Receptors, Dopamine D2

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  Subject Areas on Research

  • A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. 
  • A preliminary analysis of interactions between genotype, retrospective ADHD symptoms, and initial reactions to smoking in a sample of young adults. 
  • A rodent model of spontaneous stereotypy: initial characterization of developmental, environmental, and neurobiological factors. 
  • A2a/D2 receptor interactions are not observed in COS-7 cells transiently transfected with dopamine D2 and adenosine A2a receptor cDNA. 
  • Adjunctive brexpiprazole for the treatment of major depressive disorder. 
  • Affinity chromatography of the anterior pituitary D2-dopamine receptor. 
  • Altered activity of midbrain dopamine neurons following 7-day withdrawal from chronic cocaine abuse is normalized by D2 receptor stimulation during the early withdrawal phase. 
  • An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. 
  • Antagonism of dopamine D2 receptor/beta-arrestin 2 interaction is a common property of clinically effective antipsychotics. 
  • Associations between dopamine D2 receptor availability and BMI depend on age. 
  • Attention deficit/hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attention. 
  • Binding of [125I]-N-(p-aminophenethyl)spiroperidol to the D-2 dopamine receptor in the neurointermediate lobe of the rat pituitary gland: a thermodynamic study. 
  • Biochemical properties of D1 and D2 dopamine receptors. 
  • Brain region-specific disruption of Shank3 in mice reveals a dissociation for cortical and striatal circuits in autism-related behaviors. 
  • Characterization of the desensitization properties of five dopamine receptor subtypes and alternatively spliced variants of dopamine D2 and D4 receptors. 
  • Chimeric D2/D3 dopamine receptors efficiently inhibit adenylyl cyclase in HEK 293 cells. 
  • Chronic loss of noradrenergic tone produces β-arrestin2-mediated cocaine hypersensitivity and alters cellular D2 responses in the nucleus accumbens. 
  • Clozapine-, but not haloperidol-, induced increases in deltaFosB-like immunoreactivity are completely blocked in the striatum of mice lacking D3 dopamine receptors. 
  • Comparative studies of molecular mechanisms of dopamine D2 and D3 receptors for the activation of extracellular signal-regulated kinase. 
  • Concurrent autoreceptor-mediated control of dopamine release and uptake during neurotransmission: an in vivo voltammetric study. 
  • Conformation guides molecular efficacy in docking screens of activated β-2 adrenergic G protein coupled receptor. 
  • D1 and D2 antagonists reverse the effects of appetite suppressants on weight loss, food intake, locomotion, and rebalance spiking inhibition in the rat NAc shell. 
  • D1 and D2 dopamine receptor interactions with pilocarpine-induced oral activity in rats. 
  • D1 and D2 dopamine receptors stimulate hypothalamo-pituitary-adrenal activity in rats. 
  • D2 Dopamine Receptor G Protein-Biased Partial Agonists Based on Cariprazine. 
  • D2 dopamine receptor A1 allele in Alzheimer disease and aging. 
  • D2 dopamine receptors in the human retina: cloning of cDNA and localization of mRNA. 
  • DRD2-related TaqIA polymorphism modulates motivation to smoke. 
  • Deletion of GSK3β in D2R-expressing neurons reveals distinct roles for β-arrestin signaling in antipsychotic and lithium action. 
  • Determination of sulpiride by capillary electrophoresis with end-column electrogenerated chemiluminescence detection. 
  • Differential regional decline in dopamine receptor availability across adulthood: Linear and nonlinear effects of age. 
  • Differential regulation of the dopamine D1, D2 and D3 receptor gene expression and changes in the phenotype of the striatal neurons in mice lacking the dopamine transporter. 
  • Differential regulation of the dopamine D2 and D3 receptors by G protein-coupled receptor kinases and beta-arrestins. 
  • Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. 
  • Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties. 
  • Dopamine D1 and D2 receptor antagonism during development alters later behavior in zebrafish. 
  • Dopamine D2 and D3 receptor preferring antagonists differentially affect striatal dopamine release and metabolism in conscious rats. 
  • Dopamine D2 receptor occupancy and cognition in schizophrenia: analysis of the CATIE data. 
  • Dopamine D2 receptor relies upon PPM/PP2C protein phosphatases to dephosphorylate huntingtin protein. 
  • Dopamine autoreceptor regulation of release and uptake in mouse brain slices in the absence of D(3) receptors. 
  • Dopamine genes and ADHD. 
  • Dopamine polymorphisms and depressive symptoms predict foods intake. Results from a nationally representative sample. 
  • Dopamine receptors in a songbird brain. 
  • Dopamine receptors status after unilateral nigral 6-OHDA lesion. Autoradiographic and in situ hybridization study in the rat brain. 
  • Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis. 
  • Dopaminergic abnormalities in Hdac6-deficient mice. 
  • Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons. 
  • Dopaminergic drugs reverse the impairment of radial-arm maze performance caused by lesions involving the cholinergic medial pathway. 
  • Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice. 
  • Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors. 
  • Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder. 
  • Effects of quitting smoking on EEG activation and attention last for more than 31 days and are more severe with stress, dependence, DRD2 A1 allele, and depressive traits. 
  • Effects of the dopamine D-2 receptor agonist, LY 171555, on radial arm maze performance in rats. 
  • Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice. 
  • Efficacy of risperidone on positive features of schizophrenia. 
  • Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor. 
  • Engineered D2R Variants Reveal the Balanced and Biased Contributions of G-Protein and β-Arrestin to Dopamine-Dependent Functions. 
  • Environmental contingencies and genetic propensities: social capital, educational continuation, and dopamine receptor gene DRD2. 
  • Epidermal growth factor promotes uncoupling from adenylyl cyclase of the rat D2S receptor expressed in GH4C1 cells. 
  • Estimation of D2-like receptor occupancy by dopamine in the putamen of hemiparkinsonian Monkeys. 
  • Evaluating dopamine reward pathway in ADHD: clinical implications. 
  • Expression of dopamine 2 receptor subtype mRNA in clinically nonfunctioning pituitary adenomas. 
  • FTO affects food cravings and interacts with age to influence age-related decline in food cravings. 
  • Food for thought: the physiological relevance of ghrelin and dopamine D2 receptor heterodimerization in the regulation of appetite. 
  • Frequency-specific and D2 receptor-mediated inhibition of glutamate release by retrograde endocannabinoid signaling. 
  • Frontal cortex lesions eliminate the clock speed effect of dopaminergic drugs on interval timing. 
  • Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor. 
  • Functional selectivity of dopamine receptor agonists. I. Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase. 
  • Functional selectivity of dopamine receptor agonists. II. Actions of dihydrexidine in D2L receptor-transfected MN9D cells and pituitary lactotrophs. 
  • G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation. 
  • Helping relationships and genetic propensities: a combinatoric study of DRD2, mentoring, and educational continuation. 
  • Heterogeneity of dopamine receptors. 
  • High affinity agonist binding to the dopamine D3 receptor: chimeric receptors delineate a role for intracellular domains. 
  • High prevalence of rare dopamine receptor D4 alleles in children diagnosed with attention-deficit hyperactivity disorder. 
  • Hyperactivity and impaired response habituation in hyperdopaminergic mice. 
  • Identification of the D2-dopamine receptor binding subunit in several mammalian tissues and species by photoaffinity labeling. 
  • Identification of the ligand-binding subunit of the human 5-hydroxytryptamine1A receptor with N-(p-azido-m-[125I] iodophenethyl)spiperone, a high affinity radioiodinated photoaffinity probe. 
  • Imaging genetics and the neurobiological basis of individual differences in vulnerability to addiction. 
  • Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease. 
  • Impulsivity and genetic variants in DRD2 and ANKK1 moderate longitudinal associations between sleep problems and overweight from ages 5 to 11. 
  • In vivo evidence for preferential role of dopamine D3 receptor in the presynaptic regulation of dopamine release but not synthesis. 
  • Individual Differences in Dopamine Are Associated with Reward Discounting in Clinical Groups But Not in Healthy Adults. 
  • Individual differences in dopamine D2 receptor availability correlate with reward valuation. 
  • Interactions between genotype and retrospective ADHD symptoms predict lifetime smoking risk in a sample of young adults. 
  • Interactive effects of D1 and D2 agonists with scopolamine on radial-arm maze performance. 
  • Interhemispheric modulation of dopamine receptor interactions in unilateral 6-OHDA rodent model. 
  • Intranigral administration of D2 dopamine receptor antisense oligodeoxynucleotides establishes a role for nigrostriatal D2 autoreceptors in the motor actions of cocaine. 
  • Intravenous buspirone for the prevention of postoperative nausea and vomiting. 
  • Investigational dopamine antagonists for the treatment of schizophrenia. 
  • Involvement of dopamine D2 receptors in the suppressive effect of the thyrotropin-releasing hormone analog TA-0910 on alcohol intake in alcohol-preferring rats. 
  • Lack of consistent sex differences in D-amphetamine-induced dopamine release measured with [18F]fallypride PET. 
  • Lack of influence of rs4680 (COMT) and rs6276 (DRD2) on diagnosis and clinical outcomes in patients with major depression. 
  • Loss of autoreceptor functions in mice lacking the dopamine transporter. 
  • Loss of response to levodopa in Parkinson's disease and co-occurrence with dementia: role of D3 and not D2 receptors. 
  • Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. 
  • Modeling of bias for the analysis of receptor signaling in biochemical systems. 
