Ankyrins

• 

  Subject Areas on Research

  • 440-kD ankyrinB: structure of the major developmentally regulated domain and selective localization in unmyelinated axons. 
  • A PIK3C3-ankyrin-B-dynactin pathway promotes axonal growth and multiorganelle transport. 
  • A TRPA1-dependent mechanism for the pungent sensation of weak acids. 
  • A cardiac arrhythmia syndrome caused by loss of ankyrin-B function. 
  • A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon. 
  • A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier. 
  • A molecular defect in two families with hemolytic poikilocytic anemia: reduction of high affinity membrane binding sites for ankyrin. 
  • A new 440-kD isoform is the major ankyrin in neonatal rat brain. 
  • A requirement for ankyrin binding to clathrin during coated pit budding. 
  • A single divergent exon inhibits ankyrin-B association with the plasma membrane. 
  • ANK2 autism mutation targeting giant ankyrin-B promotes axon branching and ectopic connectivity. 
  • Abnormal cardiac Na(+) channel properties and QT heart rate adaptation in neonatal ankyrin(B) knockout mice. 
  • An Adaptable Spectrin/Ankyrin-Based Mechanism for Long-Range Organization of Plasma Membranes in Vertebrate Tissues. 
  • An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan. 
  • An isoform of ankyrin is localized at nodes of Ranvier in myelinated axons of central and peripheral nerves. 
  • Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins. 
  • Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice. 
  • Ank3-dependent SVZ niche assembly is required for the continued production of new neurons. 
  • AnkB, a periplasmic ankyrin-like protein in Pseudomonas aeruginosa, is required for optimal catalase B (KatB) activity and resistance to hydrogen peroxide. 
  • Ankyrin and spectrin associate with voltage-dependent sodium channels in brain. 
  • Ankyrin and synapsin: spectrin-binding proteins associated with brain membranes. 
  • Ankyrin binding activity shared by the neurofascin/L1/NrCAM family of nervous system cell adhesion molecules. 
  • Ankyrin regulation: an alternatively spliced segment of the regulatory domain functions as an intramolecular modulator. 
  • Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain. 
  • Ankyrin-B directs membrane tethering of periaxin and is required for maintenance of lens fiber cell hexagonal shape and mechanics. 
  • Ankyrin-B in lens architecture and biomechanics: Just not tethering but more. 
  • Ankyrin-B interactions with spectrin and dynactin-4 are required for dystrophin-based protection of skeletal muscle from exercise injury. 
  • Ankyrin-B is a PI3P effector that promotes polarized α5β1-integrin recycling via recruiting RabGAP1L to early endosomes. 
  • Ankyrin-B is required for coordinated expression of beta-2-spectrin, the Na/K-ATPase and the Na/Ca exchanger in the inner segment of rod photoreceptors. 
  • Ankyrin-B is required for intracellular sorting of structurally diverse Ca2+ homeostasis proteins. 
  • Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic β cell insufficiency. 
  • Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. 
  • Ankyrin-B structurally defines terminal microdomains of peripheral somatosensory axons. 
  • Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence. 
  • Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes. 
  • Ankyrin-G Inhibits Endocytosis of Cadherin Dimers. 
  • Ankyrin-G and beta2-spectrin collaborate in biogenesis of lateral membrane of human bronchial epithelial cells. 
  • Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments. 
  • Ankyrin-G coordinates intercalated disc signaling platform to regulate cardiac excitability in vivo. 
  • Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos. 
  • Ankyrin-G palmitoylation and βII-spectrin binding to phosphoinositide lipids drive lateral membrane assembly. 
  • Ankyrin-G promotes cyclic nucleotide-gated channel transport to rod photoreceptor sensory cilia. 
  • Ankyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth. 
  • Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP. 
  • Ankyrin-G regulates inactivation gating of the neuronal sodium channel, Nav1.6. 
  • Ankyrin-based cardiac arrhythmias: a new class of channelopathies due to loss of cellular targeting. 
  • Ankyrin-based patterning of membrane microdomains: new insights into a novel class of cardiovascular diseases. 
  • Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment. 
  • Ankyrin-binding activity of nervous system cell adhesion molecules expressed in adult brain. 
  • Ankyrin-binding proteins related to nervous system cell adhesion molecules: candidates to provide transmembrane and intercellular connections in adult brain. 
  • Ankyrin-independent membrane protein-binding sites for brain and erythrocyte spectrin. 
  • AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing. 
  • AnkyrinG is required to maintain axo-dendritic polarity in vivo. 
  • AnkyrinG. A new ankyrin gene with neural-specific isoforms localized at the axonal initial segment and node of Ranvier. 
  • Ankyrins and cellular targeting of diverse membrane proteins to physiological sites. 
  • Ankyrins. 
  • Ankyrins. Adaptors between diverse plasma membrane proteins and the cytoplasm. 
  • Association between ankyrin and the cytoplasmic domain of band 3 isolated from the human erythrocyte membrane. 
  • Association of brain ankyrin with brain membranes and isolation of active proteolytic fragments of membrane-associated ankyrin-binding protein(s). 
