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Subject Areas on Research
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A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons.
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A preliminary analysis of interactions between genotype, retrospective ADHD symptoms, and initial reactions to smoking in a sample of young adults.
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A rodent model of spontaneous stereotypy: initial characterization of developmental, environmental, and neurobiological factors.
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A2a/D2 receptor interactions are not observed in COS-7 cells transiently transfected with dopamine D2 and adenosine A2a receptor cDNA.
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Adjunctive brexpiprazole for the treatment of major depressive disorder.
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Affinity chromatography of the anterior pituitary D2-dopamine receptor.
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An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior.
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Antagonism of dopamine D2 receptor/beta-arrestin 2 interaction is a common property of clinically effective antipsychotics.
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Associations between dopamine D2 receptor availability and BMI depend on age.
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Binding of [125I]-N-(p-aminophenethyl)spiroperidol to the D-2 dopamine receptor in the neurointermediate lobe of the rat pituitary gland: a thermodynamic study.
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Biochemical properties of D1 and D2 dopamine receptors.
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Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors.
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Characterization of the desensitization properties of five dopamine receptor subtypes and alternatively spliced variants of dopamine D2 and D4 receptors.
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Chimeric D2/D3 dopamine receptors efficiently inhibit adenylyl cyclase in HEK 293 cells.
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Chronic loss of noradrenergic tone produces β-arrestin2-mediated cocaine hypersensitivity and alters cellular D2 responses in the nucleus accumbens.
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Clozapine-, but not haloperidol-, induced increases in deltaFosB-like immunoreactivity are completely blocked in the striatum of mice lacking D3 dopamine receptors.
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Comparative studies of molecular mechanisms of dopamine D2 and D3 receptors for the activation of extracellular signal-regulated kinase.
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Concurrent autoreceptor-mediated control of dopamine release and uptake during neurotransmission: an in vivo voltammetric study.
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Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor.
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D1 and D2 antagonists reverse the effects of appetite suppressants on weight loss, food intake, locomotion, and rebalance spiking inhibition in the rat NAc shell.
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D1 and D2 dopamine receptor interactions with pilocarpine-induced oral activity in rats.
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D1 and D2 dopamine receptors stimulate hypothalamo-pituitary-adrenal activity in rats.
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D2 Dopamine Receptor G Protein-Biased Partial Agonists Based on Cariprazine.
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D2 dopamine receptor A1 allele in Alzheimer disease and aging.
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D2 dopamine receptors in the human retina: cloning of cDNA and localization of mRNA.
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Deletion of GSK3β in D2R-expressing neurons reveals distinct roles for β-arrestin signaling in antipsychotic and lithium action.
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Deletion of Glycogen Synthase Kinase-3β in D2 Receptor-Positive Neurons Ameliorates Cognitive Impairment via NMDA Receptor-Dependent Synaptic Plasticity.
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Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity.
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Determination of sulpiride by capillary electrophoresis with end-column electrogenerated chemiluminescence detection.
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Differential regional decline in dopamine receptor availability across adulthood: Linear and nonlinear effects of age.
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Differential regulation of the dopamine D1, D2 and D3 receptor gene expression and changes in the phenotype of the striatal neurons in mice lacking the dopamine transporter.
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Differential regulation of the dopamine D2 and D3 receptors by G protein-coupled receptor kinases and beta-arrestins.
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Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy.
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Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties.
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Divergence of an association between depressive symptoms and a dopamine polygenic score in Caucasians and Asians.
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Do the dimensions of the temperament and character inventory map a simple genetic architecture? Evidence from molecular genetics and factor analysis.
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Dopamine D1 and D2 receptor antagonism during development alters later behavior in zebrafish.
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Dopamine D2 receptor occupancy and cognition in schizophrenia: analysis of the CATIE data.
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Dopamine D2 receptor relies upon PPM/PP2C protein phosphatases to dephosphorylate huntingtin protein.
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Dopamine autoreceptor regulation of release and uptake in mouse brain slices in the absence of D(3) receptors.
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Dopamine receptors in a songbird brain.
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Dopamine receptors status after unilateral nigral 6-OHDA lesion. Autoradiographic and in situ hybridization study in the rat brain.
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Dopaminergic abnormalities in Hdac6-deficient mice.
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Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons.
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Dopaminergic drugs reverse the impairment of radial-arm maze performance caused by lesions involving the cholinergic medial pathway.
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Dopaminergic modulation of reward discounting in healthy rats: a systematic review and meta-analysis.
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Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice.
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Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors.
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Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder.
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Effects of quitting smoking on EEG activation and attention last for more than 31 days and are more severe with stress, dependence, DRD2 A1 allele, and depressive traits.
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Effects of the dopamine D-2 receptor agonist, LY 171555, on radial arm maze performance in rats.
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Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice.
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Efficacy of risperidone on positive features of schizophrenia.
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Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor.
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Engineered D2R Variants Reveal the Balanced and Biased Contributions of G-Protein and β-Arrestin to Dopamine-Dependent Functions.
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Environmental contingencies and genetic propensities: social capital, educational continuation, and dopamine receptor gene DRD2.
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Epidermal growth factor promotes uncoupling from adenylyl cyclase of the rat D2S receptor expressed in GH4C1 cells.
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Estimation of D2-like receptor occupancy by dopamine in the putamen of hemiparkinsonian Monkeys.
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Evaluating dopamine reward pathway in ADHD: clinical implications.
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FTO affects food cravings and interacts with age to influence age-related decline in food cravings.
