Receptors, Dopamine D2

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  Subject Areas on Research

  • A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. 
  • A preliminary analysis of interactions between genotype, retrospective ADHD symptoms, and initial reactions to smoking in a sample of young adults. 
  • A rodent model of spontaneous stereotypy: initial characterization of developmental, environmental, and neurobiological factors. 
  • Adjunctive brexpiprazole for the treatment of major depressive disorder. 
  • An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. 
  • Associations between dopamine D2 receptor availability and BMI depend on age. 
  • Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors. 
  • Cholinergic neurons constitutively engage the ISR for dopamine modulation and skill learning in mice. 
  • Chronic loss of noradrenergic tone produces β-arrestin2-mediated cocaine hypersensitivity and alters cellular D2 responses in the nucleus accumbens. 
  • Concurrent autoreceptor-mediated control of dopamine release and uptake during neurotransmission: an in vivo voltammetric study. 
  • Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor. 
  • D1 and D2 antagonists reverse the effects of appetite suppressants on weight loss, food intake, locomotion, and rebalance spiking inhibition in the rat NAc shell. 
  • D1 and D2 dopamine receptor interactions with pilocarpine-induced oral activity in rats. 
  • D1 and D2 dopamine receptors stimulate hypothalamo-pituitary-adrenal activity in rats. 
  • D2 Dopamine Receptor G Protein-Biased Partial Agonists Based on Cariprazine. 
  • D2 dopamine receptor A1 allele in Alzheimer disease and aging. 
  • Deletion of GSK3β in D2R-expressing neurons reveals distinct roles for β-arrestin signaling in antipsychotic and lithium action. 
  • Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity. 
  • Determination of sulpiride by capillary electrophoresis with end-column electrogenerated chemiluminescence detection. 
  • Differential regional decline in dopamine receptor availability across adulthood: Linear and nonlinear effects of age. 
  • Differential regulation of the dopamine D2 and D3 receptors by G protein-coupled receptor kinases and beta-arrestins. 
  • Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. 
  • Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties. 
  • Divergence of an association between depressive symptoms and a dopamine polygenic score in Caucasians and Asians. 
  • Dopamine D1 and D2 receptor antagonism during development alters later behavior in zebrafish. 
  • Dopamine D2 receptor occupancy and cognition in schizophrenia: analysis of the CATIE data. 
  • Dopamine receptors in a songbird brain. 
  • Dopaminergic abnormalities in Hdac6-deficient mice. 
  • Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons. 
  • Dopaminergic drugs reverse the impairment of radial-arm maze performance caused by lesions involving the cholinergic medial pathway. 
  • Dopaminergic modulation of reward discounting in healthy rats: a systematic review and meta-analysis. 
  • Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice. 
  • Effects of quitting smoking on EEG activation and attention last for more than 31 days and are more severe with stress, dependence, DRD2 A1 allele, and depressive traits. 
  • Effects of the dopamine D-2 receptor agonist, LY 171555, on radial arm maze performance in rats. 
  • Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice. 
  • Efficacy of risperidone on positive features of schizophrenia. 
  • Environmental Contingencies and Genetic Predispositions: Social Capital, Educational Continuation, and a Dopamine Receptor Polymorphism 
  • Estimation of D2-like receptor occupancy by dopamine in the putamen of hemiparkinsonian Monkeys. 
  • Evaluating dopamine reward pathway in ADHD: clinical implications. 
  • FTO affects food cravings and interacts with age to influence age-related decline in food cravings. 
  • Frequency-specific and D2 receptor-mediated inhibition of glutamate release by retrograde endocannabinoid signaling. 
  • Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor. 
  • Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase. 
  • Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs. 
  • G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation. 
  • Helping Relationships and Genetic Propensities: A Combinatoric Study of DRD2, Mentoring, and Educational Continuation 
  • High prevalence of rare dopamine receptor D4 alleles in children diagnosed with attention-deficit hyperactivity disorder. 
  • Identification of the ligand-binding subunit of the human 5-hydroxytryptamine1A receptor with N-(p-azido-m-[125I] iodophenethyl)spiperone, a high affinity radioiodinated photoaffinity probe. 
  • Imaging genetics and the neurobiological basis of individual differences in vulnerability to addiction. 
  • Impulsivity and genetic variants in DRD2 and ANKK1 moderate longitudinal associations between sleep problems and overweight from ages 5 to 11. 
  • Individual Differences in Dopamine Are Associated with Reward Discounting in Clinical Groups But Not in Healthy Adults. 
  • Individual differences in dopamine D2 receptor availability correlate with reward valuation. 
  • Interactions between genotype and retrospective ADHD symptoms predict lifetime smoking risk in a sample of young adults. 
  • Interactive effects of D1 and D2 agonists with scopolamine on radial-arm maze performance. 
  • Involvement of dopamine D2 receptors in the suppressive effect of the thyrotropin-releasing hormone analog TA-0910 on alcohol intake in alcohol-preferring rats. 
  • Lack of consistent sex differences in D-amphetamine-induced dopamine release measured with [¹⁸ F]fallypride PET. 
  • Mesolimbic dopamine D2 receptors and neural representations of subjective value. 
  • Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. 
  • Modeling of bias for the analysis of receptor signaling in biochemical systems. 
  • Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway. 
  • Multilocus genetic profile for dopamine signaling predicts ventral striatum reactivity. 
  • Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats. 
  • Neurotensin-induced dopamine release in vivo and in vitro from substantia nigra and nucleus caudate. 
  • Opposite function of dopamine D1 and N-methyl-D-aspartate receptors in striatal cannabinoid-mediated signaling. 
  • PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia. 
  • Partial-volume correction increases estimated dopamine D2-like receptor binding potential and reduces adult age differences. 
  • Reduced effects of age on dopamine D2 receptor levels in physically active adults. 
  • Reproducibility of the correlative triad among aging, dopamine receptor availability, and cognition. 
  • Reserpine-induced up-regulation of dopamine D2 receptors in the rat striatum is enhanced by denervation but not by chronic receptor blockade. 
  • Role of insular cortex D₁ and D₂ dopamine receptors in nicotine self-administration in rats. 
  • SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families. 
  • Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses. 
  • Scopolamine interactions with D1 and D2 antagonists on radial-arm maze performance in rats. 
  • Spontaneous Eye Blink Rate (EBR) Is Uncorrelated with Dopamine D2 Receptor Availability and Unmodulated by Dopamine Agonism in Healthy Adults. 
  • Striatal dopamine D2/D3 receptor availability in male smokers. 
  • Structure-functional selectivity relationship studies of β-arrestin-biased dopamine D₂ receptor agonists. 
  • Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers. 
  • Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane. 
  • The dopamine D4 receptor and the hyperactivity phenotype: a developmental-epidemiological study. 
  • The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. 
  • The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus. 
  • Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs. 
  • Ventral hippocampal dopamine D1 and D2 systems and spatial working memory in rats.