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Subject Areas on Research
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440-kD ankyrinB: structure of the major developmentally regulated domain and selective localization in unmyelinated axons.
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A PIK3C3-ankyrin-B-dynactin pathway promotes axonal growth and multiorganelle transport.
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A TRPA1-dependent mechanism for the pungent sensation of weak acids.
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A cardiac arrhythmia syndrome caused by loss of ankyrin-B function.
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A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon.
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A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier.
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A molecular defect in two families with hemolytic poikilocytic anemia: reduction of high affinity membrane binding sites for ankyrin.
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A new 440-kD isoform is the major ankyrin in neonatal rat brain.
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A requirement for ankyrin binding to clathrin during coated pit budding.
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A single divergent exon inhibits ankyrin-B association with the plasma membrane.
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ANK2 autism mutation targeting giant ankyrin-B promotes axon branching and ectopic connectivity.
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Abnormal cardiac Na(+) channel properties and QT heart rate adaptation in neonatal ankyrin(B) knockout mice.
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An Adaptable Spectrin/Ankyrin-Based Mechanism for Long-Range Organization of Plasma Membranes in Vertebrate Tissues.
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An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan.
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An isoform of ankyrin is localized at nodes of Ranvier in myelinated axons of central and peripheral nerves.
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Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins.
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Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice.
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Ank3-dependent SVZ niche assembly is required for the continued production of new neurons.
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AnkB, a periplasmic ankyrin-like protein in Pseudomonas aeruginosa, is required for optimal catalase B (KatB) activity and resistance to hydrogen peroxide.
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Ankyrin and spectrin associate with voltage-dependent sodium channels in brain.
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Ankyrin and synapsin: spectrin-binding proteins associated with brain membranes.
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Ankyrin binding activity shared by the neurofascin/L1/NrCAM family of nervous system cell adhesion molecules.
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Ankyrin regulation: an alternatively spliced segment of the regulatory domain functions as an intramolecular modulator.
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Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain.
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Ankyrin-B directs membrane tethering of periaxin and is required for maintenance of lens fiber cell hexagonal shape and mechanics.
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Ankyrin-B in lens architecture and biomechanics: Just not tethering but more.
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Ankyrin-B interactions with spectrin and dynactin-4 are required for dystrophin-based protection of skeletal muscle from exercise injury.
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Ankyrin-B is a PI3P effector that promotes polarized α5β1-integrin recycling via recruiting RabGAP1L to early endosomes.
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Ankyrin-B is required for coordinated expression of beta-2-spectrin, the Na/K-ATPase and the Na/Ca exchanger in the inner segment of rod photoreceptors.
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Ankyrin-B is required for intracellular sorting of structurally diverse Ca2+ homeostasis proteins.
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Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic β cell insufficiency.
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Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death.
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Ankyrin-B structurally defines terminal microdomains of peripheral somatosensory axons.
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Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence.
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Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes.
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Ankyrin-G Inhibits Endocytosis of Cadherin Dimers.
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Ankyrin-G and beta2-spectrin collaborate in biogenesis of lateral membrane of human bronchial epithelial cells.
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Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments.
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Ankyrin-G coordinates intercalated disc signaling platform to regulate cardiac excitability in vivo.
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Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos.
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Ankyrin-G palmitoylation and βII-spectrin binding to phosphoinositide lipids drive lateral membrane assembly.
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Ankyrin-G promotes cyclic nucleotide-gated channel transport to rod photoreceptor sensory cilia.
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Ankyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth.
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Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP.
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Ankyrin-G regulates inactivation gating of the neuronal sodium channel, Nav1.6.
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Ankyrin-based cardiac arrhythmias: a new class of channelopathies due to loss of cellular targeting.
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Ankyrin-based patterning of membrane microdomains: new insights into a novel class of cardiovascular diseases.
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Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment.
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Ankyrin-binding activity of nervous system cell adhesion molecules expressed in adult brain.
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Ankyrin-binding proteins related to nervous system cell adhesion molecules: candidates to provide transmembrane and intercellular connections in adult brain.
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Ankyrin-independent membrane protein-binding sites for brain and erythrocyte spectrin.
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AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing.
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AnkyrinG is required to maintain axo-dendritic polarity in vivo.
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AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier.
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Ankyrins and cellular targeting of diverse membrane proteins to physiological sites.
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Ankyrins.
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Ankyrins. Adaptors between diverse plasma membrane proteins and the cytoplasm.
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Association between ankyrin and the cytoplasmic domain of band 3 isolated from the human erythrocyte membrane.