  • Atomic force microscopy captures folded ribosome bound nascent chains. 
  • Being there: cellular targeting of voltage-gated sodium channels in the heart. 
  • Brain ankyrin. A membrane-associated protein with binding sites for spectrin, tubulin, and the cytoplasmic domain of the erythrocyte anion channel. 
  • Brain ankyrin. Purification of a 72,000 Mr spectrin-binding domain. 
  • Cell-autonomous adiposity through increased cell surface GLUT4 due to ankyrin-B deficiency. 
  • Characterization of the axon initial segment of mice substantia nigra dopaminergic neurons. 
  • Cholinergic augmentation of insulin release requires ankyrin-B. 
  • Chromosomal localization of the ankyrinG gene (ANK3/Ank3) to human 10q21 and mouse 10. 
  • Clinical outcomes of splenectomy in children: report of the splenectomy in congenital hemolytic anemia registry. 
  • Colocalization of band 3 with ankyrin and spectrin at the basal membrane of intercalated cells in the rat kidney. 
  • Common human ANK2 variant confers in vivo arrhythmia phenotypes. 
  • Cysteine 70 of ankyrin-G is S-palmitoylated and is required for function of ankyrin-G in membrane domain assembly. 
  • Defects in ankyrin-based cellular pathways in metazoan physiology. 
  • Degradation of spectrin and ankyrin in the ischemic rat kidney. 
  • Developing nodes of Ranvier are defined by ankyrin-G clustering and are independent of paranodal axoglial adhesion. 
  • Developmental mechanism of the periodic membrane skeleton in axons. 
  • Distinct ankyrin isoforms at neuron cell bodies and nodes of Ranvier resolved using erythrocyte ankyrin-deficient mice. 
  • Distribution and function of the hydrogen sulfide-sensitive TRPA1 ion channel in rat urinary bladder. 
  • Diversity in membrane binding sites of ankyrins. Brain ankyrin, erythrocyte ankyrin, and processed erythrocyte ankyrin associate with distinct sites in kidney microsomes. 
  • Diversity of ankyrins in the brain. 
  • E-cadherin polarity is determined by a multifunction motif mediating lateral membrane retention through ankyrin-G and apical-lateral transcytosis through clathrin. 
  • Effect of elective surgery on subjective health in veterans with chronic posttraumatic stress disorder. 
  • Erythrocyte ankyrin: immunoreactive analogues are associated with mitotic structures in cultured cells and with microtubules in brain. 
  • Evolution in action: giant ankyrins awake. 
  • Expression of functional domains of beta G-spectrin disrupts epithelial morphology in cultured cells. 
  • FIGQY phosphorylation defines discrete populations of L1 cell adhesion molecules at sites of cell-cell contact and in migrating neurons. 
  • From anemia to cerebellar dysfunction. A review of the ankyrin gene family. 
  • Genome-wide association study of bipolar I disorder in the Han Chinese population. 
  • Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors. 
  • Giant ankyrin-G: a critical innovation in vertebrate evolution of fast and integrated neuronal signaling. 
  • Glial ankyrins facilitate paranodal axoglial junction assembly. 
  • Hereditary spherocytosis associated with deletion of human erythrocyte ankyrin gene on chromosome 8. 
  • Human erythrocyte ankyrin. Purification and properties. 
  • Identification of O-linked N-acetylglucosamine modification of ankyrinG isoforms targeted to nodes of Ranvier. 
  • Identification of two regions of beta G spectrin that bind to distinct sites in brain membranes. 
  • Immunoreactive forms of erythrocyte spectrin and ankyrin in brain. 
  • Immunoreactive forms of human erythrocyte ankyrin are localized in mitotic structures in cultured cells and are associated with microtubules in brain. 
  • In vitro proteolysis of brain spectrin by calpain I inhibits association of spectrin with ankyrin-independent membrane binding site(s). 
  • Inositol 1,4,5-trisphosphate receptor localization and stability in neonatal cardiomyocytes requires interaction with ankyrin-B. 
  • Isoform specificity among ankyrins. An amphipathic alpha-helix in the divergent regulatory domain of ankyrin-b interacts with the molecular co-chaperone Hdj1/Hsp40. 
  • Isoform specificity of ankyrin-B: a site in the divergent C-terminal domain is required for intramolecular association. 
  • Isolation and characterization of cDNAs encoding human brain ankyrins reveal a family of alternatively spliced genes. 
  • Isolation of an ankyrin-band 3 oligomer from human erythrocyte membranes. 
  • Kv3.1b is a novel component of CNS nodes. 
  • L1-dependent neuritogenesis involves ankyrinB that mediates L1-CAM coupling with retrograde actin flow. 
  • LAD-1, the Caenorhabditis elegans L1CAM homologue, participates in embryonic and gonadal morphogenesis and is a substrate for fibroblast growth factor receptor pathway-dependent phosphotyrosine-based signaling. 
  • Lateral membrane biogenesis in human bronchial epithelial cells requires 190-kDa ankyrin-G. 
