Protein Folding

• 

  Subject Areas on Research

  • 125I-labeled anti-epidermal growth factor receptor-vIII single-chain Fv exhibits specific and high-level targeting of glioma xenografts. 
  • A conserved bulged adenosine in a peripheral duplex of the antigenomic HDV self-cleaving RNA reduceskinetic trapping of inactive conformations. 
  • A gradient-directed Monte Carlo approach for protein design. 
  • A gradient-directed Monte Carlo method for global optimization in a discrete space: application to protein sequence design and folding. 
  • A mass spectrometry-based probe of equilibrium intermediates in protein-folding reactions. 
  • A miniaturized technique for assessing protein thermodynamics and function using fast determination of quantitative cysteine reactivity. 
  • A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. 
  • A single step purification for autolytic zinc proteinases. 
  • A stable dimer in the pH-induced equilibrium unfolding of the homo-hexameric enzyme 4-oxalocrotonate tautomerase (4-OT). 
  • A tale of tails: how histone tails mediate chromatin compaction in different salt and linker histone environments. 
  • AAV exploits subcellular stress associated with inflammation, endoplasmic reticulum expansion, and misfolded proteins in models of cystic fibrosis. 
  • Accuracy of SUPREX (stability of unpurified proteins from rates of H/D exchange) and MALDI mass spectrometry-derived protein unfolding free energies determined under non-EX2 exchange conditions. 
  • Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78. 
  • Adenosine nucleotides and the regulation of GRP94-client protein interactions. 
  • Analysis of protein folding and function using backbone modified proteins. 
  • Assignment of aliphatic side-chain 1HN/15N resonances in perdeuterated proteins. 
  • Asteropsin A: an unusual cystine-crosslinked peptide from porifera enhances neuronal Ca2+ influx. 
  • Atomic force microscopy captures folded ribosome bound nascent chains. 
  • Atomic force microscopy captures length phenotypes in single proteins. 
  • Biochemistry. Exciting structures. 
  • Biomedical implications of protein folding and misfolding. 
  • Capturing the mechanical unfolding pathway of a large protein with coiled-coil probes. 
  • Catalytic strategies of the hepatitis delta virus ribozymes. 
  • Cell adhesion molecule L1 in folded (horseshoe) and extended conformations. 
  • Chemically induced proximity in biology and medicine. 
  • Codon usage regulates human KRAS expression at both transcriptional and translational levels. 
  • Comparative Analysis of Protein Folding Stability-Based Profiling Methods for Characterization of Biological Phenotypes. 
  • Comparative analysis of two different amide-to-ester bond mutations in the beta-sheet of 4-oxalocrotonate tautomerase. 
  • Competing Pathways and Multiple Folding Nuclei in a Large Multidomain Protein, Luciferase. 
  • Condensin and cohesin display different arm conformations with characteristic hinge angles. 
  • Conformational kinetics reveals affinities of protein conformational states. 
  • Conformational selection or induced fit: a flux description of reaction mechanism. 
  • Conserved thermodynamic contributions of backbone hydrogen bonds in a protein fold. 
  • Construction of a family of Cys2His2 zinc binding sites in the hydrophobic core of thioredoxin by structure-based design. 
  • Contribution of a buried hydrogen bond to lambda repressor folding kinetics. 
  • Coupling coherence distinguishes structure sensitivity in protein electron transfer. 
  • Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4 Å. 
  • Crystal structure of human type III collagen Gly991-Gly1032 cystine knot-containing peptide shows both 7/2 and 10/3 triple helical symmetries. 
  • Crystal structure of the gephyrin-related molybdenum cofactor biosynthesis protein MogA from Escherichia coli. 
  • Crystal structure of the lactose operon repressor and its complexes with DNA and inducer. 
  • Crystal structures of T. brucei MRP1/MRP2 guide-RNA binding complex reveal RNA matchmaking mechanism. 
  • Cyclophilin active site mutants have native prolyl isomerase activity with a protein substrate. 
  • De novo design and molecular assembly of a transmembrane diporphyrin-binding protein complex. 
  • Design considerations for analyzing protein translation regulation by condensates. 
  • Design of helical, oligomeric HIV-1 fusion inhibitor peptides with potent activity against enfuvirtide-resistant virus. 
  • Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells. 
  • Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis. 
  • Direct analysis of backbone-backbone hydrogen bond formation in protein folding transition states. 
  • Discovery of Age-Related Protein Folding Stability Differences in the Mouse Brain Proteome. 
  • Discovery of Manassantin A Protein Targets Using Large-Scale Protein Folding and Stability Measurements. 
  • Discovery of Tamoxifen and N-Desmethyl Tamoxifen Protein Targets in MCF-7 Cells Using Large-Scale Protein Folding and Stability Measurements. 
  • Discovery of the Xenon-Protein Interactome Using Large-Scale Measurements of Protein Folding and Stability. 
  • Dissociation kinetics of the GroEL-gp31 chaperonin complex studied with Förster resonance energy transfer. 
  • Disulfide-mediated dimerization of L1 Ig domains. 
  • Domain unfolding plays a role in superfibronectin formation. 
  • Dominant kinetic paths on biomolecular binding-folding energy landscape. 
  • E. coli expression system for identifying folding mutations of human adenosine deaminase. 
  • Effect of genetic circular permutation near the active site on the activity and stability of an enzyme inhibitor. 
  • Effect of protein fusion on the transition temperature of an environmentally responsive elastin-like polypeptide: a role for surface hydrophobicity? 
  • Energetics-based methods for protein folding and stability measurements. 
  • Enhanced protein fold recognition through a novel data integration approach. 
  • Facile chemical synthesis and equilibrium unfolding properties of CopG. 
  • Fast and faster: a designed variant of the B-domain of protein A folds in 3 microsec. 
  • Fast and forceful refolding of stretched alpha-helical solenoid proteins. 
  • Fibronectin aggregation and assembly: the unfolding of the second fibronectin type III domain. 
  • Folding Landscape of Mutant Huntingtin Exon1: Diffusible Multimers, Oligomers and Fibrils, and No Detectable Monomer. 
  • Folding dynamics of phenylalanine hydroxylase depends on the enzyme's metallation state: the native metal, iron, protects against aggregate intermediates. 
  • Folding kinetics of a fluorescent variant of monomeric lambda repressor. 
  • Folding mechanism of a multiple independently-folding domain protein: double B domain of protein A. 
  • Fragility and mechanosensing in a thermalized cytoskeleton model with forced protein unfolding. 
  • Full reconstruction of a vectorial protein folding pathway by atomic force microscopy and molecular dynamics simulations. 
  • Functional expression of Mammalian odorant receptors. 
  • Functions of FKBP12 and mitochondrial cyclophilin active site residues in vitro and in vivo in Saccharomyces cerevisiae. 
  • GRP78: a chaperone with diverse roles beyond the endoplasmic reticulum. 
  • Generalized dead-end elimination algorithms make large-scale protein side-chain structure prediction tractable: implications for protein design and structural genomics. 
  • Genetic, biochemical, and structural studies of biogenesis of adhesive pili in bacteria. 
  • Global analysis of protein folding thermodynamics for disease state characterization. 
  • Global folds of proteins with low densities of NOEs using residual dipolar couplings: application to the 370-residue maltodextrin-binding protein. 
  • Guanidine-induced equilibrium unfolding of a homo-hexameric enzyme 4-oxalocrotonate tautomerase (4-OT). 
  • HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. 
  • Heat and cold denatured states of monomeric lambda repressor are thermodynamically and conformationally equivalent. 
  • How cations change peptide structure. 
  • Hsp90, an unlikely ally in the war on cancer. 
  • Identification of a new locus for autosomal recessive Charcot-Marie-Tooth disease with focally folded myelin on chromosome 11p15. 
  • Identification of a residue critical for maintaining the functional conformation of BPTI. 
  • Identification of the ligand-binding domains of CD22, a member of the immunoglobulin superfamily that uniquely binds a sialic acid-dependent ligand. 
  • Identifying key components of the PrPC-PrPSc replicative interface. 
  • Immune responses to coiled coil supramolecular biomaterials. 
  • Implications for proteasome nuclear localization revealed by the structure of the nuclear proteasome tether protein Cut8. 
  • Improving single molecule force spectroscopy through automated real-time data collection and quantification of experimental conditions. 
