Tunica Intima

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  Subject Areas on Research

  • A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. 
  • A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. 
  • A functional polymorphism in the lymphotoxin-alpha gene is associated with carotid artery wall thickness: the Diabetes Heart Study. 
  • A semiautomated ultrasound border detection program that facilitates clinical measurement of ultrasound carotid intima-media thickness. 
  • A20, a modulator of smooth muscle cell proliferation and apoptosis, prevents and induces regression of neointimal hyperplasia. 
  • Acoustic radiation force impulse imaging for noninvasive characterization of carotid artery atherosclerotic plaques: a feasibility study 
  • Activation of vascular smooth muscle cells by TNF and PDGF: overlapping and complementary signal transduction mechanisms. 
  • Adenovirus-mediated intraarterial delivery of PTEN inhibits neointimal hyperplasia. 
  • Advanced lipoprotein testing does not improve identification of subclinical atherosclerosis in young adults: the Bogalusa Heart Study. 
  • An early study on the mechanisms that allow tissue-engineered vascular grafts to resist intimal hyperplasia. 
  • Association between morning blood pressure surge and cardiovascular remodeling in treated elderly hypertensive subjects. 
  • Association of vascular health and neurocognitive performance in overweight adults with high blood pressure. 
  • Associations of carotid artery intima-media thickness (IMT) with risk factors and prevalent cardiovascular disease: comparison of mean common carotid artery IMT with maximum internal carotid artery IMT. 
  • Associations of edge-detected and manual-traced common carotid intima-media thickness measurements with Framingham risk factors: the multi-ethnic study of atherosclerosis. 
  • Atherosclerosis imaging: prognostically useful or merely more of what we know? 
  • CX3CR1 deficiency impairs dendritic cell accumulation in arterial intima and reduces atherosclerotic burden. 
  • Carotid web: an occult mechanism of embolic stroke. 
  • Carotid-wall intima-media thickness and cardiovascular events. 
  • Cerebrovascular risk factors and cerebral hyperintensities among middle-aged and older adults with major depression. 
  • Common carotid artery intima-media thickness progression as a predictor of stroke in multi-ethnic study of atherosclerosis. 
  • Cytokine-induced mobilization of circulating endothelial progenitor cells enhances repair of injured arteries. 
  • Developing aptamers into therapeutics. 
  • Diltiazem preserves direct vasodilator response but fails to suppress intimal proliferation in rat allograft coronary artery disease. 
  • Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia. 
  • Distribution and cross-sectional age-related increases of carotid artery intima-media thickness in young adults: the Bogalusa Heart Study. 
  • Distribution and predictors of carotid intima-media thickness in young adults. 
  • Effect of uniaxial, cyclic stretch on the morphology of monocytes/macrophages in culture. 
  • Enhanced inhibition of neointimal hyperplasia by genetically engineered endothelial progenitor cells. 
  • Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation. 
  • Extracellular matrix remodeling after balloon angioplasty injury in a rabbit model of restenosis. 
  • Focal increases in vascular cell adhesion molecule-1 and intimal macrophages at atherosclerosis-susceptible sites in the rabbit aorta after short-term cholesterol feeding. 
  • Focusing on inflammation in the treatment of atherosclerosis. 
  • G protein signaling and vein graft intimal hyperplasia: reduction of intimal hyperplasia in vein grafts by a Gbetagamma inhibitor suggests a major role of G protein signaling in lesion development. 
  • Gene delivery to aortocoronary saphenous vein grafts in a large animal model of intimal hyperplasia. 
  • Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene. 
  • Genetic engineering of vein grafts resistant to atherosclerosis. 
  • Graft vascular disease after cardiac transplantation and its relationship to mean acute rejection score. 
  • Graft-extrinsic cells predominate in vein graft arterialization. 
  • Heat shock protein 47 : a chaperone for the fibrous cap? 
  • Hemodynamic Parameters and Early Intimal Thickening in Branching Blood Vessels. 
  • Hemodynamic parameters and early intimal thickening in branching blood vessels. 
  • Human umbilical cord blood endothelial progenitor cells decrease vein graft neointimal hyperplasia in SCID mice. 
  • Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation. 
  • Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project. 
  • Inflammation influences vascular remodeling through AT2 receptor expression and signaling. 
  • Inhibition of apoptotic signaling and neointimal hyperplasia by tempol and nitric oxide synthase following vascular injury. 