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Food for thought: the physiological relevance of ghrelin and dopamine D2 receptor heterodimerization in the regulation of appetite.
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Frequency-specific and D2 receptor-mediated inhibition of glutamate release by retrograde endocannabinoid signaling.
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Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor.
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Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase.
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Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs.
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G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation.
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Helping relationships and genetic propensities: a combinatoric study of DRD2, mentoring, and educational continuation.
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Heterogeneity of dopamine receptors.
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High affinity agonist binding to the dopamine D3 receptor: chimeric receptors delineate a role for intracellular domains.
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High prevalence of rare dopamine receptor D4 alleles in children diagnosed with attention-deficit hyperactivity disorder.
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Hyperactivity and impaired response habituation in hyperdopaminergic mice.
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Identification of the D2-dopamine receptor binding subunit in several mammalian tissues and species by photoaffinity labeling.
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Identification of the ligand-binding subunit of the human 5-hydroxytryptamine1A receptor with N-(p-azido-m-[125I] iodophenethyl)spiperone, a high affinity radioiodinated photoaffinity probe.
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Imaging genetics and the neurobiological basis of individual differences in vulnerability to addiction.
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Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease.
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Impulsivity and genetic variants in DRD2 and ANKK1 moderate longitudinal associations between sleep problems and overweight from ages 5 to 11.
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Individual Differences in Dopamine Are Associated with Reward Discounting in Clinical Groups But Not in Healthy Adults.
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Individual differences in dopamine D2 receptor availability correlate with reward valuation.
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Interactions between genotype and retrospective ADHD symptoms predict lifetime smoking risk in a sample of young adults.
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Interactive effects of D1 and D2 agonists with scopolamine on radial-arm maze performance.
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Intranigral administration of D2 dopamine receptor antisense oligodeoxynucleotides establishes a role for nigrostriatal D2 autoreceptors in the motor actions of cocaine.
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Involvement of dopamine D2 receptors in the suppressive effect of the thyrotropin-releasing hormone analog TA-0910 on alcohol intake in alcohol-preferring rats.
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Lack of consistent sex differences in D-amphetamine-induced dopamine release measured with [18
F]fallypride PET.
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Loss of autoreceptor functions in mice lacking the dopamine transporter.
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Mesolimbic dopamine D2 receptors and neural representations of subjective value.
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Mice lacking the norepinephrine transporter are supersensitive to psychostimulants.
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Modeling of bias for the analysis of receptor signaling in biochemical systems.
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Molecular characterization of dopamine receptors.
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Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway.
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Multilocus genetic profile for dopamine signaling predicts ventral striatum reactivity.
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Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats.
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Neurotensin-induced dopamine release in vivo and in vitro from substantia nigra and nucleus caudate.
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New Concepts in Dopamine D2 Receptor Biased Signaling and Implications for Schizophrenia Therapy.
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No association between novelty seeking and dopamine D4 receptor (D4DR) exon III seven repeat alleles in Baltimore Longitudinal Study of Aging participants.
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Novel roles for β-arrestins in the regulation of pharmacological sequestration to predict agonist-induced desensitization of dopamine D3 receptors.
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Ontogeny of D1A and D2 dopamine receptor subtypes in rat brain using in situ hybridization and receptor binding.
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Opposite function of dopamine D1 and N-methyl-D-aspartate receptors in striatal cannabinoid-mediated signaling.
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PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia.
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Partial-volume correction increases estimated dopamine D2-like receptor binding potential and reduces adult age differences.
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Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists.
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Receptor, Ligand and Transducer Contributions to Dopamine D2 Receptor Functional Selectivity.
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Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter.
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Reduced effects of age on dopamine D2 receptor levels in physically active adults.
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Regulation of Akt signaling by D2 and D3 dopamine receptors in vivo.
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Regulation of responsiveness at D2 dopamine receptors by receptor desensitization and adenylyl cyclase sensitization.
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Reproducibility of the correlative triad among aging, dopamine receptor availability, and cognition.
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Reserpine-induced up-regulation of dopamine D2 receptors in the rat striatum is enhanced by denervation but not by chronic receptor blockade.
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Role of insular cortex D₁ and D₂ dopamine receptors in nicotine self-administration in rats.
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SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families.
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Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses.
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Scopolamine interactions with D1 and D2 antagonists on radial-arm maze performance in rats.
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Selective deletion of GRK2 alters psychostimulant-induced behaviors and dopamine neurotransmission.
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Selective inhibition of adenylyl cyclase type V by the dopamine D3 receptor.
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Specificity of receptor-G protein interactions. Discrimination of Gi subtypes by the D2 dopamine receptor in a reconstituted system.
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Spontaneous Eye Blink Rate (EBR) Is Uncorrelated with Dopamine D2 Receptor Availability and Unmodulated by Dopamine Agonism in Healthy Adults.
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Striatal dopamine D2/D3 receptor availability in male smokers.
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Structure-functional selectivity relationship studies of β-arrestin-biased dopamine D₂ receptor agonists.
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Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers.
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Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane.
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The dopamine D2 receptor can directly recruit and activate GRK2 without G protein activation.
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The dopamine D2, but not D3 or D4, receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice.
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The dopamine D4 receptor and the hyperactivity phenotype: a developmental-epidemiological study.
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The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry.
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The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus.
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Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs.
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Ventral hippocampal dopamine D1 and D2 systems and spatial working memory in rats.
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Withdrawal from continuous or intermittent cocaine administration: changes in D2 receptor function.