  • Incorporation of designed extended chromophores into amphiphilic 4-helix bundle peptides for nonlinear optical biomolecular materials. 
  • Induction of protein secretory pathway is required for systemic acquired resistance. 
  • Inhibition of protein misfolding/aggregation using polyglutamine binding peptide QBP1 as a therapy for the polyglutamine diseases. 
  • Insight into the mechanism of inactivation of ribonucleotide reductase by gemcitabine 5'-diphosphate in the presence or absence of reductant. 
  • Introduction: protein motifs. 
  • Kinetic role of helix caps in protein folding is context-dependent. 
  • Kinetics of thermal unfolding of phenylalanine hydroxylase variants containing different metal cofactors (FeII, CoII, and ZnII) and their isokinetic relationship. 
  • Large-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins Using SILAC-SPROX. 
  • Ligand concentration regulates the pathways of coupled protein folding and binding. 
  • Ligand-induced conformational changes in a thermophilic ribose-binding protein. 
  • Ligation-state hydrogen exchange: coupled binding and folding equilibria in ribonuclease P protein. 
  • Linked folding and anion binding of the Bacillus subtilis ribonuclease P protein. 
  • Localization of a cryptic binding site for tenascin on fibronectin. 
  • Mapping Tertiary Interactions in Protein Folding Reactions: A Novel Mass Spectrometry- and Chemical Synthesis-Based Approach 
  • Mapping staphylococcal nuclease conformation using an EDTA-Fe derivative attached to genetically engineered cysteine residues. 
  • Mass spectrometry as a readout of protein structure and function. 
  • Mass spectrometry- and lysine amidination-based protocol for thermodynamic analysis of protein folding and ligand binding interactions. 
  • Mechanical Stability of a Small, Highly-Luminescent Engineered Protein NanoLuc. 
  • Mechanical Unfolding and Refolding of NanoLuc via Single-Molecule Force Spectroscopy and Computer Simulations. 
  • Mechanical and chemical unfolding of a single protein: a comparison. 
  • Mechanical design of proteins studied by single-molecule force spectroscopy and protein engineering. 
  • Mechanical unfolding intermediates in titin modules. 
  • Mechanical unfolding of an ankyrin repeat protein. 
  • Mechanical unfolding of ubiquitin molecules. 
  • Mechanism of fast protein folding. 
  • Methionine oxidation of monomeric lambda repressor: the denatured state ensemble under nondenaturing conditions. 
  • Microsecond folding dynamics of the F13W G29A mutant of the B domain of staphylococcal protein A by laser-induced temperature jump. 
  • Microsecond protein folding through a compact transition state. 
  • Mitochondria, Oxytocin, and Vasopressin: Unfolding the Inflammatory Protein Response. 
  • Modulating protein structure with fluorous amino acids: increased stability and native-like structure conferred on a 4-helix bundle protein by hexafluoroleucine. 
  • Molecular basis of sulfite oxidase deficiency from the structure of sulfite oxidase. 
  • Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB. 
  • Multifaceted recognition of vertebrate Rev1 by translesion polymerases ζ and κ. 
  • Multiple conformations of PEVK proteins detected by single-molecule techniques. 
  • Multiscale implementation of infinite-swap replica exchange molecular dynamics. 
  • Mutations near amino end of alpha1(I) collagen cause combined osteogenesis imperfecta/Ehlers-Danlos syndrome by interference with N-propeptide processing. 
  • NMR structure note: solution structure of the core domain of MESD that is essential for proper folding of LRP5/6. 
  • NMR studies of structure, hydrogen exchange, and main-chain dynamics in a disrupted-core mutant of thioredoxin. 
  • Nanomechanics of streptavidin hubs for molecular materials. 
  • Nanospring behaviour of ankyrin repeats. 
  • Native fluorescence and mag-indo-1-protein interaction as tools for probing unfolding and refolding sequences of the bovine serum albumin subdomain in the presence of guanidine hydrochloride. 
  • Natural beta-sheet proteins use negative design to avoid edge-to-edge aggregation. 
  • Neuroinflammation in Alzheimer's disease. 
  • Nucleo-cytoplasmic Partitioning of ARF Proteins Controls Auxin Responses in Arabidopsis thaliana. 
  • Order out of disorder: working cycle of an intrinsically unfolded chaperone. 
  • Osmolyte-induced folding of an intrinsically disordered protein: folding mechanism in the absence of ligand. 
  • Painting proteins with covalent labels: what's in the picture? 
  • Parkin is not regulated by the unfolded protein response in human neuroblastoma cells. 
  • Pathogenic Mutations Induce Partial Structural Changes in the Native β-Sheet Structure of Transthyretin and Accelerate Aggregation. 
  • Phosphorylation of RNA polymerase II CTD fragments results in tight binding to the WW domain from the yeast prolyl isomerase Ess1. 
  • Picomole-scale characterization of protein stability and function by quantitative cysteine reactivity. 
  • Piecewise All-Atom SMD Simulations Reveal Key Secondary Structures in Luciferase Unfolding Pathway. 
  • Point mutations alter the mechanical stability of immunoglobulin modules. 
  • Preorganized secondary structure as an important determinant of fast protein folding. 
  • Probing the folded state of fibronectin type III domains in stretched fibrils by measuring buried cysteine accessibility. 
  • Probing the folding and unfolding dynamics of secondary and tertiary structures in a three-helix bundle protein. 
  • Probing the folding intermediate of Bacillus subtilis RNase P protein by nuclear magnetic resonance. 
  • Prokaryotic transcription regulators: more than just the helix-turn-helix motif. 
  • Proline isomerases in microorganisms and small eukaryotes. 
  • Proteasomes activate aggresome disassembly and clearance by producing unanchored ubiquitin chains. 
  • Protein Folding Stability Changes Across the Proteome Reveal Targets of Cu Toxicity in E. coli . 
  • Protein amyloidose misfolding: mechanisms, detection, and pathological implications. 
  • Protein design and folding: template trapping of self-assembled helical bundles. 
  • Protein dynamic studies move to a new time slot. 
  • Protein folding dynamics: quantitative comparison between theory and experiment. 
  • Protein synthesis inhibitors and the chemical chaperone TMAO reverse endoplasmic reticulum perturbation induced by overexpression of the iodide transporter pendrin. 
  • Protein synthesis. The perks of balancing glucose. 
  • Protein-Protein Docking Benchmark 2.0: an update. 
  • Protein-protein docking: overview and performance analysis. 
  • Proteome-Wide Characterization of Phosphorylation-Induced Conformational Changes in Breast Cancer. 
  • Proteome-Wide Structural Biology: An Emerging Field for the Structural Analysis of Proteins on the Proteomic Scale. 
  • Protocol for the thermodynamic analysis of some proteins using an H/D exchange- and mass spectrometry-based technique. 
  • Pseudomonas exotoxin A mutants. Replacement of surface exposed residues in domain II with cysteine residues that can be modified with polyethylene glycol in a site-specific manner. 
  • Quantifying kinetic paths of protein folding. 
  • Quantifying the kinetic paths of flexible biomolecular recognition. 
  • Quantitative proteomics approach for identifying protein-drug interactions in complex mixtures using protein stability measurements. 
  • R73A and H144Q mutants of the yeast mitochondrial cyclophilin Cpr3 exhibit a low prolyl isomerase activity in both peptide and protein-folding assays. 
  • Rapid determination of protein folds using residual dipolar couplings. 
  • Rapid protein global fold determination using ultrasparse sampling, high-dynamic range artifact suppression, and time-shared NOESY. 
  • Reconstruction of mechanical unfolding and refolding pathways of proteins with atomic force spectroscopy and computer simulations. 
  • Regulation of the amino-terminal transcription activation domain of progesterone receptor by a cofactor-induced protein folding mechanism. 
  • Reinterpretation of GCN4-p1 folding kinetics: partial helix formation precedes dimerization in coiled coil folding. 
  • Removal of the pro-domain does not affect the conformation of the procaspase-3 dimer. 
  • Reverse engineering of the giant muscle protein titin. 
  • Reversible inhibition of Hsp70 chaperone function by Scythe and Reaper. 
  • Reversible unfolding of fibronectin type III and immunoglobulin domains provides the structural basis for stretch and elasticity of titin and fibronectin. 