  • Localization and structure of the ankyrin-binding site on beta2-spectrin. 
  • Mapping the ankyrin-binding site of the human erythrocyte anion exchanger. 
  • Mapping the binding sites of human erythrocyte ankyrin for the anion exchanger and spectrin. 
  • Mechanical anisotropy of ankyrin repeats. 
  • Mechanism for binding site diversity on ankyrin. Comparison of binding sites on ankyrin for neurofascin and the Cl-/HCO3- anion exchanger. 
  • Membrane domains based on ankyrin and spectrin associated with cell-cell interactions. 
  • Molecular composition of the node of Ranvier: identification of ankyrin-binding cell adhesion molecules neurofascin (mucin+/third FNIII domain-) and NrCAM at nodal axon segments. 
  • Morphogenesis of the node of Ranvier: co-clusters of ankyrin and ankyrin-binding integral proteins define early developmental intermediates. 
  • Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. 
  • Nanospring behaviour of ankyrin repeats. 
  • Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes. 
  • Nervous system defects of AnkyrinB (-/-) mice suggest functional overlap between the cell adhesion molecule L1 and 440-kD AnkyrinB in premyelinated axons. 
  • Neurodevelopmental mutation of giant ankyrin-G disrupts a core mechanism for axon initial segment assembly. 
  • Of mice and men: the mice were right. 
  • Organizing the fluid membrane bilayer: diseases linked to spectrin and ankyrin. 
  • Palmitoylation of neurofascin at a site in the membrane-spanning domain highly conserved among the L1 family of cell adhesion molecules. 
  • Physiological roles of axonal ankyrins in survival of premyelinated axons and localization of voltage-gated sodium channels. 
  • Polarized distribution of Mr 210,000 and 190,000 analogs of erythrocyte ankyrin along the plasma membrane of transporting epithelia, neurons and photoreceptors. 
  • Postmitotic expression of ankyrinR and beta R-spectrin in discrete neuronal populations of the rat brain. 
  • Proteins closely related to spectrin and ankyrin are general components of cell membranes. 
  • Proteins involved in membrane--cytoskeleton association in human erythrocytes: spectrin, ankyrin, and band 3. 
  • Purification of brain analogs of red blood cell membrane skeletal proteins: ankyrin, protein 4.1 (synapsin), spectrin, and spectrin subunits. 
  • Purkinje cell degeneration associated with erythroid ankyrin deficiency in nb/nb mice. 
  • Regulation of Gap Junction Dynamics by UNC-44/ankyrin and UNC-33/CRMP through VAB-8 in C. elegans Neurons. 
  • Regulation of the association of adducin with actin filaments by Rho-associated kinase (Rho-kinase) and myosin phosphatase. 
  • Regulatory domains of erythrocyte ankyrin. 
  • Restriction of 480/270-kD ankyrin G to axon proximal segments requires multiple ankyrin G-specific domains. 
  • Specific 33-residue repeat(s) of erythrocyte ankyrin associate with the anion exchanger. 
  • Spectrin and ankyrin in brain. 
  • Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues. 
  • Spectrin- and ankyrin-based membrane domains and the evolution of vertebrates. 
  • Structural basis of diverse membrane target recognitions by ankyrins. 
  • Structural requirements for association of neurofascin with ankyrin. 
  • Subcellular organization of GABAergic synapses: role of ankyrins and L1 cell adhesion molecules. 
  • The ANK repeats of erythrocyte ankyrin form two distinct but cooperative binding sites for the erythrocyte anion exchanger. 
  • The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells. 
  • The anion exchanger and Na+K(+)-ATPase interact with distinct sites on ankyrin in in vitro assays. 
  • The ankyrin-B C-terminal domain determines activity of ankyrin-B/G chimeras in rescue of abnormal inositol 1,4,5-trisphosphate and ryanodine receptor distribution in ankyrin-B (-/-) neonatal cardiomyocytes. 
  • The cardiac Na+-Ca2+ exchanger binds to the cytoskeletal protein ankyrin. 
  • The membrane skeleton of human erythrocytes and its implications for more complex cells. 
  • The membrane-binding domain of ankyrin contains four independently folded subdomains, each comprised of six ankyrin repeats. 
  • The molecular basis for membrane - cytoskeleton association in human erythrocytes. 
  • The phosphorylation state of the FIGQY tyrosine of neurofascin determines ankyrin-binding activity and patterns of cell segregation. 
  • The role of membrane-bound ankyrin-repeat protein ACD6 in programmed cell death and plant defense. 
  • The spectrin skeleton: from red cells to brain. 
  • The spectrin-based membrane skeleton and micron-scale organization of the plasma membrane. 
  • Tyrosine phosphorylation at a site highly conserved in the L1 family of cell adhesion molecules abolishes ankyrin binding and increases lateral mobility of neurofascin. 
  • Ultrastructural localization of erythrocyte cytoskeletal and integral membrane proteins in Plasmodium falciparum-infected erythrocytes. 
  • Use of Primary Cultured Hippocampal Neurons to Study the Assembly of Axon Initial Segments. 
• 

  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute