Receptors, Dopamine D1

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  Subject Areas on Research

  • A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. 
  • A dopamine D1 receptor-dependent β-arrestin signaling complex potentially regulates morphine-induced psychomotor activation but not reward in mice. 
  • A rodent model of spontaneous stereotypy: initial characterization of developmental, environmental, and neurobiological factors. 
  • Acute and chronic interactive treatments of serotonin 5HT2C and dopamine D1 receptor systems for decreasing nicotine self-administration in female rats. 
  • Anatomically dissociable effects of dopamine D1 receptor agonists on reward and relief of withdrawal in morphine-dependent rats. 
  • Antagonism of catecholamine receptor signaling by expression of cytoplasmic domains of the receptors. 
  • Behavioral and molecular effects of dopamine D1 receptor stimulation during naloxone-precipitated morphine withdrawal. 
  • Biochemical properties of D1 and D2 dopamine receptors. 
  • Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors. 
  • Chronic nicotine working and reference memory effects in the 16-arm radial maze: interactions with D1 agonist and antagonist drugs. 
  • Cloning and characterization of the opossum kidney cell D1 dopamine receptor: expression of identical D1A and D1B dopamine receptor mRNAs in opossum kidney and brain. 
  • Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor. 
  • Conformational analysis and molecular modeling of 1-phenyl-, 4-phenyl-, and 1-benzyl-1,2,3,4-tetrahydroisoquinolines as D1 dopamine receptor ligands. 
  • Coordination of Brain-Wide Activity Dynamics by Dopaminergic Neurons. 
  • D1 and D2 antagonists reverse the effects of appetite suppressants on weight loss, food intake, locomotion, and rebalance spiking inhibition in the rat NAc shell. 
  • D1 and D2 dopamine receptor interactions with pilocarpine-induced oral activity in rats. 
  • D1 and D2 dopamine receptors stimulate hypothalamo-pituitary-adrenal activity in rats. 
  • D1 dopamine receptor binding and mRNA levels are not altered after neonatal 6-hydroxydopamine treatment: evidence against dopamine-mediated induction of D1 dopamine receptors during postnatal development. 
  • Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D1 Receptor Agonists. 
  • Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity. 
  • Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases. 
  • Differential regulation of the dopamine D1, D2 and D3 receptor gene expression and changes in the phenotype of the striatal neurons in mice lacking the dopamine transporter. 
  • Divergence of an association between depressive symptoms and a dopamine polygenic score in Caucasians and Asians. 
  • Dopamine D(5) receptor immunolocalization in rat and monkey brain. 
  • Dopamine D1 and D2 receptor antagonism during development alters later behavior in zebrafish. 
  • Dopamine D1 receptors and phosphorylation of dopamine- and cyclic AMP-regulated phosphoprotein-32 in the medial preoptic area are involved in experience-induced enhancement of male sexual behavior in rats. 
  • Dopamine attenuates evoked inhibitory synaptic currents in central amygdala neurons. 
  • Dopamine mediates vagal modulation of the immune system by electroacupuncture. 
  • Dopamine receptors in a songbird brain. 
  • Dopamine receptors status after unilateral nigral 6-OHDA lesion. Autoradiographic and in situ hybridization study in the rat brain. 
  • Dopamine tone regulates D1 receptor trafficking and delivery in striatal neurons in dopamine transporter-deficient mice. 
  • Dopaminergic abnormalities in Hdac6-deficient mice. 
  • Dopaminergic drugs reverse the impairment of radial-arm maze performance caused by lesions involving the cholinergic medial pathway. 
  • Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice. 
  • Drd1a-tdTomato BAC transgenic mice for simultaneous visualization of medium spiny neurons in the direct and indirect pathways of the basal ganglia. 
  • Elevation of cAMP is required for down-regulation, but not agonist-induced desensitization, of endogenous dopamine D1 receptors in opossum kidney cells. Studies in cells that stably express a rat cAMP phosphodiesterase (rPDE3) cDNA. 
  • Essential role of D1R in the regulation of mTOR complex1 signaling induced by cocaine. 
  • GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension. 
  • Heterogeneity of dopamine receptors. 
  • High agonist-independent activity is a distinguishing feature of the dopamine D1B receptor subtype. 
  • Hyperactivity and impaired response habituation in hyperdopaminergic mice. 
  • Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease. 
  • Inhibition of G protein-coupled receptor signaling by expression of cytoplasmic domains of the receptor. 
  • Inhibition of the dopamine D1 receptor signaling by PSD-95. 
  • Interactive effects of D1 and D2 agonists with scopolamine on radial-arm maze performance. 
  • Location and molecular cloning of D1 dopamine receptor. 
  • Mice lacking the dopamine transporter display altered regulation of distal colonic motility. 
  • Microglial dopamine receptor elimination defines sex-specific nucleus accumbens development and social behavior in adolescent rats. 
  • Molecular characterization of G-protein coupled receptors: isolation and cloning of a D1 dopamine receptor. 
  • Molecular characterization of dopamine receptors. 
  • Molecular cloning and expression of the gene for a human D1 dopamine receptor. 
  • Molecular cloning, stable expression and desensitization of the human dopamine D1b/D5 receptor. 
  • Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats. 
  • OCD-Like behaviors caused by a neuropotentiating transgene targeted to cortical and limbic D1+ neurons. 
  • Ontogeny of D1A and D2 dopamine receptor subtypes in rat brain using in situ hybridization and receptor binding. 
  • Ontogeny of the striatal neurons expressing the D1 dopamine receptor in humans. 
  • Opposite function of dopamine D1 and N-methyl-D-aspartate receptors in striatal cannabinoid-mediated signaling. 
  • Persistent attenuation of nicotine self-administration in rats by co-administration of chronic nicotine infusion with the dopamine D1 receptor antagonist SCH-23390 or the serotonin 5-HT2C agonist lorcaserin. 
  • Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists. 
  • Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter. 
  • Rod vision is controlled by dopamine-dependent sensitization of rod bipolar cells by GABA. 
  • Role of insular cortex D₁ and D₂ dopamine receptors in nicotine self-administration in rats. 
  • Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses. 
  • Scopolamine interactions with D1 and D2 antagonists on radial-arm maze performance in rats. 
  • Selective deletion of GRK2 alters psychostimulant-induced behaviors and dopamine neurotransmission. 
  • Silencing of the constitutive activity of the dopamine D1B receptor. Reciprocal mutations between D1 receptor subtypes delineate residues underlying activation properties. 
  • Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney. 
  • Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane. 
  • The human D1A dopamine receptor gene promoter directs expression of a reporter gene to the central nervous system in transgenic mice. 
  • Ventral hippocampal dopamine D1 and D2 systems and spatial working memory in rats. 
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  Keywords of People

  • Calakos, Nicole, Lincoln Financial Group Distinguished Professor of Neurobiology, Duke Science & Society