  • SILAC-pulse proteolysis: A mass spectrometry-based method for discovery and cross-validation in proteome-wide studies of ligand binding. 
  • SUPREX (Stability of Unpurified Proteins from Rates of H/D Exchange) analysis of the thermodynamics of synergistic anion binding by ferric-binding protein (FbpA), a bacterial transferrin. 
  • Self-assembling peptide-polymer hydrogels designed from the coiled coil region of fibrin. 
  • Short-lived alpha-helical intermediates in the folding of beta-sheet proteins. 
  • Single molecular force spectroscopy of modular proteins in the nervous system. 
  • Single protein misfolding events captured by atomic force microscopy. 
  • Slow histidine H/D exchange protocol for thermodynamic analysis of protein folding and stability using mass spectrometry. 
  • Solution NMR structure of the N-terminal domain of the human DEK protein. 
  • Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45. 
  • Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase. 
  • Springs and hinges: dynamic coiled coils and discontinuities. 
  • Stability of oxidized Escherichia coli thioredoxin and its dependence on protonation of the aspartic acid residue in the 26 position. 
  • Stability studies on a lipase from Bacillus subtilis in guanidinium chloride. 
  • Stable isotope labeling strategy for protein-ligand binding analysis in multi-component protein mixtures. 
  • Statistical prediction and molecular dynamics simulation. 
  • Steric factors moderate conformational fluidity and contribute to the high proton sensitivity of Root effect hemoglobins. 
  • Stretching single molecules into novel conformations using the atomic force microscope. 
  • Stretching single polysaccharides and proteins using atomic force microscopy. 
  • Stretching single protein molecules: titin is a weird spring. 
  • Structural analysis of semi-specific oligosaccharide recognition by a cellulose-binding protein of thermotoga maritima reveals adaptations for functional diversification of the oligopeptide periplasmic binding protein fold. 
  • Structural and Functional Analyses Reveal Insights into the Molecular Properties of the Escherichia coli Z Ring Stabilizing Protein, ZapC. 
  • Structural basis for ADP-mediated transcriptional regulation by P1 and P7 ParA. 
  • Structural basis for the remarkable stability of Bacillus subtilis lipase (Lip A) at low pH. 
  • Structural biology: Aerial view of the HIV genome. 
  • Structural cues involved in endoplasmic reticulum degradation of G85E and G91R mutant cystic fibrosis transmembrane conductance regulator. 
  • Structural studies of amphiphilic 4-helix bundle peptides incorporating designed extended chromophores for nonlinear optical biomolecular materials. 
  • Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain. 
  • Structure and folding of nascent polypeptide chains during protein translocation in the endoplasmic reticulum. 
  • Structure and stability of monomeric lambda repressor: NMR evidence for two-state folding. 
  • Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity. 
  • Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein. 
  • Structure of the cold- and menthol-sensing ion channel TRPM8. 
  • Structure, binding interface and hydrophobic transitions of Ca2+-loaded calbindin-D(28K). 
  • Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein. 
  • Structures of maintenance of carboxysome distribution Walker-box McdA and McdB adaptor homologs. 
  • Structures of the Escherichia coli transcription activator and regulator of diauxie, XylR: an AraC DNA-binding family member with a LacI/GalR ligand-binding domain. 
  • Structures of the activator of K. pneumonia biofilm formation, MrkH, indicates PilZ domains involved in c-di-GMP and DNA binding. 
  • Submillisecond folding of monomeric lambda repressor. 
  • Sulfite reductase structure at 1.6 A: evolution and catalysis for reduction of inorganic anions. 
  • Systematic solution to homo-oligomeric structures determined by NMR. 
  • Targeted Mass Spectrometry-Based Approach for Protein-Ligand Binding Analyses in Complex Biological Mixtures Using a Phenacyl Bromide Modification Strategy. 
  • Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection. 
  • Targeting phosphorylation of eukaryotic initiation factor-2α to treat human disease. 
  • The Mechanism of HdeA Unfolding and Chaperone Activation. 
  • The activation domain of the MotA transcription factor from bacteriophage T4. 
  • The crystal structure of the collagen-like polypeptide (glycyl-4(R)-hydroxyprolyl-4(R)-hydroxyprolyl)9 at 1.55 A resolution shows up-puckering of the proline ring in the Xaa position. 
