopathic inflammatory myopathy: allelic profiles distinguish patients with different clinical phenotypes and myositis autoantibodies. 
  • Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene. 
  • High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors. 
  • High-affinity interaction of poly(ADP-ribose) and the human DEK oncoprotein depends upon chain length. 
  • High-resolution protein structure determination starting with a global fold calculated from exact solutions to the RDC equations. 
  • High-resolution solution structure of the beryllofluoride-activated NtrC receiver domain. 
  • Highly complex neutralization determinants on a monophyletic lineage of newly transmitted subtype C HIV-1 Env clones from India. 
  • HipBA-promoter structures reveal the basis of heritable multidrug tolerance. 
  • Histone deacetylase 3 binds to and regulates the GCMa transcription factor. 
  • Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis. 
  • How cations change peptide structure. 
  • Hsp70 and the Cochaperone StiA (Hop) Orchestrate Hsp90-Mediated Caspofungin Tolerance in Aspergillus fumigatus. 
  • Human PXR forms a tryptophan zipper-mediated homodimer. 
  • Human nucleotide excision repair protein XPA: NMR spectroscopic studies of an XPA fragment containing the ERCC1-binding region and the minimal DNA-binding domain (M59-F219). 
  • Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1. 
  • Human substance P receptor lacking the C-terminal domain remains competent to desensitize and internalize. 
  • Hyperphosphorylated C-terminal repeat domain-associating proteins in the nuclear proteome link transcription to DNA/chromatin modification and RNA processing. 
  • Identification and characterization of a functional zebrafish smrt corepressor (ncor2). 
  • Identification and functional analysis of in vivo phosphorylation sites of the Arabidopsis BRASSINOSTEROID-INSENSITIVE1 receptor kinase. 
  • Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors. 
  • Identification of MAVS splicing variants that interfere with RIGI/MAVS pathway signaling. 
  • Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. 
  • Identification of a Novel Coregulator, SH3YL1, That Interacts With the Androgen Receptor N-Terminus. 
  • Identification of a cluster of residues in transmembrane segment 6 of domain III of the cockroach sodium channel essential for the action of pyrethroid insecticides. 
  • Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3. 
  • Identification of a novel mutation (C321X) in HJV. 
  • Identification of a somatodendritic targeting signal in the cytoplasmic domain of the transferrin receptor. 
  • Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70. 
  • Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance. 
  • Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation. 
  • Identification of casein kinase I substrates by in vitro expression cloning screening. 
  • Identification of gemin5 as a novel 7-methylguanosine cap-binding protein. 
  • Identification of novel interaction sites that determine specificity between fibroblast growth factor homologous factors and voltage-gated sodium channels. 
  • Identification of novel quaternary domain interactions in the Hsp90 chaperone, GRP94. 
  • Identification of the components controlling inactivation of voltage-gated Ca2+ channels. 
  • Identification of the ligand-binding domains of CD22, a member of the immunoglobulin superfamily that uniquely binds a sialic acid-dependent ligand. 
  • Identification of the nuclear localization signal in Xenopus cyclin E and analysis of its role in replication and mitosis. 
  • Identification of the yeast cytidine deaminase CDD1 as an orphan C-->U RNA editase. 
  • Identifying a transcription factor interaction site on RNA polymerase II. 
  • Implications for proteasome nuclear localization revealed by the structure of the nuclear proteasome tether protein Cut8. 
  • Imprinting evolution and the price of silence. 
  • Incorporation of high levels of chimeric human immunodeficiency virus envelope glycoproteins into virus-like particles. 
  • Influenza immunization elicits antibodies specific for an egg-adapted vaccine strain. 
  • Inhibition of NF-kappaB1 and NF-kappaB2 activation in prostate cancer cells treated with antibody against the carboxyl terminal domain of GRP78: effect of p53 upregulation. 
  • Inhibition of WNT signaling by G protein-coupled receptor (GPCR) kinase 2 (GRK2). 
  • Inhibition of human immunodeficiency virus type 1 entry by a binding domain of Porphyromonas gingivalis gingipain. 
  • Inhibition of thyroid hormone sulfotransferase activity by brominated flame retardants and halogenated phenolics. 
  • Inhibitor binding increases the mechanical stability of staphylococcal nuclease. 
  • Inhibitor of apoptosis proteins in eukaryotic evolution and development: a model of thematic conservation. 
  • Initiating cellular stress responses. 
  • Inositol 1,4,5-trisphosphate receptor localization and stability in neonatal cardiomyocytes requires interaction with ankyrin-B. 
  • Insight into F plasmid DNA segregation revealed by structures of SopB and SopB-DNA complexes. 
  • Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5'-diphosphate in the presence or absence of reductant. 
  • Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions. 
  • Integrative analysis of gene amplification in Drosophila follicle cells: parameters of origin activation and repression. 
  • Interaction of Galpha 12 and Galpha 13 with the cytoplasmic domain of cadherin provides a mechanism for beta -catenin release. 
  • Interaction of nephrocystin-4 and RPGRIP1 is disrupted by nephronophthisis or Leber congenital amaurosis-associated mutations. 
  • Interaction of the Shiga-like toxin type 1 B-subunit with its carbohydrate receptor. 
  • Interfacial cavity filling to optimize CD4-mimetic miniprotein interactions with HIV-1 surface glycoprotein. 
  • Intracellular pH regulation by Na(+)/H(+) exchange requires phosphatidylinositol 4,5-bisphosphate. 
  • Intracellular third loop domain of angiotensin II type-2 receptor. Role in mediating signal transduction and cellular function. 
  • Intracellular third loops in AT1 and AT2 receptors determine subtype specificity. 
  • Intragenic modifiers of hereditary spastic paraplegia due to spastin gene mutations. 
  • Intrinsic GTP hydrolysis is observed for a switch 1 variant of Cdc42 in the presence of a specific GTPase inhibitor. 