  • Molecular characterization of dopamine receptors. 
  • Motivation deficit in ADHD is associated with dysfunction of the dopamine reward pathway. 
  • Multilocus genetic profile for dopamine signaling predicts ventral striatum reactivity. 
  • Neural Inhibition of Dopaminergic Signaling Enhances Immunity in a Cell-Non-autonomous Manner. 
  • Neuro-anatomic mapping of dopamine D1 receptor involvement in nicotine self-administration in rats. 
  • Neurotensin-induced dopamine release in vivo and in vitro from substantia nigra and nucleus caudate. 
  • Neurotransmission-related genetic polymorphisms, negative affectivity traits, and gender predict tobacco abstinence symptoms across 44 days with and without nicotine patch. 
  • New Concepts in Dopamine D2 Receptor Biased Signaling and Implications for Schizophrenia Therapy. 
  • Novel roles for β-arrestins in the regulation of pharmacological sequestration to predict agonist-induced desensitization of dopamine D3 receptors. 
  • Ontogeny of D1A and D2 dopamine receptor subtypes in rat brain using in situ hybridization and receptor binding. 
  • Opposite function of dopamine D1 and N-methyl-D-aspartate receptors in striatal cannabinoid-mediated signaling. 
  • Partial-volume correction increases estimated dopamine D2-like receptor binding potential and reduces adult age differences. 
  • Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists. 
  • Receptor, Ligand and Transducer Contributions to Dopamine D2 Receptor Functional Selectivity. 
  • Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter. 
  • Reduced effects of age on dopamine D2 receptor levels in physically active adults. 
  • Regulation of Akt signaling by D2 and D3 dopamine receptors in vivo. 
  • Regulation of dopamine release and metabolism in rat striatum in vivo: effects of dopamine receptor antagonists. 
  • Regulation of responsiveness at D2 dopamine receptors by receptor desensitization and adenylyl cyclase sensitization. 
  • Reproducibility of the correlative triad among aging, dopamine receptor availability, and cognition. 
  • Reserpine-induced up-regulation of dopamine D2 receptors in the rat striatum is enhanced by denervation but not by chronic receptor blockade. 
  • Role of insular cortex D₁ and D₂ dopamine receptors in nicotine self-administration in rats. 
  • SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families. 
  • Sapap3 deletion causes mGluR5-dependent silencing of AMPAR synapses. 
  • Scopolamine interactions with D1 and D2 antagonists on radial-arm maze performance in rats. 
  • Selective deletion of GRK2 alters psychostimulant-induced behaviors and dopamine neurotransmission. 
  • Selective inhibition of adenylyl cyclase type V by the dopamine D3 receptor. 
  • Specificity of receptor-G protein interactions. Discrimination of Gi subtypes by the D2 dopamine receptor in a reconstituted system. 
  • Spontaneous Eye Blink Rate (EBR) Is Uncorrelated with Dopamine D2 Receptor Availability and Unmodulated by Dopamine Agonism in Healthy Adults. 
  • Striatal dopamine D2/D3 receptor availability in male smokers. 
  • Structure-functional selectivity relationship studies of β-arrestin-biased dopamine D₂ receptor agonists. 
  • Synthesis and dopamine agonist properties of (+-)-trans-3,4,4a,10b-tetrahydro-4-propyl-2H,5H-[1]benzopyrano [4,3-b]-1,4-oxazin-9-ol and its enantiomers. 
  • Synthesis and dopaminergic properties of benzo-fused analogues of quinpirole and quinelorane. 
  • The dopamine D2 receptor can directly recruit and activate GRK2 without G protein activation. 
  • The dopamine D2, but not D3 or D4, receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice. 
  • The dopamine D2/D3 antagonist DS121 potentiates the effect of cocaine on locomotion and reduces tolerance in cocaine tolerant rats. 
  • The dopamine D4 receptor and the hyperactivity phenotype: a developmental-epidemiological study. 
  • The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry. 
  • The genetic architecture of selection at the human dopamine receptor D4 (DRD4) gene locus. 
  • Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs. 
  • Ventral hippocampal dopamine D1 and D2 systems and spatial working memory in rats. 
  • Withdrawal from continuous or intermittent cocaine administration: changes in D2 receptor function. 
  • [A comparative study of the neurochemical profiles of remoxipride, raclopride and metoclopramide activity]. 
  • [Dopamine autoreceptors subtype D3 predominantly regulate the liberation of dopamine in rat brain basal ganglia]. 
  • [Regulation of liberation and metabolism of dopamine in the dorsal striatum of free-living rats: the role of D2- and D3-dopamine autoreceptors]. 
  • [Selective analyzers of dopamine D2 receptors modulate serotonin metabolism in the striatum and nucleus accumbens of the rat brain during blockade of dopaminergic impulse flow].