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Association of brain ankyrin with brain membranes and isolation of active proteolytic fragments of membrane-associated ankyrin-binding protein(s).
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Atomic force microscopy captures folded ribosome bound nascent chains.
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Being there: cellular targeting of voltage-gated sodium channels in the heart.
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Brain ankyrin. A membrane-associated protein with binding sites for spectrin, tubulin, and the cytoplasmic domain of the erythrocyte anion channel.
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Brain ankyrin. Purification of a 72,000 Mr spectrin-binding domain.
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Cell cycle dependence of group VIA calcium-independent phospholipase A2 activity.
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Cell-autonomous adiposity through increased cell surface GLUT4 due to ankyrin-B deficiency.
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Characterization of the axon initial segment of mice substantia nigra dopaminergic neurons.
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Cholinergic augmentation of insulin release requires ankyrin-B.
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Chromosomal localization of the ankyrinG gene (ANK3/Ank3) to human 10q21 and mouse 10.
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Clinical outcomes of splenectomy in children: report of the splenectomy in congenital hemolytic anemia registry.
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Colocalization of band 3 with ankyrin and spectrin at the basal membrane of intercalated cells in the rat kidney.
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Common human ANK2 variant confers in vivo arrhythmia phenotypes.
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Cysteine 70 of ankyrin-G is S-palmitoylated and is required for function of ankyrin-G in membrane domain assembly.
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Defects in ankyrin-based cellular pathways in metazoan physiology.
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Degradation of spectrin and ankyrin in the ischemic rat kidney.
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Developing nodes of Ranvier are defined by ankyrin-G clustering and are independent of paranodal axoglial adhesion.
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Developmental mechanism of the periodic membrane skeleton in axons.
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Distinct ankyrin isoforms at neuron cell bodies and nodes of Ranvier resolved using erythrocyte ankyrin-deficient mice.
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Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder.
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Diversity in membrane binding sites of ankyrins. Brain ankyrin, erythrocyte ankyrin, and processed erythrocyte ankyrin associate with distinct sites in kidney microsomes.
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Diversity of ankyrins in the brain.
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E-cadherin polarity is determined by a multifunction motif mediating lateral membrane retention through ankyrin-G and apical-lateral transcytosis through clathrin.
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Effect of elective surgery on subjective health in veterans with chronic posttraumatic stress disorder.
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Erythrocyte ankyrin: immunoreactive analogues are associated with mitotic structures in cultured cells and with microtubules in brain.
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Evolution in action: giant ankyrins awake.
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Expression of functional domains of beta G-spectrin disrupts epithelial morphology in cultured cells.
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FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons.
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From anemia to cerebellar dysfunction. A review of the ankyrin gene family.
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Genome-wide association study of bipolar I disorder in the Han Chinese population.
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Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors.
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Giant ankyrin-G: a critical innovation in vertebrate evolution of fast and integrated neuronal signaling.
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Glial ankyrins facilitate paranodal axoglial junction assembly.
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Hereditary spherocytosis associated with deletion of human erythrocyte ankyrin gene on chromosome 8.
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Human erythrocyte ankyrin. Purification and properties.
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Identification of O-linked N-acetylglucosamine modification of ankyrinG isoforms targeted to nodes of Ranvier.
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Identification of two regions of beta G spectrin that bind to distinct sites in brain membranes.
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Immunoreactive forms of erythrocyte spectrin and ankyrin in brain.
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Immunoreactive forms of human erythrocyte ankyrin are localized in mitotic structures in cultured cells and are associated with microtubules in brain.
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In vitro proteolysis of brain spectrin by calpain I inhibits association of spectrin with ankyrin-independent membrane binding site(s).
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Inositol 1,4,5-trisphosphate receptor localization and stability in neonatal cardiomyocytes requires interaction with ankyrin-B.
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Isoform specificity among ankyrins. An amphipathic alpha-helix in the divergent regulatory domain of ankyrin-b interacts with the molecular co-chaperone Hdj1/Hsp40.
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Isoform specificity of ankyrin-B: a site in the divergent C-terminal domain is required for intramolecular association.
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Isolation and characterization of cDNAs encoding human brain ankyrins reveal a family of alternatively spliced genes.
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Isolation of an ankyrin-band 3 oligomer from human erythrocyte membranes.
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Kv3.1b is a novel component of CNS nodes.
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L1-dependent neuritogenesis involves ankyrinB that mediates L1-CAM coupling with retrograde actin flow.
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LAD-1, the Caenorhabditis elegans L1CAM homologue, participates in embryonic and gonadal morphogenesis and is a substrate for fibroblast growth factor receptor pathway-dependent phosphotyrosine-based signaling.