  • Intrinsic disorder within and flanking the DNA-binding domains of human transcription factors. 
  • Inverted formin 2 mutations with variable expression in patients with sporadic and hereditary focal and segmental glomerulosclerosis. 
  • Investigating the SecY plug movement at the SecYEG translocation channel. 
  • Investigation of the role of electrostatic charge in activation of the Escherichia coli response regulator CheY. 
  • Involvement of the beta clamp in methyl-directed mismatch repair in vitro. 
  • Isoform specificity of ankyrin-B: a site in the divergent C-terminal domain is required for intramolecular association. 
  • Isolation of a human anti-HIV gp41 membrane proximal region neutralizing antibody by antigen-specific single B cell sorting. 
  • JAZ repressor proteins are targets of the SCF(COI1) complex during jasmonate signalling. 
  • JMJD6 cleaves MePCE to release positive transcription elongation factor b (P-TEFb) in higher eukaryotes. 
  • Jasmonate perception by inositol-phosphate-potentiated COI1-JAZ co-receptor. 
  • Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivator. 
  • KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development. 
  • Keeping G proteins at bay: a complex between G protein-coupled receptor kinase 2 and Gbetagamma. 
  • Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2. 
  • Knockin mice expressing a chimeric p53 protein reveal mechanistic differences in how p53 triggers apoptosis and senescence. 
  • L-selectin dimerization enhances tether formation to properly spaced ligand. 
  • L1-dependent neuritogenesis involves ankyrinB that mediates L1-CAM coupling with retrograde actin flow. 
  • LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. 
  • LRRK2 autophosphorylation enhances its GTPase activity. 
  • Large conformational changes in a kinesin motor catalyzed by interaction with microtubules. 
  • Large quantities of Abeta peptide are constitutively released during amyloid precursor protein metabolism in vivo and in vitro. 
  • Ligand-binding residues integrate affinity and efficacy in the NMDA receptor. 
  • Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts. 
  • Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells. 
  • Limited proteolysis differentially modulates the stability and subcellular localization of domains of RPGRIP1 that are distinctly affected by mutations in Leber's congenital amaurosis. 
  • Lipid modification gives rise to two distinct Haloferax volcanii S-layer glycoprotein populations. 
  • Localization and structure of the ankyrin-binding site on beta2-spectrin. 
  • Localization of a cryptic binding site for tenascin on fibronectin. 
  • Localization of the activation gate for small conductance Ca2+-activated K+ channels. 
  • Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. 
  • Long term disease-free survival and T cell and antibody responses in women with high-risk Her2+ breast cancer following vaccination against Her2. 
  • LvNumb works synergistically with Notch signaling to specify non-skeletal mesoderm cells in the sea urchin embryo. 
  • Lysine hydroxylation of collagen in a fibroblast cell culture system. 
  • MARCO is the major binding receptor for unopsonized particles and bacteria on human alveolar macrophages. 
  • Mapping Tertiary Interactions in Protein Folding Reactions: A Novel Mass Spectrometry- and Chemical Synthesis-Based Approach 
  • Mapping of a ligand-binding site for the human thromboxane A2 receptor protein. 
  • Mechanical unfolding of an ankyrin repeat protein. 
  • Mechanical unfolding of ubiquitin molecules. 
  • Mechanism and function of synaptotagmin-mediated membrane apposition. 
  • Mechanism of fast protein folding. 
  • Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes. 
  • Mechanism of local and global Ca2+ sensing by calmodulin in complex with a Ca2+ channel. 
  • Mechanism of staphylococcal multiresistance plasmid replication origin assembly by the RepA protein. 
  • Mechanism of the Class I KDPG aldolase. 
  • Mechanisms controlling agonist and antagonist potential of selective progesterone receptor modulators (SPRMs). 
  • Mechanisms of cellular protrusions branch out. 
  • Mechanisms of proinflammatory cytokine-induced biphasic NF-kappaB activation. 
  • Mechanistic studies of human molybdopterin synthase reaction and characterization of mutants identified in group B patients of molybdenum cofactor deficiency. 
  • Mechano-growth factor peptide, the COOH terminus of unprocessed insulin-like growth factor 1, has no apparent effect on myoblasts or primary muscle stem cells. 
  • Mect1-Maml2 fusion oncogene linked to the aberrant activation of cyclic AMP/CREB regulated genes. 
  • Megalin mediates renal uptake of heavy metal metallothionein complexes. 
  • Membrane topology mapping of vitamin K epoxide reductase by in vitro translation/cotranslocation. 
  • Methionine oxidation of monomeric lambda repressor: the denatured state ensemble under nondenaturing conditions. 
  • Microsecond folding dynamics of the F13W G29A mutant of the B domain of staphylococcal protein A by laser-induced temperature jump. 
  • Microtubules accelerate the kinase activity of Aurora-B by a reduction in dimensionality. 
  • Missense mutation in a von Willebrand factor type A domain of the alpha 3(VI) collagen gene (COL6A3) in a family with Bethlem myopathy. 
  • Modulating adaptive immune responses to peptide self-assemblies. 
  • Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP. 
  • Molecular abnormalities of human plasminogen isolated from synovial fluid of rheumatoid arthritis patients. 
  • Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*. 
  • Molecular evolutionary and structural analysis of the cytosolic DNA sensor cGAS and STING. 
  • Molecular evolutionary characterization of a V1R subfamily unique to strepsirrhine primates. 
  • Molecular interactions and residues involved in force generation in the T4 viral DNA packaging motor. 
  • Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB. 
  • Molecular structure and function of the novel BrnT/BrnA toxin-antitoxin system of Brucella abortus. 
  • Molecular structure of a 9-MDa icosahedral pyruvate dehydrogenase subcomplex containing the E2 and E3 enzymes using cryoelectron microscopy. 
  • Multiprotein HIV type 1 clade B DNA and MVA vaccines: construction, expression, and immunogenicity in rodents of the MVA component. 