  • Inhibition of intimal hyperplasia by direct thrombin inhibitors in an animal vein bypass model. 
  • Intima-media thickness and age of first depressive episode. 
  • Irradiation for intimal hyperplasia: implications for peripheral arterial bypass. 
  • Isolation and transplantation of autologous circulating endothelial cells into denuded vessels and prosthetic grafts: implications for cell-based vascular therapy. 
  • Localized delivery of nitric oxide from hydrogels inhibits neointima formation in a rat carotid balloon injury model. 
  • Long-term stabilization of vein graft wall architecture and prolonged resistance to experimental atherosclerosis after E2F decoy oligonucleotide gene therapy. 
  • MR microscopy of the rat carotid artery after balloon injury by using an implanted imaging coil. 
  • Modulation of phosphatidylinositol 3-kinase signaling reduces intimal hyperplasia in aortocoronary saphenous vein grafts. 
  • Neointimal hyperplasia rapidly reaches steady state in a novel murine vein graft model. 
  • Neointimal inflammation and adventitial angiogenesis correlate with severity of cardiac allograft vasculopathy in pediatric recipients. 
  • Nitric oxide-generating hydrogels inhibit neointima formation. 
  • Overcoming Chronic Rejection-Can it B? 
  • Overexpression of G protein-coupled receptor kinase-2 in smooth muscle cells reduces neointimal hyperplasia. 
  • Patient-derived endothelial progenitor cells improve vascular graft patency in a rodent model. 
  • Potential importance of tissue angiotensin-converting enzyme inhibition in preventing neointima formation. 
  • Predictors of carotid intima-media thickness progression in young adults: the Bogalusa Heart Study. 
  • Preliminary observations using optical coherence tomography to assess neointimal coverage of a metal stent in a porcine model. 
  • Premature atherosclerosis in pediatric systemic lupus erythematosus: risk factors for increased carotid intima-media thickness in the atherosclerosis prevention in pediatric lupus erythematosus cohort. 
  • Prevention of ischemically induced neointimal hyperplasia using ex vivo antisense oligodeoxynucleotides. 
  • Pulmonary artery intimal sarcoma mimicking pulmonary thromboembolism: A case report. 
  • Reduction of vascular intimal-medial hyperplasia in polytetrafluoroethylene arteriovenous grafts via expression of an inhibitor of G protein signaling. 
  • Role of prostacyclin in the cardiovascular response to thromboxane A2. 
  • Segment-specific association between plasma homocysteine level and carotid artery intima-media thickness in the Framingham Offspring Study. 
  • Separation of the arterial wall from blood contact using hydrogel barriers reduces intimal thickening after balloon injury in the rat: the roles of medial and luminal factors in arterial healing. 
  • Subclinical atherosclerotic cardiovascular disease and early age-related macular degeneration in a multiracial cohort: the Multiethnic Study of Atherosclerosis. 
  • Systemic arterial expression of matrix metalloproteinases 2 and 9 in acute Kawasaki disease. 
  • Tempol therapy attenuates medial smooth muscle cell apoptosis and neointima formation after balloon catheter injury in carotid artery of diabetic rats. 
  • The PRoject of Ex-vivo Vein graft ENgineering via Transfection IV (PREVENT IV) trial: study rationale, design, and baseline patient characteristics. 
  • The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer. 
  • The effect of heparin after microsurgical repair in traumatically damaged arteries. 
  • The role of hyaluronic acid in atherosclerosis and intimal hyperplasia. 
  • The role of integrins in saphenous vein vascular smooth muscle cell migration. 
  • Transforming growth factor-beta1 antisense treatment of rat vein grafts reduces the accumulation of collagen and increases the accumulation of h-caldesmon. 
  • Transitional features in human atherosclerosis. Intimal thickening, cholesterol clefts, and cell loss in human aortic fatty streaks. 
  • Treatment with rapamycin and mycophenolic acid reduces arterial intimal thickening produced by mechanical injury and allows endothelial replacement. 
  • Tumor necrosis factor receptor-2 signaling attenuates vein graft neointima formation by promoting endothelial recovery. 
  • Vascular age: integrating carotid intima-media thickness measurements with global coronary risk assessment. 
  • Vascular hypertrophy is an early finding in essential hypertension and is related to arterial pressure waveform contour. 
  • Vein graft neointimal hyperplasia is exacerbated by tumor necrosis factor receptor-1 signaling in graft-intrinsic cells. 
  • [Experimental approaches for gene therapy modification of vascular remodeling]. 
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  Keywords of People

  • Alexander, John Hunter Peel, Professor of Medicine, Medicine, Cardiology
  • Milano, Carmelo Alessio, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Surgery, Cardiovascular and Thoracic Surgery