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Lateral membrane biogenesis in human bronchial epithelial cells requires 190-kDa ankyrin-G.
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Localization and structure of the ankyrin-binding site on beta2-spectrin.
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Mapping the ankyrin-binding site of the human erythrocyte anion exchanger.
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Mapping the binding sites of human erythrocyte ankyrin for the anion exchanger and spectrin.
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Mechanical anisotropy of ankyrin repeats.
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Mechanism for binding site diversity on ankyrin. Comparison of binding sites on ankyrin for neurofascin and the Cl-/HCO3- anion exchanger.
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Membrane domains based on ankyrin and spectrin associated with cell-cell interactions.
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Molecular composition of the node of Ranvier: identification of ankyrin-binding cell adhesion molecules neurofascin (mucin+/third FNIII domain-) and NrCAM at nodal axon segments.
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Morphogenesis of the node of Ranvier: co-clusters of ankyrin and ankyrin-binding integral proteins define early developmental intermediates.
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Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1.
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Nanospring behaviour of ankyrin repeats.
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Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes.
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Nervous system defects of AnkyrinB (-/-) mice suggest functional overlap between the cell adhesion molecule L1 and 440-kD AnkyrinB in premyelinated axons.
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Neurodevelopmental mutation of giant ankyrin-G disrupts a core mechanism for axon initial segment assembly.
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Of mice and men: the mice were right.
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Organizing the fluid membrane bilayer: diseases linked to spectrin and ankyrin.
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Palmitoylation of neurofascin at a site in the membrane-spanning domain highly conserved among the L1 family of cell adhesion molecules.
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Physiological roles of axonal ankyrins in survival of premyelinated axons and localization of voltage-gated sodium channels.
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Polarized distribution of Mr 210,000 and 190,000 analogs of erythrocyte ankyrin along the plasma membrane of transporting epithelia, neurons and photoreceptors.
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Postmitotic expression of ankyrinR and beta R-spectrin in discrete neuronal populations of the rat brain.
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Proteins closely related to spectrin and ankyrin are general components of cell membranes.
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Proteins involved in membrane--cytoskeleton association in human erythrocytes: spectrin, ankyrin, and band 3.
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Purification of brain analogs of red blood cell membrane skeletal proteins: ankyrin, protein 4.1 (synapsin), spectrin, and spectrin subunits.
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Purkinje cell degeneration associated with erythroid ankyrin deficiency in nb/nb mice.
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Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons.
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Regulation of the association of adducin with actin filaments by Rho-associated kinase (Rho-kinase) and myosin phosphatase.
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Regulatory domains of erythrocyte ankyrin.
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Restriction of 480/270-kD ankyrin G to axon proximal segments requires multiple ankyrin G-specific domains.
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Specific 33-residue repeat(s) of erythrocyte ankyrin associate with the anion exchanger.
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Spectrin and ankyrin in brain.
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Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues.
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Spectrin- and ankyrin-based membrane domains and the evolution of vertebrates.
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Structural basis of diverse membrane target recognitions by ankyrins.
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Structural requirements for association of neurofascin with ankyrin.
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Subcellular organization of GABAergic synapses: role of ankyrins and L1 cell adhesion molecules.
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The ANK repeats of erythrocyte ankyrin form two distinct but cooperative binding sites for the erythrocyte anion exchanger.
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The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells.
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The anion exchanger and Na+K(+)-ATPase interact with distinct sites on ankyrin in in vitro assays.
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The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes.
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The cardiac Na+-Ca2+ exchanger binds to the cytoskeletal protein ankyrin.
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The membrane skeleton of human erythrocytes and its implications for more complex cells.
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The membrane-binding domain of ankyrin contains four independently folded subdomains, each comprised of six ankyrin repeats.
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The molecular basis for membrane - cytoskeleton association in human erythrocytes.
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The phosphorylation state of the FIGQY tyrosine of neurofascin determines ankyrin-binding activity and patterns of cell segregation.
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The role of membrane-bound ankyrin-repeat protein ACD6 in programmed cell death and plant defense.
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The spectrin skeleton: from red cells to brain.
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The spectrin-based membrane skeleton and micron-scale organization of the plasma membrane.
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Tyrosine phosphorylation at a site highly conserved in the L1 family of cell adhesion molecules abolishes ankyrin binding and increases lateral mobility of neurofascin.
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Ultrastructural localization of erythrocyte cytoskeletal and integral membrane proteins in Plasmodium falciparum-infected erythrocytes.
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Use of Primary Cultured Hippocampal Neurons to Study the Assembly of Axon Initial Segments.
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Keywords of People