  • Multiscale conformational heterogeneity in staphylococcal protein a: possible determinant of functional plasticity. 
  • Muscle-specific RING finger 1 is a bona fide ubiquitin ligase that degrades cardiac troponin I. 
  • Mutagenesis studies of substrate recognition and catalysis in the sortase A transpeptidase from Staphylococcus aureus. 
  • Mutation of MYH9, encoding non-muscle myosin heavy chain A, in May-Hegglin anomaly. 
  • Mutation of conserved histidines alters tertiary structure and nanomechanics of consensus ankyrin repeats. 
  • Mutations Preventing Regulated Exon Skipping in MET Cause Osteofibrous Dysplasia. 
  • Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA). 
  • Mutations near amino end of alpha1(I) collagen cause combined osteogenesis imperfecta/Ehlers-Danlos syndrome by interference with N-propeptide processing. 
  • Mutations of the BRAF gene in human cancer. 
  • Mutations that Separate the Functions of the Proofreading Subunit of the Escherichia coli Replicase. 
  • Myocilin, a component of a membrane-associated protein complex driven by a homologous Q-SNARE domain. 
  • N-terminal 1-54 amino acid sequence and Armadillo repeat domain are indispensable for P120-catenin isoform 1A in regulating E-cadherin. 
  • N-terminal PDZ domain is required for NHERF dimerization. 
  • N-terminal tyrosine modulation of the endocytic adaptor function of the beta-arrestins. 
  • NMR assignment of the N-terminal repeat domain of Bacillus subtilis ClpC. 
  • NMR solution structure and DNA-binding model of the DNA-binding domain of competence protein A. 
  • Nanospring behaviour of ankyrin repeats. 
  • Negative feedback control of jasmonate signaling by an alternative splice variant of JAZ10. 
  • Neurabin/protein phosphatase-1 complex regulates dendritic spine morphogenesis and maturation. 
  • Neutral evolution of the nonbinding region of the anthocyanin regulatory gene Ipmyb1 in Ipomoea. 
  • Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain. 
  • New tools and data for improving structures, using all-atom contacts. 
  • Nitric-oxide synthase output state. Design and properties of nitric-oxide synthase oxygenase/FMN domain constructs. 
  • Noncatalytic domains of RGS9-1.Gbeta 5L play a decisive role in establishing its substrate specificity. 
  • Novel imprinted DLK1/GTL2 domain on human chromosome 14 contains motifs that mimic those implicated in IGF2/H19 regulation. 
  • Novel protein purification system utilizing an N-terminal fusion protein and a caspase-3 cleavable linker. 
  • NuMA localization, stability, and function in spindle orientation involve 4.1 and Cdk1 interactions. 
  • Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival. 
  • O-glycosylation as a sorting determinant for cell surface delivery in yeast. 
  • Obscurin interacts with a novel isoform of MyBP-C slow at the periphery of the sarcomeric M-band and regulates thick filament assembly. 
  • Oncogenic CARD11 mutations in human diffuse large B cell lymphoma. 
  • Optimization of expression of human sulfite oxidase and its molybdenum domain. 
  • Orai proteins interact with TRPC channels and confer responsiveness to store depletion. 
  • Overlapping spectra of SMAD4 mutations in juvenile polyposis (JP) and JP-HHT syndrome. 
  • PINA is essential for growth and positively influences NIMA function in Aspergillus nidulans. 
  • PMEPA1, an androgen-regulated NEDD4-binding protein, exhibits cell growth inhibitory function and decreased expression during prostate cancer progression. 
  • Palladin is an actin cross-linking protein that uses immunoglobulin-like domains to bind filamentous actin. 
  • Parc-ing p53 in the cytoplasm. 
  • Partial glycosylation at asparagine-2181 of the second C-type domain of human factor V modulates assembly of the prothrombinase complex. 
  • Peptide binding proclivities of calcium loaded calbindin-D28k. 
  • Pertussis-toxin-sensitive Galpha subunits selectively bind to C-terminal domain of neuronal GIRK channels: evidence for a heterotrimeric G-protein-channel complex. 
  • Pervasive conformational fluctuations on microsecond time scales in a fibronectin type III domain. 
  • Phase 1 clinical trial of HER2-specific immunotherapy with concomitant HER2 kinase inhibition [corrected]. 
  • Phospho-carboxyl-terminal domain binding and the role of a prolyl isomerase in pre-mRNA 3'-End formation. 
  • Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex. 
  • Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development. 
  • Phospholipid vesicles interfere with the binding of antibody fragments to the light chain of factor VIII. 
  • Phosphoprotein Crh-Ser46-P displays altered binding to CcpA to effect carbon catabolite regulation. 
  • Phosphorylation and functions of the RNA polymerase II CTD. 
  • Phosphorylation dependence of the initiation of productive transcription of Balbiani ring 2 genes in living cells. 
  • Phosphorylation of Calcineurin at a novel serine-proline rich region orchestrates hyphal growth and virulence in Aspergillus fumigatus. 
  • Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets. 
  • Phosphorylation of RNA polymerase II CTD fragments results in tight binding to the WW domain from the yeast prolyl isomerase Ess1. 
  • Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway. 
  • Phosphorylation of the myosin phosphatase target subunit by integrin-linked kinase. 
  • Photoselected electron transfer pathways in DNA photolyase. 
  • Phylogenomic analysis of non-ribosomal peptide synthetases in the genus Aspergillus. 
  • Plasma membrane polarization during mating in yeast cells. 
  • Plasticity of lipid-protein interactions in the function and topogenesis of the membrane protein lactose permease from Escherichia coli. 
  • Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid. 
  • Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathy. 
  • Point mutations alter the mechanical stability of immunoglobulin modules. 
  • Polyglutamine domains are substrates of tissue transglutaminase: does transglutaminase play a role in expanded CAG/poly-Q neurodegenerative diseases? 