  • The cyclophilins. 
  • The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. 
  • The endoplasmic reticulum and neurological diseases. 
  • The energetic contribution of backbone--backbone hydrogen bonds to the thermodynamic stability of a hyperstable P22 Arc repressor mutant. 
  • The energy landscape of a fast-folding protein mapped by Ala-->Gly substitutions. 
  • The hydrophobic core of Escherichia coli thioredoxin shows a high tolerance to nonconservative single amino acid substitutions. 
  • The mechanical stability of ubiquitin is linkage dependent. 
  • The membrane-binding domain of ankyrin contains four independently folded subdomains, each comprised of six ankyrin repeats. 
  • The molecular elasticity of the extracellular matrix protein tenascin. 
  • The other 90% of the protein: assessment beyond the Calphas for CASP8 template-based and high-accuracy models. 
  • The promise and perils of microarray analysis. 
  • The protein backbone makes important contributions to 4-oxalocrotonate tautomerase enzyme catalysis: understanding from theory and experiment. 
  • The role of the specificity-determining loop of the integrin beta subunit I-like domain in autonomous expression, association with the alpha subunit, and ligand binding. 
  • The structural distribution of cooperative interactions in proteins: analysis of the native state ensemble. 
  • The structure of PurR mutant L54M shows an alternative route to DNA kinking. 
  • The study of protein mechanics with the atomic force microscope. 
  • The symmetrical structure of structural maintenance of chromosomes (SMC) and MukB proteins: long, antiparallel coiled coils, folded at a flexible hinge. 
  • The tyrosine corner: a feature of most Greek key beta-barrel proteins. 
  • The yeast Rab GTPase Ypt1 modulates unfolded protein response dynamics by regulating the stability of HAC1 RNA. 
  • Thermodynamic analysis of a molecular chaperone binding to unfolded protein substrates. 
  • Thermodynamic analysis of protein folding and stability using a tryptophan modification protocol. 
  • Thermodynamic analysis of protein stability and ligand binding using a chemical modification- and mass spectrometry-based strategy. 
  • Thermodynamic characterization of the osmolyte- and ligand-folded states of Bacillus subtilis ribonuclease P protein. 
  • Thermodynamic stability measurements on multimeric proteins using a new H/D exchange- and matrix-assisted laser desorption/ionization (MALDI) mass spectrometry-based method. 
  • Total chemical synthesis and biophysical characterization of the minimal isoform of the KChIP2 potassium channel regulatory subunit. 
  • Transient opening of fibronectin type III (FNIII) domains: the interaction of the third FNIII domain of FN with anastellin. 
  • Ubiquitination directly enhances activity of the deubiquitinating enzyme ataxin-3. 
  • Understanding the elasticity of fibronectin fibrils: unfolding strengths of FN-III and GFP domains measured by single molecule force spectroscopy. 
  • Unraveling the stability of polypeptide helices: critical role of van der Waals interactions 
  • Up-regulation of GRP78 and antiapoptotic signaling in murine peritoneal macrophages exposed to insulin. 
  • Variation of molecular alignment as a means of resolving orientational ambiguities in protein structures from dipolar couplings. 
  • Variations in IBD (ACAD8) in children with elevated C4-carnitine detected by tandem mass spectrometry newborn screening. 
  • Vascular smooth muscle cell migration induced by domains of thrombospondin-1 is differentially regulated. 
  • XBP1 (X-Box-Binding Protein-1)-Dependent O-GlcNAcylation Is Neuroprotective in Ischemic Stroke in Young Mice and Its Impairment in Aged Mice Is Rescued by Thiamet-G. 
  • YbiV from Escherichia coli K12 is a HAD phosphatase. 
  • ZDOCK and RDOCK performance in CAPRI rounds 3, 4, and 5. 
• 

  Keywords of People

  • Bennett, Vann, George Barth Geller Distinguished Professor of Molecular Biology, Duke Cancer Institute
  • Erickson, Harold Paul, James B. Duke Distinguished Professor Emeritus, Cell Biology
  • Oas, Terrence Gilbert, Professor of Biochemistry, Biochemistry