  • Post-transcriptional regulation of transcript abundance by a conserved member of the tristetraprolin family in Candida albicans. 
  • Potent anticoagulant aptamer directed against factor IXa blocks macromolecular substrate interaction. 
  • Poxvirus tumor necrosis factor receptor (TNFR)-like T2 proteins contain a conserved preligand assembly domain that inhibits cellular TNFR1-induced cell death. 
  • Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues. 
  • Prefusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopy. 
  • Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. 
  • Preorganized secondary structure as an important determinant of fast protein folding. 
  • Primate-specific melanoma antigen-A11 regulates isoform-specific human progesterone receptor-B transactivation. 
  • Prion protein paralog doppel protein interacts with alpha-2-macroglobulin: a plausible mechanism for doppel-mediated neurodegeneration. 
  • Probing conformational changes in human DNA topoisomerase IIα by pulsed alkylation mass spectrometry. 
  • Probing soluble guanylate cyclase activation by CO and YC-1 using resonance Raman spectroscopy. 
  • Probing the architecture of the B. subtilis RNase P holoenzyme active site by cross-linking and affinity cleavage. 
  • Probing the folded state of fibronectin type III domains in stretched fibrils by measuring buried cysteine accessibility. 
  • Probing the folding and unfolding dynamics of secondary and tertiary structures in a three-helix bundle protein. 
  • Progesterone receptor interacting coregulatory proteins and cross talk with cell signaling pathways. 
  • Protein design and folding: template trapping of self-assembled helical bundles. 
  • Protein folding dynamics: quantitative comparison between theory and experiment. 
  • Protein fragment domains identified using 2D gel electrophoresis/MALDI-TOF. 
  • Protein kinase A regulates ATP hydrolysis and dimerization by a CFTR (cystic fibrosis transmembrane conductance regulator) domain. 
  • Protein kinase CK2 phosphorylates the cell cycle regulatory protein Geminin. 
  • Protein nanotechnology: the new frontier in biosciences. 
  • Protein phosphatase regulation by endogenous inhibitors. 
  • Protein phosphorylation and intermolecular electron transfer: a joint experimental and computational study of a hormone biosynthesis pathway. 
  • Protein secondary structure determination by constrained single-particle cryo-electron tomography. 
  • Protein serine/threonine phosphatases: life, death, and sleeping. 
  • Protein-DNA binding in the absence of specific base-pair recognition. 
  • Protein-Protein Docking Benchmark 2.0: an update. 
  • Proteomic identification of the cerebral cavernous malformation signaling complex. 
  • Pseudomonas syringae Effector Avirulence Protein E Localizes to the Host Plasma Membrane and Down-Regulates the Expression of the NONRACE-SPECIFIC DISEASE RESISTANCE1/HARPIN-INDUCED1-LIKE13 Gene Required for Antibacterial Immunity in Arabidopsis. 
  • Putative telomere-recruiting domain in the catalytic subunit of human telomerase. 
  • Puzzle pieces defined: locating common packing units in tertiary protein contacts. 
  • R726L androgen receptor mutation is uncommon in prostate cancer families in the united states. 
  • R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family. 
  • R9AP targeting to rod outer segments is independent of rhodopsin and is guided by the SNARE homology domain. 
  • RANBP2 is an allosteric activator of the conventional kinesin-1 motor protein, KIF5B, in a minimal cell-free system. 
  • RECQ5 helicase associates with the C-terminal repeat domain of RNA polymerase II during productive elongation phase of transcription. 
  • RGS9-G beta 5 substrate selectivity in photoreceptors. Opposing effects of constituent domains yield high affinity of RGS interaction with the G protein-effector complex. 
  • Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cells. 
  • RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism. 
  • Rapid evolution of a pollen-specific oleosin-like gene family from Arabidopsis thaliana and closely related species. 
  • Rational design of a calcium-binding protein. 
  • Re-engineered CD40 receptor enables potent pharmacological activation of dendritic-cell cancer vaccines in vivo. 
  • Receptor-transporting protein 1 short (RTP1S) mediates translocation and activation of odorant receptors by acting through multiple steps. 
  • Recovery of a human natural antibody against the noncollagenous-1 domain of type IV collagen using humanized models. 
  • Redesigned HIV antibodies exhibit enhanced neutralizing potency and breadth. 
  • Regulation and function of the muscle glycogen-targeting subunit of protein phosphatase 1 (GM) in human muscle cells depends on the COOH-terminal region and glycogen content. 
  • Regulation of B lymphocyte development and activation by the CD19/CD21/CD81/Leu 13 complex requires the cytoplasmic domain of CD19. 
  • Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha. 
  • Regulation of MEF2 by histone deacetylase 4- and SIRT1 deacetylase-mediated lysine modifications. 
  • Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment. 
  • Regulation of cell-cell adhesion by Abi/Diaphanous complexes. 
  • Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes. 
  • Regulation of intrasteric inhibition of the multifunctional calcium/calmodulin-dependent protein kinase. 
  • Regulation of ion transport by the NHERF family of PDZ proteins. 
  • Regulation of mitochondrial antiviral signaling (MAVS) expression and signaling by the mitochondria-associated endoplasmic reticulum membrane (MAM) protein Gp78. 
  • Regulation of the amino-terminal transcription activation domain of progesterone receptor by a cofactor-induced protein folding mechanism. 
  • Regulation of thrombin activity--pharmacologic and structural aspects. 
  • Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii. 
  • Relaxed constraint and evolutionary rate variation between basic helix-loop-helix floral anthocyanin regulators in Ipomoea. 
  • Relaxed selection among duplicate floral regulatory genes in Lamiales. 
  • Release of ubiquitin-charged Cdc34-S - Ub from the RING domain is essential for ubiquitination of the SCF(Cdc4)-bound substrate Sic1. 
  • Remodeled cardiac calcium channels. 
  • Removal of the pro-domain does not affect the conformation of the procaspase-3 dimer. 
  • Requirement for Abl kinases in T cell receptor signaling. 
  • Retinoic acid-induced gene-1 (RIG-I) associates with the actin cytoskeleton via caspase activation and recruitment domain-dependent interactions. 
  • Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper. 
  • Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins. 
  • Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO. 
  • Rituximab decreases without preference all subclasses of IgG anti-BP180 autoantibodies in refractory bullous pemphigoid (BP). 
  • Role of Scd5, a protein phosphatase-1 targeting protein, in phosphoregulation of Sla1 during endocytosis. 
  • Role of residue 147 in the gene regulatory function of the Escherichia coli purine repressor. 
  • Role of the amino terminal RHAU-specific motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU. 
  • Role of the gamma-carboxyglutamic acid domain of activated factor X in the presence of calcium during inhibition by antithrombin-heparin. 
  • Role of the sixth transmembrane segment of domain IV of the cockroach sodium channel in the action of sodium channel blocker insecticides. 
  • S-Nitrosation of arginase 1 requires direct interaction with inducible nitric oxide synthase 
  • SECTM1 produced by tumor cells attracts human monocytes via CD7-mediated activation of the PI3K pathway. 
  • SREC-I, a type F scavenger receptor, is an endocytic receptor for calreticulin. 
  • SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. 
  • Saccharomyces cerevisiae Bzz1p is implicated with type I myosins in actin patch polarization and is able to recruit actin-polymerizing machinery in vitro. 
  • Saccharomyces cerevisiae MutLalpha is a mismatch repair endonuclease. 
  • Schizosaccharomyces pombe Sst4p, a conserved Vps27/Hrs homolog, functions downstream of phosphatidylinositol 3-kinase Pik3p to mediate proper spore formation. 
  • Sec63 and Xbp1 regulate IRE1α activity and polycystic disease severity. 
  • Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation. 
  • Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus. 
  • Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90. 
  • Septin phosphorylation and coiled-coil domains function in cell and septin ring morphology in the filamentous fungus Ashbya gossypii. 
  • Septin ring size scaling and dynamics require the coiled-coil region of Shs1p. 
  • Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway. 
  • Single amino acid changes can influence titer, heparin binding, and tissue tropism in different adeno-associated virus serotypes. 
  • Single molecular force spectroscopy of modular proteins in the nervous system. 
  • Single protein misfolding events captured by atomic force microscopy. 
  • Single residues in the outer pore of TRPV1 and TRPV3 have temperature-dependent conformations. 
  • Six-helix bundle assembly and characterization of heptad repeat regions from the F protein of Newcastle disease virus. 
  • Soluble guanylate cyclase is activated differently by excess NO and by YC-1: resonance Raman spectroscopic evidence. 
  • Solution NMR structure of the N-terminal domain of the human DEK protein. 
  • Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45. 
  • Solution structure of a peptide nucleic acid duplex from NMR data: features and limitations. 
  • Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis. 
  • Solution structure of the NaV1.2 C-terminal EF-hand domain. 
  • Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1. 
  • Solution structure of the Ubp-M BUZ domain, a highly specific protein module that recognizes the C-terminal tail of free ubiquitin. 
  • Sorting nexin homologues are targets of phosphatidylinositol 3-phosphate in sporulation of Schizosaccharomyces pombe. 
  • Spatial localization of the Ebola virus glycoprotein mucin-like domain determined by cryo-electron tomography. 
  • Specific interaction of the transcription elongation regulator TCERG1 with RNA polymerase II requires simultaneous phosphorylation at Ser2, Ser5, and Ser7 within the carboxyl-terminal domain repeat. 
  • Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase. 
  • Stimulation of GCMa transcriptional activity by cyclic AMP/protein kinase A signaling is attributed to CBP-mediated acetylation of GCMa. 
  • Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. 
  • Structural analyses of Ca²⁺/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation. 
  • Structural analysis of semi-specific oligosaccharide recognition by a cellulose-binding protein of thermotoga maritima reveals adaptations for functional diversification of the oligopeptide periplasmic binding protein fold. 
  • Structural and Functional Analyses Reveal Insights into the Molecular Properties of the Escherichia coli Z Ring Stabilizing Protein, ZapC. 
  • Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex. 
  • Structural basis for allosteric control of the transcription regulator CcpA by the phosphoprotein HPr-Ser46-P. 
  • Structural basis for an unexpected mode of SERM-mediated ER antagonism. 
  • Structural basis for the metal-selective activation of the manganese transport regulator of Bacillus subtilis. 
  • Structural basis for the remarkable stability of Bacillus subtilis lipase (Lip A) at low pH. 
  • Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel. 
  • Structural basis of core promoter recognition in a primitive eukaryote. 
  • Structural basis of multifunctional bovine mitochondrial cytochrome bc1 complex. 
  • Structural basis of selection and thermostability of laboratory evolved Bacillus subtilis lipase. 
  • Structural characterization of the conformational change in calbindin-D28k upon calcium binding using differential surface modification analyzed by mass spectrometry. 
  • Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides. 
  • Structural genomics of Pyrococcus furiosus: X-ray crystallography reveals 3D domain swapping in rubrerythrin. 
  • Structural mechanism of S-adenosyl methionine binding to catechol O-methyltransferase. 
  • Structural mechanism of glutamate receptor activation and desensitization. 
  • Structural mechanism of the simultaneous binding of two drugs to a multidrug-binding protein. 
  • Structural mechanisms of QacR induction and multidrug recognition. 
  • Structural reorganization and preorganization in enzyme active sites: comparisons of experimental and theoretically ideal active site geometries in the multistep serine esterase reaction cycle. 
  • Structural studies of molybdopterin synthase provide insights into its catalytic mechanism. 
  • Structural transitions accompanying the activation of peptide binding to the endoplasmic reticulum Hsp90 chaperone GRP94. 
  • Structure and functional properties of the Bacillus subtilis transcriptional repressor Rex. 
  • Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity. 
  • Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs. 
  • Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9. 
  • Structure of a four-way bridged ParB-DNA complex provides insight into P1 segrosome assembly. 
  • Structure of a high fidelity DNA polymerase bound to a benzo[a]pyrene adduct that blocks replication. 
  • Structure of an OhrR-ohrA operator complex reveals the DNA binding mechanism of the MarR family. 
  • Structure of herpes simplex virus glycoprotein D bound to the human receptor nectin-1. 
  • Structure of mammalian protein geranylgeranyltransferase type-I. 
  • Structure of protein geranylgeranyltransferase-I from the human pathogen Candida albicans complexed with a lipid substrate. 
  • Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule. 
  • Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc. 
  • Structure of the N-terminal domain of GRP94. Basis for ligand specificity and regulation. 
  • Structure of the deacetylase LpxC bound to the antibiotic CHIR-090: Time-dependent inhibition and specificity in ligand binding. 
  • Structure of the endonuclease domain of MutL: unlicensed to cut. 
  • Structure of the gating domain of a Ca2+-activated K+ channel complexed with Ca2+/calmodulin. 
  • Structure of the outer membrane translocator domain of the Haemophilus influenzae Hia trimeric autotransporter. 
  • Structure, composition, and peptide binding properties of detergent soluble bilayers and detergent resistant rafts. 
  • Structure-based classification of 45 FK506-binding proteins. 
  • Structures of BmrR-drug complexes reveal a rigid multidrug binding pocket and transcription activation through tyrosine expulsion. 
  • Structures of archaeal DNA segregation machinery reveal bacterial and eukaryotic linkages. 
  • Structures of mismatch replication errors observed in a DNA polymerase. 
  • Structures of regulatory machinery reveal novel molecular mechanisms controlling B. subtilis nitrogen homeostasis. 
  • Structures of the Escherichia coli transcription activator and regulator of diauxie, XylR: an AraC DNA-binding family member with a LacI/GalR ligand-binding domain. 
  • Structures of the T. brucei kRNA editing factor MRB1590 reveal unique RNA-binding pore motif contained within an ABC-ATPase fold. 
  • Structures of the pleiotropic translational regulator Hfq and an Hfq-RNA complex: a bacterial Sm-like protein. 
  • Structures of three polycystic kidney disease-like domains from Clostridium histolyticum collagenases ColG and ColH. 
  • Studying 3D subdomains of proteins at the nanometer scale using fluorescence spectroscopy. 
  • Substitutions in the domain III voltage-sensing module enhance the sensitivity of an insect sodium channel to a scorpion beta-toxin. 
  • Sulfate as a synergistic anion facilitating iron binding by the bacterial transferrin FbpA: the origins and effects of anion promiscuity. 
  • Sulfite reductase structure at 1.6 A: evolution and catalysis for reduction of inorganic anions. 
  • Sustained expression of human factor VIII in mice using a parvovirus-based vector. 
  • Syncoilin isoform organization and differential expression in murine striated muscle. 
  • Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation. 
  • Synergistic effect of aptamers that inhibit exosites 1 and 2 on thrombin. 
  • Syntheses, structures and antibiotic activities of LpxC inhibitors based on the diacetylene scaffold. 
  • Synthesis and characterization of a thermally-responsive tumor necrosis factor antagonist. 
  • Synthetic zinc finger proteins: the advent of targeted gene regulation and genome modification technologies. 
  • Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease. 
  • Target domain definition and classification in CASP8. 
  • Targeting cell surface F1F0 ATP synthase in cancer therapy. 
  • Targeting specific PDZ domains of PSD-95; structural basis for enhanced affinity and enzymatic stability of a cyclic peptide. 
  • Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain. 
  • Temporally distinct and ligand-specific recruitment of nuclear receptor-interacting peptides and cofactors to subnuclear domains containing the estrogen receptor. 
  • The 1.2 A structure of the human sulfite oxidase cytochrome b(5) domain. 
  • The 6.9-A structure of GlpF: a basis for homology modeling of the glycerol channel from Escherichia coli. 
  • The 9-1-1 checkpoint clamp physically interacts with polzeta and is partially required for spontaneous polzeta-dependent mutagenesis in Saccharomyces cerevisiae. 
  • The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events. 
  • The Alacoil: a very tight, antiparallel coiled-coil of helices. 
  • The Arabidopsis F-box protein SLEEPY1 targets gibberellin signaling repressors for gibberellin-induced degradation. 
  • The C-terminal domain of A1/Bfl-1 regulates its anti-inflammatory function in human endothelial cells. 
  • The C-terminal domain of the adenine-DNA glycosylase MutY confers specificity for 8-oxoguanine.adenine mispairs and may have evolved from MutT, an 8-oxo-dGTPase. 
  • The C-terminal domain of viral IAP associated factor (cVIAF) is a structural homologue of phosducin: resonance assignments and secondary structure of the C-terminal domain of VIAF. 
  • The C2 domain protein Cts1 functions in the calcineurin signaling circuit during high-temperature stress responses in Cryptococcus neoformans. 
  • The Chlamydia trachomatis Protease CPAF Contains a Cryptic PDZ-Like Domain with Similarity to Human Cell Polarity and Tight Junction PDZ-Containing Proteins. 
  • The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo. 
  • The DNA binding domain of a papillomavirus E2 protein programs a chimeric nuclease to cleave integrated human papillomavirus DNA in HeLa cervical carcinoma cells. 
  • The Drosophila Cadherin Fat regulates tissue size and planar cell polarity through different domains. 
  • The Drosophila Tis11 protein and its effects on mRNA expression in flies. 
  • The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex. 
  • The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machinery. 
  • The Haemophilus influenzae Hia autotransporter contains an unusually short trimeric translocator domain. 
  • The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during Drosophila oogenesis. 
  • The LOV domain family: photoresponsive signaling modules coupled to diverse output domains. 
  • The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair. 
  • The N- and C-terminal peptides of hIL8/CXCL8 are ligands for hCXCR1 and hCXCR2. 
  • The PDZ motif of the α1C subunit is not required for surface trafficking and adrenergic modulation of CaV1.2 channel in the heart. 
  • The RGD motif in fibronectin is essential for development but dispensable for fibril assembly. 
  • The SAF-box domain of chromatin protein DEK. 
  • The T4 phage SF1B helicase Dda is structurally optimized to perform DNA strand separation. 
  • The U1 small nuclear ribonucleoprotein (snRNP) 70K protein is transported independently of U1 snRNP particles via a nuclear localization signal in the RNA-binding domain. 
  • The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2. 
  • The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells. 
  • The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling. 
  • The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes. 
  • The aryl hydrocarbon nuclear translocator alters CD30-mediated NF-kappaB-dependent transcription. 
  • The backbone structure of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein is essentially identical to its mesophilic E. coli homolog. 
  • The betagamma subunit of heterotrimeric G proteins interacts with RACK1 and two other WD repeat proteins. 
  • The carboxyl-terminal amino acids render pro-human LC3B migration similar to lipidated LC3B in SDS-PAGE. 
  • The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon. 
  • The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia-like disease by bcr/abl. 
  • The conserved bromo-adjacent homology domain of yeast Orc1 functions in the selection of DNA replication origins within chromatin. 
  • The crystal structure of Escherichia coli MoeA and its relationship to the multifunctional protein gephyrin. 
  • The crystal structure of a collagen-like polypeptide with 3(S)-hydroxyproline residues in the Xaa position forms a standard 7/2 collagen triple helix. 
  • The crystal structure of a thermophilic glucose binding protein reveals adaptations that interconvert mono and di-saccharide binding sites. 
  • The crystal structure of the UvsW helicase from bacteriophage T4. 
  • The crystal structure of the catalytic domain of a eukaryotic guanylate cyclase. 
  • The cyclophilin-like domain of Ran-binding protein-2 modulates selectively the activity of the ubiquitin-proteasome system and protein biogenesis. 
  • The dCMP transferase activity of yeast Rev1 is biologically relevant during the bypass of endogenously generated AP sites. 
  • The deubiquitinating enzyme DUBAI stabilizes DIAP1 to suppress Drosophila apoptosis. 
  • The deubiquitinating enzyme ataxin-3, a polyglutamine disease protein, edits Lys63 linkages in mixed linkage ubiquitin chains. 
  • The distal cytoplasmic domain of the erythropoietin receptor induces granulocytic differentiation in 32D cells. 
  • The disulfide bonding pattern in ficolin multimers. 
  • The dual enzyme LRRK2 hydrolyzes GTP in both its GTPase and kinase domains in vitro. 
  • The essential sequence elements required for RNAP II carboxyl-terminal domain function in yeast and their evolutionary conservation. 
  • The human ACC2 CT-domain C-terminus is required for full functionality and has a novel twist. 
  • The human poliovirus receptor. Receptor-virus interaction and parameters of disease specificity. 
  • The identification of a second actin-binding region in spinophilin/neurabin II. 
  • The importance of Src homology 2 domain-containing leukocyte phosphoprotein of 76 kilodaltons sterile-alpha motif domain in thymic selection and T-cell activation. 
  • The inhibitor-1 C terminus facilitates hormonal regulation of cellular protein phosphatase-1: functional implications for inhibitor-1 isoforms. 
  • The integrity of a cholesterol-binding pocket in Niemann-Pick C2 protein is necessary to control lysosome cholesterol levels. 
  • The interface between membrane-spanning and cytosolic domains in Ca²+-dependent K+ channels is involved in β subunit modulation of gating. 
  • The intolerance to functional genetic variation of protein domains predicts the localization of pathogenic mutations within genes. 
  • The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2. 
  • The mechanical stability of ubiquitin is linkage dependent. 
  • The mechanism of discrimination between oxidized and reduced coenzyme in the aldehyde dehydrogenase domain of Aldh1l1. 
  • The mechanism of the translocation step in DNA replication by DNA polymerase I: a computer simulation analysis. 
  • The molecular basis for ligand specificity in a mouse olfactory receptor: a network of functionally important residues. 
  • The mouse C-type transient receptor potential 2 (TRPC2) channel: alternative splicing and calmodulin binding to its N terminus. 
  • The mouse forkhead gene Foxc1 is required for primordial germ cell migration and antral follicle development. 
  • The phosphoCTD-interacting domain of Topoisomerase I. 
  • The pore-domain of TRPA1 mediates the inhibitory effect of the antagonist 6-methyl-5-(2-(trifluoromethyl)phenyl)-1H-indazole. 
  • The pre-ligand binding assembly domain: a potential target of inhibition of tumour necrosis factor receptor function. 
  • The regulator of G protein signaling domain of axin selectively interacts with Galpha12 but not Galpha13. 
  • The retinitis pigmentosa GTPase regulator (RPGR) interacts with novel transport-like proteins in the outer segments of rod photoreceptors. 
  • The rho-guanine nucleotide exchange factor domain of obscurin regulates assembly of titin at the Z-disk through interactions with Ran binding protein 9. 
  • The role of the calponin homology domain of smoothelin-like 1 (SMTNL1) in myosin phosphatase inhibition and smooth muscle contraction. 
  • The role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding. 
  • The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair. 
  • The stem cell-expressed receptor Lgr5 possesses canonical and functionally active molecular determinants critical to β-arrestin-2 recruitment. 
  • The stoichiometry of trimeric SIV glycoprotein interaction with CD4 differs from that of anti-envelope antibody Fab fragments. 
  • The structural basis for the mutagenicity of O(6)-methyl-guanine lesions. 
  • The structural mechanism for transcription activation by MerR family member multidrug transporter activation, N terminus. 
  • The structural mechanism of GTP stabilized oligomerization and catalytic activation of the Toxoplasma gondii uracil phosphoribosyltransferase. 
  • The structure of a high fidelity DNA polymerase bound to a mismatched nucleotide reveals an "ajar" intermediate conformation in the nucleotide selection mechanism. 
  • The structure of formylmethanofuran: tetrahydromethanopterin formyltransferase in complex with its coenzymes. 
  • The structure of irisin reveals a novel intersubunit β-sheet fibronectin type III (FNIII) dimer: implications for receptor activation. 
  • The transcription factor B-Myb is maintained in an inhibited state in target cells through its interaction with the nuclear corepressors N-CoR and SMRT. 
  • The transforming growth factor-beta type III receptor mediates distinct subcellular trafficking and downstream signaling of activin-like kinase (ALK)3 and ALK6 receptors. 
  • The unusual UBZ domain of Saccharomyces cerevisiae polymerase η. 
  • Thematic review series: lipid posttranslational modifications. Structural biology of protein farnesyltransferase and geranylgeranyltransferase type I. 
  • Thermodynamic characterization of the binding interaction between the histone demethylase LSD1/KDM1 and CoREST. 
  • Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel. 
  • Tissue-specific expression and regulation of the alternatively-spliced forms of lysyl hydroxylase 2 (LH2) in human kidney cells and skin fibroblasts. 
  • Topology of mammalian isoprenylcysteine carboxyl methyltransferase determined in live cells with a fluorescent probe. 
  • Total chemical synthesis and biophysical characterization of the minimal isoform of the KChIP2 potassium channel regulatory subunit. 
  • Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination. 
  • Transcriptional control of preadipocyte determination by Zfp423. 
  • Transient opening of fibronectin type III (FNIII) domains: the interaction of the third FNIII domain of FN with anastellin. 
  • Translocator proteins in the two-partner secretion family have multiple domains. 
  • Trimeric autotransporters require trimerization of the passenger domain for stability and adhesive activity. 
  • Trimers of the fibronectin cell adhesion domain localize to actin filament bundles and undergo rearward translocation. 
  • Two classes of germline genes both derived from the V(H)1 family direct the formation of human antibodies that recognize distinct antigenic sites in the C2 domain of factor VIII. 
  • Two forms of mitochondrial DNA ligase III are produced in Xenopus laevis oocytes. 
  • Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors. 
  • Two-state displacement by the kinesin-14 Ncd stalk. 
  • Tyrosine cross-linking reveals interfacial dynamics in adeno-associated viral capsids during infection. 
  • Tyrosine-kinase-dependent recruitment of RGS12 to the N-type calcium channel. 
  • Tyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry. 
  • Ubiquitination of beta-arrestin links seven-transmembrane receptor endocytosis and ERK activation. 
  • Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia. 
  • Unconventional ubiquitin recognition by the ubiquitin-binding motif within the Y family DNA polymerases iota and Rev1. 
  • Uncoupling of the signaling and caspase-inhibitory properties of X-linked inhibitor of apoptosis. 
  • Understanding the elasticity of fibronectin fibrils: unfolding strengths of FN-III and GFP domains measured by single molecule force spectroscopy. 
  • Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases. 
  • Unique functional and structural properties of the LRRK2 protein ATP-binding pocket. 
  • Use of dominant-negative HrpA mutants to dissect Hrp pilus assembly and type III secretion in Pseudomonas syringae pv. tomato. 
  • Use of knowledge-based restraints in phenix.refine to improve macromolecular refinement at low resolution. 
  • Using context to improve protein domain identification. 
  • VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation. 
  • Vascular morphogenesis: tales of two syndromes. 
  • WHIM syndrome caused by a single amino acid substitution in the carboxy-tail of chemokine receptor CXCR4. 
  • X-ray crystal structure of the yeast Kar3 motor domain complexed with Mg.ADP to 2.3 A resolution. 
  • Xenopus Kazrin interacts with ARVCF-catenin, spectrin and p190B RhoGAP, and modulates RhoA activity and epithelial integrity. 
  • YbiV from Escherichia coli K12 is a HAD phosphatase. 
  • ZDOCK and RDOCK performance in CAPRI rounds 3, 4, and 5. 
  • [Protein transduction domain peptide mediates delivery to the brain via the blood-brain barrier in Drosophila]. 
  • c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment. 
  • c-Myc represses FOXO3a-mediated transcription of the gene encoding the p27(Kip1) cyclin dependent kinase inhibitor. 
  • cis-Proline-mediated Ser(P)5 dephosphorylation by the RNA polymerase II C-terminal domain phosphatase Ssu72. 
  • dictyBase--a Dictyostelium bioinformatics resource update. 
  • hSnm1B is a novel telomere-associated protein. 
  • pH-dependent conformational changes of ferricytochrome c induced by electrode surface microstructure. 
  • tPA-mediated generation of plasmin is catalyzed by the proteoglycan NG2. 
  • trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1. 
  • zipper Nonmuscle myosin-II functions downstream of PS2 integrin in Drosophila myogenesis and is necessary for myofibril formation. 
• 

  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Guan, Ziqiang, Research Professor in Biochemistry, Biochemistry
  • Hartemink, Alexander J., Professor in the Department of Computer Science, Biology
  • Kelsoe, Garnett H., James B. Duke Distinguished Professor of Immunology, Integrative Immunobiology
  • Luftig, Micah Alan, Professor of Molecular Genetics and Microbiology, Cell Biology
  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • Oas, Terrence Gilbert, Professor of Biochemistry, Biochemistry
  • Pitt, Geoffrey Stuart, Adjunct Professor in the Department of Medicine, Medicine, Cardiology
  • Richardson, David C., Professor Emeritus of Biochemistry, Biochemistry
  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology
  • Soderling, Scott Haydn, George Barth Geller Distinguished Professor of Molecular Biology, Cell Biology